CN117481199A - Premature/low birth weight infant food for promoting growth and development, and preparation method and application thereof - Google Patents

Premature/low birth weight infant food for promoting growth and development, and preparation method and application thereof Download PDF

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Publication number
CN117481199A
CN117481199A CN202311627629.4A CN202311627629A CN117481199A CN 117481199 A CN117481199 A CN 117481199A CN 202311627629 A CN202311627629 A CN 202311627629A CN 117481199 A CN117481199 A CN 117481199A
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Prior art keywords
mct
food
protein
infant
opo
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CN202311627629.4A
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Inventor
李艳杰
李奋昕
闫雅璐
孔小宇
刘彪
司徒文佑
段素芳
吴春梅
王学敏
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Inner Mongolia Yili Industrial Group Co Ltd
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Inner Mongolia Yili Industrial Group Co Ltd
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Priority to CN202311627629.4A priority Critical patent/CN117481199A/en
Publication of CN117481199A publication Critical patent/CN117481199A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/04—Whey; Whey preparations containing non-milk components as source of fats or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/06—Mixtures of whey with milk products or milk components
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/08—Whey; Whey preparations containing other organic additives, e.g. vegetable or animal products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby

Abstract

The invention provides a premature/low birth weight infant food for promoting growth and development, and a preparation method and application thereof. In particular, the present invention provides an infant food product comprising: hydrolyzed protein, medium Chain Triglycerides (MCT), 2-palmitoyl 1, 3-dioleate (OPO structured fat); and the food contains 10-36g/100g protein and 10-30g/100g fat based on the total dry matter content of the food. The food of the invention is particularly suitable for infants with premature birth and/or low birth weight, and can promote growth and development.

Description

Premature/low birth weight infant food for promoting growth and development, and preparation method and application thereof
Technical Field
The invention relates to a premature/low birth weight infant food for promoting growth and development and a preparation method and application thereof, in particular to a premature/low birth weight infant special medical use formula food containing a functional composition and a preparation method and application thereof, wherein the functional composition comprises hydrolyzed protein, medium Chain Triglyceride (MCT) and 1, 3-dioleate 2-palmitic acid triglyceride (OPO structural fat), and the food can promote growth and development.
Background
The field of special medical formula food refers to a formula food which is specially processed and prepared for meeting special requirements of people with limited eating, digestive absorption disorder, metabolic disorder or specific disease states on nutrients or diet.
Birth weight of a newborn is an important indicator for measuring the health of the newborn. Multiple data indicate that birth weight is closely related to postnatal health. The birth weight of premature birth/low birth weight infants is lower than 2500g, the organ function and adaptability of the premature birth/low birth weight infants are poorer than those of full-term infants or normal weight infants, the premature birth/low birth weight infants are populations needing special attention, and the aspects of weight increase, immunity, organs, especially growth and development, digestion and absorption and the like are mainly concerned on growth and development.
Reasonable nutrition support is one of the key links for improving survival rate of premature/low birth weight infants, not only relates to recent growth and disease prognosis, but also directly influences long-term prognosis, and sufficient balanced nutrition is a material basis for ensuring healthy growth of premature/low birth weight infants.
There is a need for a solution to promote growth in the field of preterm/low birth weight infant foods, such as formulas, infant formulas, complementary foods, and nutritional supplements, and there is a lack of special medical use formulas for preterm/low birth weight infants that promote growth.
Disclosure of Invention
It is an object of the present invention to provide an infant food product which promotes the growth and development.
Another object of the present invention is to provide a method for preparing said infant food.
It is a further object of the present invention to provide a related use of said infant food in promoting growth and development.
In one aspect, the present invention provides an infant food product comprising: hydrolyzed protein, medium Chain Triglycerides (MCT), 2-palmitoyl 1, 3-dioleate (OPO structured fat); and the food contains 10-36g/100g protein and 10-30g/100g fat based on the total dry matter content of the food.
According to a specific embodiment of the present invention, the infant food according to the present invention may be milk powder or liquid milk.
In some embodiments of the invention, the infant food of the invention is a special medical use formula for preterm and/or low birth weight infants.
According to some embodiments of the invention, the infant formula of the invention has a mass ratio of hydrolyzed protein, MCT, and OPO structured fat of (0.1-3.6): (0.1-3): 1.
according to some embodiments of the invention, the infant formula of the invention has a mass ratio of hydrolyzed protein, MCT, and OPO structured fat of (0.1-3.2): (0.1-3): 1.
according to some embodiments of the invention, the infant formula of the invention has a mass ratio of hydrolyzed protein, MCT, and OPO structured fat of (0.2-3.2): (0.2-3): 1.
according to some embodiments of the invention, the infant formula of the invention has a mass ratio of hydrolyzed protein, MCT, and OPO structured fat of (0.2-3.0): (0.2-2.8): 1.
according to a specific embodiment of the present invention, the infant food of the present invention may comprise other protein and fat components in addition to the hydrolyzed protein, medium Chain Triglycerides (MCT), 1, 3-dioleate 2-palmitate (OPO structured fat).
According to a specific embodiment of the present invention, in the infant food of the present invention, the hydrolyzed protein is hydrolyzed milk protein or hydrolyzed whey protein. Specifically, the hydrolyzed protein in the invention refers to protein and polypeptide fragments with molecular weight less than 10000 Da. The raw material for providing the hydrolyzed protein of the present invention may be hydrolyzed milk protein powder or hydrolyzed whey protein powder, and preferably, the content of protein and polypeptide fragments having a molecular weight of less than 10000Da in such raw material powder is not less than 30%, preferably not less than 40%. In some embodiments of the invention, the hydrolyzed protein (i.e., proteins and polypeptides having a molecular weight of less than 10000 Da) comprises 10% to 100% of the total protein content in the infant formula; preferably 10% -80%, more preferably 10% -60%.
According to a specific embodiment of the present invention, the raw material for providing protein in the infant food of the present invention may optionally include other protein-based raw materials such as one or more of raw milk, whole milk powder, skim milk powder, whey protein powder, desalted whey powder, etc., in addition to the hydrolyzed protein. The raw milk, whole milk powder, skimmed milk powder, whey protein powder and desalted whey powder can be derived from cow milk or sheep milk.
According to a specific embodiment of the invention, the MCT is a medium chain fatty acid with a carbon chain length of 8-12 in the infant formula of the invention. The source of MCT according to the present invention may be coconut oil, palm oil, MCT oil, and other edible oils that provide MCT. The specific amount of the raw material to be added to provide MCT can be scaled according to the content requirement of MCT and the purity of the raw material in the product of the present invention. In some embodiments of the invention, MCT comprises 1% -40% of the total fat content in the infant food.
According to a specific embodiment of the present invention, the OPO may be provided by an edible oil or fat powder rich in 1, 3-dioleoyl-2-palmitoyl triglyceride, and in general, the content of 1, 3-dioleoyl-2-palmitoyl triglyceride is preferably not less than 40% when the OPO-providing raw material is directly added to the infant food. Since the purity of the OPO structured lipid raw materials currently commercially available, i.e., the content of the 1, 3-dioleoyl-2-palmitic acid triglyceride in the active ingredient varies, usually about 40% -70%, in the present invention, in order to distinguish the 1, 3-dioleoyl-2-palmitic acid triglyceride as an active ingredient from the raw materials thereof, the term "1, 3-dioleoyl-2-palmitic acid triglyceride" or "OPO structured lipid" is used in describing the active ingredient, and the term "raw material for 1, 3-dioleoyl-2-palmitic acid triglyceride" or "raw material for OPO structured lipid" or "OPO structured lipid" is used in describing the food raw material for providing the active ingredient 1, 3-dioleoyl-2-palmitic acid triglyceride ". The specific amount of the raw material for providing the OPO structural fat can be converted according to the content requirement of the OPO structural fat and the purity of the raw material in the product of the invention. In some embodiments of the invention, the OPO structured fat is present in an amount of 1% to 10% of the final infant food product.
According to a specific embodiment of the present invention, the fat-providing raw materials in the infant formula of the present invention may optionally comprise, in addition to the MCT-containing raw materials, OPO-containing raw materials, milk-containing base raw materials, such as raw milk, cream, etc., and optionally vegetable oils, which may include, but are not limited to, one or more of OPO fat, sunflower oil, corn oil, soybean oil, canola oil, coconut oil, palm oil, walnut oil, MCT fat, preferably MCT fat, sunflower oil, corn oil and soybean oil, the addition of these vegetable oils providing on the one hand fat components to the product and on the other hand linoleic acid, while providing alpha-linolenic acid and medium chain triglycerides.
According to a specific embodiment of the present invention, the infant food of the present invention may comprise, in addition to the proteins, fats, other components such as one or more of carbohydrates, vitamins, minerals, DHA, ARA, EPA, nucleotides, arginine, tryptophan, lactoferrin, etc.
According to a specific embodiment of the present invention, the carbohydrate may be derived in part from lactose, in part from non-lactose sources, including but not limited to pregelatinized starch, maltodextrin, solid corn syrup, glucose syrup, and in part from modified starch-based emulsifiers. That is, in the infant food of the present invention, the carbohydrate-providing raw materials include, but are not limited to, raw lactose, an emulsifier, and a pre-hydrolyzed or gelatinized starch substance, in addition to lactose-containing base raw materials.
According to a specific embodiment of the present invention, the raw materials for providing vitamins and minerals in the infant food of the present invention may be a compound nutrient. The compound nutrient is a combination of nutrient components meeting the national standard, and different addition amounts are used according to different formulas. Preferably, the infant food of the present invention can optionally employ any one or any combination of the following compound nutrient components if necessary with the addition of a nutrient. More preferably, the compound nutrient at least comprises compound vitamin, calcium powder and mineral nutrition package, and the dosages of the components are as follows:
1) The compound vitamins comprise the following components in each gram:
taurine: 140-340mg
Vitamin a: 1700-5800. Mu.gRE
Vitamin D:25-70 mug
Vitamin B1:2000-6800 mug
Vitamin B2:3000-6900 mug
Vitamin B6:1700-4000 mug
Vitamin B12:8-20 mug
Vitamin K1:200-700 mug
Vitamin C:0-700mg
Vitamin E:10-70mg alpha-TE
Nicotinamide: 10000-41550 mug
Folic acid: 350-920 μg
Biotin: 70-245 mug
Pantothenic acid: 7100-25230 μg
Inositol: 0-250mg
L-carnitine: 0-60mg
2) Mineral II comprises the following components in each gram of mineral II:
sodium: 40-100mg
Potassium: 200-500mg
3) Minerals three, each gram of minerals three including:
calcium: 200-500mg
Phosphorus: 75-300mg
4) Mineral one, each gram of mineral one comprises:
iron: 20-110mg
Zinc: 23-90mg
Copper: 2000-4180 μg
Iodine: 500-995 μg
Selenium: 0-200 mu g
Manganese: 0-579 mug
5) Each gram of magnesium chloride package comprises:
magnesium: 80-170mg
6) Choline chloride, comprising per gram of choline chloride package:
choline: 300-950mg.
The base material of the compound nutrient is preferably lactose, solid corn syrup or L-sodium ascorbate. The amount of the compound nutrient may be 7-50 parts by weight based on 1000 parts by weight of the infant food of the present invention, such as a formula for special medical use. The compound materials used to provide each nutrient in the nutrient package may have interactions. For example, sulfate can accelerate the oxidative destruction process of vitamins, which can reduce their utilization. Because sulfate occurs in ionic form in aqueous solution, it acts as an oxidizing agent to induce oxidation of vitamins during the oxidation reaction, thereby destroying the vitamin structure. The trace elements have different capacities in oxidation-reduction reaction, and the activities of copper, zinc and iron are strongest, and manganese and selenium are used for times. B vitamins and vitamin C are susceptible to copper ions and vitamin B2 is susceptible to iron ions. To ensure nutrient utilization efficiency, the present invention selects stable nutrient dosage forms, such as: the retinol is selected from retinol acetate, and retinol contains 1 hydroxyl group and 5 double bonds, so that the retinol is very easy to oxidize, but the stability of the retinol is greatly improved under the form of the retinol acetate; vitamin E is selected from tocopheryl acetate, which is also very unstable, but the stability of tocopheryl acetate is much improved; vitamin B1 is thiamine nitrate, and in the existence form of thiamine, the thiamine nitrate is more stable than thiamine hydrochloride; the vitamin C is L-sodium ascorbate.
The above-mentioned compound nutrient component contents of the invention refer to the nutrient component contents of other raw materials for enhancing the addition amount of the nutrient substances, excluding infant foods (particularly when the infant foods are special medical use formulas).
According to some embodiments of the invention, the infant food of the invention comprises, based on 1000 parts by weight of total dry matter of the food:
preferably, the raw materials of the infant food of the present invention may further optionally include one or more of the following raw materials:
more preferably, the raw materials of the infant food comprise the compound nutrients comprising vitamins and minerals, DHA, ARA and nucleotides at the same time. The infant food is a special medical use formula for preterm/low birth weight infants.
The specific dosage of each raw material in the infant food provided by the invention, especially the premature/low birth weight infant formula, is determined on the premise of meeting the requirement of the index of the formula product. In infant formulas, particularly pre-term/low birth weight infant formulas, the product performance indicators not specified or listed in the present invention should be performed in accordance with the national standards of infant formulas or modified milk powder and the specifications of the relevant standards and regulations.
In the infant food provided by the invention, particularly the formula food with special medical application, all raw materials can be obtained commercially, and the raw materials are selected to meet the requirements of relevant standards. In addition, the compound nutrient can also be self-compounded. The invention adopts 'compound' for convenience of expression, and does not mean that all components in the compound are mixed together and then applied. All raw materials should be added and used on the premise of meeting related regulations.
In another aspect, the present invention also provides a method for preparing the infant food, which comprises:
the ratio of hydrolyzed protein, medium Chain Triglyceride (MCT), and 1, 3-dioleate 2-palmitate (OPO structured lipid) is adjusted in the food material so that the mass ratio of hydrolyzed protein, MCT, and OPO structured lipid is preferably (0.1-3.6): (0.1-3): 1, preparing the infant food.
In some embodiments of the invention, the infant food is a milk powder, the milk powder being prepared by a process comprising: the milk powder is prepared by mixing the raw materials containing hydrolyzed protein, medium Chain Triglyceride (MCT) and choline with other raw materials in the formula by adopting a wet method, a dry method or a dry-wet composite production process.
In some embodiments of the invention, the infant food is a special medical use formula for premature/low birth weight infants, the process flow of which essentially comprises: proportioning, homogenizing, concentrating, sterilizing, spray drying and dry mixing to obtain the finished product. Specifically, the preparation method comprises the following steps:
the powder raw materials are metered according to the formula and then added into a powder preparation tank through an air-assisted system;
various powder raw materials in the powder preparation tank are sucked into the vacuum mixing tank through the vacuum system;
after the grease raw materials are dissolved, the grease raw materials are pumped into the mixing tank according to the formula requirement;
dissolving nutrients, and then adding the dissolved nutrients into the mixing tank to obtain mixed feed liquid;
filtering the mixed feed liquid, homogenizing by a homogenizer, concentrating and sterilizing to obtain concentrated feed liquid;
drying and cooling the concentrated feed liquid in a fluidized bed to obtain a dried and cooled powdery material;
and mixing the weighed DHA, ARA and nucleotide with the dried and cooled powdery material in a dry mode uniformly to obtain the product.
The infant food provided by the invention can be a formula food with special medical application, and can be used for synergistically promoting the catch-up growth of premature infants aiming at premature/low birth weight infants.
According to a further aspect of the present invention there is also provided the use of hydrolyzed protein, medium Chain Triglycerides (MCT) and 1, 3-dioleate 2-palmitate (OPO structured fat) for the manufacture of a product for promoting growth and development, wherein the product is an infant food product according to the invention as described hereinbefore, preferably a special medical use formula for premature/low birth weight infants.
According to a specific embodiment of the invention, the promotion of growth and development comprises promotion of weight and/or organ health development of the infant. Preferably, the promoting growth comprises promoting healthy growth of infant weight, heart weight, spleen weight, small intestine weight and/or small intestine length.
In summary, the present invention provides an infant food comprising hydrolyzed protein, medium Chain Triglycerides (MCT) and 1, 3-dioleate 2-palmitate (OPO structured fat), which is particularly suitable for infants with premature and/or low birth weight, and which promotes the growth and development of infants with premature and/or low birth weight.
Drawings
Figure 1 shows initial body weight and final body weight for different groups of experimental animals in an embodiment of the present invention.
Figure 2 shows average daily gain for different groups of experimental animals in an embodiment of the present invention.
FIG. 3 shows milk-to-weight ratios of different groups of experimental animals in an embodiment of the present invention.
Detailed Description
Before the embodiments of the invention are further described, it is to be understood that the invention is not limited in its scope to the specific embodiments described below; it is also to be understood that the terminology used in the examples of the invention is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the invention.
Where numerical ranges are provided in the examples, it is understood that unless otherwise stated herein, both endpoints of each numerical range and any number between the two endpoints are significant both in the numerical range. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, materials used in the embodiments, any methods, devices, and materials of the prior art similar or equivalent to those described in the embodiments of the present invention may be used to practice the present invention according to the knowledge of one skilled in the art and the description of the present invention.
Unless otherwise indicated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all employ techniques conventional in the art.
In an embodiment, the hydrolyzed protein is provided as a material of hydrolyzed whey protein powder, wherein the protein and polypeptide fragments with molecular weight less than 10000Da are not less than 40%. The amount of hydrolyzed protein in the examples is based on the amount of protein and polypeptide fragments having a molecular weight of less than 10000 Da.
In the examples, the source of MCT used was a commercially available conventional MCT oil whose main component was medium chain fatty acids with carbon chain lengths of 8-12.
In the examples, the OPO used was a commercially available conventional OPO.
Example 1 premature/Low birth weight infant formula
This example provides a premature/low birth weight infant formula with the following raw materials composition (about 1000 kg prepared):
310kg of maltodextrin, 240kg of blend oil (containing 35% of MCT and 17% of OPO), 200kg of desalted whey powder, 90kg of hydrolyzed whey protein powder, 85kg of skimmed milk powder, 20kg of alpha-whey protein powder, 10kg of casein and 4kg of phospholipid. Wherein the compound nutrients comprise about 6kg of compound vitamin nutrition package, about 1kg of choline chloride nutrition package, about 19 kg of calcium powder nutrition package, 17kg of sodium potassium nutrition package, about 2kg of mineral nutrition package, about 3.0 kg of magnesium chloride nutrition package, 8.7kg of DHA powder, 15kg of ARA powder and 0.3kg of nucleotide package, and the base material of each nutrition package is lactose.
The preparation process of the preterm/low birth weight infant formula of this example is as follows:
1) Powder adding: the powder raw materials are uniformly added into a powder preparation tank for storage through an air-assisted system after being metered according to the formula;
2) Vacuum powder suction: various powder raw materials in the powder preparation tank are sucked into the vacuum mixing tank through the vacuum system;
3) Melting and oil preparing: placing the grease specified in the formula into a melting tank according to the formula requirement, and pumping the grease into a mixed oil storage tank according to the formula proportion requirement after the grease is melted;
4) And (3) storing the mixed oil: the mixed oil is stored in an oil storage tank in a heat-preserving way;
5) Weighing: pumping the mixed oil into a mixing tank through an oil pump according to the formula requirement;
6) Nutrient dissolution and addition: adding calcium powder, minerals, vitamins, etc., respectively, dissolving with purified water, respectively, adding into wet mixing tank, and flushing adding tank and pipeline with purified water;
7) And (3) filtering: filtering the mixed feed liquid through a filter screen to remove physical impurities possibly carried in the raw materials;
8) Homogenizing: homogenizing the mixed feed liquid by a homogenizer; cooling and storing;
9) And (3) concentrating and sterilizing: double-effect concentration is used during production;
10 Storage of feed liquid, preheating filtration and spray drying: the concentrated feed liquid temporarily exists in a feed liquid balance tank;
11 Drying and cooling the fluidized bed;
12 Dry blending): and uniformly mixing the weighed DHA, ARA, nucleotide and the dried and cooled powdery material in a dry mixer to obtain the product.
The present invention provides a special medical use formula for pre-term/low birth weight infants that synergistically promotes catch-up growth in pre-term infants. Wherein the protein content of the product is 14.5g/100g, the fat content is 25g/100g, the carbohydrate content is 54g/100g, the hydrolyzed protein is 6.8g/100g, the MCT is 8.4g/100g, and the OPO is 4.08g/100g. Wherein the hydrolyzed protein comprises about 46.9% of the total protein content; MCT represents about 33.6% of total fat and OPO represents about 16.3% of total fat content.
Example 2
This example provides an infant food product as a preterm/low birth weight infant formula or as a breast milk fortifier for feeding preterm/low birth weight infants, the raw materials comprising (about 1000 kg prepared):
maltodextrin 65kg, blend oil 180kg (containing MCT 20% and OPO 40%), desalted whey powder 200kg, skim milk powder 150kg, hydrolyzed whey protein powder 340kg, alpha-whey protein powder 20kg, casein 10kg and phospholipid 4kg. Wherein the compound nutrients comprise about 6kg of compound vitamin nutrition package, about 1kg of choline chloride nutrition package, about 19 kg of calcium powder nutrition package, 17kg of sodium potassium nutrition package, about 2kg of mineral nutrition package, about 3.0 kg of magnesium chloride nutrition package, 8.7kg of DHA powder, 15kg of ARA powder and 0.6kg of nucleotide package, and the base material of each nutrition package is lactose.
The infant food of this example was prepared as follows:
1) Powder adding: the powder raw materials are uniformly added into a powder preparation tank for storage through an air-assisted system after being metered according to the formula;
2) Vacuum powder suction: various powder raw materials in the powder preparation tank are sucked into the vacuum mixing tank through the vacuum system;
3) Melting and oil preparing: placing the grease specified in the formula into a melting tank according to the formula requirement, and pumping the grease into a mixed oil storage tank according to the formula proportion requirement after the grease is melted;
4) And (3) storing the mixed oil: the mixed oil is stored in an oil storage tank in a heat-preserving way;
5) Weighing: pumping the mixed oil into a mixing tank through an oil pump according to the formula requirement;
6) Nutrient dissolution and addition: adding calcium powder, minerals, vitamins, etc., respectively, dissolving with purified water, respectively, adding into wet mixing tank, and flushing adding tank and pipeline with purified water;
7) And (3) filtering: filtering the mixed feed liquid through a filter screen to remove physical impurities possibly carried in the raw materials;
8) Homogenizing: homogenizing the mixed feed liquid by a homogenizer;
9) And (3) concentrating and sterilizing: double-effect concentration is used during production;
10 Storage of feed liquid, preheating filtration and spray drying: the concentrated feed liquid temporarily exists in a feed liquid balance tank;
11 Drying and cooling the fluidized bed;
12 Dry blending): and uniformly mixing the weighed DHA, ARA, nucleotide and the dried and cooled powdery material in a dry mixer to obtain the product.
The product of this example may be used as a preterm/low birth weight infant formula or as a breast milk fortifier for feeding preterm/low birth weight infants, which may synergistically promote catch-up growth in preterm infants.
Wherein the protein content of the product is 35g/100g, the fat content is 20g/100g, the carbohydrate content is 38g/100g, the hydrolyzed protein is 25.8g/100g, the MCT is 3.6g/100g, and the OPO is 7.2g/100g, wherein the hydrolyzed protein accounts for 73.7 percent of the total protein content, the MCT accounts for 18 percent of the total fat content, and the OPO accounts for 36 percent of the total fat content.
Example 3
This example provides an infant food product as a preterm/low birth weight infant formula or as a breast milk fortifier for feeding preterm/low birth weight infants, the raw materials comprising (about 1000 kg prepared):
maltodextrin 65kg, blend oil 180kg (containing MCT 20% and OPO 40%), desalted whey powder 200kg, skim milk powder 150kg, hydrolyzed whey protein powder 300kg, alpha-whey protein powder 40kg, casein 30kg and phospholipid 4kg. Wherein the compound nutrients comprise about 6kg of compound vitamin nutrition package, about 1kg of choline chloride nutrition package, about 19 kg of calcium powder nutrition package, 17kg of sodium potassium nutrition package, about 2kg of mineral nutrition package, about 3.0 kg of magnesium chloride nutrition package, 8.7kg of DHA powder, 15kg of ARA powder and 0.6kg of nucleotide package, and the base material of each nutrition package is lactose.
The infant food of this example was prepared as follows:
1) Powder adding: the powder raw materials are uniformly added into a powder preparation tank for storage through an air-assisted system after being metered according to the formula;
2) Vacuum powder suction: various powder raw materials in the powder preparation tank are sucked into the vacuum mixing tank through the vacuum system;
3) Melting and oil preparing: placing the grease specified in the formula into a melting tank according to the formula requirement, and pumping the grease into a mixed oil storage tank according to the formula proportion requirement after the grease is melted;
4) And (3) storing the mixed oil: the mixed oil is stored in an oil storage tank in a heat-preserving way;
5) Weighing: pumping the mixed oil into a mixing tank through an oil pump according to the formula requirement;
6) Nutrient dissolution and addition: adding calcium powder, minerals, vitamins, etc., respectively, dissolving with purified water, respectively, adding into wet mixing tank, and flushing adding tank and pipeline with purified water;
7) And (3) filtering: filtering the mixed feed liquid through a filter screen to remove physical impurities possibly carried in the raw materials;
8) Homogenizing: homogenizing the mixed feed liquid by a homogenizer;
9) And (3) concentrating and sterilizing: double-effect concentration is used during production;
10 Storage of feed liquid, preheating filtration and spray drying: the concentrated feed liquid temporarily exists in a feed liquid balance tank;
11 Drying and cooling the fluidized bed;
12 Dry blending): and uniformly mixing the weighed DHA, ARA, nucleotide and the dried and cooled powdery material in a dry mixer to obtain the product.
The product of this example may be used as a preterm/low birth weight infant formula or as a breast milk fortifier for feeding preterm/low birth weight infants, which may synergistically promote catch-up growth in preterm infants.
Wherein the protein content of the product is 35g/100g, the fat content is 20g/100g, the carbohydrate content is 38g/100g, the hydrolyzed protein is 22.8g/100g, the MCT is 3.6g/100g, and the OPO is 7.2g/100g, wherein the hydrolyzed protein accounts for 65 percent of the total protein content, the MCT accounts for 18 percent of the total fat content, and the OPO accounts for 36 percent of the total fat content.
Example 4 efficacy experiment for promoting growth and development
1 laboratory animals and groups
The experiment selects 3-day-old low birth weight (BW=1.05-1.25 kg) piglets, and according to the principle that average weight is similar, pigs are randomly divided into 6 groups, each group is fed for 7 days, and the weight increase condition of the piglets is observed. 1d before the end of the test, piglets are fasted for 10 hours, weighed on an empty stomach and sacrificed by anesthesia bleeding. After blood collection, all pigs were dissected according to the conventional method and heart, liver and kidney were separated and weighed. The entire intestine was removed, and the entire small intestine portions of the duodenum, jejunum, and ileum were separated, length measured, and weighed.
The food fed by each group was formed as a base meal (piglet meal) without the addition or addition of one or more of hydrolyzed protein, OPO struct fat and MCT, the formulation specific composition being as shown in table 1.
TABLE 1
Note that: vitamins and minerals were added as required by the regulations and the contents in the experimental examples and comparative examples of the present invention were consistent.
2 experimental results
1) Different groups of piglets feed
The weight change of different groups of low weight piglets over the feeding period was followed and the effect of different nutritional compositions on the weight gain of the piglets was assessed (figure 1). The results show that the group of inventive experimental examples 1-3 to which the hydrolyzed protein + OPO + MCT nutritional composition was added had a better weight gain effect than comparative examples 1-3. It has been shown that the addition of only one or two nutritional compositions, such as OPO, or hydrolyzed protein + MCT, does not achieve a weight gain effect similar to the nutritional composition with hydrolyzed protein + OPO + MCT.
The average daily gain of the piglets of the different groups was analyzed and the results were similar to the weight gain (figure 2). The average daily gain of experimental examples 1 to 3 of the present invention was significantly increased as compared with comparative examples 1 to 3. Experimental results show that the hydrolyzed protein+MCT+OPO nutritional composition added in experimental examples 1-3 has the effect of promoting weight gain of piglets compared with comparative example 1 (no hydrolyzed protein+MCT+OPO is added), comparative example 2 (only OPO is added) or comparative example 3 (hydrolyzed protein+MCT is added). The addition of only one or two nutritional compositions, such as OPO, or hydrolyzed protein + MCT, does not achieve a body weight gain promoting effect similar to the nutritional composition with hydrolyzed protein + MCT + OPO.
The milk weight ratio is the ratio of increasing 1kg of body weight to the weight of milk powder to be consumed, and can reflect the utilization efficiency of nutrients in the milk powder. The lower the milk weight ratio, the less milk powder is needed to increase 1kg body weight, the higher the utilization efficiency of nutrients in the milk powder. Experimental examples 1-3 of the present invention have significantly lower milk weight ratios (fig. 3) than comparative example 1, indicating that the addition of hydrolyzed protein + OPO + MCT nutritional composition can significantly improve the utilization efficiency of nutrients in milk powder. Taking the experimental example 1 of the invention as an example, only 1.66kg of the experimental example formula powder of the invention is consumed for every 1kg of body weight. In contrast, 3.32kg of the comparative example 1 formulation was consumed.
The organ index of the test animal is one of the main biological characteristics, and the organ size can also explain the strength of the function to a certain extent. Compared with the comparative examples, the experimental examples of the present invention have significant advantages in terms of promoting weight and length of heart, spleen, small intestine, etc. (Table 2). The results show that the food containing the nutritional composition has advantages in not only promoting growth and catch-up, but also promoting organ development of special infant groups.
TABLE 2 influence of different formulations on organ development
Organ Comparative example 1 Comparative example 2 Comparative example 3
Heart (g) 8.0±0.38b 8.4±0.33b 8.62±0.43b
Spleen (g) 2.56±0.31b 2.66±0.28ab 2.82±0.32ab
Weight of small intestine (g) 71.8±1.63b 72.04±4.22b 82.38±4.88a
Length of small intestine (cm) 334.6±16.98b 373.6±22.1ab 402.2±5.92a
Organ Experimental example 1 of the invention Experimental example 2 of the invention Experimental example 3 of the invention
Heart (g) 9.9±0.58a 9.4±0.51a 10.1±0.44a
Spleen (g) 3.2±0.15a 3.08±0.29a 3.0±0.22a
Weight of small intestine (g) 89.65±4.55a 84.56±4.52a 84.2±3.77a
Length of small intestine (cm) 396.2±13.55a 390.5±5.01a 389.3±14.29a
The previous description of the embodiments is provided to facilitate a person of ordinary skill in the art in order to make and use the present invention. It will be apparent to those skilled in the art that various modifications can be readily made to these embodiments and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the above-described embodiments, and those skilled in the art, based on the present disclosure, should make improvements and modifications without departing from the scope of the present invention.

Claims (10)

1. An infant food product, comprising: hydrolyzed protein, medium Chain Triglycerides (MCT), 2-palmitoyl 1, 3-dioleate (OPO structured fat); and the food contains 10-36g/100g protein and 10-30g/100g fat based on the total dry matter content of the food.
2. Infant food according to claim 1, wherein the mass ratio of hydrolyzed protein, MCT and OPO structured fat is (0.1-3.6): (0.1-3): 1, a step of;
preferably, the mass ratio of hydrolyzed protein, MCT, and OPO structural fat is (0.1-3.2): (0.1-3): 1, a step of;
preferably, the mass ratio of hydrolyzed protein, MCT, and OPO structural fat is (0.2-3.2): (0.2-3): 1, a step of;
more preferably, the mass ratio of hydrolyzed protein, MCT, to OPO structural fat is (0.2-3.0): (0.2-2.8): 1.
3. infant food according to claim 1 or 2, which is milk powder or liquid milk, preferably a special medical use formula for preterm and/or low birth weight infants.
4. A baby food according to any of claims 1-3, wherein:
the hydrolyzed protein accounts for 10% -100% of the total protein content; preferably 10% to 80%, more preferably 10% to 60%;
MCT accounts for 1% -40% of the total fat content;
the OPO structural fat content is 1-10% of the final product.
5. The infant food according to any one of claim 1 to 4, wherein,
the hydrolyzed protein is hydrolyzed milk protein or hydrolyzed whey protein.
6. Infant food according to any one of claims 1-5, which comprises, based on 1000 parts by weight of total dry matter of the food:
preferably, the raw materials of the food product further comprise one or more of the following raw materials:
7. a method of preparing the infant food of any one of claims 1 to 6, the method comprising:
the ratio of hydrolyzed protein, medium Chain Triglyceride (MCT), and 1, 3-dioleate 2-palmitate (OPO structured lipid) is adjusted in the food material so that the mass ratio of hydrolyzed protein, MCT, and OPO structured lipid is preferably (0.1-3.6): (0.1-3): 1, preparing the infant food;
preferably, the infant food is a special medical use formula for preterm and/or low birth weight infants, the method of preparation comprising:
the powder raw materials are metered according to the formula and then added into a powder preparation tank through an air-assisted system;
various powder raw materials in the powder preparation tank are sucked into the vacuum mixing tank through the vacuum system;
after the grease raw materials are dissolved, the grease raw materials are pumped into the mixing tank according to the formula requirement;
dissolving nutrients, and then adding the dissolved nutrients into the mixing tank to obtain mixed feed liquid;
filtering the mixed feed liquid, homogenizing by a homogenizer, concentrating and sterilizing to obtain concentrated feed liquid;
drying and cooling the concentrated feed liquid in a fluidized bed to obtain a dried and cooled powdery material;
and mixing the weighed DHA, ARA and nucleotide with the dried and cooled powdery material in a dry mode uniformly to obtain the product.
8. Use of hydrolyzed protein, medium Chain Triglycerides (MCT), and 1, 3-dioleate 2-palmitate (OPO structured fat) for the preparation of a product for promoting growth and development, wherein the product is an infant food according to any one of claims 1-6.
9. The use of claim 8, wherein the promotion of growth development comprises promotion of infant weight and/or organ health development.
10. The use of claim 9, wherein the promoting growth comprises promoting healthy growth of infant body weight, heart weight, spleen weight, small intestine weight and/or small intestine length.
CN202311627629.4A 2023-11-30 2023-11-30 Premature/low birth weight infant food for promoting growth and development, and preparation method and application thereof Pending CN117481199A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114651967A (en) * 2022-03-23 2022-06-24 浙江科露宝食品有限公司 Infant nutritional supplement with special medical application and preparation method thereof
CN114651967B (en) * 2022-03-23 2024-05-10 浙江科露宝食品有限公司 Infant nutrition supplement for special medical use and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114651967A (en) * 2022-03-23 2022-06-24 浙江科露宝食品有限公司 Infant nutritional supplement with special medical application and preparation method thereof
CN114651967B (en) * 2022-03-23 2024-05-10 浙江科露宝食品有限公司 Infant nutrition supplement for special medical use and preparation method thereof

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