Summary of the invention
In view of this, the technical problem to be solved in the present invention is that providing a kind of suitable for premature labor/low birth weight baby
Edible formula milk and preparation method thereof, the present invention are that premature labor/low birth weight baby design formula milk can be baby
Youngster provides energy and nutritional ingredient.
The present invention provides a kind of formula milks eaten suitable for premature labor/low birth weight baby, with 1000 mass parts
Milk powder meter, by include following mass parts raw material be prepared:
The raw milk of 80~120 mass parts, the mass parts of the raw milk are with solids basis;
The desalted whey powder D90 of 70~110 mass parts;
The concentrated whey protein powder of 60~66 mass parts;
The caseinhydrolysate powder of 64~95 mass parts;
The casein phosphopeptide of 1~5 mass parts;
The maltodextrin of 204~237 mass parts;
The glucose syrup of 102~118.5 mass parts, the mass parts of the glucose syrup are with solids basis;
The polyfructosan of 18~30 mass parts;
The galactooligosaccharide of 8~12 mass parts is starched;
Bis- oleic acid -2- palmitic acid of 1,3-, three ester of 80~110 mass parts;
The medium chain triglyceride of 30~80 mass parts;
The mixing refining vegetable oil of 61~95 mass parts;
Single diglycerine fatty acid ester of 2~6 mass parts;
The phosphatide of 1~3 mass parts;
The vitamin of 7.0~11.0 mass parts;
The minerals of 25.7~32.4 mass parts;
The lutein of 0.12~0.22 mass parts;
The nucleotide of 0.30~0.50 mass parts;
The docosahexaenoic acid powder of 5.0~15.0 mass parts, and DHA effective content is 7wt%;
The arachidonic acid powder of 6.0~18.0 mass parts, and the effective content of ARA is 10wt%;
The lactoferrin of 0.5~6.0 mass parts.
Preferably, in terms of 100g milk powder, the vitamin includes:
The vitamin A of 792~3662 μ gRE;16.7~45.1 μ g vitamin Ds;17.6~49.4mg α-TE vitamin E;
59.5~134.5 μ g vitamin K1s;736~1490 μ g vitamin B1s;1159~3062 μ g vitamin B2s;524~1552 μ g dimension
Raw element B6;1.4~7.4 μ g vitamin B12s;119.6~351.7mg vitamin C;11040~24724 μ g niacinamide;165.6~
444.8 μ g folic acid;4600~9890 μ g pantothenic acid;24.3~182.1 μ g biotins;73.6~250.0mg choline;51.5~
366.2mg inositol;27.6~62.1mg taurine;7.0~50.0mg L-carnitine.
Preferably, in terms of 100g milk powder, the minerals include:
202~521mg sodium;240~621mg phosphorus;320~890mg potassium;38.4~84.8mg magnesium;384~1241mg calcium;
8.0~18.0mg iron;4.8~13.4mg zinc;74.4~289.7 μ g iodine;11.2~44.5 μ g selenium;360~1237 μ g copper;54.4
~500.0 μ g manganese;264~1117mg chlorine.
Preferably, the minerals are by including that mineral substance premix (A) and mineral substance premix (B) are prepared, wherein
The milk powder by include 6.7~8.4 mass parts mineral substance premix (A) and 19.0~24.0 mass parts mineral substance premix
(B) it is prepared, the mineral types in the mineral substance premix (A) include ferric pyrophosphate, zinc sulfate, magnesium sulfate, iodate
Potassium, manganese sulfate, sodium selenite and copper sulphate, mixing are maltodextrin with carrier;Minerals in the mineral substance premix (B)
Type includes tricalcium phosphate, sodium chloride, potassium chloride, potassium dihydrogen phosphate, sodium citrate and calcium carbonate, and mixing is that malt is pasted with carrier
Essence.
Preferably, in the concentrated whey protein powder α-lactalbumin content account for the mass percent of gross protein >=
34%;
The caseinhydrolysate powder degree of hydrolysis representative value is 37%, protein molecular weight distribution in the caseinhydrolysate powder
Typical range is in 2000Da hereinafter, wherein 1000~2000Da accounting 4%, 500~1000Da accounting 10% are less than 500Da
Accounting 86%, middle free fatty acid accounting 13% in the caseinhydrolysate powder.
Preferably, C8:0 fatty acid accounting 60%~70% in the medium chain triglyceride, C10:0 fatty acid accounting 30%
The ratio of~35%, C8:0 and C10:0 are (1.7~2.3): 1.
Preferably, the nucleotide is 5 kinds of nucleotide compounding gained, includes 5'-CMP disodium, 5'-UMP disodium,
5 ' adenosine monophosphate, 5'-inosinic acid disodium and 5'-GMP2Na.
The present invention also provides a kind of preparation sides of above-mentioned formula milk eaten suitable for premature labor/low birth weight baby
Method, comprising the following steps:
A) by maltodextrin, caseinhydrolysate powder, desalted whey powder D90, concentrated whey protein powder, polyfructosan, junket egg
White phosphoeptide investment powder cabin is stand-by, obtains powder cabin powder;
Mineral substance premix (B) is mixed with the water by preheating, obtains the first mixed liquor;
Mineral substance premix (A) is mixed with the water by preheating, obtains the second mixed liquor;
Vitamin premix and the water by preheating are mixed to get third mixed liquor;
By single diglycerine fatty acid ester, phosphatide, bis- oleic acid -2- palmitic acid of 1,3-, three ester, mixing refining vegetable oil and
Medium chain triglyceride is mixed, and the 4th mixed liquor is obtained;
By powder cabin powder, glucose syrup, galactooligosaccharide, the first mixed liquor, the second mixed liquor, third mixed liquor, the 4th
Mixed liquor sucks Vacuum Mixture tank and the raw milk mixing by preheating, obtains mixed material;
Obtained mixed material is successively preheated, homogeneous, cooling is temporary, preheats, sterilizes again, being concentrated by evaporation, is spraying
Dry, fluidized bed redrying, it is cooling, obtain original washing powder;
B) successively the first original washing powder, ARA powder, DHA powder, lactoferrin, nucleotide, lutein and the second original washing powder are put into mixed
It closes and is mixed in equipment, obtain premix;
Successively third original washing powder, premix and the 4th original washing powder are put into and mixed into mixing apparatus, obtains finished product;
It will be packed after finished product gold inspection, obtain being suitable for the formula milk that premature labor/low birth weight baby is eaten;
First original washing powder, the second original washing powder, third original washing powder and the 4th original washing powder total amount be step A) in the base that is prepared
The quality of powder.
Preferably, step A) in, by powder cabin powder, glucose syrup, galactooligosaccharide, the first mixed liquor, the second mixed liquor,
When third mixed liquor and the mixing of the raw milk by preheating, mixed using Vacuum Mixture tank, wherein the Vacuum Mixture tank
Vacuum degree is -0.7~-0.5bar;Mixing temperature is 30~40 DEG C;Incorporation time is 50~70min;Mixing concentration: 30%~
40%.
Preferably, step B) in, preparing the time mixed when premix is 2.5~5min;
When obtaining finished product, the mixed time is 1.5~4min.
Compared with prior art, the present invention provides a kind of formula milks eaten suitable for premature labor/low birth weight baby
Powder is prepared in terms of the milk powder of 1000 mass parts by the raw material for including following mass parts: the raw milk of 80~120 mass parts,
The mass parts of the raw milk are with solids basis;The desalted whey powder D90 of 70~110 mass parts;The concentration of 60~66 mass parts
PURE WHEY;The caseinhydrolysate powder of 64~95 mass parts;The casein phosphopeptide of 1~5 mass parts;204~237 mass parts
Maltodextrin;The glucose syrup of 102~118.5 mass parts, the mass parts of the glucose syrup are with solids basis;18~30 matter
Measure the polyfructosan of part;The galactooligosaccharide of 8~12 mass parts is starched;Bis- oleic acid -2- the palmitinic acid of 1,3- of 80~110 mass parts is sweet
Oily three esters;The medium chain triglyceride of 30~80 mass parts;The mixing refining vegetable oil of 61~95 mass parts;The list of 2~6 mass parts
Diglycerine fatty acid ester;The phosphatide of 1~3 mass parts;The vitamin of 7.0~11.0 mass parts;The mine of 25.7~32.4 mass parts
Substance;The lutein of 0.12~0.22 mass parts;The nucleotide of 0.30~0.50 mass parts;The 20 of 5.0~15.0 mass parts
Two carbon acid powder, it is lactose-free in the docosahexaenoic acid powder, and DHA effective content is 7wt%;6.0~18.0 mass
The arachidonic acid powder of part, the arachidonic acid powder is lactose-free, and the effective content of ARA is 10wt%;0.5~6.0 mass
The lactoferrin of part.The present invention can provide energy and battalion for premature labor/low birth weight baby design formula milk for baby
It forms point.Wherein, reasonable protein combination design has especially selected caseinhydrolysate powder to provide a part of protein, is possible
Albumen azymia or digestion power it is weak caused by upset,gastro-intestinal escort, while α-lactalbumin can provide optimal ammonia
The combination of base acid, is easily digested, and has splendid protein bio utilization rate, and α-lactalbumin tryptophan rich in;
The fat design of optimization: human body can be improved to fatty acid and calcium, magnesium etc. in addition 1,3-Dioleic acid-2-palmitoyl triglyceride
The absorptivity of minerals, while constipation of infantile can also be improved, it reduces calcium soap and is formed, softening stool reduces constipation, increases baby
Youngster's comfort;In addition butterfat+vegetable oil Combination Design can provide the cholesterol of breast milk, be formulated more scientific and reasonable;Addition
Medium chain triglyceride be absorption easy to digest energy source, can be relieved that premature's pancreatic lipase activity is lower, cholic acid and cholate
It is horizontal it is relatively low be difficult to digest long chain triglycerides (LCT) and caused by energy it is insufficient;Promote calcium formula design: the junket being especially added with
Protein phosphatase polypeptide and bis- oleic acid -2- palmitic acid of 1,3-, three ester can remarkably promote absorption of the human gastrointestinal tract to calcium;It is hypotonic
Press determination of formula thoroughly: optimization carbohydrate composition glucose syrup+maltodextrin+lactose combinations design, optimization diet are fine
It ties up Combination Design (galactooligosaccharide+polyfructosan), while adjusting sodium potassium phosphorus nitrogen level to ensure product osmotic pressure.
Specific embodiment
The present invention provides a kind of formula milks eaten suitable for premature labor/low birth weight baby, with 1000 mass parts
Milk powder meter, by include following mass parts raw material be prepared:
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby includes 80~120 mass parts
Raw milk, the mass parts of the raw milk are with solids basis, preferably 90~110 mass parts, more preferably 95~105 mass
Part.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 70~110 mass
The desalted whey powder D90 of part, preferably 80~100 mass parts, more preferably 85~95 mass parts.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 60~66 mass parts
Concentrated whey protein powder, preferably 61~65 mass parts, further preferably 62~64 mass parts.Wherein, the concentrated milk
Albumin powder is rich in α-lactalbumin, and α-lactalbumin content accounts for the quality percentage of gross protein in the concentrated whey protein powder
Than >=34%.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 64~95 mass parts
Caseinhydrolysate powder, preferably 70~90 mass parts, further preferably 75~85 mass parts.The caseinhydrolysate powder water
Solution degree representative value is 37%, and protein molecular weight is distributed typical range in 2000Da hereinafter, wherein 1000~2000Da accounting
4%, 500~1000Da accounting 10% is less than 500Da accounting 86% (wherein free fatty acid accounting 13%);
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 1~5 mass parts
Casein phosphopeptide, preferably 2~4 mass parts, further preferably 2.5~3.5 mass parts.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 204~237 mass
The maltodextrin of part, preferably 210~230 mass parts, further preferably 215~225 mass parts;
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 102~118.5 matter
The glucose syrup of part is measured, the mass parts of the glucose syrup are with solids basis.
In the present invention, lactose is replaced using maltodextrin (DE=12) and glucose syrup, to reduce formula milk infiltration
Pressure, wherein the materials ratio of maltodextrin (DE=12) and glucose syrup (in terms of dry matter) is (1.8~2.2): 1, preferably
(1.9~2.1): 1.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 18~30 mass parts
Polyfructosan, preferably 20~28 mass parts, further preferably 22~26 mass parts.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 8~12 mass parts
Galactooligosaccharide slurry, preferably 9~11 mass parts, further preferably 9.5~10.5 mass parts.
In the present invention, combination of prebiotics uses the combination of galactooligosaccharide and polyfructosan.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 80~110 mass
The 1,3-Dioleic acid-2-palmitoyl triglyceride of part, preferably 95~105 mass parts, further preferably 98~102 mass
Part;
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 30~80 mass parts
Medium chain triglyceride, preferably 40~70 mass parts, further preferably 50~60 mass parts.
C8:0 fatty acid accounting 60%~70% in the medium chain triglyceride, C10:0 fatty acid accounting 30%~35%,
The ratio of C8:0 and C10:0 is (1.7~2.3): 1.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 61~95 mass parts
Mixing refining vegetable oil, preferably 70~90 mass parts, further preferably 75~85 mass parts.Wherein, the mixing essence
Refine two kind or two kind of the vegetable oil in soybean oil, corn oil, high oleic sunflower oil, Canola Oil and sunflower oil
More than.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 2~6 mass parts
Single diglycerine fatty acid ester, preferably 3~5 mass parts, further preferably 3.5~4.5 mass parts;
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 1~3 mass parts
Phosphatide, preferably 1.5~2.5 mass parts, further preferably 1.8~2.2 mass parts;
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 7.0~11.0 matter
Measure the vitamin of part, preferably 8~10 mass parts, further preferably 8.5~10.5 mass parts;The vitamin includes:
The vitamin A of 792~3662 μ gRE;16.7~45.1 μ g vitamin Ds;17.6~49.4mg α-TE vitamin E;
59.5~134.5 μ g vitamin K1s;736~1490 μ g vitamin B1s;1159~3062 μ g vitamin B2s;524~1552 μ g dimension
Raw element B6;1.4~7.4 μ g vitamin B12s;119.6~351.7mg vitamin C;11040~24724 μ g niacinamide;165.6~
444.8 μ g folic acid;4600~9890 μ g pantothenic acid;24.3~182.1 μ g biotins;73.6~250.0mg choline;51.5~
366.2mg inositol;27.6~62.1mg taurine;7.0~50.0mg L-carnitine.
In certain specific embodiments of the invention, the vitamin includes:
The vitamin A of 1000~3000 μ gRE;25~35 μ g vitamin Ds;30~40mg α-TE vitamin E;80~100 μ g
Vitamin K1;1000~1200 μ g vitamin B1s;1800~2500 μ g vitamin B2s;800~1200 μ g vitamin B6s;3~5 μ g
Vitamin B12;200~300mg vitamin C;12000~20000 μ g niacinamide;250~350 μ g folic acid;6000~8000 μ g
Pantothenic acid;50~130 μ g biotins;150~200.0mg choline;150~260mg inositol;35~45mg taurine;20~
35.0mg L-carnitine.
The vitamin is prepared by vitamin premix: concrete composition is referring to table 1
The raw material of 1 vitamin premix of table forms
Vitamin premix optimal proportion is 8.0kg/1000kg milk powder, each monomer per kilogram accounting table as above, if single
The content of body maintains vitamin premix 8.0kg total amount constant, maltodextrin polishing is extremely when ± 15wt% range fluctuates
8.0kg。
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 25.7~32.4 matter
Measure the minerals of part, preferably 26~30 mass parts, further preferably 27~29 mass parts.Wherein, the minerals include:
202~521mg sodium;240~621mg phosphorus;320~890mg potassium;38.4~84.8mg magnesium;384~1241mg calcium;
8.0~18.0mg iron;4.8~13.4mg zinc;74.4~289.7 μ g iodine;11.2~44.5 μ g selenium;360~1237 μ g copper;54.4
~500.0 μ g manganese;264~1117mg chlorine.
In certain specific embodiments of the invention, the minerals include:
300~400mg sodium;400~500mg phosphorus;450~700mg potassium;50~70mg magnesium;500~1000mg calcium;10~
16mg iron;6~12mg zinc;150~200 μ g iodine;20~35 μ g selenium;500~1000 μ g copper;100~400.0 μ g manganese;500~
1000mg chlorine.
The minerals are by including that mineral substance premix (A) and mineral substance premix (B) are prepared, wherein the milk
By including the mineral substance premix (A) of 6.7~8.4 mass parts and the mineral substance premix (B) of 19.0~24.0 mass parts in powder
It is prepared, in certain specific embodiments of the invention, the milk powder is by the mineral substance premix including 7~8 mass parts
(A) it is prepared with the mineral substance premix of 20~23 mass parts (B),
Mineral types in the mineral substance premix (A) include ferric pyrophosphate, zinc sulfate, magnesium sulfate, potassium iodide, sulphur
Sour manganese, sodium selenite and copper sulphate, mixing are maltodextrin with carrier;Mineral types in the mineral substance premix (B)
Including tricalcium phosphate, sodium chloride, potassium chloride, potassium dihydrogen phosphate, sodium citrate and calcium carbonate, mixing is maltodextrin with carrier.
The concrete composition of the mineral substance premix (A) is referring to table 2
The concrete composition of 2 mineral substance premix of table (A)
Mineral substance premix (A) optimal proportion be 7.0kg/1000kg milk powder, each monomer per kilogram accounting table as above, if
The content of monomer maintains 7.0kg total amount constant, maltodextrin polishing to 7.0kg when ± 15wt% range fluctuates.
The concrete composition of the mineral substance premix (B) is referring to table 3
The concrete composition of 3 mineral substance premix of table (B)
Mineral substance premix (B) optimal proportion be 20.0kg/1000kg milk powder, each monomer per kilogram accounting table as above,
If the content of monomer maintains 20.0kg total amount constant, maltodextrin polishing to 20.0kg when ± 15wt% range fluctuates.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 0.12~0.22 matter
Measure the lutein of part, preferably 0.14~0.20 mass parts, further preferably 0.16~0.18 mass parts;
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 0.30~0.50 matter
Measure the nucleotide of part, preferably 0.35~0.45 mass parts, further preferably 0.38~0.42 mass parts;The nucleotide is
5 kinds of nucleotide compounding gained include 5'-CMP disodium, 5'-UMP disodium, 5 ' adenosine monophosphate acid, 5'-inosinic acid two
Sodium and 5'-GMP2Na.
In terms of every gram of nucleotide, comprising: 222.06~283.74mg 5'-CMP disodium is (with cytidylic acid
(CMP) it counts);146.33~186.97mg, 5 ' adenosine monophosphate is sour (in terms of adenylic acid (AMP));152.31~
194.62mg 5'-UMP disodium (in terms of uridylate (UMP));44.37~56.69mg5 '-Sodium guanylate (with
Guanylic acid (GMP) meter);88.32~112.86mg 5'-inosinic acid disodium (in terms of inosinic acid (IMP)).
In certain specific embodiments of the invention, in terms of every gram of nucleotide, comprising: 240~260mg 5'-CMP
Disodium (in terms of cytidylic acid (CMP));160~170mg, 5 ' adenosine monophosphate is sour (in terms of adenylic acid (AMP));
165~180mg 5'-UMP disodium (in terms of uridylate (UMP));48~52mg 5'-GMP2Na is (fast with bird
Purine nucleotide (GMP) meter);95~105mg 5'-inosinic acid disodium (in terms of inosinic acid (IMP)).
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 5.0~15.0 matter
Measure the docosahexaenoic acid powder of part, preferably 7~12 mass parts, further preferably 8~11 mass parts.22 carbon
Lactose-free or lactose content is lower than 0.5% in acid powder, and DHA effective content is 7wt%;The docosahexaenoic acid powder
It is preferably derived from tunny fish oil.
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 6.0~18.0 matter
The arachidonic acid powder of part is measured, the arachidonic acid powder is lactose-free or lactose content is lower than 0.5%, and the effective content of ARA
For 10wt%;
The formula milk provided by the invention eaten suitable for premature labor/low birth weight baby further includes 0.5~6.0 mass
The lactoferrin of part.
In certain specific embodiments of the invention, the formula eaten suitable for premature labor/low birth weight baby
Milk powder, which is characterized in that in terms of the milk powder of 1000 mass parts, be prepared by the raw material for including following mass parts:
The raw milk of 100 mass parts, the mass parts of the raw milk are with solids basis;The desalted whey powder of 90 mass parts
D90;The concentrated whey protein powder of 63 mass parts;The caseinhydrolysate powder of 80 mass parts;The casein phosphopeptide of 3 mass parts;230
The maltodextrin of mass parts;The glucose syrup of 115 mass parts, the mass parts of the glucose syrup are with solids basis;24 mass parts
Polyfructosan;The galactooligosaccharide of 10 mass parts is starched;Bis- oleic acid -2- palmitic acid of 1,3-, three ester of 90 mass parts;75 matter
Measure the medium chain triglyceride of part;The mixing refining vegetable oil of 61 mass parts;Single diglycerine fatty acid ester of 4 mass parts;2 mass parts
Phosphatide;The vitamin of 8 mass parts;The minerals of 27 mass parts;The lutein of 0.18 mass parts;The nucleosides of 0.44 mass parts
Acid;The docosahexaenoic acid powder of 8 mass parts, and DHA effective content is 7wt%;The arachidonic acid powder of 9 mass parts, and ARA
Effective content be 10wt%;The lactoferrin of 0.6 mass parts.
The present invention also provides a kind of preparation sides of above-mentioned formula milk eaten suitable for premature labor/low birth weight baby
Method, comprising the following steps:
A) by maltodextrin, caseinhydrolysate powder, desalted whey powder D90, concentrated whey protein powder, polyfructosan, junket egg
White phosphoeptide investment powder cabin is stand-by, obtains powder cabin powder;
Mineral substance premix (B) is mixed with the water by preheating, obtains the first mixed liquor, wherein water is preheating to 30~
40℃;
Mineral substance premix (A) is mixed with the water by preheating, obtains the second mixed liquor, wherein water is preheating to 30~
40℃;
Vitamin premix and the water by preheating are mixed to get third mixed liquor, wherein water is preheating to 30~40 DEG C;
By single diglycerine fatty acid ester, phosphatide, bis- oleic acid -2- palmitic acid of 1,3-, three ester, mixing refining vegetable oil and
Medium chain triglyceride is mixed, and the 4th mixed liquor is obtained;
By powder cabin powder, glucose syrup, galactooligosaccharide, the first mixed liquor, the second mixed liquor, third mixed liquor, the 4th
Mixed liquor sucks Vacuum Mixture tank and the raw milk mixing by preheating, obtains mixed material, raw milk is preheating to 30~40 DEG C;
By powder cabin powder, glucose syrup, galactooligosaccharide, the first mixed liquor, the second mixed liquor, third mixed liquor, the 4th
When mixed liquor and the mixing of the raw milk by preheating, mixed using Vacuum Mixture tank, wherein the Vacuum Mixture tank vacuum
Degree is -0.7~-0.5bar;Mixing temperature is 30~40 DEG C;Incorporation time is 50~70min;Mixing concentration: 30%~40%.
Obtained mixed material is successively preheated, homogeneous, cooling is temporary, preheats, sterilizes again, being concentrated by evaporation, is spraying
Dry, fluidized bed redrying, it is cooling, obtain original washing powder;
B) successively the first original washing powder, ARA powder, DHA powder, lactoferrin, nucleotide, lutein and the second original washing powder are put into mixed
It closes and is mixed in equipment, obtain premix;
Successively third original washing powder, premix and the 4th original washing powder are put into and mixed into mixing apparatus, obtains finished product;
It will be packed after finished product gold inspection, obtain being suitable for the formula milk that premature labor/low birth weight baby is eaten;
First original washing powder, the second original washing powder, third original washing powder and the 4th original washing powder total amount be step A) in the base that is prepared
The quality of powder.
The method comprises the steps of firstly, preparing original washing powder, method particularly includes:
Vacuum Mixture: by maltodextrin, caseinhydrolysate powder, desalted whey powder D90, concentrated whey protein powder, poly fruit
Sugar, casein phosphopeptide powder cabin are stand-by
Mineral substance premix (B) is mixed with the water by preheating, obtains the first mixed liquor, solid-liquid ratio is 1:20~1:
30;
Mineral substance premix (A) is mixed with the water by preheating, obtains the second mixed liquor, solid-liquid ratio is 1:20~1:
30;
The vitamin premix purified water for being preheating to 30~40 DEG C is dissolved by the amount of 1:20~1:30, it is mixed to obtain third
Close liquid.
Single diglycerine fatty acid ester after accurate measurement, phosphatide and 1,3-, the bis- oleic acid -2- palmitinic acid measured through measuring tank
Triglycerides, mixing refining vegetable oil, medium chain triglyceride mixing, obtain the 4th mixed liquor.
Then raw milk will by examination, cooling, quiet cream, pasteurize, cooling, preheating sucking Vacuum Mixture tank mixing
Powder cabin powder, glucose syrup, galactooligosaccharide, the first mixed liquor, the second mixed liquor, third mixed liquor, the sucking of the 4th mixed liquor
Vacuum Mixture tank mixing
Feed intake completion, and material recycles mixing between Vacuum mixer and mixing tank, until material complies with standard.It is required that throwing
Expect complete, quantity meets the requirements, and material is uniformly mixed, and no feeling of grittiness obtains mixed material.
Wherein, the Vacuum Mixture tank vacuum degree is -0.7~-0.5bar;Mixing temperature is 30~40 DEG C;Incorporation time
For 50~70min;Mixing concentration: 30~40%.
Then obtained mixed material is successively preheated, homogeneous, preheats, sterilize again, being concentrated by evaporation, being spray-dried,
Fluidized bed redrying, it is cooling, obtain original washing powder.
Wherein, after the mixed material mixed being preheating to 60~65 DEG C using plate heat exchanger, second level is carried out to feed liquid
Homogeneous, make material liquid component mixing more evenly, fine and smooth, homogenization pressure: two-stage homogeneous, level-one homogenization pressure 200bar, double-stage homogenization
Pressure 50bar, homogenizing temperature: 60~70 DEG C.
Pass through after the completion of homogeneous plate heat exchanger to feed liquid carry out it is cooling squeeze into feed liquid temporary storage tank and keep in, keep in temperature
Degree: it≤8 DEG C, temporary storage time :≤8 hours, is stirred at low speed during temporary using big paddle.
50~55 DEG C are preheating to mixed liquor after ingredient water, homogeneous with heat-exchangers of the plate type, utilizes the steaming flashed after sterilization
Vapour directly sprays rapidly pre-warming to 80~85 DEG C, total preheating time≤1min;
Feed liquid after preheating directly sprays sterilization through DSI steam, and flash tank flash distillation is directly entered after sterilization, is cooled down rapidly.
Sterilization temperature: 100~120 DEG C;Sterilizing time: >=5S.
Feed liquid after flash distillation is evaporated concentration by entering automatic falling film evaporator after the filtering of line duplex strainer;It is dense
Concentration 50~55% after contracting;
Spray drying: air is filtered, is heated to be 140~180 DEG C of hot wind, and hot wind, which is passed through into air sparger, enters drying
Dense milk droplet is dried in tower, is dispersed by adjusting the control such as drying tower angle of gun product moisture, loose density, particle
Degree reaches requirement.
Fixed fluidized bed redrying: the dry milk powder of drying tower enters fixed fluidized bed to by carrying out redrying;
Drying air temperature: 40~75 DEG C;
Vibrated fluidized bed is cooling: vibrated fluidized bed cools down milk powder, and in favor of packing, storing, vibrated bed goes out powder temperature
Degree: 24~39 DEG C.
(25kg/ bags, PE bags of internal layer, outer kraft paper bag) are packed after gold inspection to the original washing powder after production.
Then, the preparation of finished product is carried out, method particularly includes:
Ingredient is carried out in strict accordance with factory formula, is weighed, and blending process is it is ensured that material weighing precision and recipe requirements one
It causes, needs to be identified the title, specification, date etc. of material after weighing.The metering of various ingredients is adopted in negative pressure weighing room
Manually accurate weighing (accuracy should meet recipe requirements);
It feeds intake, be sieved: being checked, fed intake, be sieved by recipe requirements;
Then, successively the first original washing powder, ARA powder, DHA powder, lactoferrin, nucleotide, lutein and the second original washing powder are put into
It is mixed into mixing apparatus, obtains premix.2.5~5min of incorporation time;
Then successively third original washing powder, premix and the 4th original washing powder are put into and is mixed into mixing apparatus, obtained into
Product;1.5~4min of incorporation time;
The finished product materials mixed are delivered under the action of end-filtration compressed air by conveyance conduit pressurized seal
Finished bin keeps in use to be packaged.Temporary storage time of the finished product materials in powder cabin :≤for 24 hours;
Finished product materials to be packaged will carry out metal detection before entering baling line from finished bin.
Wherein, the detection limit of metal detecting apparatus are as follows:
304 stainless steel detection limits: 1.5mm;
Non-ferric detection limit: 1.0mm;
Iron detection limit: 0.7mm.
After the completion of gold inspection, finished product materials pass through automatic measuring packing equipment package, remaining oxygen≤3.0%;
Process flow is referring to Fig. 1 and Fig. 2.Fig. 1 is the process flow chart that the present invention prepares original washing powder;Fig. 2 is present invention preparation
The process flow chart of formula milk.
This invention address that using wet-dry change combination process produce it is a kind of suitable for premature labor/low birth weight baby eat
Formula milk and preparation method thereof-is sweet with raw milk, refining vegetable oil, medium chain triglyceride, bis- oleic acid -2- palmitinic acid of 1,3-
Oily three esters, glucose syrup, maltodextrin, desalted whey powder (D90), hydrolyzing lactoalbumin powder, concentrated whey protein powder, casein
Phosphoeptide, vitamin premix packet, mineral substance premix packet, calcium phosphorus sodium potassium premix packet, polyfructosan, galactooligosaccharide etc. are
Raw material is produced through wet processing, afterwards by dry process add arachidonic acid powder (ARA), docosahexaenoic acid powder (DHA),
Lactoferrin, nucleotide, lutein produce a kind of suitable for premature labor/low birth weight baby pursuit property growth one kind
Formula milk.
The present invention for the formula milk of premature labor/low birth weight baby design can be provided for baby energy and nutrition at
Point.Wherein, reasonable protein combination design has especially selected caseinhydrolysate powder to provide a part of protein, is possible egg
Upset,gastro-intestinal escorts caused by white azymia or digestion power are weak, while α-lactalbumin can provide optimal amino acid
Combination, is easily digested, and has splendid protein bio utilization rate, and α-lactalbumin tryptophan rich in;Optimization
Fat design: addition 1,3-Dioleic acid-2-palmitoyl triglyceride, human body can be improved to the mineral such as fatty acid and calcium, magnesium
The absorptivity of matter, while constipation of infantile can also be improved, it reduces calcium soap and is formed, softening stool reduces constipation, increases baby and relaxes
Adaptive;In addition butterfat+vegetable oil Combination Design can provide the cholesterol of breast milk, be formulated more scientific and reasonable;In addition
Chain triglyceride is the energy source of absorption easy to digest, can be relieved that premature's pancreatic lipase activity is lower, the level of cholic acid and cholate
It is relatively low be difficult to digest long chain triglycerides (LCT) and caused by energy it is insufficient;Promote calcium formula design: the casein being especially added with
Phosphoeptide and bis- oleic acid -2- palmitic acid of 1,3-, three ester can remarkably promote absorption of the human gastrointestinal tract to calcium;Hyposmolality
Determination of formula: optimization carbohydrate composition glucose syrup+maltodextrin+lactose combinations design optimizes dietary fiber group
Design (galactooligosaccharide+polyfructosan) is closed, while adjusting sodium potassium phosphorus nitrogen level to ensure product osmotic pressure.
For a further understanding of the present invention, it is suitable for premature labor/low raw body out to provided by the invention below with reference to embodiment
The formula milk and preparation method thereof of weight consumption by infants is illustrated, and protection scope of the present invention is not by the limit of following embodiment
System.
Embodiment 4
1, it is formulated, specific dosage is shown in Table 7
7 milk formula table of table
2, preparation process
Original washing powder is prepared first, method particularly includes:
By maltodextrin, caseinhydrolysate powder, desalted whey powder (D90), concentrated whey protein powder, polyfructosan, junket egg
White phosphoeptide investment powder cabin is stand-by
Then, mineral substance premix (B) is mixed with by the water for being preheated to 35 DEG C according to mass ratio 1:25, obtains first
Mixed liquor;
Mineral substance premix (A) is mixed with by the water for being preheated to 35 DEG C according to mass ratio 1:25, the second mixing is obtained
Liquid;
By the amount dissolution of the vitamin premix purified water 1:25 in mass ratio for being preheating to 35 DEG C, third mixing is obtained
Liquid.
Single diglycerine fatty acid ester after accurate measurement, phosphatide and 1,3-, the bis- oleic acid -2- palmitinic acid measured through measuring tank
Triglycerides, mixing refining vegetable oil, medium chain triglyceride mixing, obtain the 4th mixed liquor.
Then raw milk will by examination, cooling, quiet cream, pasteurize, cooling, preheating sucking Vacuum Mixture tank mixing
Powder cabin powder, glucose syrup, galactooligosaccharide, the first mixed liquor, the second mixed liquor, third mixed liquor, the sucking of the 4th mixed liquor
Vacuum Mixture tank mixing
Feed intake completion, and material recycles mixing between Vacuum mixer and mixing tank, until material complies with standard.It is required that throwing
Expect complete, quantity meets the requirements, and material is uniformly mixed, and no feeling of grittiness obtains mixed material.
Wherein, the Vacuum Mixture tank vacuum degree is -0.6bar;Mixing temperature is 35 DEG C;Incorporation time is 60min;It is mixed
Material concentration: 35%.
Then obtained mixed material is successively preheated, homogeneous, preheats, sterilize again, being concentrated by evaporation, being spray-dried,
Fluidized bed redrying, it is cooling, obtain original washing powder.
Wherein, after the mixed material mixed being preheating to 60~65 DEG C using plate heat exchanger, second level is carried out to feed liquid
Homogeneous, make material liquid component mixing more evenly, fine and smooth, homogenization pressure: two-stage homogeneous, level-one homogenization pressure 200bar, double-stage homogenization
Pressure 50bar, homogenizing temperature: 65 DEG C.
Pass through after the completion of homogeneous plate heat exchanger to feed liquid carry out it is cooling squeeze into feed liquid temporary storage tank and keep in, keep in temperature
Degree: it≤8 DEG C, temporary storage time :≤8 hours, is stirred at low speed during temporary using big paddle.
53 DEG C are preheating to mixed liquor after ingredient water, homogeneous with heat-exchangers of the plate type, it is straight using the steam flashed after sterilization
Injection rapidly pre-warming is connect to 83 DEG C, total preheating time≤1min;
Feed liquid after preheating directly sprays sterilization through DSI steam, and flash tank flash distillation is directly entered after sterilization, is cooled down rapidly.
Sterilization temperature: 110 DEG C;Sterilizing time: >=5S.
Feed liquid after flash distillation is evaporated concentration by entering automatic falling film evaporator after the filtering of line duplex strainer;It is dense
Concentration 53% after contracting;
Spray drying: air is filtered, is heated to be 165 DEG C of hot wind, and hot wind, which is passed through into air sparger, enters drying tower, right
Dense milk droplet is dried, and is reached by adjusting the control such as drying tower angle of gun product moisture, loose density, particle dispersion
It is required that.
Fixed fluidized bed redrying: the dry milk powder of drying tower enters fixed fluidized bed to by carrying out redrying;
Drying air temperature: 63 DEG C;
Vibrated fluidized bed is cooling: vibrated fluidized bed cools down milk powder, and in favor of packing, storing, vibrated bed goes out powder temperature
Degree: 30 DEG C.
(25kg/ bags, PE bags of internal layer, outer kraft paper bag) are packed after gold inspection to the original washing powder after production.
Then, the preparation of finished product is carried out, method particularly includes:
Ingredient is carried out in strict accordance with factory formula, is weighed, and blending process is it is ensured that material weighing precision and recipe requirements one
It causes, needs to be identified the title, specification, date etc. of material after weighing.The metering of various ingredients is adopted in negative pressure weighing room
Manually accurate weighing (accuracy should meet recipe requirements);
It feeds intake, be sieved: being checked, fed intake, be sieved by recipe requirements;
Then, successively the first original washing powder, ARA powder, DHA powder, lactoferrin, nucleotide, lutein and the second original washing powder are put into
It is mixed into mixing apparatus, obtains premix.Incorporation time 3min;
Then successively third original washing powder, premix and the 4th original washing powder are put into and is mixed into mixing apparatus, obtained into
Product;Incorporation time 2min;
The finished product materials mixed are delivered under the action of end-filtration compressed air by conveyance conduit pressurized seal
Finished bin keeps in use to be packaged.Temporary storage time of the finished product materials in powder cabin :≤for 24 hours;
Finished product materials to be packaged will carry out metal detection before entering baling line from finished bin.
Wherein, the detection limit of metal detecting apparatus are as follows:
304 stainless steel detection limits: 1.5mm;
Non-ferric detection limit: 1.0mm;
Iron detection limit: 0.7mm.
After the completion of gold inspection, finished product materials pass through automatic measuring packing equipment package, remaining oxygen≤3.0%.
3, product is detected, the results are shown in Table 8
Table 8
In table 2, osmotic pressure is obtained using calculating method: the reference standard STANDARD 2.9.1 INFANT new from Australia
FORMULA PRODUCTS, formula are as follows:
The present invention is converted calculation method, specific formula is as follows:
MOsm/kg=[Na (mg/100g)/23+Cl (mg/100g)/35+K (mg/100g)/39+P (mg/100g)/31+
Protein (mg/100g)/6.25/28] * 1.62 (1L standard reconstitutes in liquid containing 162g milk powder in invention.)
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.