CN108294112A - Optimize the babies ' formula milk powder and preparation method thereof of protein and amino acid pattern - Google Patents

Optimize the babies ' formula milk powder and preparation method thereof of protein and amino acid pattern Download PDF

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Publication number
CN108294112A
CN108294112A CN201810030796.3A CN201810030796A CN108294112A CN 108294112 A CN108294112 A CN 108294112A CN 201810030796 A CN201810030796 A CN 201810030796A CN 108294112 A CN108294112 A CN 108294112A
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milk powder
babies
amino acid
formula milk
protein
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CN108294112B (en
Inventor
逄金柱
刘正东
米丽娟
房洪涛
王怀勇
李菊芳
裴晨红
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Ashley International Infant Nutrition Co Ltd
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Ashley International Infant Nutrition Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/16Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1522Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1526Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1528Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/158Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics

Abstract

The present invention relates to a kind of babies ' formula milk powders and preparation method thereof of optimization protein and amino acid pattern.The babies ' formula milk powder, by weight percentage, including the following raw material component:Desalted whey powder, vegetable oil, skimmed milk powder, lactose, alpha-lactalbumin, minerals, vitamin, L cystines, L tyrosine, L leucines, L histidines, L phenylalanines, 1,3 two oleic acid, 2 palmitic acid, three ester, other functional components and probiotics.The babies ' formula milk powder is relatively beneficial to the growth and development of infant compared with existing formula milk, so that the intestinal flora of baby is distinguished situation closer to breast-feeding, contributes to the intestinal health of infant.

Description

Optimize the babies ' formula milk powder and preparation method thereof of protein and amino acid pattern
Technical field
The present invention relates to milk powder, a kind of babies ' formula milk powder more particularly to optimization protein and amino acid pattern and its Preparation method.
Background technology
Breast milk is considered as the optimal food of baby, and the protein requirement of baby is with the good mother of nutritional status The requirement of feeding infant is weighed as standard.The composition pattern of protein and amino acid is considered being most suitable for baby in breast milk Needs, contained by protein be influence the vital nutrient of infants growth and development, conjunction can not only be provided for baby At the required amino acid of oneself protein matter, also help baby resist pathogenic bacteria invasion, promote intestinal beneficial flora growth, Establish intestine immunity environment and promote gut maturation etc. plays a significant role, and provides sufficient nutrition to meet baby's physique The needs of growth and development are also rich in multiple biological activities ingredient, promote reaching maturity for the systems such as baby intestinal, nerve, immune.
Babies ' formula milk powder refers to 1 section of formula powder (the 0-6 monthly age), is main former with cow's milk (sheep breast) and its fabricated product Material, is added what suitable vitamin, minerals and other auxiliary materials were process, but the various magnanimities and micronutrient of breast milk Though all have from content or composition with cow's milk it is dramatically different, and some of which variability issues still fail to It is addressed in square milk powder, existing babies ' formula milk powder is caused to be difficult to obtain and match in excellence or beauty breast milk to the side of the growth and development of infant The problem of helping, especially leading to the intestinal health aspect of infant.
Invention content
Based on this, it is necessary to provide a kind of babies ' formula milk powder of optimization protein and amino acid pattern.The infant formula Milk powder is relatively beneficial to the growth and development of infant compared with existing formula milk, and the intestinal flora of baby can be made to be distributed feelings Condition contributes to the intestinal health of infant closer to breast-feeding.
A kind of babies ' formula milk powder of optimization protein and amino acid pattern, by weight percentage, including the following raw material Component:
Desalted whey powder 23-43%
Vegetable oil 16-30%
Skimmed milk powder 11-20%
Lactose 11-18%
α-lactalbumin 1.4-4.3%
Minerals 0.87-1.06%
Vitamin 0.11-0.13%
L-cysteine 0.028-0.085%
L-tyrosine 0.02-0.06%
L-Leu 0.02-0.06%
L-Histidine 0.015-0.045%
L-phenylalanine 0.0025-0.075%
Bis- oleic acid 2- palmitic acids of 1,3-, three ester 2.6-4.9%
Other functional components 4.59-8.84%,
And probiotics, the additive amount of the probiotics be make the viable count in the babies ' formula milk powder be no less than 1 × 106CFU/g (in terms of every gram of babies ' formula milk powder).
The babies ' formula milk powder in one of the embodiments, by weight percentage, including the following raw material group Point:
Desalted whey powder 28-38%
Vegetable oil 20-27%
Skimmed milk powder 13-18%
Lactose 12-16%
α-lactalbumin 2.78-2.94%
Minerals 0.92-1.01%
Vitamin 0.111-0.123%
L-cysteine 0.048-0.065%
L-tyrosine 0.034-0.046%
L-Leu 0.034-0.046%
L-Histidine 0.025-0.034%
L-phenylalanine 0.0043-0.057%
Bis- oleic acid 2- palmitic acids of 1,3-, three ester 3.0-4.3%
Other functional components 5.72-7.82%,
And probiotics, the additive amount of the probiotics be make the viable count in the babies ' formula milk powder be no less than 1 × 106CFU/g (in terms of every gram of babies ' formula milk powder).
The vitamin includes liposoluble vitamin and water soluble vitamin in one of the embodiments,;
The liposoluble vitamin includes axerophtholum aceticum, vitamine D3, dl- α-D-α-tocopherol acetate and phytondione; The water soluble vitamin includes L-AA, L-AA sodium, thiamine hydrochloride, riboflavin, puridoxine hydrochloride, cyanogen cobalt Amine, folic acid, niacinamide, D-VB5 calcium and D-Biotin.
In one of the embodiments, by weight percentage (accounting in the vitamin), the vitamin packet It includes:Liposoluble vitamin:Axerophtholum aceticum 0.76-0.84%, vitamine D3 0.009-0.01%, dl- α-D-α-tocopherol acetates 8.5-9.4%, phytondione 1.16-1.28%;Water soluble vitamin:L-AA 41.8-46.2%, L-AA Sodium 29.2-32.3%, thiamine hydrochloride 0.65-0.72%, riboflavin 5.2-5.7%, puridoxine hydrochloride 0.32-0.35%, cyanogen Cobalt amine 0.12-0.13%, folic acid 1.04-1.15%, niacinamide 3.4-3.8%, D-VB5 calcium 2.9-3.2%, D-Biotin 0.011-0.013%.
The probiotics is animal bifidobacteria Bb-12 in one of the embodiments,.
In one of the embodiments, the vegetable oil include sunflower oil, coconut oil, corn oil, Canola Oil, Soybean oil, phosphatide, mixed tocopherol concentrate and ascorbyl palmitate.
In one of the embodiments, by weight percentage (accounting in the vegetable oil), the vegetable oil packet Include sunflower oil 32.1-39.2%, coconut oil 20.5-25%, corn oil 14.3-17.4%, Canola Oil 12.5- 15.2%, soybean oil 9.8-12%, phosphatidase 0 .89-1.09%, mixed tocopherol concentrate 0.022-0.027%, ascorbic acid Palmitate 0.01-0.012%.
The minerals include calcium carbonate, potassium chloride, sodium citrate, magnesium sulfate, sulfuric acid Asia in one of the embodiments, Iron, zinc sulfate, copper sulphate, manganese sulfate, potassium iodide and sodium selenite.
In one of the embodiments, by weight percentage (accounting in the minerals), the minerals packet Include calcium carbonate 31.3-34.6%, potassium chloride 25.6-28.3%, sodium citrate 21.6-23.9%, magnesium sulfate 11.8-13%, sulphur Sour ferrous iron 2.9-3.3%, zinc sulfate 1.6-1.8%, copper sulphate 0.039-0.043%, manganese sulfate 0.013-0.015%, iodate Potassium 0.013-0.014%, sodium selenite 0.125-0.139%.
In one of the embodiments, the functional components include galactooligosaccharide slurry, it is eicosatetraenoic acid (AA), low In Fructooligosaccharides, docosahexaenoic acid (DHA), choline chloride, l-cn, inositol, nucleotide, taurine, lutein extremely Few one kind.
In one of the embodiments, in terms of the weight percent for accounting for the raw material components, other functional components Including following component:
Galactooligosaccharide starches 3.9-7.3%
Eicosatetraenoic acid 0.2-0.5%
Oligofructose 0.2-0.4%
Docosahexaenoic acid 0.1-0.25%
Choline chloride 0.05-0.15%
L-cn 0.07-0.09%
Inositol 0.03-0.05%
Nucleotide 0.02-0.05%
Taurine 0.02-0.05%
Lutein 0.001-0.003%.
The nucleotide includes 5' adenosine monophosphate, 5'-inosinic acid disodium, 5'- guanylic acids in one of the embodiments, Disodium, uridine 5'-monophosphate disodium and 5'-CMP disodium.
In one of the embodiments, by weight percentage (accounting in the nucleotide), the nucleotide packet It includes:5' adenosine monophosphate 19.3-21.3%, 5'-inosinic acid disodium 33.3-36.8%, 5'- Sodium guanylate 6.6-7.2%, Uridine 5'-monophosphate disodium 22.8-25.2% and 5'-CMP disodium 13.1-14.5%.
The present invention also provides the preparation methods of the optimization protein and the babies ' formula milk powder of amino acid pattern, including Following steps:
The desalted whey powder, skimmed milk powder, lactose and α-lactalbumin are added into 55-65 DEG C of hot water, maintained The temperature of gained mixture is 60-70 DEG C, obtains mixture A;
It is added into the mixture A, obtains mixed after the vegetable oil, 1,3-Dioleic acid 2-palmitoyl triglyceride are mixed Close object B;
Homogenization is carried out to the mixture B, is subsequently cooled to temperature≤6 DEG C;Add the minerals, dimension life Element obtains mixture C;
The mixture C is dry after sterilizing, concentrating, is sieved, and obtains original washing powder;
Be added in the original washing powder l-cysteine, l-tyrosine, L-Leu, L-Histidine, L-phenylalanine with And the pre-composition of the probiotics, mixing, you can.
In the preparation process in accordance with the present invention, the property of the visual raw material of other functional components is reasonable in above-mentioned steps It is added.
The preparation method includes the following steps in one of the embodiments,:
The desalted whey powder, skimmed milk powder, lactose and α-lactalbumin are added into 55-65 DEG C of hot water, maintained The temperature of gained mixture is 60-70 DEG C, obtains mixture A;
It is added into the mixture A, obtains mixed after the vegetable oil, 1,3-Dioleic acid 2-palmitoyl triglyceride are mixed Close object B;
Homogenization is carried out to the mixture B, is subsequently cooled to temperature≤6 DEG C;Add the minerals, dimension life Element, galactooligosaccharide slurry, oligofructose, choline chloride, l-cn, inositol, nucleotide, taurine, lutein, obtain mixture C;
The mixture C is dry after sterilizing, concentrating, is sieved, and obtains original washing powder;
The docosahexaenoic acid (DHA), eicosatetraenoic acid (AA), l-cysteine, L- are added in the original washing powder Tyrosine, L-Leu, L-Histidine, L-phenylalanine and the pre-composition of the probiotics, mixing, you can.
The principle of the present invention and advantage are as follows:
The present invention by a large amount of experimental studies have found that, the required ammonia of baby below traditional 6 monthly age of babies ' formula milk powder pair Base acid recommended intake is calculated based on breast milk mean intake, but these recommended intakes only account for the different food in one's mouths The variation of protein intake in newborn stage breast milk, without consider different lactation stage lactalbumin/casein ratios and The variation of Amino acid profile.Although the ratio between lactalbumin and casein in traditional babies ' formula milk powder become closer to mother Breast, but the beta lactoglobulin (being free of in breast milk) in formula milk is still most important lactalbumin in formula milk, and α-breast Then content is relatively low for albumin (major protein in breast milk).Exactly because and in breast milk and cow's milk albumen constitute difference, make two The specific composition of person's amino acid is not quite similar, and then results in the promotion that traditional babies ' formula milk powder fails to reach ideal The growth and development of infant and the effect of intestinal health.
In addition, the present invention also found in babies ' formula milk powder R&D process:When meeting infant to essential amino acid When demand, often the content of protein is excessively high compared with breast milk, and extra amino acid load must pass through kidney by dissimilation Dirty to be discharged with urine, to aggravate kidney burden, this is also the mistaken ideas place of traditional babies ' formula milk powder;And reduce albumen Content to it is close with breast milk when, part must the content of amino acid cannot then meet, such as tryptophan.
Based on this, the babies ' formula milk powder of optimization protein and amino acid pattern of the invention, by adding certain Guang ammonia The single amino acids such as acid, l-tyrosine, L-Histidine, L-Leu and nucleotide, to the amino acid and total protein in formula Matter content is adjusted, and while ensureing that sufficient serum amino acid can be measured in the infants of formula milk nursing, is reduced Its blood urea nitrogen is horizontal, avoids causing its kidney additional burden, and then be beneficial to the growth and development of infant, more be connect The intestinal flora of nearly breast-feeding infant distinguishes situation, contributes to infant's intestinal health.
Description of the drawings
Fig. 1 is breast milk and always essential amino acids in embodiment 1,2,3 and conventional infant formulas milk powder and total nonessential ammonia Comparison (0~6 monthly age) between base acid relative amount;
Fig. 2 be in breast milk and embodiment 1,2,3 and conventional infant formulas milk powder various essential amino acid relative amounts it Between comparison (0~6 monthly age);
Fig. 3 is breast milk and various nonessential amino acid relative amounts in embodiment 1,2,3 and conventional infant formulas milk powder Between comparison (0~6 monthly age).
Specific implementation mode
Below in conjunction with specific embodiment to the present invention optimization protein and amino acid pattern babies ' formula milk powder and its Preparation method is described in further detail.
Embodiment 1-3
The babies ' formula milk powder of the present embodiment three kinds of optimization protein and amino acid pattern, by the original of following weight percent Material group is grouped as (table 1):
Table 1
Wherein, (accounting in the nucleotide), the nucleotide include by weight percentage:5' adenosine monophosphate 20.3%, 5'-inosinic acid disodium 35%, 5'- Sodium guanylates 6.9%, uridine 5'-monophosphate disodium 24% and 5'-CMP disodium 13.8%;
(accounting in the vegetable oil) by weight percentage, the vegetable oil include sunflower oil 35.63%, coconut palm Seed oil 22.76%, corn oil 15.84%, Canola Oil 13.86%, soybean oil 10.89%, phosphatidase 0 .99%, mixing life Educate phenol concentrate 0.02%, ascorbyl palmitate 0.01%;
(accounting in the minerals) by weight percentage, the minerals include calcium carbonate 32.91%, chlorination Potassium 26.91%, sodium citrate 22.77%, magnesium sulfate 12.41%, ferrous sulfate 3.10%, zinc sulfate 1.71%, copper sulphate 0.041%, manganese sulfate 0.014%, potassium iodide 0.014%, sodium selenite 0.13%;
(accounting in the vitamin), the vitamin include by weight percentage:Liposoluble vitamin:Acetic acid Vitamin A 0.80%, vitamine D3 0.009%, dl- α-D-α-tocopherol acetate 8.95%, phytondione 1.22%;It is water-soluble Vitamin:L-AA 43.97%, L-AA sodium 30.73%, thiamine hydrochloride 0.68%, riboflavin 5.46%, salt Sour pyridoxol 0.33%, cyanocobalamin 0.12%, folic acid 1.09%, niacinamide 3.59%, D-VB5 calcium 3.03%, D-Biotin 0.012%.
The preparation method of above-mentioned babies ' formula milk powder, includes the following steps:
(1) dispensing, specially:Pure water is heated to 60 ± 5 DEG C, desalted whey powder, degreasing that predetermined ratio weighs is added Milk powder, lactose, α-lactalbumin are uniformly mixed, and are heated to 65 ± 5 DEG C;By the vegetable oil weighed by predetermined ratio, bis- oil of 1,3- Sour three ester of 2- palmitic acids is added after mixing;
(2) homogeneous is mixed, specially:After above-mentioned material is mixed, the homogeneous in high pressure homogenizer;
(3) cooling, specially:Homogeneous postcooling is to≤6 DEG C;
(4) it feeds, specially:Minerals, vitamin, galactooligosaccharide slurry, oligofructose, chlorination is added after homogeneous cooling Choline, l-cn, inositol, nucleotide, taurine, lutein;
(5) it sterilizes, specially:Pasteurize, optimum temperature are 86-92 DEG C, sterilize 20-60S;
(6) it is concentrated by evaporation;
(7) it is spray-dried;
(8) fluidized bed drying cools down, and is specially dried, is cooled down with fluid bed, and the moisture of control gained original washing powder is in 2- In 4% range;
(9) vibrating screen filters;
(10) batch mixing, specially:Docosahexaenoic acid (DHA), eicosatetraenoic acid (AA), l-cysteine, L- junket ammonia The small powders such as acid, L-Leu, L-Histidine, L-phenylalanine and animal bifidobacteria Bb-12 pulvis are premixed by formula, Mixing time >=2min, then put into batch mixer and be uniformly mixed to get this product with original washing powder.
The compliance test result of the optimization protein of embodiment 1-3 and the babies ' formula milk powder of amino acid pattern:
(1) with breast milk in the composition ratio of protein and amino acid comparison
Initial research longitudinally acquires (Beijing, Jinan, Shenzhen, Kunming, Chengdu, Nanjing, Xi'an, packet header) 0~June of nursing period 10 times interior breast milks cover colostrum, transitional milk, early stage ripe breast and late period ripe breast, test analysis difference lactation stage comprehensively Protein content and aminogram.
The test job of protein in 8 city breast milks:1529 parts of sample, wherein 191 parts of Beijing, Shenzhen 152 are detected altogether Part, 298 parts of Jinan, 268 parts of Xining, 114 parts of Nanjing, 288 parts of packet header, 103 parts of Kunming, 115 parts of Chengdu.Protein tests foundation 《The measurement GB5009.5-2010 of national food safety standard Protein in Food》Protein contains in Kjeldahl's method test breast milk Amount.
The test job of amino acid in 8 city breast milks:1614 parts of sample, wherein 201 parts of Beijing, Shenzhen 152 are detected altogether Part, 312 parts of Jinan, 247 parts of Xining, 117 parts of Nanjing, 299 parts of packet header, 104 parts of Kunming, 182 parts of Chengdu.Serum amino acid spectrum analysis is adopted Amino acid content in breast milk is tested with automatic amino acid analyzer, wherein 16 kinds of amino acid foundations《The measurement of amino acid in food GB/T 5009.124-2003》Examination with computer after being hydrolyzed 20 hours using 6mol/L hydrochloric acid, cystine used first after an acidic hydrolysis The examination with computer again of acid oxidase 2 hours, examination with computer after tryptophan is hydrolyzed 26 hours using 4.2mol/L potassium hydroxide.Each sample The test analysis of 18 kinds of amino acid is carried out, used instrument is 8900 automatic amino acid analyzer of Hitachi.
As a result as shown in table 2-3 and Fig. 1-3:
The comparison (%) of 2 breast milk of table and formula milk protein absolute content
Comparison (%) between 3 breast milk of table and formula milk amino acid relative amount
(2) with the comparison of the clinical feeding effect of breast milk
Research and design:
The newborn for recruiting 15 -day-old is divided into 3 groups as research object, about every group 40 people, carries out breast-feeding, right respectively According to milk powder (conventional formulation milk powder) feed and test milk powder (babies ' formula milk powder of embodiment 2) feed, specific nutrition at Divide and be shown in Table 3, feeds to 6 monthly ages.
Test the specific formula detailed in Example 2 of milk powder;Compare the formula of milk powder, protein content 2.21g/ 100kcal is not added with amino acid monomer, remaining functional component is consistent with experiment milk powder.
5 protein component of table compares
Breast milk Compare milk powder Embodiment 2
Protein (g/100kcal) 1.68 2.21 1.91
α-lactalbumin (% protein) 21 7.6 13.4
α-lactalbumin (g/L) 2.3 1.20 1.73
Tested baby 124, breast-feeding group (n=43), control milk powder nursing group (n=41), the examination of embodiment 2 are recruited altogether Test milk powder nursing group (n=40).Physical signs when record volunteer enters group:Weight, height, head circumference.
When 6 monthly age, following index is detected respectively:Weight, height;Blood urea nitrogen, Amino Acid are horizontal;Enteron aisle Tiny ecosystem.
Result of study:
1, growth and development
6 volunteer of table enters a group indicator-specific statistics (average ± standard deviation)
Table 7 volunteer, 6 monthly age indicator-specific statistics (average ± standard deviation)
In conjunction with table 6 and 7 it is found that after feeding 6 months, 2 nursing group of embodiment and control milk powder nursing group infant weight, height Increase no notable difference with head circumference, also without notable difference compared with breast feeding babies.
2, enteric microorganism is analyzed
8 fecal bacteria sum log values (average ± standard deviation) of table
As shown in Table 8, when feeding to 4 monthly age, Bifidobacterium and lactobacillus quantity in milk powder nursing group infant faeces are compareed Substantially less than breast-feeding group, and 2 nursing group baby of embodiment is not significantly different with breast feeding babies.
3, blood urea nitrogen
9 blood urea nitrogen content (mg/100ml) of table
As shown in Table 9, compared with breast feeding babies, control fed infant blood urea nitrogen is horizontal significantly to be increased, but 2 nursing group baby blood urea nitrogen of embodiment has downward trend compared with compareing milk powder.
In conclusion the babies ' formula milk powder fed infant of embodiment 2, feeds in height, weight and head circumference with breast milk Foster baby's indifference is compared with traditional formula milk in terms of intestinal flora closer to breast milk, and blood urea nitrogen level is low In traditional formula milk fed infant.Therefore, total by adding α-lactalbumin and single amino acid reduction formula milk The product of protein content is relatively beneficial to the growth and development of baby, there is the intestinal flora difference feelings of closer breast feeding babies Condition contributes to intestinal health.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.

Claims (10)

1. a kind of babies ' formula milk powder of optimization protein and amino acid pattern, which is characterized in that by weight percentage, including The following raw material component:
Desalted whey powder 23-43%
Vegetable oil 16-30%
Skimmed milk powder 11-20%
Lactose 11-18%
α-lactalbumin 1.4-4.3%
Minerals 0.87-1.06%
Vitamin 0.11-0.13%
L-cysteine 0.028-0.085%
L-tyrosine 0.02-0.06%
L-Leu 0.02-0.06%
L-Histidine 0.015-0.045%
L-phenylalanine 0.0025-0.075%
Bis- oleic acid 2- palmitic acids of 1,3-, three ester 2.6-4.9%
Other functional components 4.59-8.84%,
And probiotics, the additive amount of the probiotics are that the viable count in the babies ' formula milk powder is made to be no less than 1 × 106CFU/ g。
2. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 1, which is characterized in that with weight Measure percentages, including the following raw material component:
Desalted whey powder 28-38%
Vegetable oil 20-27%
Skimmed milk powder 13-18%
Lactose 12-16%
α-lactalbumin 2.78-2.94%
Minerals 0.92-1.01%
Vitamin 0.111-0.123%
L-cysteine 0.048-0.065%
L-tyrosine 0.034-0.046%
L-Leu 0.034-0.046%
L-Histidine 0.025-0.034%
L-phenylalanine 0.0043-0.057%
Bis- oleic acid 2- palmitic acids of 1,3-, three ester 3.0-4.3%
Other functional components 5.72-7.82%,
And probiotics, the additive amount of the probiotics are that the viable count in the babies ' formula milk powder is made to be no less than 1 × 106CFU/ g。
3. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 1 or 2, which is characterized in that The vitamin includes liposoluble vitamin and water soluble vitamin;
The liposoluble vitamin includes axerophtholum aceticum, vitamine D3, dl- α-D-α-tocopherol acetate and phytondione;It is described Water soluble vitamin include L-AA, L-AA sodium, thiamine hydrochloride, riboflavin, puridoxine hydrochloride, cyanocobalamin, Folic acid, niacinamide, D-VB5 calcium and D-Biotin.
4. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 3, which is characterized in that described Probiotics is animal bifidobacteria Bb-12.
5. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 1 or 2, which is characterized in that The vegetable oil includes sunflower oil, coconut oil, corn oil, Canola Oil, soybean oil, phosphatide, mixed tocopherol concentration Object and ascorbyl palmitate.
6. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 1 or 2, which is characterized in that The minerals include calcium carbonate, potassium chloride, sodium citrate, magnesium sulfate, ferrous sulfate, zinc sulfate, copper sulphate, manganese sulfate, iodine Change potassium and sodium selenite.
7. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 1 or 2, which is characterized in that The functional components include galactooligosaccharide slurry, eicosatetraenoic acid, oligofructose, docosahexaenoic acid, choline chloride, At least one of l-cn, inositol, nucleotide, taurine, lutein.
8. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 7, which is characterized in that account for The weight percent meter of the raw material components, other functional components include following component:
Galactooligosaccharide starches 3.9-7.3%
Eicosatetraenoic acid 0.2-0.5%
Oligofructose 0.2-0.4%
Docosahexaenoic acid 0.1-0.25%
Choline chloride 0.05-0.15%
L-cn 0.07-0.09%
Inositol 0.03-0.05%
Nucleotide 0.02-0.05%
Taurine 0.02-0.05%
Lutein 0.001-0.003%.
9. the babies ' formula milk powder of optimization protein and amino acid pattern according to claim 8, which is characterized in that described Nucleotide includes 5' adenosine monophosphate, 5'-inosinic acid disodium, 5'- Sodium guanylates, uridine 5'-monophosphate disodium and 5'-CMP two Sodium.
10. claim 1-9 any one of them optimizes the preparation method of the babies ' formula milk powder of protein and amino acid pattern, It is characterised in that it includes following steps:
The desalted whey powder, skimmed milk powder, lactose and α-lactalbumin are added into 55-65 DEG C of hot water, gained is maintained The temperature of mixture is 60-70 DEG C, obtains mixture A;
It is added into the mixture A after the vegetable oil, 1,3-Dioleic acid 2-palmitoyl triglyceride are mixed, obtains mixture B;
Homogenization is carried out to the mixture B, is subsequently cooled to temperature≤6 DEG C;The minerals, vitamin are added, is obtained Mixture C;
The mixture C is dry after sterilizing, concentrating, is sieved, and obtains original washing powder;
The l-cysteine, l-tyrosine, L-Leu, L-Histidine, L-phenylalanine and institute are added in the original washing powder The pre-composition of probiotics is stated, is mixed, you can.
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793044A (en) * 2019-03-21 2019-05-24 贝因美(杭州)食品研究院有限公司 A kind of formula milk and preparation method thereof eaten suitable for premature labor/low birth weight baby
CN109874870A (en) * 2019-01-25 2019-06-14 上海花冠营养乳品有限公司 A kind of infant milk powder of simulation breast milk proteins composition and immune function
CN110999975A (en) * 2019-12-19 2020-04-14 白永纯 Formula milk powder for promoting bone growth of children and preparation method thereof
CN113519687A (en) * 2021-07-22 2021-10-22 青岛圣桐营养食品有限公司 Infant milk protein partial hydrolysis formula food for special medical use
WO2022052794A1 (en) * 2020-09-09 2022-03-17 北京三元食品股份有限公司 Infant formula milk powder rich in milk fat globule membrane protein, phospholipid and oligosaccharide, and preparation method therefor

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008675A1 (en) * 1989-12-20 1991-06-27 Slattery Charles W Human infant formulas containing recombinant human alpha-lactalbumin and beta-casein
US20050142249A1 (en) * 2001-12-21 2005-06-30 Wyeth Methods for reducing adverse effects of feeding formula to infants
CN1792194A (en) * 2006-01-06 2006-06-28 石家庄三鹿集团股份有限公司 Formula milk powder for babies
CN102422900A (en) * 2011-11-24 2012-04-25 黑龙江飞鹤乳业有限公司 Formula milk powder for promoting absorption of fatty acid and calcium and preparation method thereof
CN102524422A (en) * 2012-02-22 2012-07-04 浙江康恩贝健康产品有限公司 Infant formula milk powder containing alpha-lactalbumin and lactoferrin and preparation method for infant formula milk powder
CN103651857A (en) * 2013-12-27 2014-03-26 光明乳业股份有限公司 Probiotics-containing infant formula, and preparation method and storage method thereof
CN104351356A (en) * 2014-11-25 2015-02-18 澳优乳业(中国)有限公司 Novel fourth-generation infant formula and preparation method thereof
CN105746728A (en) * 2016-03-14 2016-07-13 上海晨冠乳业有限公司 Infant formula milk powder simulating breast milk and preparation method of infant formula milk powder

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991008675A1 (en) * 1989-12-20 1991-06-27 Slattery Charles W Human infant formulas containing recombinant human alpha-lactalbumin and beta-casein
US20050142249A1 (en) * 2001-12-21 2005-06-30 Wyeth Methods for reducing adverse effects of feeding formula to infants
CN1792194A (en) * 2006-01-06 2006-06-28 石家庄三鹿集团股份有限公司 Formula milk powder for babies
CN102422900A (en) * 2011-11-24 2012-04-25 黑龙江飞鹤乳业有限公司 Formula milk powder for promoting absorption of fatty acid and calcium and preparation method thereof
CN102524422A (en) * 2012-02-22 2012-07-04 浙江康恩贝健康产品有限公司 Infant formula milk powder containing alpha-lactalbumin and lactoferrin and preparation method for infant formula milk powder
CN103651857A (en) * 2013-12-27 2014-03-26 光明乳业股份有限公司 Probiotics-containing infant formula, and preparation method and storage method thereof
CN104351356A (en) * 2014-11-25 2015-02-18 澳优乳业(中国)有限公司 Novel fourth-generation infant formula and preparation method thereof
CN105746728A (en) * 2016-03-14 2016-07-13 上海晨冠乳业有限公司 Infant formula milk powder simulating breast milk and preparation method of infant formula milk powder

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
中华人民共和国卫生部: "食品安全国家标准婴儿配方食品 GB10765-2010", 《中华人民共和国国家标准》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109874870A (en) * 2019-01-25 2019-06-14 上海花冠营养乳品有限公司 A kind of infant milk powder of simulation breast milk proteins composition and immune function
CN109793044A (en) * 2019-03-21 2019-05-24 贝因美(杭州)食品研究院有限公司 A kind of formula milk and preparation method thereof eaten suitable for premature labor/low birth weight baby
CN110999975A (en) * 2019-12-19 2020-04-14 白永纯 Formula milk powder for promoting bone growth of children and preparation method thereof
WO2022052794A1 (en) * 2020-09-09 2022-03-17 北京三元食品股份有限公司 Infant formula milk powder rich in milk fat globule membrane protein, phospholipid and oligosaccharide, and preparation method therefor
CN113519687A (en) * 2021-07-22 2021-10-22 青岛圣桐营养食品有限公司 Infant milk protein partial hydrolysis formula food for special medical use

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