CN104351356A - Novel fourth-generation infant formula and preparation method thereof - Google Patents
Novel fourth-generation infant formula and preparation method thereof Download PDFInfo
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Abstract
The invention provides a novel fourth-generation infant formula. The novel fourth-generation infant formula comprises the following ingredients: lactose, desalted whey powder, 1,3-dioleoyl 2-palmitoyl triglyceride, hydrolyzed whey protein, fructo-oligosaccharide, galactooligosaccharide, mineral substance premix compound, casein hydrolysate, whey protein concentrate, soyabean lecithin, vitamin premix, lactoferrin, L-tyrosine, nucleotide, L-tryptophan, L-methionine and the like. The infant formula is added with appropriate amount of 1,3-dioleoyl 2-palmitoyl triglyceride, appropriate amount of protein hydrolysate, monomer amino acid and the like, mineral contents such as phosphorus, sodium and the like in milk powder are reduced, therefore, the fat structure, the amino acid composition, the amino acid content and the osmotic pressure in the milk powder are close to those of the breast milk, the infant formula is balanced and comprehensive in nutrition and is appropriate in composition, all substances have synergistic effect, the bioavailability of protein and the fat is effectively improved, and the infant formula can promote digestive absorption and skeletal development of babies and can reduce the visceral organ burden.
Description
Technical field
The present invention relates to baby formula field, especially, relate to a kind of forth generation novel infant formula milk powder through fatty acid structure breast milk, gal4 amino acid composition breast milk, adjustment osmotic pressure, interpolation combination of prebiotics, DHA, ARA.
Background technology
Breast milk is the optimal food of ewborn infant, but due to reasons such as work, health, in recent years, Chinese breastfeeding rate dropped to about 35% year by year, and big and medium-sized cities breastfeeding rate is then lower.At breast milk not enough or without breast milk time, become the optimal selection of father and mother to baby closest to the baby milk of breast milk, meet the energy of baby needed for special growth and development stage and nutritional need.
Early stage baby milk, based on cow's milk, adds carbohydrate, emphatically " Power supply ".After this formed gradually to improve protein, fat content, the second generation formula milk of " Macronutrient adjustment " emphatically, with the third generation formula milk of strengthening monomer nutrient, emphatically " trace element strengthening ", milk power for infant and young children commercially available at present has a great development on nutrient is formed, but still cannot reach the profound requirement of nutrient equilibrium, " one-tenth is grouped into and structure accurate analog breast milk ".
Fat is the main energy supply material of baby.In human milk fat, 70% palmitic acid is positioned at triglycerides 2-position, and in common vegetable oil, palmitic acid multidigit is in triglycerides 1,3-position, i.e. P-O-P structure.Structuring fat OPO is the triglycerides that a kind of 1,3-position is 2 oleic acid, 2-position is 1 palmitic acid, more easy to digest, promotes the absorption of calcium and aliphatic acid, help skeleton development while reducing stool hardness.Current commercially available baby formula milk powder mainly adds common vegetable oil, is easily combined with calcium and forms calcium soap, affect calcium and fatty acid absorption, baby Yi Shanghuo, constipation in digestion process.
Protein is baby's important nutrient, and its amino acid composition (especially required and semi-dispensable amino acid) is more close to breast milk, and the easier efficient absorption of baby, reduces kidney burden.High-quality protein has protein hydrolysate, alpha lactalbumin, lactoferrin etc.Protein hydrolysate is by hydrolysis technology, intact proteins is hydrolyzed into Small molecular peptide chain, and by rejecting stodgy protein part, the amino acid ratio of acquisition forms more rationally, the protein peptide section more easily digested and assimilated.Alpha lactalbumin is in amino acid ratio configuration aspects, and all closely similar with human milk on functional characteristic.Baby milk lactalbumin and the casein ratio of current domestic use all reach 60:40, but considerably less to the research and apply of amino acid composition and absorbing proteins aspect.
Milk powder osmotic pressure is extremely important to infantile health, but industry is very few to osmotic pressure research.Investigation shows, most of baby milk powder osmotic pressure is 320mosmmol/kgH
2more than O, breast milk osmotic pressure is 290-310mosmmol/kg H
2o.Infant eats the formula milk of hyperosmosis for a long time, in body cell can there is conduct disorder in various bioactivator, cause the dysequilibrium of the humoral systems such as water, electrolyte, soda acid, increase kidney load, the initial inducement of chronic disease after growing up may be become.
To sum up, according to breast milk nutrition and design feature, breast milk is carried out to fat, protein, amino acid, osmotic pressure, increase the bioactive ingredients be rich in multiple prebiotics and breast milk, the baby formula milk powder of constituent and structure accurate analog breast milk thereof, to breast milk substitute truly be become in industry field, and make baby obtain nutrition balanced more comprehensively.
Summary of the invention
The first object of the present invention is to provide a kind of forth generation novel infant formula milk powder through fatty acid structure breast milk, gal4 amino acid composition breast milk, adjustment osmotic pressure, interpolation combination of prebiotics, DHA, ARA, solve the problem of existing baby milk powder function singleness from product nutritional labeling composition and molecular structure, concrete technical scheme is as follows:
A kind of forth generation novel infant formula milk powder, comprise following component by weight percentage: lactose 8-25%, desalted whey powder 20-50%, skimmed milk power 8-35%, vegetable oil 16-27%, 1, 3-bis-oleic acid 2-palmitic acid three ester 2.4-9.6%, hydrolyzing lactoalbumin 1-9%, galactooligosaccharide 0-6%, FOS 0-6%, mineral substance premix 0.8-1.9%, arachidonic acid 0.3-1.8%, caseinhydrolysate 0.2-1.5%, containing the WPC 0.2-1.8% of 25-45% alpha lactalbumin, soybean lecithin 0.2-1.3%, DHA 0.2-1.2%, water soluble vitamin premix 0.1-0.4%, lactoferrin 0.02-0.1%, TYR 0-0.09%, nucleotides 0.018-0.06%, liposoluble vitamin premix 0.01-0.06%, L-Trp 0-0.06%, L-Methionine 0-0.06%, taurine 0.01-0.05% and VBT 0.005-0.02%.
Preferred in above technical scheme, comprise following component by weight percentage: lactose 22.0%, desalted whey powder 26.2%, skimmed milk power 14%, vegetable oil 20.2%, 1, 3-bis-oleic acid 2-palmitic acid three ester 4.8%, hydrolyzing lactoalbumin 3.1%, galactooligosaccharide 3.0%, FOS 1.0%, mineral substance premix 1.5%, arachidonic acid 1.01%, caseinhydrolysate 0.6%, containing the WPC 0.7% of 43% alpha lactalbumin, soybean lecithin 0.6%, DHA 0.86%, water soluble vitamin premix 0.2%, lactoferrin 0.052%, TYR 0.05%, nucleotides 0.023%, liposoluble vitamin premix 0.019%, L-Trp 0.022%, L-Methionine 0.021%, taurine 0.028% and VBT 0.015%,
Or lactose 10.0%, desalted whey powder 35%, skimmed milk power 20%, vegetable oil 18.2%, 1, 3-bis-oleic acid 2-palmitic acid three ester 3.8%, hydrolyzing lactoalbumin 5.0%, galactooligosaccharide 1.6%, FOS 1.0%, mineral substance premix 1.1%, arachidonic acid 1.0%, caseinhydrolysate 0.6%, containing the WPC 1.0% of 43% alpha lactalbumin, soybean lecithin 0.6%, DHA 0.72%, water soluble vitamin premix 0.18%, lactoferrin 0.06%, TYR 0.03%, nucleotides 0.023%, liposoluble vitamin premix 0.02%, L-Trp 0.021%, taurine 0.031% and VBT 0.015%.
Preferred in above technical scheme, described mineral substance premix comprises calcium carbonate 3.2%, potassium chloride 35.2%, magnesium sulfate 15.1%, natrium citricum 18%, tricalcium phosphate 21%, ferrous sulfate 2.0%, zinc sulfate 5.34%, copper sulphate 0.13%, manganese sulfate 0.02%, KI 0.006% and sodium selenate 0.004% by weight percentage;
Or tricalcium phosphate 27.1%, potassium chloride 28.7%, natrium citricum 21%, magnesium sulfate 10.3%, calcium carbonate 8.4%, ferrous sulfate 3.4%, zinc sulfate 0.9%, copper sulphate 0.15%, manganese sulfate 0.033%, KI 0.013% and sodium selenate 0.004%.
Preferred in above technical scheme, described vegetable oil is the mixed vegetable oil be made up of the three kinds or more in sunflower oil, coconut oil, soybean oil, rapeseed oil, palm oil and palm-kernel oil.
Preferred in above technical scheme, described vegetable oil comprises high oleic sunflower oil 30-40%, soybean oil 18-35%, coconut oil 15-30%, palm oil 10-25% and rapeseed oil 10-15% by weight percentage.
Preferred in above technical scheme, described water soluble vitamin premix by weight percentage comprises L-AA sodium 53.47%, Choline Chloride 21.9%, inositol 20.6%, niacinamide 1.82%, D-VB5 calcium 1.0%, Bio 0.12%, cyanocobalamin 0.34%, thiamine hydrochloride 0.25%, puridoxine hydrochloride 0.18%, riboflavin 0.28% and folic acid 0.04%;
Or: L-AA sodium 43.8%, Choline Chloride 32.2%, inositol 19.4%, niacinamide 1.98%, D-VB5 calcium 1.15%, Bio 0.39%, cyanocobalamin 0.286%, thiamine hydrochloride 0.28%, puridoxine hydrochloride 0.26%, riboflavin 0.25%, folic acid 0.004%.
Preferred in above technical scheme, described liposoluble vitamin premix by weight percentage comprise 95.7% dl-α-D-α-tocopherol acetate, the axerophtholum aceticum of 3.7%, the Vitamin D3 of 0.05% and 0.55% phytondione;
Or the dl-α-D-α-tocopherol acetate of 95.55%, the axerophtholum aceticum of 3.8%, the Vitamin D3 of 0.05% and 0.6% phytondione.
Apply forth generation novel infant formula milk powder of the present invention, there is following technique effect:
1, structuring aliphatic acid (1 is added, 3-bis-oleic acid 2-palmitic acid three ester, be called for short OPO) and adopt the proportioning of 2.4-9.6%, make fatty acid structure in baby formula milk powder closer to breast milk level, to improve the absorption rate of aliphatic acid, promote calcium uptake, prevent baby's constipation.
2, in the present invention by adding the L-Methionine of the hydrolyzing lactoalbumin of 1-9%, the caseinhydrolysate of 0.2-1.5%, the alpha-lactoalbumin containing WPC of richness of 0.2-1.8%, the lactoferrin of 0.02-0.1%, the TYR of 0-0.09%, the L-Trp of 0-0.06% and 0-0.06%, adopt the concrete proportioning of this several combination adjustment amino acid, both can make up in existing milk powder and only there is the amino acid whose defect of partial monosomy, can adjust amino acid whose component in formula milk makes it closer to breast milk simultaneously, improves rate of ultilization of amino acid; It is not enough that the hydrolyzing lactoalbumin adopted and caseinhydrolysate can make up infants endoprotease activity, improves protein utilization in milk powder.
3, also added complex prebiotics combination (FOS, galactooligosaccharide) in the present invention, effectively selectively can stimulate one or more beneficial bacterium growth and breedings in intestines, and not by the material of Host Digestion; Prebiotics can make pathogen stick on oligosaccharide substrate and not contact with intestinal epithelial cell; pathogen cannot be fixed up in enteron aisle; the enteron aisle that available protecting baby is tender and lovely; the level improving Immunoglobulin IgG in body can be helped; help baby to set up self immune system better, strengthen resistance against diseases.
4, by regulating the content of the mineral matters such as the phosphorus in formula milk, sodium, make osmotic pressure in whole formula milk closer to breast milk level, the bioavailability of infant to protein, fat is effectively improved again in conjunction with baby formula milk powder aliphatic acid breast milk, protein breast milk, amino acid breast milkization, improve the growth of baby's digestion and absorption function and bone, thus greatly reduce the burden of the internal organs such as kidney, promote the healthy growth of infant.
5, pass through the aliphatic acid breast milk in formula milk, protein breast milk, amino acid breast milk and osmotic pressure breast milk in the present invention, whole formula milk is made to solve the problem of existing baby milk powder function singleness from product nutritional labeling composition and molecular structure, namely make baby formula milk powder of the present invention closer to breast milk level, thus make the nutrition in baby formula milk powder more balanced comprehensively, more be conducive to infant growth, improve immunity, reduce irritated risk.
The second object of the present invention is the preparation method of openly a kind of forth generation novel infant formula milk powder, comprises the following steps:
Step one: batching, be specially: by the skimmed milk power taken by predetermined ratio, desalted whey powder, lactose, hydrolyzing lactoalbumin, the WPC containing 25-45% alpha lactalbumin, galactooligosaccharide, FOS, mineral substance premix, caseinhydrolysate, water soluble vitamin premix, taurine, VBT is dissolved in alleged material gross weight 3.0-4.0 times and temperature is in the water of 40-55 DEG C, squeezes into temporary storage tank I after mixing; Temporary storage tank II is squeezed into by after the vegetable oil taken by predetermined ratio, OPO, soybean lecithin and liposoluble vitamin premix mixing;
Step 2: mixing homogeneous, is specially: by the mixing of materials of temporary storage tank I and temporary storage tank II, homogeneous in high pressure homogenizer;
Step 3: sterilization;
Step 4: concentrated, is specially: use double-effect falling film evaporator to concentrate;
Step 5: spraying dry;
Step 6: fluidized bed drying cools, and is specially: carry out fluidized bed drying, cooling, controls moisture content of material 2.0-4.0%, obtains base stock powder;
Step 7: batch mixing, be specially: adopt three-dimensional dry-mixed machine, arachidonic acid, DHA, lactoferrin, nucleotides, TYR, L-Trp and/or L-Methionine is taken by predetermined ratio, after carrying out premix, drop into dry-mixed machine to mix together with base stock powder, obtain forth generation novel infant formula milk powder.
Preferred in above technical scheme, the batching in described step one can also in the following way: pasteurize fresh milk being carried out at 70-75 DEG C 18-22 second, obtained skim milk after being then separated by fat; The desalted whey powder taken by predetermined ratio, lactose, hydrolyzing lactoalbumin, WPC containing 25-45% alpha lactalbumin, galactooligosaccharide, FOS, mineral substance premix, caseinhydrolysate, water soluble vitamin premix, taurine and VBT are added in skim milk, after mixing, squeezes into temporary storage tank I; Temporary storage tank II is squeezed into by after the vegetable oil taken by predetermined ratio, OPO (OPO), soybean lecithin, liposoluble vitamin premix mixing; After above-mentioned skim milk meets spraying dry, the amount of gained skimmed milk power is equal with the amount of directly adding skimmed milk power.
Preferred in above technical scheme, in described step 2, the temperature of homogeneous is 55-70 DEG C, and the pressure of homogeneous is 10-20MPa; In described step 3, sterilization process is specially: sterilization 15-25 second at 85-95 DEG C; Actual conditions concentrated in described step 4 is: the first effect vacuum is 30-42kPa, and evaporating temperature is 70-75 DEG C; Second effect vacuum is 60-70kPa, and evaporating temperature is 45-52 DEG C; Material being concentrated into Baume degrees is 15-25 ° of B é; In described step 5, spray-drying process is specially: pressure be 12-20MPa, EAT carries out spraying dry under be 150-190 DEG C and temperature of outgoing air being the condition of 70-90 DEG C; Mixing time in described step 7 in dry-mixed machine is 15-20 minute.
Adopt preparation method of the present invention, integrated artistic is simplified, and equipment easily obtains; Batch mixing in different ways, meets the different needs; In preparation method, each technological parameter easily controls, and the baby formula milk powder prepared solves the problem of existing baby milk powder function singleness from product nutritional labeling composition and molecular structure, close to female composition of milk, nutrition is more balanced comprehensively, effective raising protein, fatty bioavailability, promotion baby digest and assimilate and skeleton development, reduce internal organs burden.
Except object described above, feature and advantage, the present invention also has other object, feature and advantage.Below with reference to embodiment, the present invention is further detailed explanation.
Detailed description of the invention
Below in conjunction with embodiment, embodiments of the invention are described in detail, but the multitude of different ways that the present invention can limit according to claim and cover is implemented.
Embodiment 1:
A kind of forth generation novel infant formula milk powder, its formula following (being all calculated in mass percent below):
Comprise lactose 22.0%, desalted whey powder 26.2%, skimmed milk power 14%, vegetable oil 20.2%, 1, 3-bis-oleic acid 2-palmitic acid three ester 4.8%, hydrolyzing lactoalbumin 3.1%, galactooligosaccharide 3.0%, FOS 1.0%, mineral substance premix 1.5%, arachidonic acid 1.01%, caseinhydrolysate 0.6%, containing the WPC 0.7% of 43% alpha lactalbumin, soybean lecithin 0.6%, DHA 0.86%, water soluble vitamin premix 0.2%, lactoferrin 0.052%, TYR 0.05%, nucleotides 0.023%, liposoluble vitamin premix 0.019%, L-Trp 0.022%, L-Methionine 0.021%, taurine 0.028% and VBT 0.015%.
Wherein, described vegetable oil is mixed vegetable oil, specifically by oleic acid account for TFA ratio be 80% high oleic sunflower oil 30.6%, soybean oil 23.2%, coconut oil 18.1%, palm oil 15.8% and rapeseed oil 12.3% form.
Described mineral substance premix is specifically made up of potassium chloride 35.2%, tricalcium phosphate 21%, natrium citricum 18%, magnesium sulfate 15.1%, calcium carbonate 3.2%, zinc sulfate 5.34%, ferrous sulfate 2.0%, copper sulphate 0.13%, manganese sulfate 0.02%, KI 0.006% and sodium selenate 0.004%.
Described water soluble vitamin premix is made up of L-AA sodium 53.47%, Choline Chloride 21.9%, inositol 20.6%, niacinamide 1.82%, D-VB5 calcium 1.0%, Bio 0.12%, cyanocobalamin 0.34%, thiamine hydrochloride 0.25%, puridoxine hydrochloride 0.18%, riboflavin 0.28% and folic acid 0.04%.
Described liposoluble vitamin premix by 95.7% dl-α-D-α-tocopherol acetate, the axerophtholum aceticum of 3.7%, the Vitamin D3 of 0.05% and 0.55% phytondione form.
The preparation method of above-mentioned forth generation novel infant formula milk powder, comprises the following steps:
The first step: batching, is specially: fresh milk is carried out pasteurize 21 seconds under 72 degrees Celsius, obtained skim milk after then fat being separated; Take desalted whey powder by predetermined ratio, lactose, hydrolyzing lactoalbumin, alpha lactalbumin content be 43% WPC, galactooligosaccharide, FOS, mineral substance premix, caseinhydrolysate, water soluble vitamin premix, taurine, VBT add in skim milk, after the amount of skim milk used meets spraying dry, the amount of gained skimmed milk power is equal with the amount of directly adding skimmed milk power, squeezes into temporary storage tank I after mixing; Temporary storage tank II is squeezed into by after the vegetable oil taken in proportion, OPO (structured lipid OPO), soybean lecithin and liposoluble vitamin premix mixing;
Second step: mixing homogeneous, be specially: by the mixing of materials of temporary storage tank I and II, homogeneous in high pressure homogenizer, homogenizing temperature is 68 DEG C, and homogenization pressure is 18MPa;
3rd step: sterilization, is specially: the sterilization 25 seconds at 85 DEG C of the mixed material after homogeneous will be carried out in second step;
4th step: concentrated, is specially: use double-effect falling film evaporator to concentrate the mixed material after sterilization in the 3rd step, and the first effect vacuum is 40kPa, and evaporating temperature is 73 DEG C; Second effect vacuum is 65kPa, and evaporating temperature is 50 DEG C, material is concentrated into the concentrated material that Baume degrees is 20 ° of B é;
5th step: spraying dry, is specially: pressure be 18MPa, EAT carries out spraying dry to the concentrated material that the 4th step obtains under be 180 DEG C and temperature of outgoing air being the condition of 80 DEG C, obtains dry mixed material;
6th step: dry cooling, is specially: the dry mixed material the 5th step obtained, by fluidized bed drying, cooling, controls material moisture 2.5%, obtains base stock powder;
7th step: batch mixing, be specially: adopt three-dimensional dry-mixed machine, the arachidonic acid taken by predetermined ratio, DHA, lactoferrin, nucleotides, TYR, L-Trp, L-Methionine obtain premix after carrying out premix, premix is dropped in dry-mixed machine together with the 6th step gained base stock powder and mixes, mixing time is 15 minutes, obtains baby formula milk powder powder;
Above-mentioned technique also comprises packaging step, is specially: the baby formula milk powder powder the 7th step obtained adopts vacuum nitrogen or carbon dioxide gas to transfer in row packaging, and concrete packing specification is determined according to the actual requirements.
In the present embodiment 1 forth generation novel infant formula milk powder must and semi-dispensable amino acid, OPO content and osmotic pressure molar density value and breast milk to such as showing shown in 1-1:
Must contrast with semi-dispensable amino acid, OPO content and osmotic pressure molar density value and breast milk in table 1-1 baby formula milk powder of the present invention
| Parameter/group | Formulation content (g/100g protein) | Breast milk * (g/100g protein) |
| Phenylalanine | 4.01±0.2 | 3.9 |
| Methionine | 1.78±0.3 | 1.6 |
| Isoleucine | 6.11±0.2 | 5.9 |
| Leucine | 10.02±0.3 | 9.7 |
| Lysine | 6.52±0.3 | 6.8 |
| Threonine | 4.44±0.5 | 4.7 |
| Valine | 6.61±0.2 | 6.4 |
| Tryptophan | 1.93±0.2 | 1.8** |
| Cystine | 2.27±0.2 | 2.1** |
| Histidine | 2.37±0.3 | 2.3 |
| Tyrosine | 4.24±0.3 | 4.2 |
| OPO | 4.4±0.4 | / |
| Osmotic pressure | 289±4.6(mosmmol/kg H 2O) | 290～310(mosmmol/kg H 2O) |
Wherein: * draws from " modern dairy industry handbook " (China Light Industry Press);
* draws breast milk amino acid average content in international food code CODEX STAN 72-1981Revision 2007;
* * draws the relation research [J] from mothers' diet nutrient intake and breast milk osmotic pressure, Chinese food and nutrition, 2012,18 (7): 74-78.
Known by table 1-1: in the present embodiment 1 forth generation novel infant formula milk powder, required and semi-dispensable amino acid, OPO content and osmotic pressure molar density value and breast milk are closely.
Carry out clinical feeding trial to the forth generation novel infant formula milk powder that embodiment 1 obtains, Details as Follows:
1, the selection of subjects
96 neonates or baby's (21.3 ± 19.7 days ages) is selected as research object, often to organize 32 people.Research object is divided into three groups at random: group 1 feeds common babies ' formula milk powder, as a control group; Group 2 feeds the baby formula milk powder of embodiment 1, as test group; Organize 3 with breast-feeding, as breast-feeding group.Wherein, research object age between each group, sex, childbirth options, maternal age, mother education level and occupation, income situation equal distribution are balanced, there was no significant difference.
2, the impact of different formulations milk powder and breast-feeding on infants anthropometic
For body weight, height, BMI, head circumference, chest measurement five indices in anthropometic index, adopt Z scoring assistant analysis, Z=(X-M)/SD=(X-M)/(S*M), wherein X is measured value, M is mean, S is the coefficient of variation, and SD is standard deviation, the age in difference week that mean, the coefficient of variation are announced with reference to WHO, the anthropometic standard at monthly age.When feeding 3 months, test group and breast-feeding group infant weight, chest measurement increasing value are significantly higher than common babies ' formula milk powder nursing group (p < 0.05), and all the other indices are unknown significance difference between three groups, refer to table 1-2.
Table 1-2 different formulations milk powder and the breast-feeding impact on physical growth of infants in 3 months
| Parameter/group | Control group | Test group | Breast-feeding group |
| Weight gain value (g) | 2546.0±659.8 | 3468.0±1023.5* | 3240.0±878.2* |
| Body weight Z marks increasing value | 0.76±1.03 | 1.23±1.01 | 1.10±1.02 |
| Height increasing value (cm) | 9.94±2.01 | 9.89±2.72 | 9.90±4.08 |
| Height Z marks increasing value | 0.93±1.10 | 0.62±1.26 | 0.63±1.7 |
| BMI(kg/m2) | 17.9±1.8 | 18.3±1.1 | 18.4±1.6 |
| BMI Z marks | 0.42±1.12 | 1.02±1.06 | 1.05±1.08 |
| Head circumference increasing value (cm) | 3.59±1.32 | 4.61±1.68 | 4.71±2.12 |
| Head circumference scoring increasing value | 0.20±1.08 | 0.29±1.21 | 0.38±1.58 |
| Chest measurement increasing value (cm) | 3.74±1.81 | 5.34±3.15* | 5.27±3.23* |
| Chest measurement scoring increasing value | 2.82±2.44 | 4.52±3.14 | 5.53±4.63 |
Wherein: band " * " expression is compared with common baby formula milk powder group significant difference (p < 0.05), compares without significant difference with breast-feeding group; Data in table all adopt
expression way, i.e. mean value plus/minus amplitude of variation.
3, the impact of different formulations milk powder and breast-feeding on infants peripheral blood element
The tip blood calcium at 3 the end of month of test group Infants'feeding and iron content are apparently higher than common babies ' formula milk powder nursing group (p < 0.05), and its excess-three group has no notable difference, refer to table 1-3.
Table 1-3 different formulations milk powder and the breast-feeding impact on baby's peripheral blood element level in 3 months
| Element/group | Control group | Test group | Breast-feeding group |
| Calcium | 66.37±12.41 | 74.82±9.23* | 69.31±13.41 |
| Magnesium | 31.88±2.52 | 32.48±4.82 | 33.07±5.52 |
| Iron | 338.89±26.14 | 383.58±28.46* | 342.42±48.56 |
| Zinc | 2.66±0.89 | 3.96±2.76 | 3.91±2.25 |
Wherein: band " * " expression is compared with common baby formula milk powder group significant difference (p < 0.05), compares without significant difference with breast-feeding group; Data in table all adopt
expression way, i.e. mean value plus/minus amplitude of variation.
4, different formulations milk powder is on the impact of baby's defecation, aliphatic acid and calcium uptake
Respectively to the stool quality of nursing the 6th week, the 12 weeks babies that mother has assessed, feces volume and calculate by stool aliphatic acid, calcium content the aliphatic acid intestinal absorption rate and calcium intestinal absorption rate data analysis that obtain.Test group defecation is smooth and easy, stool quality is soft, stool aliphatic acid, calcium content are low.Have no notable difference with breast-feeding group, refer to table 1-4.
Table 1-4 different formulations milk powder and the breast-feeding impact on baby's defecation, aliphatic acid and calcium uptake in 3 months
| Parameter/group | Control group | Test group | Breast-feeding group |
| Stool stiffness (%) | 22±1.8 | 8.1±1.3* | 8.4±0.9 |
| Each stool amount (ml) | 6.5±0.4 | 7.1±0.8 | 7.5±0.5 |
| Aliphatic acid intestinal absorption rate (%) | 90.3±4.6 | 96.9±1.6* | 97.2±0.1 |
| Calcium intestinal absorption rate (%) | 33.7±1.2 | 54.6±1.3* | 55.0±1.0 |
Wherein: band " * " expression is compared with common baby formula milk powder group significant difference (p < 0.05), compares without significant difference with breast-feeding group; Data in table all adopt
expression way, i.e. mean value plus/minus amplitude of variation.
5, different formulations milk powder is on the impact of infant bone marrow mineral deposition
Adopt single photon absorptiometry (SPA) to measure different formulations milk powder and the breast-feeding infant bone marrow density of 12 weeks, refer to table 1-5.Result shows, and the bone density of test group baby is close to breast-feeding group baby, slightly higher than common babies ' formula milk powder nursing group.
Table 1-5 different formulations milk powder and the breast-feeding impact on infant bone marrow mineral deposition in 3 months
| Parameter/group | Control group | Test group | Breast-feeding group |
| Bone density (g/cm 2) | 0.218±0.245 | 0.248±0.103* | 0.253±0.124 |
Wherein: band " * " expression is compared with common baby formula milk powder group significant difference (p < 0.05), compares without significant difference with breast-feeding group; Data in table all adopt
expression way, i.e. mean value plus/minus amplitude of variation.
In sum, through the nursing of different formulations milk powder and breast milk, by growing, the display of the index analysis such as peripheral blood element, defecation situation, fatty acid absorption, calcium uptake and bone mineral deposition: calcium after 3 months in infant weight, chest measurement, peripheral blood fed by test group milk powder and iron level and stool quality, fatty acid absorption, calcium uptake and bone density etc. are obviously better than control group (common babies ' formula milk powder nursing group), and every result of the test of test group is close to the result of breast-feeding group.
Therefore, the baby formula milk powder of the embodiment of the present invention 1 has following effect: a, interpolation hydrolyzing lactoalbumin and caseinhydrolysate and its proportioning are selected rationally, can effectively promote baby's digesting and assimilating protein; B, alpha lactalbumin and amino acid are recombinated rightly (mainly because proportioning is selected rationally), improve protein bio utilization rate, make baby's nutrition more balanced, enhancing development; The increase of c, structured lipid OPO and its proportioning are selected rationally, can help the absorption promoting calcium and aliphatic acid, effectively promote skeleton development, reduce constipation.
Embodiment 2:
The present embodiment discloses another kind of forth generation novel infant formula milk powder, its formula following (being all calculated in mass percent below):
By lactose 10.0%, vegetable oil 18.2%, desalted whey powder 35%, skimmed milk power 20%, hydrolyzing lactoalbumin 5.0%, galactooligosaccharide 1.6%, FOS 1.0%, arachidonic acid (ARA) 1.0%, mineral substance premix 1.1%, DHA (DHA) 0.72%, 1, 3-bis-oleic acid 2-palmitic acid three ester 3.8%, alpha lactalbumin content is the WPC 1.0% of 43%, soybean lecithin 0.6%, caseinhydrolysate 0.6%, water soluble vitamin premix 0.18%, lactoferrin 0.06%, TYR 0.03%, taurine 0.031%, nucleotides 0.023%, L-Trp 0.021%, liposoluble vitamin premix 0.02% and VBT 0.015% form.
Wherein: described vegetable oil is mixed vegetable oil, by oleic acid account for TFA ratio be 80% high oleic sunflower oil 30.6%, soybean oil 23.2%, coconut oil 18.1%, palm oil 15.8% and rapeseed oil 12.3% form.
Described mineral substance premix is made up of tricalcium phosphate 27.1%, potassium chloride 28.7%, natrium citricum 21%, magnesium sulfate 10.3%, calcium carbonate 8.4%, ferrous sulfate 3.4%, zinc sulfate 0.9%, copper sulphate 0.15%, manganese sulfate 0.033%, KI 0.013% and sodium selenate 0.004%.
Described water soluble vitamin premix is made up of L-AA sodium 43.8%, Choline Chloride 32.2%, inositol 19.4%, niacinamide 1.98%, D-VB5 calcium 1.15%, Bio 0.39%, cyanocobalamin 0.286%, thiamine hydrochloride 0.28%, puridoxine hydrochloride 0.26%, riboflavin 0.25% and folic acid 0.004%.
Described liposoluble vitamin premix by 95.55% dl-α-D-α-tocopherol acetate, the axerophtholum aceticum of 3.8%, the Vitamin D3 of 0.05% and 0.6% phytondione form.
The preparation method of above-mentioned forth generation novel infant formula milk powder, comprises the following steps:
The first step: batching, is specially: fresh milk is carried out pasteurize 25 seconds under 75 degrees Celsius, obtained skim milk after then fat being separated; Take desalted whey powder by predetermined ratio, lactose, hydrolyzing lactoalbumin, alpha lactalbumin content be 43% WPC, galactooligosaccharide, FOS, mineral substance premix, caseinhydrolysate, water soluble vitamin premix, taurine, VBT add in skim milk, after the amount of skim milk used meets spraying dry, the amount of gained skimmed milk power is equal with the amount of directly adding skimmed milk power, squeezes into temporary storage tank I after mixing; Temporary storage tank II is squeezed into by after the vegetable oil taken in proportion, OPO (structured lipid OPO), soybean lecithin and liposoluble vitamin premix mixing;
Second step: mixing homogeneous, be specially: by the mixing of materials of temporary storage tank I and II, homogeneous in high pressure homogenizer, homogenizing temperature is 68 DEG C, and homogenization pressure is 18MPa;
3rd step: sterilization, is specially: the sterilization 25 seconds at 85 DEG C of the mixed material after homogeneous will be carried out in second step;
4th step: concentrated, is specially: use double-effect falling film evaporator to concentrate the mixed material after sterilization in the 3rd step, and the first effect vacuum is 40kPa, and evaporating temperature is 73 DEG C; Second effect vacuum is 65kPa, and evaporating temperature is 50 DEG C, material is concentrated into the concentrated material that Baume degrees is 20 ° of B é;
5th step: spraying dry, is specially: pressure be 18MPa, EAT carries out spraying dry to the concentrated material that the 4th step obtains under be 180 DEG C and temperature of outgoing air being the condition of 80 DEG C, obtains dry mixed material;
6th step: dry cooling, is specially: the dry mixed material the 5th step obtained, by fluidized bed drying, cooling, controls material moisture 2.5%, obtains base stock powder;
7th step: batch mixing, be specially: adopt three-dimensional dry-mixed machine, the arachidonic acid taken by predetermined ratio, DHA, lactoferrin, nucleotides, TYR and L-Trp obtain premix after carrying out premix, premix is dropped in dry-mixed machine together with the 6th step gained base stock powder and mixes, mixing time is 18 minutes, obtains baby formula milk powder powder;
8th step: packaging, is specially: the baby formula milk powder powder the 7th step obtained adopts vacuum nitrogen or carbon dioxide gas to transfer in row packaging, and concrete packing specification is determined according to the actual requirements.
In the present embodiment 2 gained baby formula milk powder must and semi-dispensable amino acid, OPO content and osmotic pressure molar density and breast milk to such as showing shown in 2-1:
Must contrast with semi-dispensable amino acid, OPO content and osmotic pressure molar density value and breast milk in table 2-1 baby formula milk powder of the present invention
| Project | Formulation content (g/100g protein) | Breast milk *(g/100g protein) |
| Phenylalanine | 4.01±0.2 | 3.9 |
| Methionine | 1.78±0.3 | 1.6 |
| Isoleucine | 6.11±0.2 | 5.9 |
| Leucine | 10.02±0.3 | 9.7 |
| Lysine | 6.52±0.3 | 6.8 |
| Threonine | 4.44±0.5 | 4.7 |
| Valine | 6.61±0.2 | 6.4 |
| Tryptophan | 1.93±0.2 | 1.8 ** |
| Cystine | 2.27±0.2 | 2.1 ** |
| Histidine | 2.37±0.3 | 2.3 |
| Tyrosine | 4.24±0.3 | 4.2 |
| OPO | 4.4±0.4 | / |
| Osmotic pressure | 289±4.6(mosmmol/kg H 2O) | 290～310(mosmmol/kg H 2O) |
Wherein: * draws from " modern dairy industry handbook " (China Light Industry Press);
* draws breast milk amino acid average content in international food code CODEX STAN 72-1981Revision 2007;
* * draws the relation research [J] from mothers' diet nutrient intake and breast milk osmotic pressure, Chinese food and nutrition, 2012,18 (7): 74-78.
Adopt embodiment 2 gained baby formula milk powder to carry out clinical feeding trial, Details as Follows:
1, the selection of subjects
Select 3-4 month infant as research object, often organize 20 people.Group 1 (man 11, female 9) feeds common babies ' formula milk powder, as a control group; Group 2 (man 11, female 9) feeds the baby formula milk powder of embodiment 2, as test group; Organize 3 (man 7, female 13) with breast-feeding, as breast-feeding group.Wherein: 28.5 ± 3.5 years old mother's mean age; Research object sex between each group, childbirth options, maternal age, mother education level and occupation, income situation equal distribution are balanced, there was no significant difference.
2, the impact occurred the various symptom of baby fed by different formulations milk powder
Duration of test, the mode such as to visit by telephone interview weekly, follow-up and visiting, follow up a case by regular visits to the duration of test disease of above three groups of nursing group babies: with regard to Biography of Medical Figures (diagnosis, prognosis of disease), infectious diseases symptom: heating, respiratory symptom (cough, runny nose), the generation people number of times of the various disease symptom such as fash, statistics incidence, the results detailed in Table 2-2.
Known by table 2-2: the various symptom incidences such as runny nose, cough, heating have no notable difference between three groups, but total incidence test group of various symptom (embodiment 2 baby formula milk powder nursing group) is starkly lower than control group (common babies ' formula milk powder nursing group) (P<0.05).
The comparison of the various symptom incidence of table 2-2 different formulations fed infant
Wherein: have conspicuousness, P<0.05 with " * " expression with test group comparing difference.
In sum, through different formulations milk powder and breast-feeding, after the baby formula milk powder of the present embodiment 2 feeds 3 months, the total incidences of symptom such as baby's runny nose, cough, heating, eczema and breast-fed babies close, but be starkly lower than common babies ' formula milk powder group.Therefore, compared with common babies ' formula milk powder, the embodiment of the present invention 2 baby formula milk powder can strengthen infant to the resistivity of disease, reduce irritated risk.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a forth generation novel infant formula milk powder, it is characterized in that: comprise following component by weight percentage: lactose 8-25%, desalted whey powder 20-50%, skimmed milk power 8-35%, vegetable oil 16-27%, 1, 3-bis-oleic acid 2-palmitic acid three ester 2.4-9.6%, hydrolyzing lactoalbumin 1-9%, galactooligosaccharide 0-6%, FOS 0-6%, mineral substance premix 0.8-1.9%, arachidonic acid 0.3-1.8%, caseinhydrolysate 0.2-1.5%, containing the WPC 0.2-1.8% of 25-45% alpha lactalbumin, soybean lecithin 0.2-1.3%, DHA 0.2-1.2%, water soluble vitamin premix 0.1-0.4%, lactoferrin 0.02-0.1%, TYR 0-0.09%, nucleotides 0.018-0.06%, liposoluble vitamin premix 0.01-0.06%, L-Trp 0-0.06%, L-Methionine 0-0.06%, taurine 0.01-0.05% and VBT 0.005-0.02%.
2. forth generation novel infant formula milk powder according to claim 1, it is characterized in that: comprise following component by weight percentage: lactose 22.0%, desalted whey powder 26.2%, skimmed milk power 14%, vegetable oil 20.2%, 1, 3-bis-oleic acid 2-palmitic acid three ester 4.8%, hydrolyzing lactoalbumin 3.1%, galactooligosaccharide 3.0%, FOS 1.0%, mineral substance premix 1.5%, arachidonic acid 1.01%, caseinhydrolysate 0.6%, containing the WPC 0.7% of 43% alpha lactalbumin, soybean lecithin 0.6%, DHA 0.86%, water soluble vitamin premix 0.2%, lactoferrin 0.052%, TYR 0.05%, nucleotides 0.023%, liposoluble vitamin premix 0.019%, L-Trp 0.022%, L-Methionine 0.021%, taurine 0.028% and VBT 0.015%,
Or lactose 10.0%, desalted whey powder 35%, skimmed milk power 20%, vegetable oil 18.2%, 1, 3-bis-oleic acid 2-palmitic acid three ester 3.8%, hydrolyzing lactoalbumin 5.0%, galactooligosaccharide 1.6%, FOS 1.0%, mineral substance premix 1.1%, arachidonic acid 1.0%, caseinhydrolysate 0.6%, containing the WPC 1.0% of 43% alpha lactalbumin, soybean lecithin 0.6%, DHA 0.72%, water soluble vitamin premix 0.18%, lactoferrin 0.06%, TYR 0.03%, nucleotides 0.023%, liposoluble vitamin premix 0.02%, L-Trp 0.021%, taurine 0.031% and VBT 0.015%.
3. forth generation novel infant formula milk powder according to claim 2, is characterized in that: described mineral substance premix comprises calcium carbonate 3.2%, potassium chloride 35.2%, magnesium sulfate 15.1%, natrium citricum 18%, tricalcium phosphate 21%, ferrous sulfate 2.0%, zinc sulfate 5.34%, copper sulphate 0.13%, manganese sulfate 0.02%, KI 0.006% and sodium selenate 0.004% by weight percentage;
Or tricalcium phosphate 27.1%, potassium chloride 28.7%, natrium citricum 21%, magnesium sulfate 10.3%, calcium carbonate 8.4%, ferrous sulfate 3.4%, zinc sulfate 0.9%, copper sulphate 0.15%, manganese sulfate 0.033%, KI 0.013% and sodium selenate 0.004%.
4. forth generation novel infant formula milk powder according to claim 2, is characterized in that: described vegetable oil is the mixed vegetable oil be made up of the three kinds or more in sunflower oil, coconut oil, soybean oil, rapeseed oil, palm oil and palm-kernel oil.
5. forth generation novel infant formula milk powder according to claim 4, is characterized in that: described vegetable oil comprises high oleic sunflower oil 30-40%, soybean oil 18-35%, coconut oil 15-30%, palm oil 10-25% and rapeseed oil 10-15% by weight percentage.
6. forth generation novel infant formula milk powder according to claim 2, is characterized in that: described water soluble vitamin premix by weight percentage comprises L-AA sodium 53.47%, Choline Chloride 21.9%, inositol 20.6%, niacinamide 1.82%, D-VB5 calcium 1.0%, Bio 0.12%, cyanocobalamin 0.34%, thiamine hydrochloride 0.25%, puridoxine hydrochloride 0.18%, riboflavin 0.28% and folic acid 0.04%;
Or: L-AA sodium 43.8%, Choline Chloride 32.2%, inositol 19.4%, niacinamide 1.98%, D-VB5 calcium 1.15%, Bio 0.39%, cyanocobalamin 0.286%, thiamine hydrochloride 0.28%, puridoxine hydrochloride 0.26%, riboflavin 0.25%, folic acid 0.004%.
7. forth generation novel infant formula milk powder according to claim 2, is characterized in that: described liposoluble vitamin premix by weight percentage comprise 95.7% dl-α-D-α-tocopherol acetate, the axerophtholum aceticum of 3.7%, the Vitamin D3 of 0.05% and 0.55% phytondione;
Or the dl-α-D-α-tocopherol acetate of 95.55%, the axerophtholum aceticum of 3.8%, the Vitamin D3 of 0.05% and 0.6% phytondione.
8. a preparation method for the forth generation novel infant formula milk powder as described in claim 1-7 any one, is characterized in that: comprise the following steps:
Step one: batching, be specially: by the skimmed milk power taken by predetermined ratio, desalted whey powder, lactose, hydrolyzing lactoalbumin, the WPC containing 25-45% alpha lactalbumin, galactooligosaccharide, FOS, mineral substance premix, caseinhydrolysate, water soluble vitamin premix, taurine, VBT is dissolved in alleged material gross weight 3.0-4.0 times and temperature is in the water of 40-55 DEG C, squeezes into temporary storage tank I after mixing; Temporary storage tank II is squeezed into by after the vegetable oil taken by predetermined ratio, OPO, soybean lecithin and liposoluble vitamin premix mixing;
Step 2: mixing homogeneous, is specially: by the mixing of materials of temporary storage tank I and temporary storage tank II, homogeneous in high pressure homogenizer;
Step 3: sterilization;
Step 4: concentrated, is specially: use double-effect falling film evaporator to concentrate;
Step 5: spraying dry;
Step 6: fluidized bed drying cools, and is specially: carry out fluidized bed drying, cooling, controls moisture content of material 2.0-4.0%, obtains base stock powder;
Step 7: batch mixing, be specially: adopt three-dimensional dry-mixed machine, arachidonic acid, DHA, lactoferrin, nucleotides, TYR, L-Trp and/or L-Methionine is taken by predetermined ratio, after carrying out premix, drop into dry-mixed machine to mix together with base stock powder, obtain forth generation novel infant formula milk powder.
9. the preparation method of forth generation novel infant formula milk powder according to claim 8, it is characterized in that: the batching in described step one can also in the following way: pasteurize fresh milk being carried out at 70-75 DEG C 18-22 second, obtained skim milk after then fat being separated; The desalted whey powder taken by predetermined ratio, lactose, hydrolyzing lactoalbumin, WPC containing 25-45% alpha lactalbumin, galactooligosaccharide, FOS, mineral substance premix, caseinhydrolysate, water soluble vitamin premix, taurine and VBT are added in skim milk, after mixing, squeezes into temporary storage tank I; Temporary storage tank II is squeezed into by after the vegetable oil taken by predetermined ratio, OPO (OPO), soybean lecithin, liposoluble vitamin premix mixing; After above-mentioned skim milk meets spraying dry, the amount of gained skimmed milk power is equal with the amount of directly adding skimmed milk power.
10. the preparation method of forth generation novel infant formula milk powder according to claim 8, is characterized in that: in described step 2, the temperature of homogeneous is 55-70 DEG C, and the pressure of homogeneous is 10-20MPa; In described step 3, sterilization process is specially: sterilization 15-25 second at 85-95 DEG C; Actual conditions concentrated in described step 4 is: the first effect vacuum is 30-42kPa, and evaporating temperature is 70-75 DEG C; Second effect vacuum is 60-70kPa, and evaporating temperature is 45-52 DEG C; Material being concentrated into Baume degrees is 15-25 ° of B é; In described step 5, spray-drying process is specially: pressure be 12-20MPa, EAT carries out spraying dry under be 150-190 DEG C and temperature of outgoing air being the condition of 70-90 DEG C; Mixing time in described step 7 in dry-mixed machine is 15-20 minute.
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