CN114009510A - Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof - Google Patents
Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof Download PDFInfo
- Publication number
- CN114009510A CN114009510A CN202111402835.6A CN202111402835A CN114009510A CN 114009510 A CN114009510 A CN 114009510A CN 202111402835 A CN202111402835 A CN 202111402835A CN 114009510 A CN114009510 A CN 114009510A
- Authority
- CN
- China
- Prior art keywords
- milk
- parts
- powder
- goat
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 152
- 235000020251 goat milk Nutrition 0.000 title claims abstract description 53
- 235000013350 formula milk Nutrition 0.000 title claims abstract description 52
- 230000000774 hypoallergenic effect Effects 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 64
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 61
- 241000283707 Capra Species 0.000 claims abstract description 44
- 235000021119 whey protein Nutrition 0.000 claims abstract description 44
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 38
- 235000021240 caseins Nutrition 0.000 claims abstract description 38
- 239000005018 casein Substances 0.000 claims abstract description 37
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 28
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims abstract description 26
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 22
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims abstract description 22
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 22
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 21
- 235000010755 mineral Nutrition 0.000 claims abstract description 21
- 239000011707 mineral Substances 0.000 claims abstract description 21
- 239000005862 Whey Substances 0.000 claims abstract description 20
- 239000011782 vitamin Substances 0.000 claims abstract description 20
- 229940088594 vitamin Drugs 0.000 claims abstract description 19
- 229930003231 vitamin Natural products 0.000 claims abstract description 19
- 235000013343 vitamin Nutrition 0.000 claims abstract description 19
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract description 18
- 235000019197 fats Nutrition 0.000 claims abstract description 17
- 239000006041 probiotic Substances 0.000 claims abstract description 15
- 235000018291 probiotics Nutrition 0.000 claims abstract description 15
- 235000021342 arachidonic acid Nutrition 0.000 claims abstract description 13
- 229940114079 arachidonic acid Drugs 0.000 claims abstract description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000011575 calcium Substances 0.000 claims abstract description 11
- 235000001465 calcium Nutrition 0.000 claims abstract description 11
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 11
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 11
- 235000010216 calcium carbonate Nutrition 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims abstract description 11
- 229960005375 lutein Drugs 0.000 claims abstract description 11
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims abstract description 11
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims abstract description 11
- 235000019341 magnesium sulphate Nutrition 0.000 claims abstract description 11
- 239000001103 potassium chloride Substances 0.000 claims abstract description 11
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 11
- 239000001508 potassium citrate Substances 0.000 claims abstract description 11
- 229960002635 potassium citrate Drugs 0.000 claims abstract description 11
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims abstract description 11
- 235000011082 potassium citrates Nutrition 0.000 claims abstract description 11
- 239000001509 sodium citrate Substances 0.000 claims abstract description 11
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 11
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims abstract description 11
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims abstract description 11
- 235000020185 raw untreated milk Nutrition 0.000 claims abstract description 10
- -1 compound vitamin Chemical class 0.000 claims abstract description 9
- 229940090949 docosahexaenoic acid Drugs 0.000 claims abstract description 9
- 235000012680 lutein Nutrition 0.000 claims abstract description 9
- 239000001656 lutein Substances 0.000 claims abstract description 9
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims description 24
- 241001494479 Pecora Species 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 21
- 230000007062 hydrolysis Effects 0.000 claims description 19
- 238000006460 hydrolysis reaction Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 235000020256 human milk Nutrition 0.000 claims description 12
- 210000004251 human milk Anatomy 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 238000001694 spray drying Methods 0.000 claims description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 8
- 229940062827 2'-fucosyllactose Drugs 0.000 claims description 8
- HWHQUWQCBPAQQH-UHFFFAOYSA-N 2-O-alpha-L-Fucosyl-lactose Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC(C(O)CO)C(O)C(O)C=O HWHQUWQCBPAQQH-UHFFFAOYSA-N 0.000 claims description 8
- HWHQUWQCBPAQQH-BWRPKUOHSA-N 2-fucosyllactose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O HWHQUWQCBPAQQH-BWRPKUOHSA-N 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- SNFSYLYCDAVZGP-UHFFFAOYSA-N UNPD26986 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(OC(O)C(O)C2O)CO)OC(CO)C(O)C1O SNFSYLYCDAVZGP-UHFFFAOYSA-N 0.000 claims description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 8
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 7
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 7
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims description 7
- 229960000511 lactulose Drugs 0.000 claims description 7
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims description 7
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 5
- 229910052742 iron Inorganic materials 0.000 claims description 5
- 239000011669 selenium Substances 0.000 claims description 5
- 229910052711 selenium Inorganic materials 0.000 claims description 5
- 235000011083 sodium citrates Nutrition 0.000 claims description 5
- 239000011715 vitamin B12 Substances 0.000 claims description 5
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 4
- 229930003268 Vitamin C Natural products 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 229960002685 biotin Drugs 0.000 claims description 4
- 235000020958 biotin Nutrition 0.000 claims description 4
- 239000011616 biotin Substances 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 229960000304 folic acid Drugs 0.000 claims description 4
- 235000019152 folic acid Nutrition 0.000 claims description 4
- 239000011724 folic acid Substances 0.000 claims description 4
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 4
- 229940055726 pantothenic acid Drugs 0.000 claims description 4
- 235000019161 pantothenic acid Nutrition 0.000 claims description 4
- 239000011713 pantothenic acid Substances 0.000 claims description 4
- 235000020254 sheep milk Nutrition 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 4
- 239000011691 vitamin B1 Substances 0.000 claims description 4
- 239000011716 vitamin B2 Substances 0.000 claims description 4
- 239000011726 vitamin B6 Substances 0.000 claims description 4
- 235000019154 vitamin C Nutrition 0.000 claims description 4
- 239000011718 vitamin C Substances 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 3
- 229930003316 Vitamin D Natural products 0.000 claims description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 150000004667 medium chain fatty acids Chemical class 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 239000011772 phylloquinone Substances 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 235000019166 vitamin D Nutrition 0.000 claims description 3
- 239000011710 vitamin D Substances 0.000 claims description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 229940045997 vitamin a Drugs 0.000 claims description 3
- 229940046008 vitamin d Drugs 0.000 claims description 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 2
- CILYIEBUXJIHCO-UHFFFAOYSA-N 102778-91-6 Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC2C(C(O)C(O)OC2CO)O)OC(CO)C1O CILYIEBUXJIHCO-UHFFFAOYSA-N 0.000 claims description 2
- DVGKRPYUFRZAQW-UHFFFAOYSA-N 3 prime Natural products CC(=O)NC1OC(CC(O)C1C(O)C(O)CO)(OC2C(O)C(CO)OC(OC3C(O)C(O)C(O)OC3CO)C2O)C(=O)O DVGKRPYUFRZAQW-UHFFFAOYSA-N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000186000 Bifidobacterium Species 0.000 claims description 2
- 241000186012 Bifidobacterium breve Species 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 2
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 2
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 2
- CILYIEBUXJIHCO-UITFWXMXSA-N N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O[C@H](CO)[C@@H]1O CILYIEBUXJIHCO-UITFWXMXSA-N 0.000 claims description 2
- OIZGSVFYNBZVIK-UHFFFAOYSA-N N-acetylneuraminosyl-D-lactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1O OIZGSVFYNBZVIK-UHFFFAOYSA-N 0.000 claims description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 2
- 229960001231 choline Drugs 0.000 claims description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 2
- 229960000367 inositol Drugs 0.000 claims description 2
- 229940012969 lactobacillus fermentum Drugs 0.000 claims description 2
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 2
- RBMYDHMFFAVMMM-PLQWBNBWSA-N neolactotetraose Chemical compound O([C@H]1[C@H](O)[C@H]([C@@H](O[C@@H]1CO)O[C@@H]1[C@H]([C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]1O)O)NC(=O)C)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O RBMYDHMFFAVMMM-PLQWBNBWSA-N 0.000 claims description 2
- 229960003512 nicotinic acid Drugs 0.000 claims description 2
- 235000001968 nicotinic acid Nutrition 0.000 claims description 2
- 239000011664 nicotinic acid Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 229920000157 polyfructose Polymers 0.000 claims description 2
- 230000000529 probiotic effect Effects 0.000 claims description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 2
- 229960003080 taurine Drugs 0.000 claims description 2
- 235000008210 xanthophylls Nutrition 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 235000013336 milk Nutrition 0.000 abstract description 40
- 239000008267 milk Substances 0.000 abstract description 40
- 210000004080 milk Anatomy 0.000 abstract description 40
- 235000016709 nutrition Nutrition 0.000 abstract description 9
- 230000036039 immunity Effects 0.000 abstract description 6
- 230000035764 nutrition Effects 0.000 abstract description 5
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 102000011632 Caseins Human genes 0.000 description 36
- 108010076119 Caseins Proteins 0.000 description 36
- 208000010668 atopic eczema Diseases 0.000 description 18
- 239000000463 material Substances 0.000 description 18
- 230000000172 allergic effect Effects 0.000 description 17
- 239000000203 mixture Substances 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 15
- 208000024891 symptom Diseases 0.000 description 15
- 208000026935 allergic disease Diseases 0.000 description 13
- 206010020751 Hypersensitivity Diseases 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 12
- 230000007815 allergy Effects 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 206010070834 Sensitisation Diseases 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 9
- 238000007580 dry-mixing Methods 0.000 description 9
- 238000001704 evaporation Methods 0.000 description 9
- 230000008020 evaporation Effects 0.000 description 9
- 241000283690 Bos taurus Species 0.000 description 8
- 102000004142 Trypsin Human genes 0.000 description 8
- 108090000631 Trypsin Proteins 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 8
- 238000004659 sterilization and disinfection Methods 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000012588 trypsin Substances 0.000 description 8
- 238000001816 cooling Methods 0.000 description 7
- 108090000145 Bacillolysin Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000035092 Neutral proteases Human genes 0.000 description 6
- 108091005507 Neutral proteases Proteins 0.000 description 6
- 239000013566 allergen Substances 0.000 description 6
- 235000013351 cheese Nutrition 0.000 description 6
- 235000020247 cow milk Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 238000000265 homogenisation Methods 0.000 description 6
- 238000010008 shearing Methods 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 206010016946 Food allergy Diseases 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 235000014121 butter Nutrition 0.000 description 4
- 230000009849 deactivation Effects 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 229940091258 selenium supplement Drugs 0.000 description 4
- 230000008313 sensitization Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 description 3
- 241000186226 Corynebacterium glutamicum Species 0.000 description 3
- 102000004407 Lactalbumin Human genes 0.000 description 3
- 108090000942 Lactalbumin Proteins 0.000 description 3
- 208000009793 Milk Hypersensitivity Diseases 0.000 description 3
- 102000014171 Milk Proteins Human genes 0.000 description 3
- 108010011756 Milk Proteins Proteins 0.000 description 3
- 208000003455 anaphylaxis Diseases 0.000 description 3
- 235000020246 buffalo milk Nutrition 0.000 description 3
- 235000015155 buttermilk Nutrition 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 235000021239 milk protein Nutrition 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 235000021241 α-lactalbumin Nutrition 0.000 description 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 description 2
- 108050000244 Alpha-s1 casein Proteins 0.000 description 2
- 108050001786 Alpha-s2 casein Proteins 0.000 description 2
- 238000011725 BALB/c mouse Methods 0.000 description 2
- 241001134770 Bifidobacterium animalis Species 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 241000254697 Lactobacillus rhamnosus HN001 Species 0.000 description 2
- 108010063045 Lactoferrin Proteins 0.000 description 2
- 102000010445 Lactoferrin Human genes 0.000 description 2
- 102000008192 Lactoglobulins Human genes 0.000 description 2
- 108010060630 Lactoglobulins Proteins 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 201000010859 Milk allergy Diseases 0.000 description 2
- 101100003139 Mus musculus Atp8b5 gene Proteins 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 241000607626 Vibrio cholerae Species 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940118852 bifidobacterium animalis Drugs 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000000498 cooling water Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000007731 hot pressing Methods 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 230000006058 immune tolerance Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 2
- 235000021242 lactoferrin Nutrition 0.000 description 2
- 229940078795 lactoferrin Drugs 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 108010071421 milk fat globule Proteins 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000008476 powdered milk Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 230000001235 sensitizing effect Effects 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 229940118696 vibrio cholerae Drugs 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000008939 whole milk Nutrition 0.000 description 2
- 235000021247 β-casein Nutrition 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 102000009366 Alpha-s1 casein Human genes 0.000 description 1
- 208000029751 Amino acid metabolism disease Diseases 0.000 description 1
- 101000693922 Bos taurus Albumin Proteins 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010051841 Exposure to allergen Diseases 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- 201000010538 Lactose Intolerance Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 230000037446 allergic sensitization Effects 0.000 description 1
- 235000020616 amino acid formula Nutrition 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940021722 caseins Drugs 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- 229960000355 copper sulfate Drugs 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000909 electrodialysis Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 239000011706 ferric diphosphate Substances 0.000 description 1
- 235000007144 ferric diphosphate Nutrition 0.000 description 1
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 description 1
- 229940036404 ferric pyrophosphate Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 235000021474 generally recognized As safe (food) Nutrition 0.000 description 1
- 235000021473 generally recognized as safe (food ingredients) Nutrition 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000020207 hydrolysed-protein milk formula Nutrition 0.000 description 1
- 235000020215 hypoallergenic milk formula Nutrition 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- 235000013384 milk substitute Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000021049 nutrient content Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000014786 phosphorus Nutrition 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 229960004839 potassium iodide Drugs 0.000 description 1
- 235000007715 potassium iodide Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 235000021249 α-casein Nutrition 0.000 description 1
- 235000021246 κ-casein Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/06—Mixtures of whey with milk products or milk components
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
- A23C21/026—Whey; Whey preparations containing, or treated with, microorganisms or enzymes containing, or treated only with, lactic acid producing bacteria, bifidobacteria or propionic acid bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/08—Whey; Whey preparations containing other organic additives, e.g. vegetable or animal products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C21/00—Whey; Whey preparations
- A23C21/10—Whey; Whey preparations containing inorganic additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/515—Animalis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dairy Products (AREA)
Abstract
The invention relates to the technical field of infant formula milk powder, in particular to hypoallergenic infant goat milk-based formula milk powder and a preparation method thereof, wherein the hypoallergenic infant goat milk-based formula milk powder comprises the following components in parts by weight: 0-15 parts of raw milk, 5-10 parts of goat casein powder, 50-70 parts of desalted goat whey powder, 7-15 parts of hydrolyzed goat whey protein powder, 5-15 parts of hydrolyzed casein powder, 16-40 parts of fat, 0.06-0.3 part of compound vitamin, 0.06-0.2 part of compound mineral, 0.2-0.4 part of calcium carbonate, 0.1-0.4 part of calcium hydrophosphate, 0.2-0.5 part of sodium citrate, 0.4-0.6 part of potassium chloride, 0.01-0.15 part of magnesium sulfate, 0.05-0.15 part of potassium citrate, 0.5-2 parts of docosahexaenoic acid, 0.5-2 parts of arachidonic acid, 0.01-0.04 part of lutein, 5-10 parts of prebiotics and 0.06-0.12 part of probiotics. Has the advantages of low allergenicity, comprehensive nutrition and good immunity enhancing effect.
Description
Technical Field
The invention relates to the technical field of infant formula milk powder, in particular to low-sensitization infant goat milk-based formula milk powder and a preparation method thereof.
Background
The prevalence of allergic diseases in children and young adults is on the rise. A large body of experimental and clinical data suggests that early exposure to allergens in the diet may be critical for the development of allergies, especially food allergy and Atopic Dermatitis (AD). The best nutritional choice for newborns is breast milk. However, some infants may not receive breast feeding alone during the first month of life. In this case, another substitute for breast milk must be provided. This replacement results in 2-6% of children suffering from an allergic disease known as Cow's Milk Protein Allergy (CMPA).
Today, the most common substitutes are soy and hydrolyzed formula. However, there is evidence that 10-20% of children allergic to cow's milk are intolerant to soy derivatives and some cases of high immune response to hydrolyzed formulas have been reported. Allergy to cow's milk is generally divided into immunoglobulin e (IgE) -mediated allergy and non-IgE-mediated allergy. Milk contains more than 25 proteins, but only whey protein, alpha-lactalbumin, beta-lactoglobulin, BSA and lactoferrin and 4 caseins were identified as allergens. The casein fraction consists of α s1, α s2, β and κ -casein, which, based on IgE and T cell recognition data, appears to be the major allergen.
The ingredients of goat milk have certain advantages over cow's milk. Infants and children who are sensitive to milk-based products will generally be better tolerated when replacing goat milk-based products. There is at least 99% similarity between the protein sequences of the sheep and the sheep alpha S1 and alpha S2, but the two are significantly different from the protein sequences of the cattle alpha S1 and alpha S2. This fact indicates that goat milk can promote less allergic sensitization. Whey protein also plays an important role in people allergic to milk, but no sensitization data on sheep whey protein is reported at present.
The goat milk is high in nutrient content, so that the goat milk can be considered as an ideal milk substitute for an allergic person. Specific antibodies in humans allergic to cow ' S milk (IgE) hardly recognize the protein components α S1-casein, α S2-casein and β -casein in sheep ' S milk and sheep ' S milk. The nutritional suitability of buffalo and sheep milks for humans and children with cow, goat, sheep and buffalo milk was assessed by studies on the amino acid composition, secondary structure, CLUSTALW2 analysis and phylogenetic relationships of cow, goat, sheep and buffalo milk, and the results showed that for infants with cow's milk allergy, the goat milk was suitable and acceptable because the whey proteins of sheep and goat were nearly identical.
It is currently recommended to replace the first 4 to 6 months of life of infants at risk of allergic disease with partially hydrolyzed formulas and extensively hydrolyzed formulas to reduce early allergens. However, moderate hydrolysis and deep hydrolysis are unfavorable for the establishment of infant immune tolerance, and are not suitable for long-term use, which may cause amino acid metabolism disorder.
Most current research on the formulation of protein hydrolysate formulas for food-allergic infants focuses on their effect on allergy and little evaluation of their ability to provide normal nutritional status. Infants fed the hydrolyzed formula had lower iron content than the breast-fed group and the general formula group. The hydrolyzed formula appears to provide an excess amount of amino acids compared to the conventional formula, which is reflected in higher serum urea nitrogen and higher plasma amino acid concentrations.
In addition, the hypoallergenic formulas patent applications currently being searched are all bovine milk-based formulas involving partial hydrolysis of bovine whey proteins and/or partial hydrolysis of bovine milk proteins including whey proteins and casein proteins, which, although the inclusion of hydrolyzed proteins may reduce allergenicity, still contain large amounts of readily allergenic bovine milk intact proteins. The hypoallergenic newborn formula milk powder disclosed in patent application CN106509130A reduces allergens and improves infant immunity to solve the problem of infant allergy, and the formula contains whole milk, skim milk, alpha lactalbumin, hydrolyzed whey protein and hydrolyzed casein, and at the same time, one or more of lactoferrin, immunoglobulin and sialic acid as bioactive substances are added. Patent application CN101978841A discloses an anti-protein allergy and nutritional infant formula milk powder containing fresh milk and desalted whey powder, wherein whey small peptide with molecular weight less than 10000 Dalton is added, the anti-protein allergy and anti-protein allergy milk powder has the advantages of immunity regulation, good water solubility, high absorption rate, no stimulation to stomach and intestine, and simultaneously, amino acid chelated trace elements and selenium-enriched yeast powder are added to meet the requirements of trace elements and amino acid. A hypoallergenic infant formula powder described in patent application CN104430899A contains fresh cow's milk, alpha-lactalbumin. A 0-6 month infant formula powder for the prevention of lactose intolerance and protein allergy as described in patent application CN105831284A comprises a fresh milk spray dried powder and a concentrated hydrolysed whey protein powder.
On the basis of previous research, the selection of milk powder suitable for infants is an important target of research. Therefore, the formula milk powder for improving the milk protein intestinal tolerance, allergy high risk and normal nutrition of the infant is developed, more food choices are provided for the infant with allergy risk who cannot be breastfed, and the formula milk powder has important value and wide market.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the hypoallergenic infant goat milk-based formula milk powder with low allergenicity, comprehensive nutrition and good immunity enhancing effect and the preparation method thereof.
The invention is realized by the following technical scheme:
the hypoallergenic infant goat milk-based formula milk powder comprises the following components in parts by weight: 0-15 parts of raw milk, 5-10 parts of goat casein powder, 50-70 parts of desalted goat whey powder, 7-15 parts of hydrolyzed goat whey protein powder, 5-15 parts of hydrolyzed casein powder, 16-40 parts of fat, 0.06-0.3 part of compound vitamin, 0.06-0.2 part of compound mineral, 0.2-0.4 part of calcium carbonate, 0.1-0.4 part of calcium hydrophosphate, 0.2-0.5 part of sodium citrate, 0.4-0.6 part of potassium chloride, 0.01-0.15 part of magnesium sulfate, 0.05-0.15 part of potassium citrate, 0.5-2 parts of docosahexaenoic acid (DHA), 0.5-2 parts of arachidonic acid (ARA), 0.01-0.04 part of lutein, 5-10 parts of prebiotics and 0.06-0.12 part of probiotics.
Preferably, the raw milk comprises at least one of fresh goat milk, whole goat milk powder or defatted goat milk powder. The fresh goat milk can be fresh goat milk conventionally used in the field, the full-fat goat milk powder can be goat full-fat milk powder conventionally used in the field, and the defatted goat milk powder can be goat defatted milk powder conventionally used in the field.
In the invention, the main components of the desalted sheep whey powder are whey protein and lactose. The desalted whey powder is prepared by removing mineral salts from whey powder. For infants, high mineral content increases the kidney burden on the baby, and therefore, demineralization must be performed. And can adjust the protein ratio to approach the level of breast milk. The whey is subjected to electrodialysis and/or ion exchange to reduce the mineral content by 90%. The desalted whey was concentrated by evaporation to a total solids content of 58% and then rapidly cooled to convert as much lactose as possible into fine crystals. The cooled whey concentrate is spray dried.
The goat cheese milk powder is prepared by whipping cream to form butter, then pasteurizing before concentration to obtain liquid butter, and removing water in the liquid butter. The buttermilk yield is 1.7-1.8 times of the butter yield. It has a moisture content of no more than 5% by weight and a milk fat content of no less than 4.5% by weight. The protein content of the buttermilk powder is not less than 30%. In 8.5-9.0% of solid matters, the protein accounts for 3.2-3.5%. The high biological value of the protein in the cheese milk is represented by the good quantity balance of the essential amino acids contained in the cheese milk (containing high lysine, egg and cystine with remarkable anti-cardiovascular sclerosis property), the cheese milk also serves as a source of calcium, phosphorus, riboflavin and vitamin B12, and the cheese milk powder has high nutritional value due to the rich Milk Fat Globule Membrane (MFGM), and is suitable for being used as a raw material for extracting the fat globule membrane industrially and on a large scale.
Preferably, the degree of hydrolysis of the hydrolyzed goat whey protein powder is 10-14%.
In the invention, the hydrolyzed sheep whey protein powder is whey protein hydrolyzed by adopting a conventional method in the field, as known by the technical personnel in the field, generally, the hydrolyzed whey protein is prepared by hydrolyzing sheep whey protein by trypsin and neutral protease, wherein the content of beta-lactoglobulin is reduced, and low-sensitivity protein can be provided for the low-sensitivity infant formula milk powder.
More preferably, the hydrolysis process of the hydrolyzed sheep whey protein powder is as follows: controlling the concentration of the sheep whey protein substrate to be 10-12%, adding KOH at about 55 ℃, adjusting the pH value of the solution to be 6.8-7.0, then respectively adding trypsin and neutral protease according to 0.2% and 0.23% of the content of the whey protein, keeping the temperature to be 53-55 ℃, carrying out enzymolysis for 50min, and after the enzymolysis is finished, carrying out enzyme deactivation at 85 ℃ for 15 min.
Preferably, the degree of hydrolysis of the hydrolyzed casein powder is 3-25%.
In the invention, the hydrolyzed casein powder is hydrolyzed casein which is hydrolyzed by a conventional method in the field, and preferably hydrolyzed feta protein powder. As known to those skilled in the art, in general, hydrolyzed feta protein is produced by hydrolyzing casein with trypsin and a neutral protease, wherein the alpha-casein content is reduced, and it is possible to provide hypoallergenic infant formula powder with hypoallergenic proteins. In the present invention, the hydrolyzed casein is preferably hydrolyzed casein having a degree of hydrolysis of 3 to 10% and 10 to 25%, more preferably 10 to 25%.
More preferably, the hydrolysis process of the hydrolyzed casein powder comprises the following steps: controlling the concentration of casein substrate at about 5%, adjusting pH value at about 60 deg.C to 7.5, immediately adding trypsin according to 0.2% of casein content, maintaining at 60 + -2 deg.C, performing enzymolysis for 140min, and inactivating enzyme at 85 deg.C for 15min after the enzymolysis is finished.
Preferably, the fat comprises 2-5 parts of sheep cream, 5-15 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride, 3-5 parts of medium-chain fatty acid MCT, 1-5 parts of olive oil and 5-10 parts of soybean oil in parts by weight.
Preferably, the prebiotics are 5 to 10 parts by weight.
In the present invention, the multivitamin is a multivitamin which is conventional in the art. The compound vitamin is a semi-finished product compound raw material formed by uniformly mixing a plurality of vitamin monomers. The composition and the dosage of the compound vitamin only need to meet the requirement that all vitamins in the final product reach the content of all vitamins in the infant formula food.
The compound vitamin comprises vitamin A, vitamin D, vitamin E, and vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12At least two of niacin, folic acid, pantothenic acid, vitamin C, and biotin.
Preferably, the complex minerals include minerals that provide the elements copper, iron, zinc, manganese, iodine, and selenium. Preferably copper sulfate, ferric pyrophosphate, zinc sulfate, manganese sulfate, potassium iodide, sodium selenite and the like, and is mainly used as a nutrition enhancer in infant formula food products.
Preferably, the composition per gram of the composite mineral is as follows: 3000-4100 mu g of copper, 42-58 mg of iron, 40-54 mg of zinc, 200-280 mu g of manganese, 800-108 mu g of iodine and 200-270 mu g of selenium.
Preferably, the composition per gram of multivitamin is as follows: 2000-2700 mu gRE of vitamin A, 68-92 mu g of vitamin D, 45-60 mg of alpha-TE of vitamin E and K of vitamin1300-400 mu g, vitamin B13000-4100 μ g, vitamin B22000-2700 ug, vitamin B61500-2100 mug of vitamin B122.6-3.5 μ g, 38-52 μ g biotin, 16000-22000 μ g nicotinamide, 450-620 μ g folic acid, 13000-18000 μ g pantothenic acid, 400-550 mg vitamin C.
Preferably, the prebiotic comprises at least one of a human milk derived prebiotic, a fructooligosaccharide, a galactooligosaccharide, a polyfructose, lactulose and a xylooligosaccharide.
More preferably, the human milk-derived prebiotic comprises at least one of 2 '-fucosyllactose, 3' -sialyllactose, and N-neotetraose lactate.
More preferably, the prebiotic is a mixture of 2' -fucosyllactose, galacto-oligosaccharides and lactulose.
More preferably, the mass ratio of 2' -fucosyllactose, galactooligosaccharide and lactulose is 1:2-4: 2-4.
More preferably, the recombinant corynebacterium glutamicum (c.glutamicum) for producing 2' -fucosyllactose, which is a strain of corynebacterium glutamicum of GRAS certified by FDA according to the present invention, is safer than the existing escherichia coli.
Preferably, the probiotic bacteria comprise at least one of bifidobacteria, bifidobacterium lactis, bifidobacterium breve, lactobacillus rhamnosus, lactobacillus fermentum and lactobacillus reuteri.
Preferably, the hypoallergenic infant goat milk-based formula milk powder further comprises 0.04-0.38 parts by weight of additive.
More preferably, the adjunct comprises at least one of inositol, L-carnitine, taurine, nucleotides, and choline.
Preferably, the hypoallergenic goat milk-based formula milk powder for infants has the water content of 2-3%, preferably 2.5%; water activity is conventional in the art. Water Activity awPreferably 0.15-0.2%, preferably 0.2%.
The invention also relates to a preparation process of the hypoallergenic infant goat milk-based formula milk powder, which comprises the following steps:
(1) firstly, adding water, raw milk, desalted goat whey powder, goat casein powder, hydrolyzed goat whey protein powder and hydrolyzed casein powder into a mixing tank, then adding fat, and finally slowly pouring multivitamins, compound mineral substances, calcium carbonate, calcium hydrophosphate, sodium citrate, potassium chloride, magnesium sulfate and potassium citrate into the mixing tank to obtain feed liquid A;
(2) homogenizing the feed liquid A, sterilizing, concentrating, and spray drying to obtain base powder B;
(3) mixing the base powder B with xanthophyll, prebiotics, probiotics, docosahexaenoic acid and arachidonic acid.
Namely, the preparation process comprises the steps of material preparation, homogenization, sterilization, concentration, spray drying and dry mixing.
Preferably, the step (1) comprises the following steps: accurately metering the components according to the formula, adding the components into a shearing mixing tank filled with hot water, and mixing. The preparation method comprises the following steps of adding 50-60 ℃ water into a mixing tank, starting shearing and stirring, adding raw milk, desalted goat whey powder, goat casein powder, hydrolyzed goat whey protein powder and hydrolyzed casein powder, then adding fat, finally slowly pouring multivitamins, complex minerals, calcium carbonate, calcium hydrophosphate, sodium citrate, potassium chloride, magnesium sulfate and potassium citrate into the mixing tank, mixing and stirring for about 10 minutes to obtain a feed liquid A, and adding the feed liquid A into a tank to be homogenized.
Preferably, the homogenization process in step (2) is as follows: and homogenizing the feed liquid A under the condition that the pressure is 16-20 MPa.
Preferably, the sterilization process in step (2) is as follows: after homogenization, the feed liquid is sterilized for a short time (about 6s) at the temperature of 110 ℃ and 120 ℃ and then cooled to the temperature of 10-20 ℃.
Preferably, the concentration conditions in step (2) are as follows: and (4) concentrating the sterilized feed liquid in a triple-effect evaporator, wherein the amount of the concentrated dry matter is about 40-55%.
Preferably, the spray drying process of step (2) is as follows: and (3) feeding the concentrated feed liquid into a spray drying tower, adjusting the pressure of a high-pressure pump to be more than 15MPa when the exhaust temperature reaches 90 ℃ and the inlet temperature is more than 130 ℃, starting spray drying, and cooling by a fluidized bed to obtain base powder B.
Preferably, the dry mixing process of step (3) is as follows: firstly, 4% -8% of base powder B, lutein, prebiotics, probiotics, docosahexaenoic acid and arachidonic acid are mixed and premixed for more than 5min to obtain a premix, and then the premix and the rest base powder are subjected to dry mixing operation for more than 8min to obtain the milk powder.
More preferably, the preparation method of the hypoallergenic infant goat milk-based formula milk powder comprises the following steps:
(1) preparing materials: after checking the relevant information, the raw and auxiliary materials are accurately metered into a shearing and mixing tank filled with hot water according to the formula for mixing. The preparation method comprises the following steps of adding 50-60 ℃ (temperature can be adjusted according to seasons) of preparation water into a material mixing tank, starting shearing and stirring, adding raw milk, desalted goat whey powder, goat casein powder, hydrolyzed goat whey protein powder and hydrolyzed casein powder, then adding fat, finally slowly pouring multivitamins, complex minerals, calcium carbonate, calcium hydrophosphate, sodium citrate, potassium chloride, magnesium sulfate and potassium citrate into the material mixing tank, mixing and stirring for about 10 minutes to obtain a material liquid A, and adding the material liquid A into a tank to be homogenized.
(2) Homogenizing and sterilizing: after the material pump is opened, the homogenizing pressure is slowly adjusted to be (16-20) MPa, and after the homogenization, the material liquid is cooled and pumped into a temporary storage tank for temporary storage after short-time sterilization at the temperature of 110 ℃ and 120 ℃ (about 6 seconds). Before homogenization is completed, the foam in the mixing cylinder is flushed with warm water, and the fat floats into lumps.
(3) Cooling and storing materials: cooling the homogenized and sterilized materials to 10-20 ℃ in time, cooling by cold air discharge according to the actual production condition, adding the dissolved vitamins, and uniformly stirring. The temporary storage time should not exceed 2 hours, and the temporary storage tank needs to be added with stirring.
(4) Sterilization and concentration: after sterilization, the feed liquid enters a triple-effect evaporator for concentration, when the pressure of a boiler reaches 0.8MPa, the pressure of compressed air reaches over 0.4MPa, the temperature of a sterilizer reaches 92-98 ℃, and the evaporation temperature meets the process requirements, a feed valve is opened, and a reflux valve is closed to feed materials to a thick milk tank. The pressure of the triple effect cylinder is more than or equal to 0.8MPa, and the pressure of the hot-pressing pump is 0.3-0.8 MPa. The sterilization temperature is 92-98 ℃ for about 15 s. The primary evaporation temperature is 68-75 ℃, the secondary evaporation temperature is 54-60 ℃, the tertiary evaporation temperature is 46-54 ℃, and the cooling water discharge temperature is less than or equal to 40 ℃. The vacuum of the first-effect separator is-0.065-0.071 MPa, the vacuum of the second-effect separator is-0.081-0.084 MPa, the vacuum of the third-effect separator is-0.084-0.091 MPa, and the amount of the concentrated dry matter is about 40-55%.
(5) Spray drying: and (3) feeding the concentrated feed liquid into a spray drying tower, adjusting the pressure of a high-pressure pump to be more than 15MPa when the exhaust temperature reaches 90 ℃ and the inlet temperature is more than 130 ℃, starting spray drying, and cooling by a fluidized bed to obtain base powder B.
(6) Dry mixing: in order to ensure the uniformity of dry mixing, 4-8% of base powder, lutein, prebiotics, probiotics, docosahexaenoic acid and arachidonic acid are mixed and premixed for more than 5min to obtain premix, and then the premix and the rest base powder are subjected to dry mixing operation for more than 8min to obtain the milk powder.
The invention has the beneficial effects that:
the low-sensitization infant goat milk-based formula milk powder provided by the invention gives consideration to both low-sensitization and amino acid balance, solves the problem of infant allergy, reduces allergen, optimizes the hydrolysis degree of raw materials, and avoids blood amino acid abnormality caused by partial hydrolysis, deep hydrolysis and amino acid formula. Meanwhile, the health food contains substances beneficial to immunity, such as prebiotics, probiotics and the like. The preparation process is simple, the milk powder has good solubility, the shelf life is stable, and the oxidation is not easy.
The low-sensitization infant goat milk-based formula milk powder provided by the invention is comprehensive in nutrition and is suitable for infants to eat.
The invention optimizes the composition of prebiotics, and particularly when the prebiotics are the mixture of 2' -fucosyllactose, galacto-oligosaccharide and lactulose, the composition of the milk powder is closer to breast milk.
The invention adopts a goat milk-based formula, and has the characteristic of low sensitization compared with a cow milk-based formula.
The sheep buttermilk powder contains the milk fat globule membrane, so that the milk powder composition is closer to breast milk.
Drawings
FIG. 1 shows the results of the test for the total IgE content in the serum of mouse in test example 2 of the present invention.
Detailed Description
The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
In each of the embodiments described below, the following,
the preparation process of the hydrolyzed sheep whey protein powder comprises the following steps: adding water to control the concentration of the goat whey protein substrate to be 12%, adjusting the temperature to be about 55 ℃, adjusting the pH value of the solution to be 6.8, then respectively adding trypsin and neutral protease according to 0.2% and 0.23% of the goat whey protein content, keeping the temperature at 55 ℃, carrying out enzymolysis for 50min, after the enzymolysis is finished, carrying out enzyme deactivation at 85 ℃ for 15min, and detecting that the hydrolysis degree is 14%.
The hydrolysis process of the hydrolyzed casein powder comprises the following steps: adding water to control casein substrate concentration to 5%, adjusting pH to 7.5 at 60 deg.C, immediately adding trypsin according to 0.2% of casein content, maintaining at 60 deg.C, performing enzymolysis for 140min, after enzymolysis, inactivating enzyme at 85 deg.C for 15min, and detecting hydrolysis degree of 12%.
The goat cheese milk powder is purchased from Qingdao Biao trading Co., Ltd, and the desalted goat whey powder is purchased from Qingdao Biao trading Co., Ltd.
The fat specifically consists of: 3 parts of sheep cream, 10 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride, 4 parts of medium-chain fatty acid MCT, 3 parts of olive oil and 8 parts of soybean oil.
The prebiotics specifically consist of: the mixture of 2' -fucosyllactose, galacto-oligosaccharide and lactulose, wherein the mass ratio of the two is 1: 3: 3.
the probiotics specifically consist of: bifidobacterium animalis Bb-12, Bifidobacterium lactis HN019 and Lactobacillus rhamnosus HN001, wherein the mass ratio of the Bifidobacterium animalis to the Lactobacillus rhamnosus HN001 is 1:1: 1.
The compound mineral is purchased from Beijing Jinkanpu food science and technology company, wherein each gram of the compound mineral comprises the following components: 3550 mug of copper, 50mg of iron, 47mg of zinc, 240 mug of manganese, 940 mug of iodine and 235 mug of selenium.
The vitamin complex is purchased from Beijing Jinkanpu food science and technology company, wherein each gram of the vitamin complex comprises the following components: vitamin A2350 μ gRE, vitamin D80 μ g, vitamin E53 mg alpha-TE, vitamin K 1350 mug of vitamin B13550 mug of vitamin B22350 μ g, vitamin B61800 μ g, vitamin B123.1 mug, 45 mug biotin, 19000 mug nicotinamide, 535 mug folic acid, 15500 mug pantothenic acid and 475mg vitamin C.
Example 1
The milk powder comprises 10 parts of fresh goat milk, 8 parts of goat casein powder, 55 parts of desalted goat whey powder, 8 parts of hydrolyzed goat whey protein powder, 9 parts of hydrolyzed casein powder, 30 parts of fat, 0.25 part of compound vitamin, 0.1 part of compound mineral, 0.3 part of calcium carbonate, 0.4 part of calcium hydrophosphate, 0.45 part of sodium citrate, 0.5 part of potassium chloride, 0.05 part of magnesium sulfate, 0.1 part of potassium citrate, 1.0 part of docosahexaenoic acid (DHA), 1.5 parts of arachidonic acid (ARA), 0.03 part of lutein, 6 parts of prebiotics and 0.06 part of probiotics.
Example 2
The milk powder comprises 5 parts of goat casein powder, 50 parts of desalted goat whey powder, 7 parts of hydrolyzed goat whey protein powder, 5 parts of hydrolyzed casein powder, 16 parts of fat, 0.06 part of compound vitamin, 0.06 part of compound mineral, 0.2 part of calcium carbonate, 0.1 part of calcium hydrophosphate, 0.2 part of sodium citrate, 0.4 part of potassium chloride, 0.01 part of magnesium sulfate, 0.05 part of potassium citrate, 0.5 part of docosahexaenoic acid, 0.5 part of arachidonic acid, 0.01 part of lutein, 5 parts of prebiotics and 0.06 part of probiotics.
Example 3
The milk powder comprises 15 parts of fresh goat milk, 10 parts of goat casein powder, 70 parts of desalted goat whey powder, 15 parts of hydrolyzed goat whey protein powder, 15 parts of hydrolyzed casein powder, 40 parts of fat, 0.3 part of compound vitamin, 0.2 part of compound mineral, 0.4 part of calcium carbonate, 0.4 part of calcium hydrophosphate, 0.5 part of sodium citrate, 0.6 part of potassium chloride, 0.15 part of magnesium sulfate, 0.15 part of potassium citrate, 2 parts of docosahexaenoic acid, 2 parts of arachidonic acid, 0.04 part of lutein, 10 parts of prebiotics and 0.12 part of probiotics.
Comparative example 1
The difference from example 1 is that the prebiotics are used in the same amount, have different compositions, are galactooligosaccharides only, and the other conditions are the same.
Comparative example 2
The difference from the example 1 is only that the dosage of the prebiotics is unchanged, the composition is different, and the prebiotics is only a mixture of 2' -fucosyllactose and lactulose, and the mass ratio of the prebiotics to the prebiotics is 1: 3 the other conditions were the same.
Comparative example 3
The difference from example 1 is only that the degree of hydrolysis of the hydrolysed whey protein is 25% and the remaining conditions are the same. The enzymolysis conditions were as follows: controlling the concentration of the sheep whey protein substrate to be 10%, adding KOH at about 55 ℃, adjusting the pH value of the solution to be 7.0, then respectively adding trypsin and neutral protease according to 0.2% and 0.23% of the content of the whey protein, keeping the temperature at about 55 ℃, carrying out enzymolysis for 2h, and after the enzymolysis is finished, carrying out enzyme deactivation at 85 ℃ for 15 min.
Comparative example 4
The difference from example 1 is only that the degree of hydrolysis of the hydrolysed whey protein is 4% and the remaining conditions are the same. The enzymolysis conditions were as follows: controlling the concentration of the sheep whey protein substrate to be 10%, adding KOH at about 55 ℃, adjusting the pH value of the solution to be 7.0, then respectively adding trypsin and neutral protease according to 0.2% and 0.23% of the content of the whey protein, keeping the temperature to be about 55 ℃, carrying out enzymolysis for 20min, and after the enzymolysis is finished, carrying out enzyme deactivation at 85 ℃ for 15 min.
Preparation example
A preparation method of low-sensitization infant goat milk-based formula milk powder comprises the following steps:
(1) preparing materials: after checking the relevant information, the raw and auxiliary materials are accurately metered into a shearing and mixing tank filled with hot water according to the formula for mixing. The preparation method comprises the following steps of adding 65 ℃ of preparation water into a mixing tank according to the liquid-material ratio of 3:1, starting shearing and stirring, adding raw milk, desalted goat whey powder, goat casein powder, hydrolyzed goat whey protein powder and hydrolyzed casein powder, then adding fat, finally slowly pouring multivitamins, complex minerals, calcium carbonate, calcium hydrogen phosphate, sodium citrate, potassium chloride, magnesium sulfate and potassium citrate into the mixing tank, mixing and stirring for about 10 minutes to obtain a material liquid A, and adding the material liquid A into a tank to be homogenized.
(2) Homogenizing and sterilizing: opening the material pump, slowly adjusting homogenizing pressure to 20MPa, sterilizing at 110 deg.C for about 6s, and rapidly cooling to 10 deg.C. Before homogenization is completed, the foam in the mixing cylinder is flushed with warm water, and the fat floats into lumps.
(3) Concentration: after sterilization, the feed liquid enters a triple-effect evaporator for concentration, when the pressure of a boiler reaches 0.8MPa, the pressure of compressed air reaches over 0.4MPa, the temperature of a sterilizer reaches 95 ℃ and the evaporation temperature meets the process requirements, a feed valve is opened, and a reflux valve is closed to feed materials to a thick milk tank. The pressure of the triple effect cylinder is more than or equal to 0.8MPa, and the pressure of the hot-pressing pump is 0.5 MPa. The sterilization temperature is 95 ℃ for about 15 s. The primary evaporation temperature is 70 ℃, the secondary evaporation temperature is 58 ℃, the tertiary evaporation temperature is 50 ℃, and the cooling water discharge temperature is less than or equal to 40 ℃. The vacuum of the first-effect separator is-0.065 MPa, the vacuum of the second-effect separator is-0.081 MPa, and the vacuum of the third-effect separator is-0.084 MPa.
(5) Spray drying: and (3) feeding the concentrated feed liquid into a spray drying tower, adjusting the pressure of a high-pressure pump to be more than 15MPa when the exhaust temperature reaches 90 ℃ and the inlet temperature is more than 130 ℃, starting spray drying, and cooling by a fluidized bed to obtain base powder B.
(6) Dry mixing: in order to ensure the uniformity of dry mixing, 4 percent of base powder, lutein, prebiotics, probiotics, docosahexaenoic acid and arachidonic acid are mixed and premixed for more than 5min to obtain premix, and then the premix and the rest base powder are subjected to dry mixing operation for more than 8min to obtain the milk powder.
Inventive examples 1-3 were all prepared using the method of this preparation example.
Test example 1 amino acid to fatty acid alignment
(1) The amino acid composition of the milk powder of example 1 of the present invention is compared with commercially available normal goat milk powder (babs goat milk powder) and breast milk, as shown in table 1 below.
TABLE 1
(2) The fatty acid composition of the milk powder of example 1 of the present invention was compared with commercially available conventional goat milk powder and breast milk, as shown in table 2 below.
TABLE 2
As can be seen from tables 1 and 2, the composition of the powdered milk of the present invention is closer to that of breast milk.
Test example 2 animal experiments
2.1 Experimental animals: 4 week old female BALB/c mice of SPF grade: shandong Shanglu anti-medicine, Inc. The SPF-level experimental animal center of south China university provides sufficient milk-free protein to maintain mouse food and clean drinking water, the relative humidity is 50% -55%, the average temperature is 23 +/-2 ℃, and the illumination period is 12 h.
2.2 Experimental samples: the invention of example 1 milk powder A, common commercial goat milk powder B, 80% concentrated whey protein powder C (WPC 80).
2.3, method:
2.3.1 Experimental design: 110 BALB/C mice were divided into 11 groups (n: 10) of blank, CT, inventive example 1 milk powder A, ordinary commercial goat milk powder B, 80% concentrated whey protein powder (WPC80) C, examples 2-3 and comparative examples 1-4. Wherein, the group C of 80% concentrated whey protein powder (WPC80) is a positive control group, the blank group is not treated at all, and the CT group is only drenched with 10 mug/piece of vibrio Cholerae (CT). The sensitization period was 6 weeks, once a week. The sensitizing dose of the first 5 times of the gavage of the experimental group is 20 mg/mouse, 10 mu g/mouse of vibrio Cholerae Toxin (CT) is supplemented to prevent the mouse from generating immune tolerance, and the sensitizing dose of the last time of the gavage is 50 mg/mouse. Each group takes ultrapure water as a solvent, and the intragastric volume is 0.3 mL. The weight of each group of mice was weighed before the last gavage, and each group of mice was scored for allergic symptoms 1h after gavage. Mice were sacrificed and blood was collected and stored in a-80 ℃ freezer.
2.3.2 determination of serum Total IgE content
Standing the blood at room temperature of 25 deg.C for 2 hr, centrifuging at 4000r/min in a low temperature refrigerated centrifuge for 15min, carefully sucking the supernatant, and storing in a refrigerator at-80 deg.C. If precipitation occurs during storage, it is centrifuged again before use. The content of total IgE in serum was determined using a commercial enzyme linked immunosorbent assay kit.
2.3.3 allergy symptom score
Allergic symptoms appear 15-30 min after the gavage, and reach the peak value 40-50 min after the first symptom appears. The following scoring criteria system was used to evaluate the allergic symptoms in mice: 0 ═ no symptoms; 1-scratching and rubbing around the nose and head; edema around the eyes and mouth, hair sticking, reduced activity and/or reduced activity with shortness of breath; 3-wheezing, shortness of breath and cyanosis around the mouth and tail; 4-no activity after stimulation, tremors and convulsions; and 5 death.
2.4 analysis of results
2.4.1 mouse allergy score
The effect of different samples on the allergic symptoms in mice is shown in table 3 below.
TABLE 3
As shown in table 3, the allergic symptoms score of the group C (WPC80) was highest, the allergic symptoms score of the group B (ordinary commercially available goat milk powder) was lower, and the allergic symptoms score of the blank group, the group CT and the group a (milk powder of example 1 of the present invention) were all 0, indicating that the sensitization with whey protein concentrate was the strongest, resulting in severe allergy in the group of mice, and the mice of the commercially available goat milk powder group were slightly allergic, whereas the milk powder of example 1 of the present invention had no allergic symptoms.
2.4.2 Total IgE content in mouse sera, as shown in FIG. 1.
Serum total IgE levels are one of the markers of allergic reactions, and are clearly associated with allergic symptoms in children. As shown in fig. 1, the total IgE levels in group C (WPC80) sera were significantly higher than those in blank, CT, a and B groups, indicating that: the whey protein is used as an important allergen in milk protein, can obviously improve the content of total IgE in the serum of an allergic mouse, further strongly stimulates the generation of IgE-mediated immediate-type anaphylactic reaction, and can obviously weaken the stimulation of the whey protein on the IgE-mediated immediate-type anaphylactic reaction after being moderately hydrolyzed.
In conclusion, mice in group C (WPC80) were most allergic and group B (commercially available plain goat milk powder) had mild allergic symptoms. The mice in group A (goat milk powder in the invention example 1) have no anaphylaxis symptom.
Test example 3 test for enhancing immunity
3.1 Experimental sample: examples 1 to 3, comparative examples 1 to 4;
3.2 Experimental animals and groups: 4 week old female BALB/c mice of SPF grade; adaptive feeding for one week, mice were divided into normal group, model group, examples 1 to 3 groups, and comparative examples 1 to 4 groups. Then, half of the original daily dose of the feed was given daily to each of the other groups except the normal group, and the mice exhibited typical symptoms of malnutrition by continuous feeding for four weeks: dull hair, decreased activity and thinness.
3.3 test methods: the formula powder of the corresponding group of the groups of examples 1-3 and comparative examples 1-4, which are respectively gazed in the morning, noon and evening, is 20g/kg once (the daily dose is 8 times of the recommended dose of a human body), three times a day, the normal group and the model group are given physiological saline with the same volume, water is freely drunk for 15 days continuously, 24 hours after the last administration, eyeballs of anesthetized mice are picked to take blood, the mice are stood at room temperature and centrifuged to take serum, and an ELISA detection kit is used for detecting the IgG level in the serum of the mice; and dissecting and taking the liver, spleen and kidney of the mouse, and weighing the liver, spleen and kidney of the mouse to obtain the viscera body ratio compared with the body weight of the mouse. The results are shown in Table 4.
TABLE 4
Different letters in the same column indicate significant statistical differences between the corresponding groups, p < 0.05.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (10)
1. The hypoallergenic infant goat milk-based formula milk powder is characterized by comprising the following components in parts by weight: 0-15 parts of raw milk, 5-10 parts of goat casein powder, 50-70 parts of desalted goat whey powder, 7-15 parts of hydrolyzed goat whey protein powder, 5-15 parts of hydrolyzed casein powder, 16-40 parts of fat, 0.06-0.3 part of compound vitamin, 0.06-0.2 part of compound mineral, 0.2-0.4 part of calcium carbonate, 0.1-0.4 part of calcium hydrophosphate, 0.2-0.5 part of sodium citrate, 0.4-0.6 part of potassium chloride, 0.01-0.15 part of magnesium sulfate, 0.05-0.15 part of potassium citrate, 0.5-2 parts of docosahexaenoic acid, 0.5-2 parts of arachidonic acid, 0.01-0.04 part of lutein, 5-10 parts of prebiotics and 0.06-0.12 part of probiotics.
2. The hypoallergenic infant goat milk-based formula milk powder according to claim 1, wherein said raw milk comprises at least one of fresh goat milk, whole goat milk powder and skimmed goat milk powder; the hydrolysis degree of the hydrolyzed sheep whey protein powder is 5-14%; the hydrolysis degree of the hydrolyzed casein powder is 3-25%.
3. The hypoallergenic infant goat milk-based formula milk powder according to claim 1, characterized in that the fat comprises, in parts by weight, 2-5 parts of sheep cream, 5-15 parts of 1, 3-dioleate-2-palmitic acid triglyceride, 3-5 parts of medium-chain fatty acid MCT, 1-5 parts of olive oil, and 5-10 parts of soybean oil.
4. The hypoallergenic infant goat milk-based formula milk powder according to claim 1, wherein said complex minerals include minerals that provide the elements copper, iron, zinc, manganese, iodine and selenium.
5. The hypoallergenic infant goat milk-based formula milk powder according to claim 1, wherein said vitamin complex comprises vitamin a, vitamin D, vitamin E, vitamin K1Vitamin B1Vitamin B2Vitamin B6Vitamin B12At least two of niacin, folic acid, pantothenic acid, vitamin C, and biotin.
6. The hypoallergenic infant goat milk-based formula milk powder according to claim 1, wherein said prebiotics include at least one of human milk derived prebiotics, fructooligosaccharides, galactooligosaccharides, polyfructose, lactulose, and xylooligosaccharides; the probiotic bacteria comprise at least one of bifidobacterium, bifidobacterium lactis, bifidobacterium breve, lactobacillus rhamnosus, lactobacillus fermentum and lactobacillus reuteri.
7. The hypoallergenic infant goat milk-based formula milk powder according to claim 6, characterized in that said human milk-derived prebiotics comprise at least one of 2 '-fucosyllactose, 3' -sialyllactose and N-neotetraose lactate.
8. The hypoallergenic baby goat milk-based formula milk powder according to claim 1, characterized by further comprising 0.04-0.38 parts by weight of additives.
9. The hypoallergenic infant goat milk-based formula milk powder of claim 8, wherein said adjunct includes at least one of inositol, L-carnitine, taurine, nucleotides, and choline.
10. The process for the preparation of hypoallergenic infant sheep milk-based formula according to any one of claims 1 to 8, characterized in that it comprises the following steps:
(1) firstly, adding water, raw milk, desalted goat whey powder, goat casein powder, hydrolyzed goat whey protein powder and hydrolyzed casein powder into a mixing tank, then adding fat, and finally slowly pouring multivitamins, compound mineral substances, calcium carbonate, calcium hydrophosphate, sodium citrate, potassium chloride, magnesium sulfate and potassium citrate into the mixing tank to obtain feed liquid A;
(2) homogenizing the feed liquid A, sterilizing, concentrating, and spray drying to obtain base powder B;
(3) mixing the base powder B with xanthophyll, prebiotics, probiotics, docosahexaenoic acid and arachidonic acid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111402835.6A CN114009510A (en) | 2021-11-24 | 2021-11-24 | Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111402835.6A CN114009510A (en) | 2021-11-24 | 2021-11-24 | Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114009510A true CN114009510A (en) | 2022-02-08 |
Family
ID=80066005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111402835.6A Pending CN114009510A (en) | 2021-11-24 | 2021-11-24 | Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114009510A (en) |
Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102283289A (en) * | 2011-09-15 | 2011-12-21 | 澳优乳业(中国)有限公司 | Anti-inflaming infant formula milk powder and preparation process thereof |
US20130089572A1 (en) * | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Partially Hydrolyzed Casein-Whey Nutritional Compositions For Reducing The Onset Of Allergies |
CN103053694A (en) * | 2013-02-18 | 2013-04-24 | 杨凌圣妃乳业有限公司 | Infant goat milk powder simulating components of breast milk and preparation method thereof |
US20130243797A1 (en) * | 2010-11-23 | 2013-09-19 | Norbert Sprenger | Composition comprising hydrolysed proteins and oligisaccharides for treating skin diseases |
CN103582426A (en) * | 2010-11-23 | 2014-02-12 | 雀巢产品技术援助有限公司 | Oligosaccharide mixture and food product comprising this mixture, especially infant formula |
CN104351356A (en) * | 2014-11-25 | 2015-02-18 | 澳优乳业(中国)有限公司 | Novel fourth-generation infant formula and preparation method thereof |
CN104522175A (en) * | 2014-12-29 | 2015-04-22 | 光明乳业股份有限公司 | Preparation and detecting method for muting sensitive infant formula milk powder |
US20150201635A1 (en) * | 2012-04-04 | 2015-07-23 | Nestec S.A. | Shelf-stable acidified dairy or dairy-like products and methods for making same |
US20150305384A1 (en) * | 2014-04-25 | 2015-10-29 | Mead Johnson Nutrition Company | Pediatric nutritional composition with human milk oligosaccahrides, prebiotics and probiotics |
WO2016029113A1 (en) * | 2014-08-22 | 2016-02-25 | Abbott Laboratories | Methods of increasing endogenous production of beta-hydroxy-beta-methylbutyrate |
CN105532883A (en) * | 2015-12-21 | 2016-05-04 | 海普诺凯营养品有限公司 | Formula goat milk powder for infants and young children and preparation method thereof |
CN105767186A (en) * | 2016-03-11 | 2016-07-20 | 北安宜品努卡乳业有限公司 | High fat dairy product and preparation method thereof |
CN107668211A (en) * | 2017-11-13 | 2018-02-09 | 海普诺凯营养品有限公司 | A kind of infant formula goat milk powder for strengthening immunologic function and preparation method thereof |
CN109122902A (en) * | 2018-08-15 | 2019-01-04 | 西安安诺乳业有限公司 | A kind of baby formula milk powder and preparation method thereof containing lutein |
CN109221443A (en) * | 2018-08-15 | 2019-01-18 | 西安安诺乳业有限公司 | A kind of baby formula milk powder and preparation method thereof containing inositol and taurine |
CN111345358A (en) * | 2020-04-09 | 2020-06-30 | 北安宜品努卡乳业有限公司 | Child formula goat milk powder rich in lactophospholipid and preparation method thereof |
CN112167360A (en) * | 2020-09-30 | 2021-01-05 | 石家庄君乐宝乳业有限公司 | Low-sensitization infant formula goat milk powder |
CN112998080A (en) * | 2021-03-16 | 2021-06-22 | 北安宜品努卡乳业有限公司 | Infant formula milk powder added with yolk phospholipid, soybean phospholipid and milk phospholipid |
-
2021
- 2021-11-24 CN CN202111402835.6A patent/CN114009510A/en active Pending
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130243797A1 (en) * | 2010-11-23 | 2013-09-19 | Norbert Sprenger | Composition comprising hydrolysed proteins and oligisaccharides for treating skin diseases |
CN103582426A (en) * | 2010-11-23 | 2014-02-12 | 雀巢产品技术援助有限公司 | Oligosaccharide mixture and food product comprising this mixture, especially infant formula |
CN102283289A (en) * | 2011-09-15 | 2011-12-21 | 澳优乳业(中国)有限公司 | Anti-inflaming infant formula milk powder and preparation process thereof |
US20130089572A1 (en) * | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Partially Hydrolyzed Casein-Whey Nutritional Compositions For Reducing The Onset Of Allergies |
US20150201635A1 (en) * | 2012-04-04 | 2015-07-23 | Nestec S.A. | Shelf-stable acidified dairy or dairy-like products and methods for making same |
CN103053694A (en) * | 2013-02-18 | 2013-04-24 | 杨凌圣妃乳业有限公司 | Infant goat milk powder simulating components of breast milk and preparation method thereof |
US20150305384A1 (en) * | 2014-04-25 | 2015-10-29 | Mead Johnson Nutrition Company | Pediatric nutritional composition with human milk oligosaccahrides, prebiotics and probiotics |
WO2016029113A1 (en) * | 2014-08-22 | 2016-02-25 | Abbott Laboratories | Methods of increasing endogenous production of beta-hydroxy-beta-methylbutyrate |
CN104351356A (en) * | 2014-11-25 | 2015-02-18 | 澳优乳业(中国)有限公司 | Novel fourth-generation infant formula and preparation method thereof |
CN104522175A (en) * | 2014-12-29 | 2015-04-22 | 光明乳业股份有限公司 | Preparation and detecting method for muting sensitive infant formula milk powder |
CN105532883A (en) * | 2015-12-21 | 2016-05-04 | 海普诺凯营养品有限公司 | Formula goat milk powder for infants and young children and preparation method thereof |
CN105767186A (en) * | 2016-03-11 | 2016-07-20 | 北安宜品努卡乳业有限公司 | High fat dairy product and preparation method thereof |
CN107668211A (en) * | 2017-11-13 | 2018-02-09 | 海普诺凯营养品有限公司 | A kind of infant formula goat milk powder for strengthening immunologic function and preparation method thereof |
CN109122902A (en) * | 2018-08-15 | 2019-01-04 | 西安安诺乳业有限公司 | A kind of baby formula milk powder and preparation method thereof containing lutein |
CN109221443A (en) * | 2018-08-15 | 2019-01-18 | 西安安诺乳业有限公司 | A kind of baby formula milk powder and preparation method thereof containing inositol and taurine |
CN111345358A (en) * | 2020-04-09 | 2020-06-30 | 北安宜品努卡乳业有限公司 | Child formula goat milk powder rich in lactophospholipid and preparation method thereof |
CN112167360A (en) * | 2020-09-30 | 2021-01-05 | 石家庄君乐宝乳业有限公司 | Low-sensitization infant formula goat milk powder |
CN112998080A (en) * | 2021-03-16 | 2021-06-22 | 北安宜品努卡乳业有限公司 | Infant formula milk powder added with yolk phospholipid, soybean phospholipid and milk phospholipid |
Non-Patent Citations (3)
Title |
---|
PAMPURA, A. N等: "A highly hydrolyzed formula based on whey protein with the prebiotics galactooligosaccharides and fructooligosaccharides effectively abolishes the symptoms of atopic dermatitis: Results of a multicenter open-label trial in Russia", 《PHARMACOLOGY & PHARMACY》, vol. 59, no. 4, pages 91 - 99 * |
王文杰: "复合酶解法制备低致敏奶粉及其工厂设计", 《中国优秀硕士学位论文全文数据库工程科技Ⅰ辑(电子期刊)》, no. 02, pages 024 - 407 * |
石佳琪等: "适度水解乳清蛋白婴儿配方奶粉的致敏性评价", 《食品研究与开发》, vol. 41, no. 10, pages 16 - 20 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TWI301052B (en) | Infant formula compositions comprising increased amounts of alpha-lactalbumin | |
US9226945B2 (en) | Prevention of allergy at weaning | |
US20130064923A1 (en) | Liquid Milk Beverage For Toddlers | |
WO2019104390A1 (en) | Milk substitute compositions | |
JP2019517246A (en) | Heat-sterilized high protein enteral composition having whey protein and casein source comprising whey protein micelles | |
CN112998080A (en) | Infant formula milk powder added with yolk phospholipid, soybean phospholipid and milk phospholipid | |
US20240138463A1 (en) | Infant formulas containing human breast milk proteins | |
EP3232820A1 (en) | Infant nutrition with hydrolysed protein, ionic calcium and palmitic acid | |
CN111642566A (en) | Goat milk powder beneficial to children's height and intelligence development | |
McSweeney et al. | Nutritional formulae for infants and young children | |
CN114009510A (en) | Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof | |
Tiwari et al. | Nutritional Values and Therapeutic Uses of Capra hircus Milk. | |
Falcão et al. | Infant Formulas: A Long Story | |
Kumar et al. | Bioactive and functional ingredients from dairy products | |
EP3897213B1 (en) | Protein compositions with high isoelectric proteins | |
CN116548608B (en) | Full-nutrition formula powder for children and preparation method and application thereof | |
Meena et al. | Nutraceutical properties of goat milk than cow milk | |
Guo | Chemical and nutritional aspects of human milk and infant formula formulation and processing | |
Lloyd | US whey products and child nutrition | |
KR20220017079A (en) | Liquid milk composition | |
Mwenze et al. | Functional Properties of Goat Milk: A Review Paper | |
CN112167347A (en) | Infant formula milk powder containing gastrointestinal regulatory peptide and preparation method thereof | |
CN115702653A (en) | Sleep-assisting middle-aged and old-aged modified goat milk powder and preparation method thereof | |
Kaddouri et al. | Cow’s Milk: a Food and a Potential Source of Allergens | |
Vij et al. | Bio-functional Attributes of Whey Based Functional Beverages |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |