CN112167360A - Low-sensitization infant formula goat milk powder - Google Patents

Low-sensitization infant formula goat milk powder Download PDF

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Publication number
CN112167360A
CN112167360A CN202011059738.7A CN202011059738A CN112167360A CN 112167360 A CN112167360 A CN 112167360A CN 202011059738 A CN202011059738 A CN 202011059738A CN 112167360 A CN112167360 A CN 112167360A
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parts
infant formula
milk powder
goat milk
powder
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Inventor
魏立华
袁庆彬
封肖颖
王世杰
贾晓江
刘建光
刘海荣
荀一萍
冯丽莉
薛玉玲
张栋
张旭普
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Shijiazhuang Junlebao Dairy Co Ltd
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Shijiazhuang Junlebao Dairy Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/06—Mixtures of whey with milk products or milk components
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/04—Whey; Whey preparations containing non-milk components as source of fats or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/08—Whey; Whey preparations containing other organic additives, e.g. vegetable or animal products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/165—Paracasei

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)

Abstract

The invention belongs to the field of food, and particularly discloses a hypoallergenic infant formula goat milk powder, which comprises raw goat milk, high-oil desalted goat whey powder, lactose, goat whey protein powder, soybean oil, 1, 3-dioleate-2-palmitic acid triglyceride, linseed oil, anhydrous cream, arachidonic acid powder, fish oil powder, compound minerals, compound vitamins, lactoferrin, calcium carbonate, osteopontin, potassium hydroxide, choline chloride, nucleotides, phospholipids and lactobacillus paracasei N1115. The composition of the hypoallergenic infant formula goat milk powder provided by the invention is close to breast milk, so that nutrition required by growth and development of infants is ensured, cow milk protein allergy of newborns is avoided, the immunity of newborns is enhanced, and therefore, infection and illness of newborns are prevented. The invention is suitable for infants of 0-6 months, in particular to newborns with low resistance.

Description

Low-sensitization infant formula goat milk powder
Technical Field
The invention belongs to the field of food, and relates to milk powder, in particular to hypoallergenic infant formula goat milk powder.
Background
The breast milk is 'gold' food for the newborn, provides ideal nutrient components for the newborn, and plays an important role in the growth and development of the newborn and the defense of external bacteria and virus invasion before the newborn can ingest and digest other foods by himself. The World Health Organization (WHO) recommends that the infant is fed with pure breast milk within the first 6 months after birth and the breast milk is continuously fed for 2 years or longer, however, the breast milk feeding rate in China is still low at present, and the infant formula milk powder is generally applied to families which cannot continuously feed the infant with breast milk as a breast milk substitute.
According to statistics, the incidence rate of cow milk protein allergy in infants is up to 2% -6%, cow milk protein can cause infantile diarrhea, rash, iron deficiency anemia and dysplasia, and the growth and development of infants are seriously affected. In the event of a severe allergic reaction, laryngeal edema and anaphylactic shock may even be caused, leading to death. In recent years, due to the fact that allergy cases caused by infant formula milk powder are increased continuously, people have more and more cognition on concepts such as nutrition and health, goat milk with rich nutritional value and formula milk powder taking goat milk as a main raw material are widely concerned by people, and the infant formula goat milk powder can replace the infant formula milk powder to become a better choice of a food for infants suffering from cow's milk allergy.
Disclosure of Invention
The invention aims to provide infant formula goat milk powder with low allergenicity for infants, so that the infant cow milk protein allergy is avoided, and meanwhile, the immunity of artificially fed infants is enhanced.
In order to achieve the purpose, the invention adopts the following technical scheme:
the infant formula goat milk powder with low sensitization comprises, by weight, 52-66 parts of raw goat milk, 9-11 parts of high-oil desalted goat whey powder, 8-10 parts of lactose, 5.8-7.5 parts of goat whey protein powder, 4-6 parts of soybean oil, 3.1-4.8 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride, 1.6-2.4 parts of linseed oil, 0.8-1.2 parts of anhydrous cream, 0.1-0.5 part of arachidonic acid powder, 0.1-0.4 part of fish oil powder, 0.1-0.3 part of compound mineral, 0.1-0.3 part of compound vitamin, 0.1-0.2 part of lactoferrin, 0.05-0.1 part of calcium carbonate, 0.025-0.05 part of osteopontin, 0.01-0.05 part of potassium hydroxide, 0.01-0.05 part of choline chloride, 0.01-0.05 part of nucleotide, 0.05-0.05 part of phospholipid, 0.05 part of sodium chloride, 0.05-0.05 part of lecithin, 0.01-0.05 part of lactobacillus paracasei N1115.
As a limitation: the raw materials for preparing the effective components of the medicine also comprise 0.5 to 1.2 parts of galacto-oligosaccharide and 0.2 to 0.7 part of fructo-oligosaccharide in parts by weight.
As a further limitation: the raw materials for preparing the effective components of the medicine also comprise 0.01 to 0.02 portion of ganglioside in portion by weight.
As yet a further limitation: the content of Lactobacillus paracasei N1115 is 1 × 1011-1×1012 CFU/g。
As a further limitation: the adding proportion of the lactoferrin to the osteopontin in the raw materials for preparing the effective components is 4:1 in parts by weight.
The lactobacillus paracasei N1115 related in the formula is separated and screened from traditional fermented milk products of Mongolia in China, has been preserved in the strain preservation center of the institute of microbiology of Chinese academy of sciences in 3 months of 2011, and has the preservation number of CGMCC No. 4691. The gene sequence of lactobacillus paracasei N1115 has been disclosed in chinese patent application No. 2011103570588 entitled "lactobacillus casei N1115, its immunomodulatory effect and use".
Due to the adoption of the scheme, compared with the prior art, the invention has the beneficial effects that:
(1) the infant formula goat milk powder with low sensitization provided by the invention is not added with any cow milk protein, so that the sensitization is greatly reduced, and in addition, lactoferrin, osteopontin and lactobacillus paracasei N1115 are added, so that the immunity of an infant is enhanced, and the morbidity of a newborn is reduced; in addition, the linseed oil and the 1, 3-dioleic acid-2-palmitic acid triglyceride are added into the milk powder, so that the contents of alpha-linolenic acid and sn-2-position palmitic acid are improved, the composition of the infant formula goat milk powder with low allergenicity is closer to the composition of fatty acid in breast milk, the nutrition required by growth and development of infants is ensured, and the immunity of newborns is enhanced;
(2) the low-sensitization infant formula goat milk powder provided by the invention is added with two prebiotics, namely fructo-oligosaccharide and galacto-oligosaccharide, so that the proliferation of bifidobacteria in intestinal tracts is promoted, the intestinal development and maturity of infants are promoted, and the immune function of the infants is enhanced, so that the infants are protected from infection and illness;
(3) the ganglioside is added into the hypoallergenic infant formula goat milk powder provided by the invention, so that the intestinal flora of the newborn is regulated, the development of the intestinal immune system of the newborn is promoted, and the early infection of the infant is prevented.
In conclusion, the composition of the hypoallergenic infant formula goat milk powder provided by the invention is close to breast milk, so that nutrition required by growth and development of infants is ensured, the generation of cow milk protein allergy of newborns is avoided, the immunity of newborns is enhanced, and the infection and illness of newborns are prevented.
The invention is suitable for infants of 0-6 months, in particular to newborns with cow milk allergy and low resistance.
Drawings
The invention is described in further detail below with reference to the figures and the embodiments.
FIG. 1 is a graph showing the results of the IL-18 secretion amount of the combination of lactoferrin, osteopontin and Lactobacillus paracasei N1115 in example 7 of the present invention;
FIG. 2 is a graph showing the results of measuring the concentration of total IgE in serum of a mouse in example 8 of the present invention.
Detailed Description
The present invention is further described with reference to the following examples, but it should be understood by those skilled in the art that the present invention is not limited to the following examples, and any modifications and variations based on the specific examples of the present invention are within the scope of the claims of the present invention.
Examples 1-6 hypoallergenic infant formula goat milk powder
Examples 1-6 are a method for preparing hypoallergenic infant formula goat milk powder, the raw material composition of which is shown in table 1, and the process parameters for preparing the milk powder are shown in table 2.
The preparation method comprises the following steps:
s1, standardizing raw goat milk, separating impurities, pasteurizing at 70-75 ℃ for 15-18S to obtain goat milk, adding high-oil desalted goat whey powder, lactose, goat whey protein powder, soybean oil, 1, 3-dioleate-2-palmitic acid triglyceride, linseed oil, galacto-oligosaccharide, anhydrous cream, fructo-oligosaccharide, compound minerals, compound vitamins, calcium carbonate, potassium hydroxide, choline chloride and phospholipid into the goat milk, mixing, and fully dissolving to obtain a material A;
s2, preheating the material A to 58-62 ℃, homogenizing under the pressure of 15-18MPa, and then heating to 85-95 ℃ for sterilization for 20-30S to obtain a material B;
s3 and B are subjected to four-effect falling film evaporationConcentrating to obtain concentrated milk C with density of 1100-3；
S4, pumping the concentrated milk C into a drying tower by a high-pressure pump for spray drying, wherein the air inlet temperature is 170-;
s5, adding arachidonic acid powder, fish oil powder, lactoferrin, osteopontin, nucleotide, lactobacillus paracasei N1115 and ganglioside into the material D, and uniformly mixing to obtain the hypoallergenic infant formula goat milk powder.
Table 1 examples 1-6 raw materials for hypoallergenic infant formula goat milk powder
Figure 414746DEST_PATH_IMAGE001
The content of lactobacillus paracasei N1115 in examples 1-6 was in order: 2X 1011 CFU/g、8×1011 CFU/g、5×1011 CFU/g、1×1011 CFU/g、1×1012 CFU/g、6×1011CFU/g. The multivitamins of examples 1-6 contain the following components: vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, nicotinamide, folic acid, vitamin C, biotin, and pantothenic acid; the compound mineral comprises the following components: sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine and selenium.
TABLE 2 Process parameters for examples 1-6
Figure 269569DEST_PATH_IMAGE002
Example 7 in vitro cell model evaluation
In this example, different Lactoferrin (LF) and Osteopontin (OPN) addition ratios are set for the composite lactobacillus paracasei N1115, and the dominance ratios of the ingredients are evaluated by an in vitro cell model, specifically the evaluation method is as follows:
caco-2 cells were cultured for 2 hours in a serum-free medium, and then incubated for 72 hours at 37 ℃ in a cell culture medium containing 1% fetal calf serum supplemented with Lactoferrin (LF), Osteopontin (OPN) and Lactobacillus paracasei N1115, respectively, and LF-OPN mixture at different concentration ratios combined with Lactobacillus paracasei N1115 (the specific addition concentration is shown in Table 3, diluted 20 times). The cell culture medium was collected, concentrated by an ultrafiltration centrifuge tube, and the content of IL-18 was measured using an ELISA kit.
TABLE 3 mixture composition
Figure 236257DEST_PATH_IMAGE003
Referring to fig. 1, it is shown from fig. 1 that lactoferrin, osteopontin, and N1115 can promote the Caco-2 cells to secrete IL-18, and the lactoferrin effect is more significant when the three are used alone. Lactoferrin (LF), Osteopontin (OPN) and lactobacillus paracasei N1115 combinations promoted IL-18 secretion most effectively, and most effectively at LF: OPN =4: 1.
Example 8 hypoallergenic infant formula goat milk powder sensitization test
40 male mice were selected and randomly divided into 4 groups, namely a blank group, a CT group, an experimental group 1 and an experimental group 2, wherein each group contains 10 mice, the culture period is 6 weeks, and the gavage is performed 1 time per week. Wherein the blank group is not treated, the CT group only drenches 10 mug of vibrio Cholerae Toxin (CT) per mouse, the hypoallergenic infant formula goat milk powder of the experimental group 1 in the former 5 times of drenching is 20mg per mouse, and 10 mug of vibrio Cholerae Toxin (CT) is used as an auxiliary material to prevent the mice from generating immune tolerance, the hypoallergenic infant formula goat milk powder of the last drenching is 50mg per mouse, the former 5 times of drenching is 20mg of common skimmed milk powder of the experimental group 2, and 10 mug of vibrio Cholerae Toxin (CT) is used as an auxiliary material to prevent the mice from generating immune tolerance, the last time of drenching is 50mg of common skimmed milk powder, and each group takes ultrapure water as a solvent and the drenching volume is 0.3 mL. After the test, the mouse blood was collected, and the IgE content in the mouse serum was measured, and the test results are shown in fig. 2.
Serum total IgE levels are among the markers of allergic reactions, e.g.FIG. 2 shows that the serum IgE concentration in the experimental group 2 is significantly higher than that in the blank group, the CT group and the experimental group 1: (p<0.05), between blank group, CT group and experiment group 1, the concentration of serum IgE of the experiment group 1 is lower, and the result shows that: the common defatted milk powder has high allergenicity, the content of total IgE in the serum of an allergic mouse is high, further the IgE-mediated immediate-type anaphylactic reaction is strongly stimulated, and the low-allergenicity infant formula goat milk powder can obviously weaken the stimulation of the IgE-mediated immediate-type anaphylactic reaction.

Claims (8)

1. The infant formula goat milk powder with low sensitization is characterized in that the raw materials for preparing the active ingredients of the infant formula goat milk powder comprise, by weight, 52-66 parts of raw goat milk, 9-11 parts of high-oil desalted goat whey powder, 8-10 parts of lactose, 5.8-7.5 parts of goat whey protein powder, 4-6 parts of soybean oil, 3.1-4.8 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride, 1.6-2.4 parts of linseed oil, 0.8-1.2 parts of anhydrous cream, 0.1-0.5 part of arachidonic acid powder, 0.1-0.4 part of fish oil powder, 0.1-0.3 part of composite mineral substance, 0.1-0.3 part of composite vitamin, 0.1-0.2 part of lactoferrin, 0.05-0.1 part of calcium carbonate, 0.025-0.05 part of osteopontin, 0.01-0.05 part of potassium hydroxide, 0.01-0.05 part of choline, 0.05 part of choline chloride and 0.05-0.05 part of chloride, 0.01-0.05 part of phospholipid and 0.01-0.05 part of lactobacillus paracasei N1115.
2. The hypoallergenic infant formula goat milk powder according to claim 1, characterized in that the raw material composition of the active ingredients further comprises, in parts by weight, 0.5-1.2 parts of galacto-oligosaccharides, 0.2-0.7 parts of fructo-oligosaccharides.
3. The hypoallergenic infant formula goat milk powder according to claim 1 or 2, characterized in that the raw material composition of the active ingredients further comprises 0.01-0.02 parts by weight of gangliosides.
4. Hypoallergenic infant formula goat milk powder according to claim 1 or 2, characterized in that the content of lactobacillus paracasei N1115 is 1 x 1011-1×1012 CFU/g。
5. Hypoallergenic infant formula sheep milk powder according to claim 3, characterized in that the content of Lactobacillus paracasei N1115 is 1 x 1011-1×1012 CFU/g。
6. The hypoallergenic infant formula goat milk powder according to any one of claims 1, 2 and 5, characterized in that the ratio of lactoferrin to osteopontin added to the raw materials from which the active ingredients are made is 4:1 in parts by weight.
7. The hypoallergenic infant formula goat milk powder according to claim 3, characterized in that the ratio of lactoferrin to osteopontin added to the raw materials of which the active ingredients are made is 4:1 in parts by weight.
8. The hypoallergenic infant formula goat milk powder according to claim 4, characterized in that the ratio of lactoferrin to osteopontin added to the raw materials of which the active ingredients are made is 4:1 in parts by weight.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113475720A (en) * 2021-06-15 2021-10-08 合生元（广州）健康产品有限公司 Application of osteopontin in increasing diversity of intestinal flora and increasing content of intestinal short-chain fatty acids
CN113693132A (en) * 2021-08-23 2021-11-26 西安百跃羊乳集团有限公司 Intelligence-improving goat milk powder for improving intestinal digestion capacity and preparation method thereof
CN114009510A (en) * 2021-11-24 2022-02-08 北安宜品努卡乳业有限公司 Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof
CN115068591A (en) * 2022-07-06 2022-09-20 合生元（广州）健康产品有限公司 Probiotic composition containing osteopontin

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113475720A (en) * 2021-06-15 2021-10-08 合生元（广州）健康产品有限公司 Application of osteopontin in increasing diversity of intestinal flora and increasing content of intestinal short-chain fatty acids
CN113475720B (en) * 2021-06-15 2023-07-25 合生元（广州）健康产品有限公司 Application of osteopontin in increasing intestinal flora diversity and increasing intestinal short-chain fatty acid content
CN113693132A (en) * 2021-08-23 2021-11-26 西安百跃羊乳集团有限公司 Intelligence-improving goat milk powder for improving intestinal digestion capacity and preparation method thereof
CN114009510A (en) * 2021-11-24 2022-02-08 北安宜品努卡乳业有限公司 Hypoallergenic infant goat milk-based formula milk powder and preparation method thereof
CN115068591A (en) * 2022-07-06 2022-09-20 合生元（广州）健康产品有限公司 Probiotic composition containing osteopontin

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