CN111919889A - Mother-emulsified infant formula goat milk powder capable of improving immunity and preparation method thereof - Google Patents

Mother-emulsified infant formula goat milk powder capable of improving immunity and preparation method thereof Download PDF

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CN111919889A
CN111919889A CN202010639093.8A CN202010639093A CN111919889A CN 111919889 A CN111919889 A CN 111919889A CN 202010639093 A CN202010639093 A CN 202010639093A CN 111919889 A CN111919889 A CN 111919889A
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powder
goat milk
oil
milk powder
parts
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魏立华
荀一萍
朱宏
王世杰
贾晓江
刘海荣
朱素芳
封肖颖
冯丽莉
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Shijiazhuang Junlebao Dairy Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23C9/16Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1522Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
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    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1528Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/156Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
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    • A23C9/152Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/158Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics

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Abstract

The invention discloses a mother-emulsified infant formula goat milk powder for improving immunity and a preparation method thereof, belonging to the technical field of food, and relating to infant formula goat milk powder raw materials mainly comprising raw goat milk, high-oil desalted goat whey powder, goat whey protein powder, low-trans fatty acid composite vegetable oil, composite oligosaccharide, composite fruit and vegetable powder and various nutrient substances, so that the proportion of amino acids contained in the formula goat milk powder is closer to that of the breast milk, and the infant immunity is improved and the burden of an infant digestive system is relieved through reasonable compatibility of various nutrient substances; the invention also relates to a preparation method of the formula goat milk powder, which comprises the steps of checking and accepting raw goat milk, purifying the raw goat milk, pre-pasteurizing, wet mixing, preheating, homogenizing, sterilizing, concentrating, spray drying, dry mixing and the like, and has the advantages of simple operation and easy control of the process; the invention is suitable for infants, and the preparation method is suitable for preparing the formula goat milk powder.

Description

Mother-emulsified infant formula goat milk powder capable of improving immunity and preparation method thereof
Technical Field
The invention belongs to the technical field of food, and relates to infant milk powder, in particular to infant formula goat milk powder for improving immunity and optimizing the composition of amino acid and fatty acid and a preparation method thereof.
Background
Breast milk is a natural food most suitable for infants and is also the gold standard for the design of formula milk powder. For infants, the bioavailability of breast milk is the best, and breast feeding has great advantages in aspects such as nutrition, immunity, physiological and psychological needs and the like. However, not all mothers have enough breast milk to feed babies after the babies live, a large part of newborn babies are fed with the breast milk and the formula milk powder in a mixed mode at present, and even some babies eat the formula milk powder all the time from birth.
Infant formula is the most important breast milk substitute in the modern infant feeding process, and like breast milk, formula also supports the development of the body, immune function and behavior of the newborn by providing nitrogen and essential and semi-essential amino acids. The main raw material of the existing formula milk powder is cow milk or goat milk, but due to the difference among species, the types and the contents of nutrients of animal milk, such as cow milk, goat milk, horse milk, camel milk and the like, and human milk are different. Compared with cow milk, the goat milk has the advantages of higher whey protein content, easier digestion and absorption by human bodies and contribution to improving the problem of cow milk protein allergy of infants, and researches show that the protein and fat structures in the goat milk are more similar to those of the cow milk. Therefore, based on milk source difference, the protein content and the amino acid composition in the infant formula goat milk powder are adjusted and optimized, the protein absorption utilization rate of the infant in the formula goat milk powder is improved, the amino acid ratio mother emulsified formula goat milk powder more suitable for the growth of infants in China is developed, and the improvement of the nutrition absorption and growth development of the infants is facilitated. Therefore, based on the difference of amino acid composition, the amino acid content in the infant formula milk powder is adjusted and optimized, the absorption and utilization rate of the infant to the amino acid in the formula milk powder is improved, the burden of a digestive system is relieved, and the method is an important direction in formula milk powder development.
The current development trend of infant formula milk powder is closer to breast milk, and in order to enable the formula of the infant formula milk powder to be closer to the nutrient content of breast milk, European and American countries gradually determine the dietary reference intake of infants and the formula of infant food according to the breast milk nutrient content data of the countries. While the design ability of the Chinese formula milk powder is slightly behind, most of the formula milk powder refers to foreign research data. However, the foreign infant food formula is not necessarily suitable for our infants in China based on the differences of dietary culture, living environment and self genes of different regions and races. Therefore, the formula milk powder which is more suitable for being eaten by the infants in China in terms of amino acid composition is urgently needed to be developed according to the nutrient component data of the breast milk in China and the physical quality and growth needs of the infants.
Disclosure of Invention
The invention aims to provide the maternal-emulsion infant formula goat milk powder for improving immunity, which is closer to the amino acid composition of Chinese breast milk, has a feeding effect more similar to that of the breast milk, and meets the growth and development requirements of the Chinese infants.
The invention also aims to provide a preparation method of the mother-emulsified infant formula goat milk powder for improving immunity.
In order to achieve the purpose, the invention adopts the following technical scheme:
the mother-emulsified infant formula goat milk powder for improving immunity comprises the following components in parts by weight:
35-45 parts of raw goat milk;
28-36 parts of high-oil desalted goat whey powder;
6-10.5 parts of goat whey protein powder;
6-10 parts of lactose;
3-5 parts of anhydrous cream;
9-15 parts of low trans-fatty acid composite vegetable oil;
3-5 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride powder;
1.1-11 parts of composite oligosaccharide;
0.1-1 part of phospholipid;
0.1-0.5 parts of DHA algae oil powder;
0.1-0.3 parts of arachidonic acid powder;
0.05-0.3 part of sialic acid;
0.2-0.6 part of calcium carbonate;
0.01-0.06 parts of nucleotide;
0.1-0.5 parts of compound vitamin;
0.1-0.3 part of composite mineral;
0.1-2 parts of composite fruit and vegetable powder.
As a limitation of the present invention, in the mother emulsified infant formula goat milk powder for improving immunity, raw goat milk: high-oil desalted goat whey powder: the weight ratio of the sheep whey protein powder is 5:4: 1.5.
as another limitation of the present invention, the low trans fatty acid composite vegetable oil is corn oil, grape seed oil, walnut oil, coconut oil, sunflower oil.
As a further limitation of the invention, the corn oil: grape seed oil: walnut oil: coconut oil: the weight ratio of the sunflower oil is 3:2:2:1: 1.
As a third limitation of the present invention, the complex oligosaccharide is galacto-oligosaccharide, fructo-oligosaccharide, 3' sialyllactose.
As a still further limitation of the present invention, the weight ratio of galactooligosaccharide to fructooligosaccharide to 3' sialyllactose is 9:1: 1.
As a fourth limitation of the present invention, the composite fruit and vegetable powder is a mangosteen powder and a guava powder.
The invention also relates to a preparation method of the mother emulsified infant formula goat milk powder for improving immunity, which comprises the following steps:
checking and accepting raw sheep milk and purifying the milk
Standardizing raw goat milk to obtain a material A, and then carrying out impurity separation on the material A to obtain a material B;
second, pre-barking
Pasteurizing the material B at 52-58 ℃, and then cooling to obtain a material C;
three, wet mixing
Weighing high-oil desalted goat whey powder, goat whey protein powder, lactose, anhydrous cream, low-trans fatty acid composite vegetable oil, 1, 3-dioleoyl-2-palmitic acid triglyceride powder, composite oligosaccharide, phospholipid, calcium carbonate, nucleotide, composite vitamin and composite mineral, adding the materials into the material C, uniformly mixing, and fully dissolving to obtain a material D;
fourthly, preheating
Preheating the material D to 60-65 ℃ to obtain a material E;
fifthly, homogenizing and sterilizing
Homogenizing the material E, heating to 95 ℃ for sterilization after homogenizing, and keeping the temperature for 5s to obtain a material F;
sixthly, concentration
Carrying out triple effect concentration on the material F to obtain concentrated milk G;
seventhly, spray drying
Spray drying the concentrated milk G to obtain H, and then cooling the material H;
eighth, dry blending
Adding DHA algae oil powder, arachidonic acid powder, sialic acid and composite fruit and vegetable powder into the material H, and uniformly mixing to obtain a material I, namely the maternal emulsified infant formula goat milk powder for improving immunity.
As a limitation of the invention, the pressure during homogenization is 190-210 bar.
As another limitation of the invention, the first-effect pressure of the triple-effect concentration is 300-320 bar, and the first-effect temperature is 71-73 ℃; the double-effect pressure is 240-260 bar, and the double-effect temperature is 65-67 ℃; the triple effect temperature is 61-63 ℃.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following beneficial effects:
(1) grape seed oil contains rich unsaturated fatty acid, linoleic acid and oleic acid are main components, linoleic acid is essential fatty acid for human body, arachidonic acid can be produced after metabolism, and arachidonic acid and DHA have important effect on development of retina and nervous system. The grape seed oil also contains phytosterol and polyphenols, has good antioxidant activity, and is helpful for preventing obesity of infants in late growth stage.
(2) The walnut oil also contains abundant linoleic acid, and the composition of triglyceride of the walnut oil is rich in triolein and olein linoleate and linolenate. Linolenic acid and linoleic acid are essential amino acids for human bodies, can directly become constituent substances of cell membranes, and can participate in metabolism to form important polyunsaturated fatty acids such as EPA and DHA. It and corn oil contain abundant squalene, and can reduce intracellular reactive oxygen species level, prevent hydrogen peroxide induced oxidative damage, and improve oxidative stress of tissues and organs.
(3) The coconut oil has coconut fragrance, is rich in medium-chain fatty acid, can be directly absorbed by small intestine without enzymolysis, reduces accumulation in vivo, and rapidly provides energy for infants.
(4) The mangosteen is a functional fruit, is rich in various nutrient substances such as protein, polysaccharide, vitamins and mineral substances beneficial to human bodies, contains polyphenol compounds with rich structures, and has various biological activities such as pathogenic bacteria inhibition, oxidation resistance, immunity improvement and the like.
(5) Guava has unique fruit taste and rich nutrition and medicinal value, and has the functions of promoting metabolism, regulating physiological function, promoting the growth and development of infants, and the like.
(6) The addition of various oligosaccharides can promote the proliferation of bifidobacterium in intestinal tracts of infants and ensure the stability of intestinal microecology.
(7) The amino acid composition of the formula goat milk powder is more suitable for breast milk, so that the nutrient substances in the formula goat milk powder are more easily absorbed by infants in lactation, the burden of the digestive system of the infants is relieved, and the growth and development of the infants are promoted.
(8) Compared with cow milk, the formula goat milk powder provided by the invention has the advantages that nutrients in the goat milk powder are easier to absorb by infants, and the allergy problem of the infants to cow milk protein can be improved.
In conclusion, the maternal emulsified infant formula goat milk powder for improving immunity is a food formula determined according to the nutritional ingredient data of breast milk in China, and meets the physical quality and growth needs of infants in China. Meanwhile, the immunity of the infants is improved, and the burden of the digestive system of the infants is relieved. The method for preparing the formula goat milk powder is simple and easy to control, the process is easy to control, and the material loss is reduced.
Drawings
The invention is described in further detail below with reference to the figures and the embodiments.
FIG. 1 is a line graph showing the proliferation of bifidobacteria in intestinal tract of mice fed with three formulas of goat milk powder including the present invention;
FIG. 2 is a line graph of the fold increase of body weight after mice eat three formulas of goat milk powder including the invention;
FIG. 3 shows IgA content in feces and serum of mice fed with three formulations of goat milk powder including the present invention;
FIG. 4 shows the abundance of intestinal flora in infants of 12 months after eating breast milk, the formula goat milk powder of the invention and other formula goat milk powders.
Detailed Description
Preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood that the description of the preferred embodiment is only for purposes of illustration and understanding, and is not intended to limit the invention.
Example 1A maternal emulsified infant formula goat milk powder for improving immunity
The invention relates to a mother emulsified infant formula goat milk powder for improving immunity, which comprises the following components:
35 kg of raw goat milk;
28 kg of high-oil desalted goat whey powder;
10.5 kg of sheep whey protein powder;
10 kg of lactose;
5 kg of anhydrous cream;
5 kg of corn oil;
3.33 kg of grape seed oil;
3.33 kg of walnut oil;
1.67 kg of sunflower oil;
1.67 kg of coconut oil;
5 kg of 1, 3-dioleic acid-2-palmitic acid triglyceride powder;
9 kg of galacto-oligosaccharides;
1 kg of fructo-oligosaccharide;
1 kg of 3' sialyllactose;
1 kg of phospholipid;
0.5 kg of DHA algae oil powder;
0.3 kg of arachidonic acid powder;
sialic acid 0.3 kg;
0.6 kg of calcium carbonate;
0.06 kg of nucleotide;
0.5 kg of compound vitamin;
0.3 kg of compound mineral;
1 kg of mangosteen powder;
1 kg of guava powder.
Example 2 preparation method of mother emulsified infant formula goat milk powder for improving immunity
This example is a method for preparing the infant formula goat milk powder in example 1, which includes the following steps performed in sequence:
checking and accepting raw sheep milk and purifying the milk
Standardizing 35 kg of raw goat milk to obtain a material A1, and then carrying out impurity separation on the material A1 to obtain a material B1;
second, pre-barking
Pasteurizing the material B1 at 52 ℃, and then cooling to obtain a material C1;
three, wet mixing
Weighing 28 kg of high-oil desalted goat whey powder, 10.5 kg of goat whey protein powder, 10 kg of lactose, 5 kg of anhydrous cream, 5 kg of corn oil, 3.33 kg of grape seed oil, 3.33 kg of walnut oil, 1.67 kg of sunflower oil, 1.67 kg of coconut oil, 5 kg of 1, 3-dioleate-2-palmitic acid triglyceride powder, 9 kg of galacto-oligosaccharide, 1 kg of fructo-oligosaccharide, 1 kg of 3' sialyllactose, 1 kg of phospholipid, 0.6 kg of calcium carbonate, 0.06 kg of nucleotide, 0.5 kg of vitamin complex and 0.3 kg of compound mineral, adding the materials into the material C1, uniformly mixing and fully dissolving to obtain a material D1;
fourthly, preheating
Preheating the material D1 at 60 ℃ to obtain a material E1;
fifthly, homogenizing and sterilizing
Homogenizing the material E1 under 190bar, heating to 95 deg.C for sterilization after homogenizing, and keeping the temperature for 5s to obtain material F1;
sixthly, concentration
And (4) performing triple-effect concentration on the material F1 to obtain concentrated milk G1. Wherein the first-effect pressure is 300 bar, the first-effect temperature is 71 ℃, the second-effect pressure is 240 bar, the second-effect temperature is 65 ℃, and the third-effect temperature is 61 ℃;
seventhly, spray drying
Spray drying the concentrated milk G1 to obtain a material H1, and then cooling the material H1;
eighth, dry blending
Adding 0.5 kg of DHA algae oil powder, 0.3 kg of arachidonic acid powder, 0.3 kg of sialic acid, 1 kg of mangosteen powder and 1 kg of guava powder into the material H1, and uniformly mixing to obtain a material I1, namely the maternal emulsified infant formula goat milk powder for improving immunity.
Example 3-7 mother emulsified infant formula goat milk powder for improving immunity
Examples 3 to 7 are the same raw materials as the infant formula goat milk powder related to example 1 except that the raw materials are different in material consumption, and the material consumption is shown in table 1:
table 1:
Figure 55981DEST_PATH_IMAGE001
Figure 973121DEST_PATH_IMAGE002
example 8-12 preparation method of mother-emulsified infant formula goat milk powder for improving immunity
Examples 8 to 12 respectively correspond to the preparation methods of the maternal-emulsion infant formula goat milk powder for improving immunity described in examples 3 to 7, the preparation methods are completely the same as example 2, and the differences are only that the relevant parameters in some steps are different, and the specific relevant parameters are shown in table 2:
table 2:
Figure 628225DEST_PATH_IMAGE003
example 13 optimization of amino acid profile of formula goat milk powder
The content of essential amino acid in breast milk, raw goat milk, high-oil desalted goat whey powder and goat whey protein powder is respectively detected, and the protein proportion of the formula goat milk powder is optimized according to the essential amino acid mode suitable for infant groups. Samples are taken 100 mg respectively, 10 mL of 6 mol/L hydrochloric acid and a small amount of phenol solution are added, ice bath is carried out for 3-5 min, nitrogen is blown for 15 min, hydrolysis is carried out at high temperature for 22 h, and then cooling is carried out to room temperature. Filtering the hydrolysate, taking 1 ml, drying by nitrogen, hydrolyzing again, and filtering with 0.22 μm filter membrane. The results of the detection by the HPLC are shown in Table 3:
table 3:
Figure 23434DEST_PATH_IMAGE004
the detection result shows that the amino acid composition in the breast milk is greatly different from that of raw goat milk, high-oil desalted goat whey powder and goat whey protein powder, so that the amino acid composition of the breast milk is closer to the growth requirements of infants, the formula goat milk powder can be easily digested and absorbed by the infants, and the different requirements of the infants on different amino acids can be met. The invention optimizes the adding proportion of the raw goat milk, the high-oil desalted goat whey powder and the goat whey protein powder according to the amino acid composition of the breast milk, so that the ratio of the raw goat milk to the high-oil desalted goat whey powder to the goat whey protein powder is 5:4: 1.5.
Example 14 optimization of fatty acid content of formula goat milk powder
Palmitic acid (C) of formula goat milk powder and traditional formula goat milk powder respectively detecting breast milk and different vegetable oil ratios160), oleic acid (C)180), linoleic acid (C)182), alpha-linolenic acid (C)183), arachidonic acid (C)204) and DHA (C)226) content, and evaluating the optimal optimized proportion of the vegetable oil in the invention. GB 5009.168-2016 is adopted in foodFatty acid measurement method, the results are shown in table 4:
table 4:
Figure 837806DEST_PATH_IMAGE005
note: the weight ratio of the corn oil to the grape seed oil to the walnut oil to the coconut oil to the sunflower oil is =3:2:2:1:1, the weight ratio of the corn oil to the grape seed oil to the walnut oil to the coconut oil to the sunflower oil is =3:3:1:1:2, and the weight ratio of the corn oil to the grape seed oil to the walnut oil to the coconut oil to the sunflower oil is =3:2:1:2:2 in the ratio 3.
The lipid in breast milk has a plurality of important functions, wherein the fatty acid can not only generate energy through oxidative decomposition, promote the growth and development of bones and maintain the normal life activity function of an organism, but also is a composition component of brain and nervous tissues of infants and is indispensable in the development of vision and intelligence. The five vegetable oils are selected and the addition proportion of the five vegetable oils is optimized, so that the fatty acid composition in the formula goat milk powder is better than that of the goat milk powder in the traditional formula.
Example 15 different oligosaccharide ratios of formula goat milk powder for promoting intestinal bifidobacteria proliferation
Selecting 60 Kunming mice, half of which are male and female, and randomly dividing the mice into 3 groups: the control group was gavaged daily in the morning with 0.2 mL of traditional formula goat milk powder (only galacto-oligosaccharide and fructo-oligosaccharide added); the intervention group drenches 0.2 mL of formula goat milk powder with different oligosaccharide adding ratios every day for 2 weeks, and detects the amount of bifidobacterium in the mouse excrement on 0, 3, 5, 7, 9, 11, 13, 15 and 21 days. Wherein, the intervention group 1 is galactooligosaccharide-fructooligosaccharide 3 ' sialyllactose =9:3:1, the intervention group 2 is galactooligosaccharide-fructooligosaccharide 3 ' sialyllactose =9:1:1, the intervention group 3 is only added with galactooligosaccharide, the intervention group 4 is only added with fructooligosaccharide, and the intervention group 5 is only added with 3 ' sialyllactose. All ingredients of the dry group were proportioned as in example 5.
The results of 2-week gavage feeding and 1-week tracking detection show that the results are shown in fig. 1, and the results show that the formula goat milk powder added with three oligosaccharides can better promote the proliferation of bifidobacterium in intestinal tracts of mice and is beneficial to the establishment of intestinal flora of infants compared with 3-5 of a control group and an intervention group. Among them, galactooligosaccharide, fructooligosaccharide, 3' sialyllactose =9:1:1, has the best proliferation promoting effect.
EXAMPLE 16 protective Effect of goat milk powder in suckling rat intestinal health
60 newborn C57BL/6 mice are selected, the sex is half of each mouse, the mice are randomly divided into 3 groups, the control group is fed with the goat milk powder with the traditional formula, the intervention group 1 is fed with the goat milk powder with the formula of the invention in the embodiment 5, and the intervention group 2 is fed with the goat milk powder with the traditional formula, wherein the goat milk powder with the traditional formula is added with the mangosteen powder and the guava powder. Continuously feeding for 3 weeks, recording body mass every 2 days, collecting feces and tail vein blood of mice every 7 days, and collecting intestinal tract tissue of mice of each group for detection at 21 days.
Compared with the traditional formula goat milk powder, as shown in figure 2, the formula goat milk powder provided by the invention has the advantages that the growth rate of the fed mice is increased, and the growth and development of the suckling mice are facilitated.
The ileum tissues T-AOC and CAT of the formula goat milk powder for feeding mice are higher than those of the traditional formula goat milk powder, and the T-AOC and CAT of the traditional formula goat milk powder added with the mangosteen powder and the guava powder are also higher than those of the traditional formula goat milk powder but lower than those of the formula goat milk powder. The polyphenol substances of the mangosteen powder and the guava powder, and squalene rich in the corn oil and the walnut oil have antioxidant capacity, and as shown in table 5, the two components synergistically increase, so that the oxidative stress of intestinal tracts is improved, and the intestinal health of suckling mice is better promoted.
Table 5:
Figure 34170DEST_PATH_IMAGE006
according to the formula goat milk powder and the traditional formula goat milk powder added with the mangosteen powder and the guava powder, the fecal IgA and serum IgA levels of mice fed with the formula goat milk powder and the traditional formula goat milk powder are higher than those of the traditional formula goat milk powder, meanwhile, the fecal IgA and serum IgA levels of the mice in the intervention group 1 are higher than those of the intervention group 2, and as shown in figure 3, the formula goat milk powder disclosed by the invention has the effects of the mangosteen powder and the guava powder, and various nutritional ingredients in the formula goat milk powder disclosed by the invention can synergistically gain and enhance the immunocompetence of the mice.
EXAMPLE 17 intestinal health Effect of goat milk powder formula on infants
The intestinal flora of infants gradually develops to be stable along with time after birth, an in vitro intestinal flora simulation system is established in the research, and the influence of the formula milk powder on the intestinal flora is researched. Infant intestinal flora models of 6 months and 12 months are respectively established, and 3 groups (a control group, an intervention group and a breast milk group) are respectively set. The control group is added with the traditional formula goat milk powder, the intervention group is added with the formula goat milk powder of the invention in the embodiment 5, the breast milk group is added with breast milk, all the additives are degraded by the compound gastrointestinal digestive enzyme, the samples are collected for 3 months continuously, and the samples are collected every month for microbiological analysis.
Wherein, the intestinal flora of the infant is in the development stage after birth, is influenced by the pregnancy stage, the production mode, the feeding mode and the like, enters the transition stage at 14-15 months, and the diversity of the flora is increased and then tends to be stable. The intestinal tract of infants of 6 months is dominated by bifidobacteria, and the differences of the phylum firmicutes, the phylum actinomycetes, the phylum bacteroidetes and the like are large along with the change of time. In the research, after the prognosis of the intestinal flora model of the infant for 6 months, the intestinal flora among 3 groups has no obvious difference, which shows that the formula milk powder has no obvious influence on the development period with large flora fluctuation. The intestinal flora of the infant of 12 months is at the end of the development period, and gradually changes to the transition period during the intervention period, the abundance of the flora tends to be stable, and the flora difference is small along with the change of time. Therefore, after intervention of 3 months, in a 12-month infant intestinal flora model, as shown in fig. 4, compared with a control group, the flora composition of an intervention group is more similar to that of breast milk, so that the formula milk powder disclosed by the invention does not influence the development of the intestinal flora of infants at low ages, aims to promote the development of the intestinal flora of the infants, accelerates the abundance of the flora to be stable, enables the intestinal flora to be more similar to that of breast milk feeding, is superior to the traditional formula milk powder, and is beneficial to the intestinal health requirements of the infants.
Although the present invention has been described in detail with reference to the above embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described above, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. The mother-emulsified infant formula goat milk powder for improving immunity is characterized by comprising the following raw materials in parts by weight:
35-45 parts of raw goat milk;
28-36 parts of high-oil desalted goat whey powder;
6-10.5 parts of goat whey protein powder;
6-10 parts of lactose;
3-5 parts of anhydrous cream;
9-15 parts of low trans-fatty acid composite vegetable oil;
3-5 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride powder;
1.1-11 parts of composite oligosaccharide;
0.1-1 part of phospholipid;
0.1-0.5 parts of DHA algae oil powder;
0.1-0.3 parts of arachidonic acid powder;
0.05-0.3 part of sialic acid;
0.2-0.6 part of calcium carbonate;
0.01-0.06 parts of nucleotide;
0.1-0.5 parts of compound vitamin;
0.1-0.3 part of composite mineral;
0.1-2 parts of composite fruit and vegetable powder.
2. The maternal-emulsified infant formula goat milk powder for improving immunity according to claim 1, wherein the raw goat milk: high-oil desalted goat whey powder: the weight ratio of the sheep whey protein powder is 5:4: 1.5.
3. the infant formula goat milk powder for optimizing amino acid pattern and improving immunity according to claim 1, wherein the low trans fatty acid compound vegetable oil is corn oil, grape seed oil, walnut oil, coconut oil, sunflower oil.
4. The maternal-emulsion infant formula goat milk powder for improving immunity according to claim 3, wherein the ratio of corn oil: grape seed oil: walnut oil: coconut oil: the weight ratio of the sunflower oil is 3:2:2:1: 1.
5. The maternal-emulsion infant formula goat milk powder for improving immunity according to claim 1, wherein the complex oligosaccharide is galacto-oligosaccharide, fructo-oligosaccharide, 3' sialyllactose.
6. The maternal-emulsion infant formula goat milk powder for improving immunity according to claim 5, wherein the weight ratio of galactooligosaccharide to fructooligosaccharide to 3' sialyllactose is 9:1: 1.
7. The maternal emulsified infant formula goat milk powder for improving immunity according to claim 1, wherein the composite fruit and vegetable powder is a mangosteen powder and a guava powder.
8. The preparation method of the maternal-emulsion infant formula goat milk powder for improving immunity according to any one of claims 1 to 7, which is characterized by comprising the following steps: checking and accepting raw goat milk and cleaning the milk; pre-pasteurizing; wet mixing, namely weighing high-oil desalted goat whey powder, goat whey protein powder, lactose, anhydrous cream, low-trans fatty acid composite vegetable oil, 1, 3-dioleic acid-2-palmitic acid triglyceride powder, composite oligosaccharide, phospholipid, calcium carbonate, nucleotide, composite vitamin and composite mineral, adding the weighed materials into pre-pasteurized raw goat milk, uniformly mixing and fully dissolving; preheating; homogenizing and sterilizing; triple effect concentration; spray drying; and (3) dry-mixing, namely adding DHA algae oil powder, arachidonic acid powder, sialic acid and composite fruit and vegetable powder into the dried material, and uniformly mixing to obtain the maternal emulsified infant formula goat milk powder for improving the immunity.
9. The method for preparing a maternal-emulsion infant formula goat milk powder for improving immunity according to claim 8, wherein the pressure during homogenization is 190-210 bar.
10. The method for preparing a maternal-emulsion infant formula goat milk powder for improving immunity according to claim 8 or 9, wherein the triple effect concentration has a one-effect pressure of 300-320 bar and a one-effect temperature of 71-73 ℃; the double-effect pressure is 240-260 bar, and the double-effect temperature is 65-67 ℃; the triple effect temperature is 61-63 ℃.
CN202010639093.8A 2020-07-06 2020-07-06 Mother-emulsified infant formula goat milk powder capable of improving immunity and preparation method thereof Withdrawn CN111919889A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112655767A (en) * 2020-12-07 2021-04-16 长沙重链抗体研究院 Immunoglobulin probiotic formula camel milk powder and application thereof
CN114568528A (en) * 2020-11-30 2022-06-03 内蒙古伊利实业集团股份有限公司 Infant formula food capable of regulating and controlling intestinal immunity and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114568528A (en) * 2020-11-30 2022-06-03 内蒙古伊利实业集团股份有限公司 Infant formula food capable of regulating and controlling intestinal immunity and application thereof
CN112655767A (en) * 2020-12-07 2021-04-16 长沙重链抗体研究院 Immunoglobulin probiotic formula camel milk powder and application thereof

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Application publication date: 20201113