CN105581331A - Calcium supplementing nutrition composition - Google Patents
Calcium supplementing nutrition composition Download PDFInfo
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- CN105581331A CN105581331A CN201511014069.0A CN201511014069A CN105581331A CN 105581331 A CN105581331 A CN 105581331A CN 201511014069 A CN201511014069 A CN 201511014069A CN 105581331 A CN105581331 A CN 105581331A
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- CN
- China
- Prior art keywords
- calcium
- nutritive composition
- supplementing nutritive
- supplementing
- tea
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 124
- 239000011575 calcium Substances 0.000 title claims abstract description 124
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 124
- 239000000203 mixture Substances 0.000 title claims abstract description 87
- 230000001502 supplementing effect Effects 0.000 title abstract description 9
- 235000016709 nutrition Nutrition 0.000 title abstract description 8
- 230000035764 nutrition Effects 0.000 title abstract description 8
- 230000002485 urinary effect Effects 0.000 claims abstract description 10
- 230000000050 nutritive effect Effects 0.000 claims description 73
- 241001122767 Theaceae Species 0.000 claims description 51
- 235000000346 sugar Nutrition 0.000 claims description 51
- 150000001875 compounds Chemical class 0.000 claims description 41
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 18
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 13
- 239000011707 mineral Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 9
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 229930003316 Vitamin D Natural products 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 4
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 4
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims description 4
- 150000003271 galactooligosaccharides Chemical class 0.000 claims description 4
- 235000019166 vitamin D Nutrition 0.000 claims description 4
- 239000011710 vitamin D Substances 0.000 claims description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 4
- 229940046008 vitamin d Drugs 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- 239000003623 enhancer Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 230000007413 intestinal health Effects 0.000 claims description 2
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims description 2
- -1 sugarAlcohol compound Chemical class 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 abstract description 7
- 238000010521 absorption reaction Methods 0.000 abstract description 7
- 206010020772 Hypertension Diseases 0.000 abstract description 4
- 201000001421 hyperglycemia Diseases 0.000 abstract description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000015924 Lithiasis Diseases 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 34
- 241000700159 Rattus Species 0.000 description 34
- 210000002700 urine Anatomy 0.000 description 27
- 239000008280 blood Substances 0.000 description 21
- 210000004369 blood Anatomy 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 18
- 230000037182 bone density Effects 0.000 description 18
- 210000003734 kidney Anatomy 0.000 description 15
- 239000005913 Maltodextrin Substances 0.000 description 14
- 229920002774 Maltodextrin Polymers 0.000 description 14
- 229940035034 maltodextrin Drugs 0.000 description 14
- 238000002425 crystallisation Methods 0.000 description 12
- 230000008025 crystallization Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 239000000843 powder Substances 0.000 description 12
- 235000013336 milk Nutrition 0.000 description 11
- 239000008267 milk Substances 0.000 description 11
- 210000004080 milk Anatomy 0.000 description 11
- 235000006408 oxalic acid Nutrition 0.000 description 11
- 230000037396 body weight Effects 0.000 description 10
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 230000036772 blood pressure Effects 0.000 description 8
- 239000007910 chewable tablet Substances 0.000 description 8
- 239000000845 maltitol Substances 0.000 description 8
- 235000010449 maltitol Nutrition 0.000 description 8
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 8
- 229940035436 maltitol Drugs 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- QLOKJRIVRGCVIM-UHFFFAOYSA-N 1-[(4-methylsulfanylphenyl)methyl]piperazine Chemical compound C1=CC(SC)=CC=C1CN1CCNCC1 QLOKJRIVRGCVIM-UHFFFAOYSA-N 0.000 description 7
- 206010002091 Anaesthesia Diseases 0.000 description 7
- 241000256856 Vespidae Species 0.000 description 7
- 230000037005 anaesthesia Effects 0.000 description 7
- 230000003197 catalytic effect Effects 0.000 description 7
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 7
- 230000008021 deposition Effects 0.000 description 7
- 238000009547 dual-energy X-ray absorptiometry Methods 0.000 description 7
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- 210000002436 femur neck Anatomy 0.000 description 7
- 238000007912 intraperitoneal administration Methods 0.000 description 7
- 230000002503 metabolic effect Effects 0.000 description 7
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000003647 oxidation Effects 0.000 description 7
- 238000007254 oxidation reaction Methods 0.000 description 7
- 239000012188 paraffin wax Substances 0.000 description 7
- 238000004321 preservation Methods 0.000 description 7
- 235000020183 skimmed milk Nutrition 0.000 description 7
- 238000002798 spectrophotometry method Methods 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 230000003203 everyday effect Effects 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- 235000008939 whole milk Nutrition 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 229940069978 calcium supplement Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 230000000927 lithogenic effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides calcium supplementing nutrition composition. The calcium supplementing nutrition composition comprises calcium, oligosaccharides and matcha. Compared with the conventional calcium supplementing nutrition composition, the calcium supplementing nutrition composition has the advantages that the calcium absorption and the bioavailability can be improved remarkably, the problems of constipation and urinary system lithiasis caused by calcium supplementing can be prevented or reduced, and the calcium supplementing nutrition composition is especially suitable for the middle- and old-aged or calcium supplementing crowd with hypertension, hyperlipidemia and hyperglycemia to eat.
Description
Technical field
The invention belongs to functional food, health food technology field, specifically a kind of calcium-supplementing nutritive composition.
Background technology
Calcium is the macroelement in human nutrition element, occupies the first place of nutrient. It promote skeleton growth andMaintain on the normal function of heart and all play vital effect. And mid-aged population calcium absorptivity itself is just lower, calcium currentLose manyly, and also can be easier to follow the symptoms such as hypertension, high fat of blood, hyperglycaemia when calcium deficiency, thereby safety is replenished the calcium to itMore important.
The product of replenishing the calcium on the market is at present a lot, but mostly is single calcium or calcium and product micro-as that dimension D, CPP are combinedProduct. In the process of absorption of human body calcium, due to positively charged calcium ion and electronegative anion, all can not to see through small intestine thinAfter birth, and be combined into corresponding slightly solubility calcium salt with phytic acid or oxalic acid, excrete with ight soil. Thereby this class calcium supplementing product, calciumHuman body utilization rate extremely low, long-term taking also may cause the bad reactions such as constipation, has the risk of calculi in urinary system.
The disclosed a kind of compound calcium preparation for astronaut of CN200510123442.6, CN200810079874.5 are disclosedImprove health products and the disclosed a kind of high milk calcium granule of CN200610023698.4 of bone and function of joint,These three kinds of calcium-supplementing preparations have added a certain amount of compound sugar, have improved to a certain extent the absorptivity of calcium, have reduced by replenishing the calciumThe constipation problem causing. But, because compound sugar and gut flora utilize degree different, can cause flatulence or hydrochloric acid in gastric juice etc., especiallyBe not suitable for the crowd of function of intestinal canal weakness.
Therefore, develop a kind of safer, rationally, calcium-supplementing nutritive composition is still very urgent effectively.
Summary of the invention
The object of the present invention is to provide the one composition of replenishing the calcium safely and effectively, this composition of replenishing the calcium has higher calciumAbsorptivity and bioavailability, can effectively prevent or reduce by the improper constipation causing and the calculi in urinary system of replenishing the calcium simultaneously, thisCan also assist outward reduce blood pressure, blood sugar and blood lipid level.
For addressing the above problem, the present invention adopts following technical scheme:
A kind of calcium-supplementing nutritive composition, comprises calcium, compound sugar and smear tea, and three's mass ratio is calcium: compound sugar: smearing tea is1∶0.3-6∶0.1-2。
Compound sugar itself has and promotes the calcium to absorb, promote the activation of Bifidobacterium in human body intestinal canal and maintain intestinal healthFunction. In addition the SCFA producing when compound sugar ferments, can stimulate intestines peristalsis, increases ight soil wettability, Constipation.
In calcium-supplementing nutritive composition, add that to smear tea be because smear the calcium content of tea vitamin C higher and that smear in tea own and can urgeEnter the absorption of human body to calcium. Smear tea and also contain abundant active material as catechin, tea polysaccharide etc., can reduce blood fat, blood sugar waterFlat, increase urinary calculi, thereby alleviate the constipation that the insoluble calcium after calcium absorbs causes, prevention calculi in urinary system, especiallyThe three high patients that applicable needs are replenished the calcium.
The composition of replenishing the calcium of the present invention, has determined the formula ratio of three kinds of compositions, and such combination has not only ensured three kinds of battalionFoster thing is giving full play to of effect separately, and have each other the effect of Synergistic: smear the bacteriostasis of tea and compound sugarBeneficial bacterium activation combines, better balance the flora of enteron aisle, effectively avoided produce sour aerogenesis phenomenon; Not only improveThe body absorption rate of calcium, has also increased the bioavailability of calcium, and eater is being stopped after supplementary copy invention alimentation compositionIn the long time, still there is good bone-forming effect and do not take a turn for the worse. The more important thing is, such combination can realize reduce orEffect of prevention calculi in urinary system, has overcome existing calcium preparation and has easily led lithogenic drawback, meets three high patient and renal functionsThe demands of special physiological crowd to safety, effective calcium-supplement such as complete, functions of intestines and stomach decline crowd.
As preferably, calcium in described calcium-supplementing nutritive composition: compound sugar: the mass ratio of smearing tea is 1: 0.5-3: 0.3-1.
Replenish the calcium in composition calcium, compound sugar and smear the ratio between tea, inventor has carried out a large amount of zooperies and has facedBed is tested the mass ratio of finding three kinds of crucial composition calcium, compound sugar and smearing tea, and numerical value is more approaching therewith, and its calcium absorptivity moreHeight, this fully shows suitable ratio and can strengthen the synergistic function of three kinds of materials.
As preferably, the calcium source in described calcium-supplementing nutritive composition be newborn mineral salt, calcium phosphate, calcium monohydrogen phosphate, calcium carbonate,One or more in amino acid chelated calcium. Phosphorus has synergistic effect to the absorption of calcium, and natural phosphorous calcium source is easy to moreAbsorb, and have no side effect, in human body, not needing too many hydrochloric acid in gastric juice to participate in is the separable ionic condition that presents, and then direct by human bodyAbsorb, regulate rapidly blood calcium balance, build up health, excitant is much smaller, substantially without repelling and allergic phenomena. Amino acid chelaClosing calcium is a kind of organic calcium class material being generated by chemosynthesis reaction by several amino acids and inorganic calcium salt, can be greatlyImprove the absorptivity of human body to calcium. The calcium content the highest (40%) of calcium carbonate, has better therapeutic action to osteoporosis, is applicable toHigh calcium supplements crowd.
As preferably, described calcium is newborn mineral salt. Breast mineral salt contains coordinates rational 2: 1 calcium phosphorus rations, natural existenceThe natural nutrition composition such as vitamin D, CPP (CPP), all contribute to the absorption of calcium. Compare with other calcium sources, itsComposition is abundanter, and the absorbability of calcium is better.
As preferably, the compound sugar in described calcium-supplementing nutritive composition is trehalose, FOS, galactooligosaccharide, waterOne or more in threose and isomaltoketose. The effect that be absorbed with remarkable enhancing of compound sugar to calcium, and in enteron aisleThe propagation facilitation effect of Bifidobacterium, lactobacillus acidophilus better.
As preferably, the tea fineness of smearing of described calcium-supplementing nutritive composition is more than 800 orders. The increase of smearing tea fineness, makesThe active principle of smearing in tea is absorbed by the body more fully, and effect that it is auxiliary replenished the calcium, regulated stomach, hypoglycemic, reducing blood lipid moreAdd obviously.
As preferably, in described calcium-supplementing nutritive composition, also comprise short calcium enhancer vitamin D, K2, one in CPP, CBPKind or several. Short calcium enhancer can participate in the delivery of calcium, promotes the absorption efficiency of calcium.
As preferably, in described calcium-supplementing nutritive composition, also add glycitols compound. Sugar alcohol can effectively improve the suction of calciumYield and retention rate, and its sugariness is high, calorific value is low, does not make blood sugar raise, and does not increase cholesterol, thereby can reduce body fatExcessive accumulation, and can prevent and adjuvant treatment of diseases. Due to the good stability of sugar alcohol, make preparation and more can ensure the matter of productAmount. Meanwhile, in the refrigerant mouthfeel energy of sugar alcohol and the astringent taste of calcium, make composition there is good mouthfeel.
As preferably, described calcium-supplementing nutritive composition comprises oral administration solid, liquid or semisolid preparation, as chewable tablets, thinFilm garment piece, capsule, pulvis and granule etc.
As preferably, described calcium-supplementing nutritive composition is applied to replenishes the calcium, protects intestinal health, reduces or prevent urinary systemCalculus.
In sum, the present invention has following beneficial effect:
1, not only ensured three's nutrients fully sending out of effect separately according to the calcium-supplementing nutritive composition of ratio preparation of the present inventionWave, and have each other the effect of Synergistic.
2, calcium-supplementing nutritive composition of the present invention has not only improved absorptivity, the bioavailability of calcium greatly, can also prevent orReduce by incorrect constipation and the calculi in urinary system of replenishing the calcium and causing, overcome the drawback of existing calcium preparation, be particularly suitable for kidney meritMid-aged population that can be weak.
3, calcium-supplementing nutritive composition of the present invention, except thering is good effect of supplemented calcium, can also assist reduce blood pressure,Blood fat and blood sugar, be particularly suitable for the high crowd of person in middle and old age three edible.
Detailed description of the invention
Further illustrate realization, functional characteristics and the beneficial effect of the object of the invention below in conjunction with specific embodiment. ThisSpecific embodiment is only explanation of the invention, and it is not limitation of the present invention, and those skilled in the art are readingAfter this description, can make to the present embodiment the amendment that there is no creative contribution as required, but as long as in right of the present inventionIn claimed range, be all subject to the protection of Patent Law.
1. calcium-supplementing nutritive composition
Embodiment 1
Take mass percent and be 50% amino acid chelated calcium, 20% trehalose, 10% FOS, 10% and smear tea, 9.998% woodSugar alcohol, 0.002% vitamin D powder. After all supplementary materials are mixed, then be distributed into 5.0g/ bag, obtain calcium-supplementing nutritive combinationMedicinal powder.
Embodiment 2
Take mass percent and be 10% calcium monohydrogen phosphate, 7.1% calcium phosphate, 15% galactooligosaccharide, 5% and smear tea, 37.65% Fructus Hordei GerminatusDextrin, 25% whole milk powder, 0.2% dolomol, 0.05%CPP. First above-mentioned supplementary material is mixed, then add pure in right amountChange water and granulate, be dried, after compressing tablet, dressing, obtain the film coated tablet of calcium-supplementing nutritive composition.
Embodiment 3
Take mass percent and be 43.5% calcium monohydrogen phosphate, 10% stachyose, 3% smear tea, 1% mulberry leaf powder, 20% xylitol,22.3% maltodextrin, 0.2% dolomol. After above-mentioned supplementary material is mixed, with capsule-filling agent filling, through throwingAfter light, packing, obtain nutrient combination composite capsule.
Embodiment 4
Take mass percent and be 40% newborn mineral salt, 5% isomaltoketose, 5% smear tea, 0.05% farnoquinone, 30%Maltitol, 19.85% whole-fat milk powder, 0.05%CMC, 0.05% potassium sorbate. First CMC is added suitable quantity of water fully swelling allAfter even, then add above-mentioned supplementary material to mix, after sterilizing, quantitative separating, obtain calcium-supplementing nutritive composition oral liquid.
Embodiment 5
Take mass percent and be 37.5% newborn mineral salt, 5% FOS, 3% smear tea, 31% maltitol, 15% full-creamMilk powder, 8.2% maltodextrin, 0.3% dolomol, calcium, compound sugar and to smear tea three mass ratio be 1:0.5:0.3. WillAfter above-mentioned supplementary material mixes, obtain calcium-supplementing nutritive composition chewable tablets through granulating, after dry, compressing tablet.
Embodiment 6
Take mass percent and be 20% newborn mineral salt, 25% FOS, 10% smear tea, 21.5% maltitol, 15% completeFat milk powder, 8.2% maltodextrin, 0.3% dolomol, calcium, compound sugar and to smear tea three mass ratio be 1:5:2. By upperAfter stating supplementary material and mixing, obtain calcium-supplementing nutritive composition chewable tablets through granulating, after dry, compressing tablet.
Embodiment 7
Take mass percent and be 20% newborn mineral salt, 10% FOS, 5% smear tea, 35% maltitol, 15% full-creamMilk powder, 14.8% maltodextrin, 0.3% dolomol, calcium, compound sugar and to smear tea three mass ratio be 1:2:1. By above-mentionedAfter supplementary material mixes, obtain calcium-supplementing nutritive composition chewable tablets through granulating, after dry, compressing tablet.
Embodiment 8
Take mass percent and be 37.5% calcium carbonate, 5% xylo-oligosaccharide, 1.5% and smear tea, 19.5% skimmed milk power, 30% lengthen one's lifeSugar, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, compound sugar and to smear tea three mass ratio be 1:0.3:0.1. After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition grain through granulating, after dry, packing.
Embodiment 9
Take mass percent and be 25% calcium carbonate, 20% xylo-oligosaccharide, 10% and smear tea, 19.5% skimmed milk power, 19% lengthen one's lifeSugar, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, compound sugar and to smear tea three mass ratio be 1:2:1. After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition grain through granulating, after dry, packing.
Embodiment 10
Take mass percent and be 12.5% calcium carbonate, 30% xylo-oligosaccharide, 10% and smear tea, 19.5% skimmed milk power, 21.5% benefitLongevity sugar, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, compound sugar and to smear tea three mass ratio be 1:6:2. After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition grain through granulating, after dry, packing.
Embodiment 11
Take mass percent and be 36% newborn mineral salt, 5% trehalose, 5% galactooligosaccharide, 2% smear tea, 4% mulberry leaf powder,20% maltitol, 15% skimmed milk powder, 12.8% maltodextrin, 0.2% dolomol. Above-mentioned supplementary material is mixed allAfter even, obtain calcium-supplementing nutritive composition chewable tablets through granulating, after dry, compressing tablet.
Comparative example 1
Take mass percent and be 37.5% calcium carbonate, 5% xylo-oligosaccharide, 19.5% skimmed milk power, 31.5% isomalt, 5.9%Maltodextrin, 0.5% CBP, 0.1% milk flavour. After above-mentioned supplementary material is mixed, through granulating, after dry, packingObtain calcium-supplementing nutritive composition grain.
Comparative example 2
Take mass percent and be 37.5% calcium carbonate, 5% xylo-oligosaccharide, 1.2% and smear tea, 19.5% skimmed milk power, 30% lengthen one's lifeSugar, 6.2% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, compound sugar and to smear tea three mass ratio be 1:0.3:0.08. After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition grain through granulating, after dry, packing.
Comparative example 3
Take mass percent and be 12.5% calcium carbonate, 30% xylo-oligosaccharide, 10.5% and smear tea, 20% skimmed milk power, 20.5% benefitLongevity sugar, 5.9% maltodextrin, 0.5% CBP, 0.1% milk flavour, calcium, compound sugar and to smear tea three mass ratio be 1:6:2.1. After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition grain through granulating, after dry, packing.
Comparative example 4
Take mass percent and be 37.5% newborn mineral salt, 5% white granulated sugar, 3% smear tea, 31% maltitol, 15% rich milkPowder, 8.2% maltodextrin, 0.3% dolomol. After above-mentioned supplementary material is mixed, through granulating, after dry, compressing tabletObtain calcium-supplementing nutritive composition chewable tablets.
Comparative example 5
Take mass percent and be 20% newborn mineral salt, 25% FOS, 10.2% smear tea, 21.3% maltitol, 15%Whole-fat milk powder, 8.2% maltodextrin, 0.3% dolomol, calcium, compound sugar and to smear tea three mass ratio be 1:5:2.5.After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition chewable tablets through granulating, after dry, compressing tablet.
Comparative example 6
Take mass percent and be 37.5% newborn mineral salt, 2.5% FOS, 5% smear tea, 31.5% maltitol, 15%Whole-fat milk powder, 8.2% maltodextrin, 0.3% dolomol, calcium, compound sugar and to smear tea three mass ratio be 1:0.28:0.5. After above-mentioned supplementary material is mixed, obtain calcium-supplementing nutritive composition chewable tablets through granulating, after dry, compressing tablet.
2. the animal experiment of effect of supplemented calcium:
10 monthly ages clean level male SD rat for experiment, body weight 300-330g. Under equivalent environment, adapt to feed after 1 week, divide at randomIt is 7 groups: test 1 group, test 2 groups, test 3 groups, blank group, contrast 1 group, contrast 2 groups, contrast 3 groups, 10 every group. Rat drink1% ethylene glycol+1% chlorination ammoniacal liquor (induction rat produces calcinm oxalate calculus), weighs weekly once, feeds 5 weeks. Guarantee every ratCalcium intake be about 150mg/d.
Embodiment 12
Test in the feed of 1 group of rat and be added with calcium-supplementing nutritive composition, described calcium-supplementing nutritive composition compound method is as implementedExample 6, calcium in rats intake is about 150mg/d.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Embodiment 13
Test in the feeds of 2 groups of rats and be added with calcium-supplementing nutritive composition, described calcium-supplementing nutritive composition compound method is as implementedExample 9, calcium in rats intake is about 150mg/d.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Embodiment 14
Test in the feeds of 3 groups of rats and be added with calcium-supplementing nutritive composition, described calcium-supplementing nutritive composition compound method is as implementedExample 10, calcium in rats intake is about 150mg/d.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Comparative example 7
Blank group feeding normal diet.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Comparative example 8
Contrast in the feed of 1 group of rat and be added with calcium-supplementing nutritive composition, described calcium-supplementing nutritive composition compound method as rightThan embodiment 1, calcium in rats intake is about 150mg/d.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Comparative example 9
Contrast in the feeds of 2 groups of rats and be added with calcium-supplementing nutritive composition, described calcium-supplementing nutritive composition compound method is as contrastEmbodiment 2, calcium in rats intake is about 150mg/d.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Comparative example 10
Contrast in the feeds of 3 groups of rats and be added with calcium-supplementing nutritive composition, described calcium-supplementing nutritive composition compound method is as contrastEmbodiment 3, calcium in rats intake is about 150mg/d.
Experiment finishes rear with every rat 24h urine of metabolic cage collection, adds concentrated hydrochloric acid anticorrosion, 4 DEG C of preservations. Potassium chromate oxidation firstThe red Catalytic Spectrophotometric Analysis of base is surveyed urine oxalic acid, and measures urine calcium concentration.
Rat is weighed, and left side internal carotid is isolated in 4% yellow Jackets (40mg/kg) intraperitoneal anesthesia, then disconnected neck placeExtremely. Take out two kidneys, longitudinally cut open, left kidney is fixed with 10% formaldehyde, the HE paraffin section that dyes, 200 times of light Microscopic observation nephridial tissue grassAcid calcium crystallization deposition situation.
Table 1: animal test results
(note: taking comparative example's 7 empty group Rat renal tubule crystalline states as 10 points, more approach 10 points and represent that crystallization is thickerGreatly, in heaps and be tending towards connecting in flakes; Mark is lower, represents that crystallization is more tiny, disperses, and crystallization bright spot is less)
As shown in table 1, the rat urine oxalic acid value of experimental group, renal tubule crystallization score value be lower than blank group and control group, urine calcium valueHigher than blank group and control group, this shows that calcium-supplementing nutritive composition of the present invention can reduce calculi in urinary system risk. Experimental groupThe calcium-supplementing nutritive composition of rat institute feeding has added compound sugar, calcium simultaneously and has smeared tea, and 8 groups of rats of comparative example and experimentThe difference of group is not add and smears tea, although 9 groups, 10 groups of comparative examples are contained calcium, compound sugar and smear tea, three simultaneouslyPerson's mass ratio is not at calcium: in the scope of compound sugar: smear tea=1: 0.3-6: 0.1-2. Little from rat urine oxalic acid, urine calcium, kidneyThe brilliant numerical value that waits of duct ligation can find out that each numerical value of experimental group is obviously better than control group, and the crystallization of urine oxalic acid has the trend reducing. This tableIn visible subsidy calcium alimentation composition, calcium, compound sugar and the appropriate proportioning of smearing tea have better effect to slowing down of calculi in urinary system.
3. clinical testing:
Test crowd: adopt random sampling group technology, select 60 examples through clinical definite hypertension and accompany in osteoporotic oldYear people, age 40-70 year, and it is divided into experimental group 1, experimental group 2, experimental group 3, blank group, 1 group of contrast, contrast 2 at random3 groups of group, contrasts, every group of 8 examples. Calcium intake reaches 800mg/d. Measure initial blood pressure, blood sugar, bone density value, body weight, observe largeJust situation.
Embodiment 15
Experimental group is taken in the calcium-supplementing nutritive composition of the present embodiment 5 every day, makes calcium intake reach 800mg. After three months, to itBlood pressure, blood sugar, bone density, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Embodiment 16
Experimental group is taken in the calcium-supplementing nutritive composition of the present embodiment 6 every day, makes calcium intake reach 800mg. After three months, to itBlood pressure, blood sugar, bone density, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Embodiment 17
Experimental group is taken in the calcium-supplementing nutritive composition of the present embodiment 7 every day, makes calcium intake reach 800mg. After three months, to itBlood pressure, blood sugar, bone density, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Comparative example 11
Blank group is still pressed normal diet, does not take any calcium-supplementing nutritive composition. After three months, close to its blood pressure, blood sugar, boneDegree, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Comparative example 12
Contrast 1 group, take in comparative example 4 calcium-supplementing nutritive composition every day, make calcium intake reach 800mg. After three months,Its blood pressure, blood sugar, bone density, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Comparative example 13
Contrast 2 groups, take in comparative example 5 calcium-supplementing nutritive composition every day, make calcium intake reach 800mg. After three months,Its blood pressure, blood sugar, bone density, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Comparative example 14
Contrast 2 groups, take in comparative example 6 calcium-supplementing nutritive composition every day, make calcium intake reach 800mg. After three months,Its blood pressure, blood sugar, bone density, body weight are measured. Adopt dual energy X-ray absorptiometry instrument to measure its femoral neck bone density (BMD).
Table 2 clinical trial result
As shown in table 2, the calcium-supplementing nutritive composition of the present invention that experimental group patient takes contains calcium simultaneously, smears tea and compound sugar, skyBai Zuwei takes any calcium-supplementing nutritive thing, and the calcium-supplementing preparation that 1 group of patient of contrast takes is containing compound sugar, contrasts 2 groups, 3 groupsCalcium: compound sugar: smear the mass ratio of tea not 1: in the scope of 0.3-6: 0.1-2.
Experimental data in table 2 shows, experimental group patient's systolic pressure reduces that value, fasting blood-glucose reduce value, bone density increasesValue is obviously better than control group patient, illustrates that calcium-supplementing nutritive composition of the present invention, in increasing bone density, also contributes to fall bloodPress, blood sugar, be applicable to hypertension, hyperglycemic patients is replenished the calcium. In addition, the data of stool frequency and the data of changes of weight show thisInvention calcium-supplementing nutritive composition more helps relax bowel, and reduces body weight. Compared with experimental group, 2 groups and 3 groups patients' of contrast contractionPressure reduces the physical signs such as value, fasting blood sugar, urine calcium, bone density value added and is also starkly lower than experimental group, this battalion that shows to replenish the calciumSupport calcium, compound sugar in composition and smear the proportioning of tea whether suitable to they absorb human calcium, the reduction of blood pressure and blood sugar level,It is most important whether the aspects such as the increase of bone density play synergistic function.
Claims (10)
1. a calcium-supplementing nutritive composition, is characterized in that: described calcium-supplementing nutritive composition comprises calcium, compound sugar and smears tea, calcium:Compound sugar: the mass ratio of smearing tea is 1: 0.3～6: 0.1～2.
2. a kind of calcium-supplementing nutritive composition as claimed in claim 1, is characterized in that: described calcium: compound sugar: the mass ratio of smearing teaExample is 1: 0.5～3: 0.3～1.
3. a kind of calcium-supplementing nutritive composition as described in claim 1 or 2 any one, is characterized in that: described calcium be newborn mineral salt,One or more in calcium phosphate, calcium monohydrogen phosphate, calcium carbonate, amino acid chelated calcium.
4. a kind of calcium-supplementing nutritive composition as claimed in claim 3, is characterized in that: described calcium is newborn mineral salt.
5. a kind of calcium-supplementing nutritive composition as described in claim 1 or 2 any one, is characterized in that: described compound sugar is marine algaOne or more in sugar, FOS, galactooligosaccharide, stachyose and isomaltoketose.
6. a kind of calcium-supplementing nutritive composition as described in claim 1 or 2 any one, is characterized in that: described in smear tea fineness at leastBe 800 orders.
7. a kind of calcium-supplementing nutritive composition as claimed in claim 6, is characterized in that: described calcium-supplementing nutritive composition also comprises shortCalcium enhancer vitamin D, K2, one or more in CPP, CBP.
8. a kind of calcium-supplementing nutritive composition as claimed in claim 7, is characterized in that: described calcium-supplementing nutritive composition also comprises sugarAlcohol compound.
9. a kind of calcium-supplementing nutritive composition as claimed in claim 8, is characterized in that: described calcium-supplementing nutritive composition comprises solidBody, liquid and semisolid oral formulations.
10. a kind of calcium-supplementing nutritive composition as described in claim 1-9 any one, is characterized in that: described calcium-supplementing nutritive combinationThing is applied to and replenishes the calcium, protects intestinal health, reduces or prevent calculi in urinary system.
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| CN113133511A (en) * | 2020-01-20 | 2021-07-20 | 山西振东五和健康科技股份有限公司 | Calcium fruit composite fruit juice beverage and preparation method thereof |
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Denomination of invention: A calcium supplement nutritional composition Effective date of registration: 20230505 Granted publication date: 20180824 Pledgee: Hangzhou United Rural Commercial Bank Limited by Share Ltd. Zhongshan branch Pledgor: ZHEJIANG CANOBANK HEALTH PRODUCT Co.,Ltd. Registration number: Y2023980039787 |