CN102551073A - Nutritional composition containing alpha-lactoalbumin and lactoferrin and application of nutritional composition - Google Patents
Nutritional composition containing alpha-lactoalbumin and lactoferrin and application of nutritional composition Download PDFInfo
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a nutritional composition or food containing alpha-lactoalbumin and lactoferrin and application of the nutritional composition or the food. The nutritional composition contains the alpha-lactoalbumin and the lactoferrin in a weight ratio of (1:99)-(99:1). The invention also provides the application of the nutritional composition or the food containing the alpha-lactoalbumin and the lactoferrin to the strengthening of immunity. The alpha-lactoalbumin and the lactoferrin which have the specific content are contained in the nutritional composition containing the alpha-lactoalbumin and the lactoferrin, and are close to immune factors in human milk. By supplementing an immune essence which is close to breast milk in vitro, the nutritional composition has the effects of effectively improving the resistance and immunity of infants, and effectively improves the immunity of the kind of crowd. The invention has the advantages that: the nutritional composition is high in safety, has a good effect, and does not have toxic or side effect after being taken for a long time. The nutritional composition can be taken as food or a health-care product, can be used for a long time, and can bring a good social benefit.
Description
Technical field
The present invention relates to a kind of alimentation composition, more particularly, relate to a kind of alimentation composition and application in bread and cheese, health products or medicine thereof that contains ALA and lactoferrin.
Background technology
Because infant's the later ability of immune system is full-fledged; So its immunity and resistance are all more weak; Anti-infectious ability is relatively poor, and a lot of infants can occur that gastrointestinal function, immunologic function imperfection, Abwehrkraft des Koepers are weak, the disorders of digestion, and infectious diseases etc.This has not only hindered the g and D of baby's physique, and the cognitive growth of baby's intelligence, the growth of emotion sociability are all brought influence in various degree.
Existing product such as colostrum of building up resistance to the infant on the market, contain antibiotic medicine etc. and all have such-and-such drawback: contain hormone like colostrum, possible induced precocity; Antibiotics is taken certain toxic and side effect for a long time, particularly infant's normal development is had adverse influence.
Lactoferrin (lactoferrin is called for short LF) is a kind of natural glycoprotein with immunologic function, is changed by transferrins, and also the someone is called " red eggs are white ", mainly is present in breast milk and the cow's milk.The content of lactoferrin in human milk is abundant especially, can reach 7g/L in first Ruzhong especially.Along with its content of maturation of milk can descend to some extent, be about lg/L during suckling.Content is then lower in cow's milk, generally is merely 0.1g/L, and content is much lower than breast milk.
ALA is present in all mammiferous milk, and it is the main protein in the human milk, and ALA helps improving the conversion of digesting and assimilating, promote lactose and improves cognitive ability.The concentration of ALA is 0.2-0.3g/100ml in human milk, accounts for the 10-20% of total protein, compares, and in cow's milk, only accounts for the 2-5% of total protein.Data shows that the nutritive quality of ALA is higher than the milk protein of standard, is not only because it contains the high essential amino acid of content, the essential amino acid of also having ready conditions.ALA more can combine with micronutrient.But according to present existing lactalbumin and Casilan, the meals that need limit specific proteins for the infant also can not improve the amino acid composition that its protein is prepared burden.Future development possibly used the essential amino acid part that protein lacks in the specific proteins composition supplement formula.For reaching the optimum protein of these purposes is the ALA in the lactalbumin.
Summary of the invention
The purpose of this invention is to provide a kind of alimentation composition and application in bread and cheese, health food or medicine thereof that contains ALA and lactoferrin.This alimentation composition can effectively improve infant's resistance and immunity, and near the human milk immune factor.
Technical scheme of the present invention is:
A kind of alimentation composition that contains ALA and lactoferrin comprises ALA and lactoferrin, and the percentage by weight of ALA and lactoferrin is 1 in the said composition: 99-99: 1.
As preferably, in the described composition ALA and the ratio of lactoferrin be 1: 50-50: 1.
As preferably, in the described composition ALA and the ratio of lactoferrin be 1: 25-25: 1.
As preferably, in the described composition ALA and the ratio of lactoferrin be 1: 10-10: 1.
As preferably, in the described composition ALA and the ratio of lactoferrin be 1: 3-3: 1.
A kind of alimentation composition that contains ALA and lactoferrin; Formulation is solid beverage, tablet, soft capsule, hard shell capsules, microcapsules, granule, beverage, pulvis or dairy products; Comprise each above-mentioned described alimentation composition, described alimentation composition accounts for the 1%-100% of finished product gross mass.
As preferably, described alimentation composition accounts for the 10%-90% of finished product gross mass.
As preferably, described alimentation composition accounts for the 15%-80% of finished product gross mass.
As preferably, described alimentation composition accounts for the 20%-70% of finished product gross mass.
As preferably, described alimentation composition accounts for the 30%-60% of finished product gross mass.
The above-mentioned alimentation composition that contains ALA and lactoferrin, the application aspect enhance immunity power.
Beneficial effect of the present invention is following:
Drawback according to existing product; Special in infant crowd; The invention provides a kind of alimentation composition that comprises ALA and lactoferrin; In the described alimentation composition that contains ALA and lactoferrin, comprise the ALA and the lactoferrin of certain content, near the human milk immune factor.Through external immune elite of replenishing near breast milk, demonstrate the effect that better effectively improves infant's resistance and immunity, effectively improve such crowd's immunity.
It is good that described alimentation composition has a security, effective and take advantage without any side effects for a long time.
Described alimentation composition can be used as bread and cheese, health products or medicine, is suitable for long-term use, will bring good social benefit.
The specific embodiment
Through following examples the present invention is described further below, it will help to understand the present invention, but not limit content of the present invention.
Embodiment 1 (hard shell capsules)
With ALA powder 1%; Lactoferrin powder 99%; After mixing in proportion, fill, promptly get with capsule filling machine.
Embodiment 2 (pulvis)
With ALA powder 1.2%; Lactoferrin powder 60%; Vitamin C 0.2%; Fruit powder 4.6%; FOS 34%; After mixing in proportion, carry out packing, promptly get.
Embodiment 3 (granule)
With ALA powder 2.7%; Lactoferrin powder 67.5%; Lactose 29.8%; After mixing in proportion,, after the drying, carry out packing again, promptly get through granulating.
Embodiment 4 (microcapsules)
With ALA powder 7%; Lactoferrin powder 70%; Maltodextrin 10%; PURE WHEY 13%; After earlier ALA powder and lactoferrin powder being mixed in proportion, carry out embedding, after the low temperature drying, carry out packing again, promptly get with the mixed liquor of maltodextrin and PURE WHEY.
Embodiment 5 (pulvis)
With ALA powder 22.5%; Lactoferrin powder 67.5%; Fruit powder 2%; Inulin 8%; After mixing in proportion, carry out packing, promptly get.
Embodiment 6 (soft capsule)
With ALA powder 22.5%; Lactoferrin powder 7.5%; Beeswax 4%; Lecithin 3%; Vegetable oil 63%; Mix in proportion content; With gelatin, glycerine, water=in proportion be mixed and made into glue at 1: 0.4: 1, carry out pelleting in addition, after drying, promptly get with automatic soft capsule pellet press.
Embodiment 7 (solid beverage)
With ALA powder 20%; Lactoferrin powder 2%; Xylo-oligosaccharide 13%; Oligoisomaltose 15%; Glucose 30%; Milk powder 20%; After mixing in proportion, carry out packing, promptly get.
Embodiment 8 (tablet)
With ALA powder 15%; Lactoferrin powder 0.6%; Galactooligosaccharide 20%; Maltodextrin 64.4%; After mixing in proportion,, carry out compressing tablet after the drying again, promptly get through granulating.
Embodiment 9 (dairy products)
With a-lactoalbumin powder 10%; Lactoferrin powder 0.2%; Whole milk powder 11.5%; Water 78.3%; After mixing in proportion, packing promptly gets.
Embodiment 10 (beverage)
With ALA powder 0.99%; Lactoferrin powder 0.01%; Vitamin C 0.4%; Cobastab
10.13%; Cobastab
20.12%; Cobastab
60.12%; Glucose 10%; Milk powder 10%; Purified water 78.23%; After mixing makes dissolving evenly fully in proportion, carry out packing again, promptly get.
The invention provides the above-mentioned alimentation composition that contains ALA and lactoferrin, the application aspect enhance immunity power.Below be to effect research of the present invention:
Lactoferrin is one of most important bioactivator in the milk, and protection body, treatment disease are all played an important role.Multiple biologically actives such as quantity research shows greatly, and it is antibiotic, anti-oxidant, anticancer that lactoferrin has.The health food that can be used for development of new.In baby formula milk powder or baby food, add lactoferrin, can help the infant to resist microorganisms such as Escherichia coli, reduce baby's common diseases such as diarrhoea that virus causes, improve its immunity.
The nutritive quality of ALA is higher than the milk protein of standard, is not only because it contains the high essential amino acid of content, and the essential amino acid of also having ready conditions, ALA more can combine with micronutrient.Therefore, the inventor thinks that ALA has the immunity of benefiting and nervous system, and promotes the maturation of internal organ and the growth of the internal organ microbiologic population of health.
1, experiment material
Sample: the sample that ALA powder, lactoferrin powder make by embodiment 1.
Animal used as test: quality is the mouse about 18～22g, and 90, the male and female dual-purpose is divided into 3 at random and organizes greatly, and every big group is divided into 3 groups again at random and makes an experiment.
Test method: be recommended as 0.01g/kg according to the human body taking dose; So establish that composition is low, high dose is 0.05g/kg and 0.2g/kg (be equivalent to respectively human body recommended amounts 5 times, 20 times); With sample be made into receive test solution after, by to mouse stomach, control group filling stomach is with equal-volume distilled water; Once a day, continuous 30 days.
2, function of enhancing immunity evaluation method
The mouse spleen lymphocyte transformation experiment of inducing through ConA: mtt assay: serum hemolysin is measured: the blood clotting method; Antibody-producting cell detects: Jerne improves slide method; Turnover of Mouse Peritoneal Macrophages is engulfed the chicken red blood cell experiment: half intracorporal method.
3, function of enhancing immunity evaluation result
3.1 the influence that composition produces the mice serum hemolysin
Table 1 composition is to the influence of mice serum blood lysin antibody product
Annotate
*P＜0.05 is compared in expression with control group
Can know that by table 1 low, high dose group compares with control group mice, the antibody product has significant difference (P＜0.05).
3.2 composition is to the influence of mouse antibodies cellulation
Table 2 composition is to the influence of mouse antibodies cellulation
Annotate
*P＜0.01 is compared in expression with control group
Can know that by table 2 low, high dose group compares with control group mice, the antibody-producting cell number average has significant difference (P＜0.01)
3.3 composition is to the influence of Turnover of Mouse Peritoneal Macrophages chicken red blood cell ability
Table 3 composition is engulfed the influence of chicken red blood cell ability to Turnover of Mouse Peritoneal Macrophages
Annotate
*P＜0.05 is compared in expression with control group
Can know that by table 3 low, high dose group compares with control group mice, its peritoneal macrophage has significant difference (P＜0.05) to the phagocytic percentage phagocytic index of chicken red blood cell.
3.4 the functional evaluation result is shown by above-mentioned experimental result: engulf in the chicken red blood cell experiment in mice serum hemolysin determination experiment, antibody-producting cell test experience, Turnover of Mouse Peritoneal Macrophages, its result has significant difference.Can think that according to evaluation criterion composition has the function of enhance immunity power.
2 composition security toxicological evaluations
2.1 material
Sample: the sample that ALA powder, lactoferrin powder make by embodiment 1.
Animal used as test: cleaning level Kunming mouse and SD rat
2.2 security toxicological evaluation method
Composition is carried out acute toxicity testing (MTD method), genetoxic experiment and rat fed experiment in 30 days.Wherein the genetoxic experiment comprises Ames experiment, PCEMNR micronucleus test and mouse sperm deformity experiment.
2.3 security toxicological evaluation result
The acute oral toxicity experiment: the acute oral MTD of SD rat and Kunming mouse all belongs to actual non-toxic type greater than 20g/kg.bw.
Genetoxic experiment Ames experiment: PCEMNR micronucleus test and 3 genetoxic experimental results of mouse sperm deformity experiment are all negative, show that this product does not have mutagenesis and teratogenesis.
Rat was fed experiment in 30 days: maximum dose level is 100 times of human body recommended amounts, and this product does not cause the ANOMALOUS VARIATIONS of each item important indicators such as rat holistic health biochemical functions and organ-tissue morphology.
Above-described only is preferred implementation of the present invention; Should be pointed out that the those of ordinary skill in the art, under the prerequisite that does not break away from core technology characteristic of the present invention; Can also make some improvement, these improvement and retouching also should be regarded as protection scope of the present invention.
Claims (11)
1. an alimentation composition that contains ALA and lactoferrin comprises ALA and lactoferrin, it is characterized in that, the percentage by weight of ALA and lactoferrin is 1 in the said composition: 99-99: 1.
2. the alimentation composition that contains ALA and lactoferrin according to claim 1 is characterized in that, in the described composition ALA and the ratio of lactoferrin be 1: 50-50: 1.
3. the alimentation composition that contains ALA and lactoferrin according to claim 2 is characterized in that, in the described composition ALA and the ratio of lactoferrin be 1: 25-25: 1.
4. the alimentation composition that contains ALA and lactoferrin according to claim 3 is characterized in that, in the described composition ALA and the ratio of lactoferrin be 1: 10-10: 1.
5. the alimentation composition that contains ALA and lactoferrin according to claim 4 is characterized in that, in the described composition ALA and the ratio of lactoferrin be 1: 3-3: 1.
6. alimentation composition that contains ALA and lactoferrin; Formulation is solid beverage, tablet, soft capsule, hard shell capsules, microcapsules, granule, beverage, pulvis or dairy products; It is characterized in that; Comprise each described alimentation composition in the claim 1 to 5, described alimentation composition accounts for the 1%-100% of finished product gross mass.
7. the alimentation composition that contains ALA and lactoferrin according to claim 6 is characterized in that described alimentation composition accounts for the 10%-90% of finished product gross mass.
8. the alimentation composition that contains ALA and lactoferrin according to claim 7 is characterized in that described alimentation composition accounts for the 15%-80% of finished product gross mass.
9. the alimentation composition that contains ALA and lactoferrin according to claim 8 is characterized in that described alimentation composition accounts for the 20%-70% of finished product gross mass.
10. the alimentation composition that contains ALA and lactoferrin according to claim 9 is characterized in that described alimentation composition accounts for the 30%-60% of finished product gross mass.
11. each described alimentation composition that contains ALA and lactoferrin in the claim 1 to 10, the application aspect enhance immunity power.
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| WO2015154260A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them. |
| CN105286022A (en) * | 2015-10-12 | 2016-02-03 | 十堰天翔生物科技股份有限公司 | Compound protein powder rich in content of essential amino acids and reasonable in composition and preparation method of compound protein powder |
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| CN109938104A (en) * | 2017-12-21 | 2019-06-28 | 刘爱民 | Agree in one kind containing a piece of |
| CN110115387A (en) * | 2018-02-05 | 2019-08-13 | 常州英莱克斯生物工程有限公司 | A kind of lactoferrin piece health food and its production method |
| CN110115294A (en) * | 2018-02-05 | 2019-08-13 | 常州英莱克斯生物工程有限公司 | A kind of lactoferrin particle health food and its production method |
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| CN108813632A (en) * | 2018-07-13 | 2018-11-16 | 李钟� | A kind of alimentation composition and its application containing lactoferrin |
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