CN106418553A - Milk gamma globulin immune capsules and preparation method thereof - Google Patents

Milk gamma globulin immune capsules and preparation method thereof Download PDF

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Publication number
CN106418553A
CN106418553A CN201610840873.2A CN201610840873A CN106418553A CN 106418553 A CN106418553 A CN 106418553A CN 201610840873 A CN201610840873 A CN 201610840873A CN 106418553 A CN106418553 A CN 106418553A
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CN
China
Prior art keywords
gamma globulin
vitamin
capsule
parts
preparation
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Pending
Application number
CN201610840873.2A
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Chinese (zh)
Inventor
方雅悯
于胜龙
丁海燕
杨春花
方存林
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Individual
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Individual
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39508Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from milk, i.e. lactoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/424Gynostemma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies

Abstract

The invention discloses milk gamma globulin immune capsules and a preparation method thereof. The milk gamma globulin immune capsules comprise capsule housings and contents, wherein the contents are made from the following raw materials in parts by weight: 30-60 parts of milk gamma globulin, 10-30 parts of alpha-lactalbumin, 20-40 parts of vitamin C, 0.5-2 parts of vitamin A, 2-5 parts of gynostemma pentaphyllum, 1-5 parts of radix glycyrrhizae preparata powder and 70-120 parts of soybean salad oil. The milk gamma globulin immune capsules disclosed by the invention are neat and artistic, easy to swallow, uniform in color and free from obvious bubbles, and besides, natural active ingredients are added, so that the milk gamma globulin immune capsules are quite effectively on enhancing immunity.

Description

A kind of breast gamma globulin immunity capsule and preparation method thereof
Technical field
The present invention relates to a kind of breast gamma globulin immunity capsule and preparation method thereof, belong to medicine and field of health care products.
Background technology
Immunity is the defense mechanism of human body itself, is human bioequivalence and any foreign body eliminating external intrusion(Viral, thin Bacterium etc.), process aging, damage, the dead, own cells of degeneration and identification and process vivo mutations cell and virus infect carefully The ability of born of the same parents.Immunology Today is thought, immunity is human bioequivalence and the physiological reaction of exclusion " dissident ".This is executed in human body Function is immune system.
The body of hypoimmunity is easy to infected or cancer stricken;Immunity is extraordinary also to produce insalubrious knot Really, as caused anaphylaxiss, autoimmune disease etc..
A variety of causes makes immune system can not normally play protective effect, in the case, easily cause antibacterial, virus, Funguses etc. infect, and therefore hypoimmunity the most directly shows is exactly liable to illness.Because often ill, increase disappearing of body Consumption, thus typically have a delicate constitution, reductions of malnutrition, lethargy, fatigue and weak, appetite, the performance such as sleep disorder, give birth to Disease, having an injection to take medicine has become homely food.Sick every time will be lot more time to recover, and usually recurrent exerbation.Grow this Body and intelligent development can be led in the past bad, also easily induced major disease.
Gamma globulin contains the various antibody that healthy population serum has, and is combined with antibacterial, virus and toxin, is allowed to Lose function of causing a disease, have treatment, inhibitory action to inflammation, tumor etc., thus have enhancing body resistance with pre- aseptic work With.
Alpha-lactalbumin is the fabulous source of essential amino acids and branched-chain amino acid, is also uniquely can be with metallic element and calcium The whey protein fraction that element combines.Nearest research more finds, it is likely to be of anti-cancer function.In addition lactalbumin is in amino Acid ratio example configuration aspects, and all closely similar with human milk on functional characteristic.Energy enhance immunity, reduces disease and occurs. More preferably digest and assimilate, mitigate kidney burden.Promote calcium absorption, lift effect of supplemented calcium.Containing abundant tryptophan(Happy factors), sleep Dormancy, emotion are more preferable, appetite stimulator.
Also do not have to prepare enhance immunity medicine using gamma globulin and alpha-lactalbumin as primary raw material at present Report.
Content of the invention
The present invention relates to a kind of breast gamma globulin immunity capsule and preparation method thereof, it can greatly improve exempting from of human body Epidemic disease power.
The technical scheme is that:
A kind of breast gamma globulin immunity capsule, including capsule shell and content, described content includes following weight portion Raw material:
Newborn gamma globulin 30-60
Alpha-lactalbumin 10-30
Vitamin C 20-40
Vitamin A 0.5-2
Herb Gynostemmae Pentaphylli 2-5
Radix Glycyrrhizae Preparata powder 1-5
Soybean salad oil 70-120
More preferably, described content includes the raw material of following weight portion:
Newborn gamma globulin 30-60
Alpha-lactalbumin 10-30
Vitamin C 20-40
Vitamin A 0.5-2
Herb Gynostemmae Pentaphylli 2-5
Radix Glycyrrhizae Preparata powder 1-5
Soybean salad oil 70-120
The preparation method of above-mentioned breast gamma globulin immunity capsule, comprises the following steps:
A) dispensing:Take newborn gamma globulin, alpha-lactalbumin, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae Preparata powder, vitamin C, vitamin A, Semen sojae atricolor color Oily mix homogeneously is drawn to obtain content.
b)Colloidal sol:Suitable quantity of water is fully swelling to obtain gelatin solution to take gelatin to add;Water is mixed with glycerol, heats in water-bath To 60-80 DEG C, it is subsequently adding above-mentioned gelatin solution, stirring makes its mix homogeneously make rubber cement;Wherein gelatin is 150-200 weight Part, glycerol is 50-80 weight portion, and the water adding in the water adding in gelatin and glycerol is total up to 150-200 weight portion;
c)Pill:Rubber cement and content are put into capsule machine and makes capsule;
d)Washing:Wash away lubricating oil with ethanol;
e)It is dried:Dry, pelletization.
It is further preferred that described step b)Middle mixing time is 1-1.5h.
It is further preferred that described step d)In ethanol be 95% ethanol.
It is further preferred that described step e)Middle drying temperature is 30-35 DEG C.
Beneficial effect
Product of the present invention is neat and artistic, easily swallows, uniform color, no substantially bubble, and with the addition of active skull cap components, to carrying High immunity is largely effective.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is described further.
Embodiment 1
By newborn gamma globulin 30kg, alpha-lactalbumin 15kg, vitamin C 20kg, vitamin A 0.5kg, Herb Gynostemmae Pentaphylli 2kg, Radix Glycyrrhizae Preparata powder 1kg, soybean salad oil 70kg stir, deaeration, and capsule, every 500mg of capsule are made in last fill.
Embodiment 2
By newborn gamma globulin 45kg, alpha-lactalbumin 20kg, Catergen 5kg, retinol1 kg, Herb Gynostemmae Pentaphylli 4kg, process sweet Grass meal 3kg, soybean salad oil 80kg stir, deaeration, and soft capsule, every 500mg of capsule are made in last fill.
Embodiment 3
By newborn gamma globulin 50kg, alpha-lactalbumin 22kg, Catergen 8kg, retinol1 kg, Herb Gynostemmae Pentaphylli 4kg, process sweet Grass meal 3kg, soybean salad oil 90kg stir, deaeration, and capsule, every 500mg of capsule are made in last fill.
Toxicity test
This experiment adopts healthy SD rat, and the drug dose gradient of oral administration embodiment 1-3 preparation is 0.01g/kg And 0.1g/kg, successive administration 30 days, it is observed that animal growth state, activity drink within 1 week during rat administration and after being discontinued Food, hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc. all have no significant effect, and show that clinical application safely may be used Lean on.
Result on trial:
In being embodied as operation, invite 80 frequent emotions agitations, anxiety, recurrent exerbation of catching a cold, work not hard, warp The sub-health population grouping experiment often feeling exhausted.The results are shown in Table one
Group project Number of cases(People) Cycle(My god) Total effective rate(%)
Matched group 20 30 0
Embodiment 1 20 30 90
Embodiment 2 20 30 95
Embodiment 3 20 30 98
Can be obtained by upper table one, continuously foretaste embodiment 1-3 immunity capsule after one month, compare matched group(Do not eat immune glue Capsule), embodiment 1,2,3 groups of total effective rate significantly improves.Show that present invention breast gamma globulin immunity capsule has aobvious The enhance immunity effect writing.

Claims (6)

1. a kind of breast gamma globulin immunity capsule is it is characterised in that include capsule shell and content, described content bag Include the raw material of following weight portion:
Newborn gamma globulin 30-60
Alpha-lactalbumin 10-30
Vitamin C 20-40
Vitamin A 0.5-2
Herb Gynostemmae Pentaphylli 2-5
Radix Glycyrrhizae Preparata powder 1-5
Soybean salad oil 70-120.
2. according to claim 1 breast gamma globulin immunity capsule it is characterised in that described content include following heavy The raw material of amount part:
Newborn gamma globulin 30-60
Alpha-lactalbumin 10-30
Vitamin C 20-40
Vitamin A 0.5-2
Herb Gynostemmae Pentaphylli 2-5
Radix Glycyrrhizae Preparata powder 1-5
Soybean salad oil 70-120.
3. the preparation method of the newborn gamma globulin immunity capsule described in claim 1 or 2 is it is characterised in that include following walking Suddenly:
A) dispensing:Take newborn gamma globulin, alpha-lactalbumin, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae Preparata powder, vitamin C, vitamin A, Semen sojae atricolor color Draw oily mix homogeneously, vacuum defoamation obtains content;
b)Colloidal sol:Suitable quantity of water is fully swelling to obtain gelatin solution to take gelatin to add;Water is mixed with glycerol, is heated in water-bath 60-80 DEG C, it is subsequently adding above-mentioned gelatin solution, stirring makes its mix homogeneously make rubber cement;Wherein gelatin is 150-200 weight portion, Glycerol is 50-80 weight portion, and the water adding in the water adding in gelatin and glycerol is total up to 150-200 weight portion;
c)Pill:Rubber cement and content are put into capsule machine and makes capsule;
d)Washing:Wash away lubricating oil with ethanol;
e)It is dried:Dry, pelletization.
4. the preparation method of breast gamma globulin immunity capsule according to claim 3 is it is characterised in that described step b) Middle mixing time is 1-1.5h.
5. the preparation method of breast gamma globulin immunity capsule according to claim 3 is it is characterised in that described step d) In ethanol be 95% ethanol.
6. the preparation method of breast gamma globulin immunity capsule according to claim 3 is it is characterised in that described step e) Middle drying temperature is 30-35 DEG C.
CN201610840873.2A 2016-08-24 2016-09-22 Milk gamma globulin immune capsules and preparation method thereof Pending CN106418553A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016107136552 2016-08-24
CN201610713655 2016-08-24

Publications (1)

Publication Number Publication Date
CN106418553A true CN106418553A (en) 2017-02-22

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1174742A (en) * 1997-08-06 1998-03-04 上海科星生物技术有限公司 Complex cow's milk gamma globulin and the making method thereof
CN1545922A (en) * 2003-07-31 2004-11-17 余国华 Gamma globulin health food (SARS health food) and manufacturing process thereof
CN1557489A (en) * 2004-01-15 2004-12-29 高春平 Preparation of oral administered immune globulin from whey
CN1939537A (en) * 2005-09-27 2007-04-04 程国根 Production of gamma immune protein capsules
CN101301078A (en) * 2008-05-29 2008-11-12 陈西喆 Nutrient health care food and preparation process thereof
CN102551073A (en) * 2012-02-22 2012-07-11 浙江康恩贝健康产品有限公司 Nutritional composition containing alpha-lactoalbumin and lactoferrin and application of nutritional composition
CN103349125A (en) * 2013-07-22 2013-10-16 北京绿源求证科技发展有限责任公司 Health-preserving food tea granule capable of improving sleeping

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1174742A (en) * 1997-08-06 1998-03-04 上海科星生物技术有限公司 Complex cow's milk gamma globulin and the making method thereof
CN1545922A (en) * 2003-07-31 2004-11-17 余国华 Gamma globulin health food (SARS health food) and manufacturing process thereof
CN1557489A (en) * 2004-01-15 2004-12-29 高春平 Preparation of oral administered immune globulin from whey
CN1939537A (en) * 2005-09-27 2007-04-04 程国根 Production of gamma immune protein capsules
CN101301078A (en) * 2008-05-29 2008-11-12 陈西喆 Nutrient health care food and preparation process thereof
CN102551073A (en) * 2012-02-22 2012-07-11 浙江康恩贝健康产品有限公司 Nutritional composition containing alpha-lactoalbumin and lactoferrin and application of nutritional composition
CN103349125A (en) * 2013-07-22 2013-10-16 北京绿源求证科技发展有限责任公司 Health-preserving food tea granule capable of improving sleeping

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
闫丽霞: "《药物制剂技术》", 31 August 2012, 华中科技大学出版社 *

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Application publication date: 20170222