CN108026094B - 取代的4-氮杂吲哚以及它们作为glun2b受体调节剂的用途 - Google Patents

取代的4-氮杂吲哚以及它们作为glun2b受体调节剂的用途 Download PDF

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CN108026094B
CN108026094B CN201680052507.9A CN201680052507A CN108026094B CN 108026094 B CN108026094 B CN 108026094B CN 201680052507 A CN201680052507 A CN 201680052507A CN 108026094 B CN108026094 B CN 108026094B
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pyrrolo
pyridin
methyl
fluoro
phenyl
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CN108026094A (zh
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C.C.车罗菲安
M.A.勒塔维
J.C.雷奇
A.索尤德-乔恩森
J.L.瓦尔
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Janssen Pharmaceutica NV
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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CN201680052507.9A 2015-07-09 2016-07-07 取代的4-氮杂吲哚以及它们作为glun2b受体调节剂的用途 Active CN108026094B (zh)

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US201562190416P 2015-07-09 2015-07-09
US62/190416 2015-07-09
PCT/US2016/041339 WO2017007938A1 (en) 2015-07-09 2016-07-07 Substituted 4-azaindoles and their use as glun2b receptor modulators

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CN108026094B true CN108026094B (zh) 2021-02-09

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US (2) US9963447B2 (https=)
EP (1) EP3319963B1 (https=)
JP (2) JP6964576B2 (https=)
KR (1) KR20180026760A (https=)
CN (1) CN108026094B (https=)
AU (1) AU2016291158B2 (https=)
BR (1) BR112018000468A2 (https=)
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SM (1) SMT202000134T1 (https=)
WO (1) WO2017007938A1 (https=)
ZA (1) ZA201800827B (https=)

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US10071988B2 (en) 2016-02-10 2018-09-11 Janssen Pharmaceutica Nv Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
WO2019193516A2 (en) * 2018-04-04 2019-10-10 Janssen Pharmaceutica Nv Substituted pyridine and pyrimidines and their use as glun2b receptor modulators
TW202112774A (zh) 2019-06-14 2021-04-01 比利時商健生藥品公司 經取代之吡唑并－吡啶醯胺及其作為ｇｌｕｎ２ｂ受體調節劑之用途
AU2020293642A1 (en) * 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
CA3143103A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Pyridine carbamates and their use as glun2b receptor modulators
MX2021015511A (es) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Carbamatos de pirazina y sus usos como moduladores del receptor glun2b.
JP7667097B2 (ja) * 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
BR112021025141A2 (pt) 2019-06-14 2022-01-25 Janssen Pharmaceutica Nv Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
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CN114621125B (zh) * 2020-12-14 2024-07-09 中国科学技术大学 Nlrp3炎症小体抑制剂及其应用

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TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途

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CN101754759A (zh) * 2007-05-18 2010-06-23 史密丝克莱恩比彻姆公司 用作pi3激酶抑制剂的喹啉衍生物
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PT3319963T (pt) 2020-04-09
JP2018520170A (ja) 2018-07-26
CA2991765C (en) 2023-10-03
ES2781867T3 (es) 2020-09-08
HK1255160A1 (en) 2019-08-09
MA42397B1 (fr) 2020-02-28
KR20180026760A (ko) 2018-03-13
US20180208595A1 (en) 2018-07-26
ZA201800827B (en) 2019-09-25
DK3319963T3 (da) 2020-02-03
HRP20200410T1 (hr) 2020-08-21
AU2016291158A1 (en) 2018-02-01
MX2018000352A (es) 2018-08-15
EA033197B1 (ru) 2019-09-30
AU2016291158B2 (en) 2020-04-30
WO2017007938A1 (en) 2017-01-12
CA2991765A1 (en) 2017-01-12
EA201890245A1 (ru) 2018-06-29
IL256758A (en) 2018-03-29
CY1123007T1 (el) 2021-10-29
EP3319963A1 (en) 2018-05-16
EP3319963B1 (en) 2020-01-08
JP2021193099A (ja) 2021-12-23
JP7369743B2 (ja) 2023-10-26
US9963447B2 (en) 2018-05-08
CN108026094A (zh) 2018-05-11
JP6964576B2 (ja) 2021-11-10
BR112018000468A2 (pt) 2018-09-18
LT3319963T (lt) 2020-03-25
HUE047460T2 (hu) 2020-04-28
MD3319963T2 (ro) 2020-05-31
SI3319963T1 (sl) 2020-02-28
SMT202000134T1 (it) 2020-05-08
US10377753B2 (en) 2019-08-13
US20170008890A1 (en) 2017-01-12

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