CN108026059A - 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物 - Google Patents

四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物 Download PDF

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Publication number
CN108026059A
CN108026059A CN201680033152.9A CN201680033152A CN108026059A CN 108026059 A CN108026059 A CN 108026059A CN 201680033152 A CN201680033152 A CN 201680033152A CN 108026059 A CN108026059 A CN 108026059A
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CN
China
Prior art keywords
crystal form
anavex19
metabolin
diphenyl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680033152.9A
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English (en)
Chinese (zh)
Inventor
P·约克
L·A·伦纳德
D·M·莱杰
L·S·丹特里
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Anavex Life Sciences Corp
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Anavex Life Sciences Corp
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Priority to CN202411518463.7A priority Critical patent/CN119390667A/zh
Publication of CN108026059A publication Critical patent/CN108026059A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CN201680033152.9A 2015-07-22 2016-07-19 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物 Pending CN108026059A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411518463.7A CN119390667A (zh) 2015-07-22 2016-07-19 四氢-n,n-二甲基-2,2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562195486P 2015-07-22 2015-07-22
US62/195,486 2015-07-22
PCT/IB2016/001181 WO2017013498A2 (en) 2015-07-22 2016-07-19 Crystal forms of tetra-hydro-n, n-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride, processes for making such forms, and their pharmaceutical compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411518463.7A Division CN119390667A (zh) 2015-07-22 2016-07-19 四氢-n,n-二甲基-2,2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物

Publications (1)

Publication Number Publication Date
CN108026059A true CN108026059A (zh) 2018-05-11

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CN201680033152.9A Pending CN108026059A (zh) 2015-07-22 2016-07-19 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物
CN202411518463.7A Pending CN119390667A (zh) 2015-07-22 2016-07-19 四氢-n,n-二甲基-2,2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物

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Country Status (7)

Country Link
US (4) US10413519B2 (https=)
EP (2) EP3325456B1 (https=)
JP (3) JP7304043B2 (https=)
CN (2) CN108026059A (https=)
CA (1) CA2986349A1 (https=)
HK (1) HK1247926A1 (https=)
WO (1) WO2017013498A2 (https=)

Cited By (1)

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WO2023208133A1 (zh) * 2022-04-29 2023-11-02 苏州科睿思制药有限公司 布拉美森盐酸盐的晶型及其制备方法和用途

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Publication number Priority date Publication date Assignee Title
CN108026059A (zh) * 2015-07-22 2018-05-11 阿纳韦克斯生命科学公司 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物
US10426754B2 (en) 2017-06-14 2019-10-01 Anavex Life Sciences Corp. Crystalline form of ANAVEX2-73 for the treatment of Alzheimer's disease
JP2020523417A (ja) * 2017-06-14 2020-08-06 アナベックス ライフ サイエンス コーポレイション アルツハイマー病の治療のためのａｎａｖｅｘ２−７３
WO2019200345A1 (en) * 2018-04-12 2019-10-17 Anavex Life Sciences Corp. A2-73 crystalline polymorph compositions of matter and methods of use thereof
EP3794345B1 (en) 2018-05-18 2025-02-26 Anavex Life Sciences Corp. Optimized sigma-1 agonist method of responder selection and treatment
US12473268B2 (en) 2020-02-04 2025-11-18 Assia Chemical Industries, Ltd. Solid state forms of Blarcamesine salts
US12018005B1 (en) * 2023-07-25 2024-06-25 Egis Gyógyszergyár Zrt. Blarcamesine co-crystals for the manufacture of pharmaceutical dosage form

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Publication number Priority date Publication date Assignee Title
WO2023208133A1 (zh) * 2022-04-29 2023-11-02 苏州科睿思制药有限公司 布拉美森盐酸盐的晶型及其制备方法和用途

Also Published As

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HK1247926A1 (zh) 2018-10-05
CA2986349A1 (en) 2017-01-26
EP3325456A4 (en) 2019-01-23
US11661405B2 (en) 2023-05-30
JP7304043B2 (ja) 2023-07-06
US10966952B2 (en) 2021-04-06
US20190350892A1 (en) 2019-11-21
US20230278973A1 (en) 2023-09-07
EP4616852A2 (en) 2025-09-17
US20180169060A1 (en) 2018-06-21
EP3325456A2 (en) 2018-05-30
JP2023083528A (ja) 2023-06-15
WO2017013498A3 (en) 2017-03-02
JP7492781B2 (ja) 2024-05-30
JP2021073300A (ja) 2021-05-13
US20210220321A1 (en) 2021-07-22
US10413519B2 (en) 2019-09-17
CN119390667A (zh) 2025-02-07
JP2018524307A (ja) 2018-08-30
WO2017013498A2 (en) 2017-01-26
EP4616852A3 (en) 2025-10-22
EP3325456B1 (en) 2025-09-03

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