CN108014259B - 一种改善睡眠的中药组合物及其片剂 - Google Patents
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- CN108014259B CN108014259B CN201711375729.7A CN201711375729A CN108014259B CN 108014259 B CN108014259 B CN 108014259B CN 201711375729 A CN201711375729 A CN 201711375729A CN 108014259 B CN108014259 B CN 108014259B
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
中药材 | 日用量,g | 干膏粉,g | 百分比,% |
酸枣仁 | 3 | 0.45 | 17.65 |
<u>刺</u>五加 | 3 | 0.45 | 17.65 |
百合 | 3 | 0.45 | 17.65 |
五味子 | 2 | 0.3 | 11.76 |
灵芝 | 3 | 0.45 | 17.65 |
首乌藤 | 3 | 0.45 | 17.65 |
总计 | 17 | 2.55 | 制成0.75g*8片 |
Claims (9)
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CN109364183A (zh) * | 2018-12-29 | 2019-02-22 | 张晶莹 | 一种治疗失眠的中药制剂及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1701683A (zh) * | 2005-06-14 | 2005-11-30 | 王浩贵 | 一种酸枣仁保健面条 |
CN104435299A (zh) * | 2014-12-16 | 2015-03-25 | 天津中新药业集团股份有限公司达仁堂制药厂 | 一种改善睡眠的中药组合物及其制备方法 |
CN107029125A (zh) * | 2017-06-08 | 2017-08-11 | 湖南云从科技有限公司 | 一种安神改善睡眠的颗粒药物配方及其制备方法 |
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2017
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1701683A (zh) * | 2005-06-14 | 2005-11-30 | 王浩贵 | 一种酸枣仁保健面条 |
CN104435299A (zh) * | 2014-12-16 | 2015-03-25 | 天津中新药业集团股份有限公司达仁堂制药厂 | 一种改善睡眠的中药组合物及其制备方法 |
CN107029125A (zh) * | 2017-06-08 | 2017-08-11 | 湖南云从科技有限公司 | 一种安神改善睡眠的颗粒药物配方及其制备方法 |
Non-Patent Citations (2)
Title |
---|
五味子汤治疗失眠68例临床观察;余丹凤等;《黑龙江中医药》;19991231(第03期);7-8 * |
百乐眠治疗失眠的临床观察;方圆;《海峡药学》;20170915;第29卷(第09期);229 * |
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