CN107954936B - 一种制备氘代咪唑二酮类化合物的方法 - Google Patents

一种制备氘代咪唑二酮类化合物的方法 Download PDF

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Publication number
CN107954936B
CN107954936B CN201610901502.0A CN201610901502A CN107954936B CN 107954936 B CN107954936 B CN 107954936B CN 201610901502 A CN201610901502 A CN 201610901502A CN 107954936 B CN107954936 B CN 107954936B
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China
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formula
compound
compound shown
reaction
methyl
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CN201610901502.0A
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Chinese (zh)
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CN107954936A (zh
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陈元伟
杜武
匡通滔
耿熙
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Haichuang Pharmaceutical Co Ltd
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Haichuang Pharmaceutical Co Ltd
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Priority to CN201610901502.0A priority Critical patent/CN107954936B/zh
Application filed by Haichuang Pharmaceutical Co Ltd filed Critical Haichuang Pharmaceutical Co Ltd
Priority to US16/342,912 priority patent/US20200087261A1/en
Priority to FIEP16919556.7T priority patent/FI3527556T3/fi
Priority to PCT/CN2016/110978 priority patent/WO2018072300A1/fr
Priority to PL16919556.7T priority patent/PL3527556T3/pl
Priority to AU2016426847A priority patent/AU2016426847B2/en
Priority to DK16919556.7T priority patent/DK3527556T3/da
Priority to HUE16919556A priority patent/HUE061557T2/hu
Priority to CA3040785A priority patent/CA3040785C/fr
Priority to EP16919556.7A priority patent/EP3527556B1/fr
Priority to PT169195567T priority patent/PT3527556T/pt
Priority to JP2019520547A priority patent/JP7241682B2/ja
Priority to ES16919556T priority patent/ES2943011T3/es
Priority to TW106109895A priority patent/TWI728077B/zh
Publication of CN107954936A publication Critical patent/CN107954936A/zh
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Publication of CN107954936B publication Critical patent/CN107954936B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201610901502.0A 2016-10-17 2016-10-17 一种制备氘代咪唑二酮类化合物的方法 Active CN107954936B (zh)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CN201610901502.0A CN107954936B (zh) 2016-10-17 2016-10-17 一种制备氘代咪唑二酮类化合物的方法
PT169195567T PT3527556T (pt) 2016-10-17 2016-12-20 Método para a preparação de composto de imidazol dicetona deuterado
PCT/CN2016/110978 WO2018072300A1 (fr) 2016-10-17 2016-12-20 Procédé de préparation d'un composé d'imidazole dicétone deutéré
PL16919556.7T PL3527556T3 (pl) 2016-10-17 2016-12-20 Sposób wytwarzania deuterowanych związków imidazolodiketonowych
AU2016426847A AU2016426847B2 (en) 2016-10-17 2016-12-20 Method for preparing deuterated imidazole diketone compound
DK16919556.7T DK3527556T3 (da) 2016-10-17 2016-12-20 Fremgangsmåde til fremstilling af deutereret imidazoldiketonforbindelse
HUE16919556A HUE061557T2 (hu) 2016-10-17 2016-12-20 Eljárás deuterizált imidazol-diketon vegyület elõállítására
CA3040785A CA3040785C (fr) 2016-10-17 2016-12-20 Procede de preparation d'un compose d'imidazole dicetone deutere
US16/342,912 US20200087261A1 (en) 2016-10-17 2016-12-20 Method for preparing deuterated imidazole diketone compound
FIEP16919556.7T FI3527556T3 (fi) 2016-10-17 2016-12-20 Menetelmä deuteroidun imidatsolidiketoniyhdisteen valmistamiseksi
JP2019520547A JP7241682B2 (ja) 2016-10-17 2016-12-20 重水素化イミダゾリジンジオン系化合物を調製する方法
ES16919556T ES2943011T3 (es) 2016-10-17 2016-12-20 Procedimiento de preparación del compuesto imidazol dicetona deuterado
EP16919556.7A EP3527556B1 (fr) 2016-10-17 2016-12-20 Procédé de préparation d'un composé d'imidazole dicétone deutéré
TW106109895A TWI728077B (zh) 2016-10-17 2017-03-24 氘代咪唑二酮類化合物的製備方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610901502.0A CN107954936B (zh) 2016-10-17 2016-10-17 一种制备氘代咪唑二酮类化合物的方法

Publications (2)

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CN107954936A CN107954936A (zh) 2018-04-24
CN107954936B true CN107954936B (zh) 2021-03-19

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Country Link
US (1) US20200087261A1 (fr)
EP (1) EP3527556B1 (fr)
JP (1) JP7241682B2 (fr)
CN (1) CN107954936B (fr)
AU (1) AU2016426847B2 (fr)
CA (1) CA3040785C (fr)
DK (1) DK3527556T3 (fr)
ES (1) ES2943011T3 (fr)
FI (1) FI3527556T3 (fr)
HU (1) HUE061557T2 (fr)
PL (1) PL3527556T3 (fr)
PT (1) PT3527556T (fr)
TW (1) TWI728077B (fr)
WO (1) WO2018072300A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109180511A (zh) * 2018-08-22 2019-01-11 辽宁东科药业有限公司 一种盐酸丁卡因的制备方法
CN114621109B (zh) * 2020-12-14 2024-04-26 成都苑东生物制药股份有限公司 一种阿帕他胺的合成方法及其中间体
CN113698310B (zh) * 2021-08-20 2023-03-17 江西金丰药业有限公司 一种恩杂鲁胺双酯中间体的制备方法

Citations (6)

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CN102421291A (zh) * 2009-02-24 2012-04-18 梅迪维新前列腺医疗股份有限公司 具体的二芳基乙内酰脲和二芳基乙内酰硫脲化合物
CN103108549A (zh) * 2010-02-24 2013-05-15 梅迪维新前列腺医疗股份有限公司 合成二芳基乙内酰硫脲和二芳基乙内酰脲化合物的方法
CN104016924A (zh) * 2014-06-16 2014-09-03 上海鼎雅药物化学科技有限公司 一种“一锅法”合成恩杂鲁胺的方法
CN104211683A (zh) * 2013-05-29 2014-12-17 成都海创药业有限公司 咪唑二酮类化合物及其用途
CN104024228B (zh) * 2011-12-14 2015-07-08 成都海创药业有限公司 咪唑二酮类化合物及其用途
CN104803918A (zh) * 2014-01-26 2015-07-29 上海医药工业研究院 恩杂鲁胺的制备方法

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EP2656842B1 (fr) * 2006-03-27 2016-08-10 The Regents of The University of California Modulateur de récepteur androgène pour le traitement du cancer de la prostate et de maladies associées au récepteur androgène
CN101817787B (zh) * 2009-02-26 2013-07-24 童友之 抗前列腺癌的雄性激素受体拮抗剂
CN104341352A (zh) 2013-08-09 2015-02-11 南京衡杰生物科技有限公司 作为雄激素受体拮抗剂的二芳基乙内酰脲化合物及其应用
RU2557235C1 (ru) * 2014-07-08 2015-07-20 Александр Васильевич Иващенко Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
CN102421291A (zh) * 2009-02-24 2012-04-18 梅迪维新前列腺医疗股份有限公司 具体的二芳基乙内酰脲和二芳基乙内酰硫脲化合物
CN103108549A (zh) * 2010-02-24 2013-05-15 梅迪维新前列腺医疗股份有限公司 合成二芳基乙内酰硫脲和二芳基乙内酰脲化合物的方法
CN104024228B (zh) * 2011-12-14 2015-07-08 成都海创药业有限公司 咪唑二酮类化合物及其用途
CN104211683A (zh) * 2013-05-29 2014-12-17 成都海创药业有限公司 咪唑二酮类化合物及其用途
CN104803918A (zh) * 2014-01-26 2015-07-29 上海医药工业研究院 恩杂鲁胺的制备方法
CN104016924A (zh) * 2014-06-16 2014-09-03 上海鼎雅药物化学科技有限公司 一种“一锅法”合成恩杂鲁胺的方法

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"An improved and practical route for the synthesis of enzalutamide and potential impurities study";Zhou, Ai-Nan, et al.;《Chinese Chemical Letters》;20160921;第28卷(第2期);第426-430页，supporting information *

Also Published As

Publication number Publication date
JP2019532075A (ja) 2019-11-07
PT3527556T (pt) 2023-05-02
CA3040785C (fr) 2021-06-15
DK3527556T3 (da) 2023-05-01
TW201815768A (zh) 2018-05-01
EP3527556A4 (fr) 2020-04-29
EP3527556B1 (fr) 2023-01-25
WO2018072300A1 (fr) 2018-04-26
EP3527556A1 (fr) 2019-08-21
PL3527556T3 (pl) 2023-08-14
FI3527556T3 (fi) 2023-04-25
HUE061557T2 (hu) 2023-07-28
US20200087261A1 (en) 2020-03-19
ES2943011T3 (es) 2023-06-08
AU2016426847B2 (en) 2020-11-26
CN107954936A (zh) 2018-04-24
TWI728077B (zh) 2021-05-21
AU2016426847A1 (en) 2019-06-06
JP7241682B2 (ja) 2023-03-17
CA3040785A1 (fr) 2018-04-26

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Application publication date: 20180424

Assignee: SICHUAN HAISCO PHARMACEUTICAL Co.,Ltd.

Assignor: Chengdu Haichuang Pharmaceutical Co.,Ltd.

Contract record no.: X2020510000020

Denomination of invention: Method for preparing deuterated imidazole diketone compounds

License type: Exclusive License

Record date: 20200727

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Address after: No.2 and No.3, floor 4, building 1, Rongyao building, No.5 Keyuan South Road, high tech Zone, Chengdu, Sichuan 610000

Applicant after: Haichuang Pharmaceutical Co., Ltd

Address before: Room 801, C1 incubation building, Tianfu Life Science Park, 88 Keyuan South Road, high tech Zone, Chengdu, Sichuan 610000

Applicant before: Chengdu Haichuang Pharmaceutical Co.,Ltd.

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Assignee: SICHUAN HAISCO PHARMACEUTICAL Co.,Ltd.

Assignor: Chengdu Haichuang Pharmaceutical Co.,Ltd.

Contract record no.: X2020510000020

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