CN107858333B - T细胞受体基因修饰小鼠 - Google Patents

T细胞受体基因修饰小鼠 Download PDF

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Publication number
CN107858333B
CN107858333B CN201710930556.4A CN201710930556A CN107858333B CN 107858333 B CN107858333 B CN 107858333B CN 201710930556 A CN201710930556 A CN 201710930556A CN 107858333 B CN107858333 B CN 107858333B
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tcr
human
gene segments
unrearranged human
gene
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CN107858333A (zh
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L·麦克唐纳
A·J·莫菲
J·麦克沃克
N·图
V·沃罗宁那
C·古雷尔
K·梅格尔
S·史蒂文斯
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Regeneron Pharmaceuticals Inc
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    • C07K14/70503—Immunoglobulin superfamily
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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CN201710930556.4A 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠 Active CN107858333B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161552582P 2011-10-28 2011-10-28
US61/552,582 2011-10-28
US201261621198P 2012-04-06 2012-04-06
US61/621,198 2012-04-06
US201261700908P 2012-09-14 2012-09-14
US61/700,908 2012-09-14
CN201280064216.3A CN104011071B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
PCT/US2012/062065 WO2013063361A1 (en) 2011-10-28 2012-10-26 Genetically modified t cell receptor mice

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CN201280064216.3A Division CN104011071B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠

Publications (2)

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CN107858333A CN107858333A (zh) 2018-03-30
CN107858333B true CN107858333B (zh) 2022-05-27

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Application Number Title Priority Date Filing Date
CN201710930556.4A Active CN107858333B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN201280064216.3A Active CN104011071B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN202210507359.2A Pending CN114891797A (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN201710930555.XA Pending CN107858332A (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN202210507387.4A Active CN114891798B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠

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CN201280064216.3A Active CN104011071B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN202210507359.2A Pending CN114891797A (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN201710930555.XA Pending CN107858332A (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠
CN202210507387.4A Active CN114891798B (zh) 2011-10-28 2012-10-26 T细胞受体基因修饰小鼠

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US (4) US9113616B2 (https=)
EP (3) EP3795587A1 (https=)
JP (7) JP6254528B2 (https=)
KR (5) KR102542272B1 (https=)
CN (5) CN107858333B (https=)
AU (5) AU2012327204B2 (https=)
BR (1) BR112014009203B1 (https=)
CA (1) CA2853707A1 (https=)
CY (2) CY1120945T1 (https=)
DK (2) DK3424947T3 (https=)
ES (2) ES2691475T3 (https=)
HR (2) HRP20181626T1 (https=)
HU (1) HUE053444T2 (https=)
IL (4) IL315445A (https=)
IN (1) IN2014CN03890A (https=)
LT (2) LT3424947T (https=)
MX (2) MX353134B (https=)
PL (2) PL2771357T3 (https=)
PT (2) PT3424947T (https=)
RS (2) RS61455B1 (https=)
RU (1) RU2661106C2 (https=)
SG (2) SG11201401030WA (https=)
SI (2) SI3424947T1 (https=)
SM (2) SMT202100243T1 (https=)
WO (1) WO2013063361A1 (https=)

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