IN2014CN03890A - - Google Patents

Download PDF

Info

Publication number
IN2014CN03890A
IN2014CN03890A IN3890CHN2014A IN2014CN03890A IN 2014CN03890 A IN2014CN03890 A IN 2014CN03890A IN 3890CHN2014 A IN3890CHN2014 A IN 3890CHN2014A IN 2014CN03890 A IN2014CN03890 A IN 2014CN03890A
Authority
IN
India
Prior art keywords
non human
human animal
making
same
genetically modified
Prior art date
Application number
Inventor
Lynn Macdonald
Andrew J Murphy
John Mcwhirter
Naxin Tu
Vera Voronina
Cagan Gurer
Karolina Meagher
Sean Stevens
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IN2014CN03890A publication Critical patent/IN2014CN03890A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a genetically modified non human animal that comprises in its genome unrearranged T cell receptor variable gene loci as well as non human embryos cells and tissues comprising the same. Also provided are constructs for making said genetically mod ified non human animal and methods of making the same. Various methods of using the genetically modified non human animal are also provided.
IN3890CHN2014 2011-10-28 2012-10-26 IN2014CN03890A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161552582P 2011-10-28 2011-10-28
US201261621198P 2012-04-06 2012-04-06
US201261700908P 2012-09-14 2012-09-14
PCT/US2012/062065 WO2013063361A1 (en) 2011-10-28 2012-10-26 Genetically modified t cell receptor mice

Publications (1)

Publication Number Publication Date
IN2014CN03890A true IN2014CN03890A (en) 2015-10-16

Family

ID=47178340

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3890CHN2014 IN2014CN03890A (en) 2011-10-28 2012-10-26

Country Status (25)

Country Link
US (4) US9113616B2 (en)
EP (3) EP3795587A1 (en)
JP (7) JP6254528B2 (en)
KR (5) KR101964776B1 (en)
CN (5) CN104011071B (en)
AU (4) AU2012327204B2 (en)
BR (1) BR112014009203B1 (en)
CA (1) CA2853707A1 (en)
CY (2) CY1120945T1 (en)
DK (2) DK2771357T3 (en)
ES (2) ES2691475T3 (en)
HK (1) HK1198171A1 (en)
HR (2) HRP20181626T1 (en)
HU (1) HUE053444T2 (en)
IL (3) IL274914B2 (en)
IN (1) IN2014CN03890A (en)
LT (2) LT3424947T (en)
MX (1) MX353134B (en)
PL (2) PL3424947T3 (en)
PT (2) PT3424947T (en)
RS (2) RS57893B1 (en)
RU (1) RU2661106C2 (en)
SG (2) SG10201914043XA (en)
SI (2) SI2771357T1 (en)
WO (1) WO2013063361A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012327204B2 (en) * 2011-10-28 2016-01-21 Regeneron Pharmaceuticals, Inc. Genetically modified T cell receptor mice
WO2013107413A1 (en) * 2012-01-19 2013-07-25 中国科学院上海巴斯德研究所 Use of phosphorylation pathway-related factor in regulating function of regulatory t cell
WO2013163394A1 (en) 2012-04-25 2013-10-31 Regeneron Pharmaceuticals, Inc. Nuclease-mediated targeting with large targeting vectors
GB2508414A (en) * 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
JP6411463B2 (en) 2013-04-16 2018-10-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Targeted modification of rat genome
RU2685914C1 (en) 2013-12-11 2019-04-23 Регенерон Фармасьютикалс, Инк. Methods and compositions for genome targeted modification
PL3152312T3 (en) * 2014-06-06 2020-08-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for modifying a targeted locus
MX2016016903A (en) * 2014-06-19 2017-03-27 Regeneron Pharma Non-human animals having a humanized programmed cell death 1 gene.
MX2016017317A (en) 2014-06-26 2017-08-24 Regeneron Pharma Methods and compositions for targeted genetic modifications and methods of use.
CA2959428A1 (en) * 2014-09-19 2016-03-24 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors
KR102531016B1 (en) 2014-11-21 2023-05-10 리제너론 파마슈티칼스 인코포레이티드 METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAs
SI3223605T1 (en) * 2014-11-24 2021-03-31 Regeneron Pharmaceuticals, Inc. Non-human animals expressing humanized cd3 complex
RU2707137C2 (en) 2014-12-19 2019-11-22 Регенерон Фармасьютикалз, Инк. Methods and compositions for targeted genetic modification by single-step multiple targeting
MX2017012829A (en) * 2015-04-06 2018-02-23 Regeneron Pharma Humanized t cell mediated immune responses in non-human animals.
ES2905525T3 (en) 2015-05-06 2022-04-11 Snipr Tech Ltd Alteration of microbial populations and modification of the microbiota
MX2018005389A (en) 2015-11-20 2018-09-05 Regeneron Pharma Non-human animals having a humanized lymphocyte-activation gene 3.
CA3020330A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
KR102473964B1 (en) 2016-04-08 2022-12-06 이뮤노코어 리미티드 T cell receptor
CN113907043B (en) * 2016-06-03 2023-08-01 瑞泽恩制药公司 Non-human animals expressing exogenous terminal deoxynucleotidyl transferase
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
AU2018283319B2 (en) * 2017-06-16 2023-11-09 Mayo Foundation For Medical Education And Research Materials and methods for increasing immune responses
MX2020003536A (en) 2017-10-03 2020-09-14 Juno Therapeutics Inc Hpv-specific binding molecules.
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
BR112020020245A2 (en) * 2018-04-05 2021-04-06 Editas Medicine, Inc. METHODS OF PRODUCING CELLS EXPRESSING A RECOMBINANT RECEIVER AND RELATED COMPOSITIONS
JP7422365B2 (en) * 2018-07-26 2024-01-26 国立大学法人京都大学 Method for producing foreign antigen receptor gene-transfected cells
US11851663B2 (en) 2018-10-14 2023-12-26 Snipr Biome Aps Single-vector type I vectors
WO2021050948A1 (en) * 2019-09-12 2021-03-18 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
AU2020395122A1 (en) 2019-12-02 2022-06-09 Regeneron Pharmaceuticals, Inc. Peptide-MHC II protein constructs and uses thereof
CA3177181A1 (en) * 2020-03-27 2021-09-30 2Seventy Bio, Inc. T cell receptors
CN113684258A (en) * 2020-05-18 2021-11-23 上海赛比曼生物科技有限公司 Kit and method for detecting mouse-derived TCR transgene copy number
AU2022249328A1 (en) 2021-03-31 2023-09-21 Regeneron Pharmaceuticals, Inc. Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire
WO2024035962A2 (en) * 2022-08-12 2024-02-15 Ingenious Targeting Laboratories Genetically modified non-human having humanized gamma and delta tcr variable genes
WO2024064860A1 (en) 2022-09-22 2024-03-28 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing components of human cellular immune system

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1994006908A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Transgenic non-human animals having targeted lymphocyte transduction genes
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
WO1997032603A1 (en) 1996-03-05 1997-09-12 The Scripps Research Institute Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
US6320306B1 (en) * 1996-08-05 2001-11-20 Samsung Display Devices Co., Ltd. Shadow mask with porous insulating layer and heavy metal layer
CA2616914C (en) 1996-12-03 2012-05-29 Abgenix, Inc. Egfr-binding antibody
AU1023401A (en) 1999-10-12 2001-04-23 Institut Pasteur Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice
US7462486B2 (en) 2000-05-12 2008-12-09 Oregon Health & Science University Methods of selecting T cell receptor V peptides for therapeutic use
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JPWO2002047474A1 (en) 2000-12-13 2004-04-15 住友製薬株式会社 HLA-A24 expressing transgenic animals and uses thereof
DK1409646T3 (en) 2000-12-19 2012-08-06 Altor Bioscience Corp Transgenic animals comprising a humanized immune system
FR2827302B1 (en) 2001-07-13 2003-10-10 Genoway TRANSGENIC CELL AND ANIMAL MODELING HUMAN ANTIGENIC PRESENTATION AND USES THEREOF
DE60203125T2 (en) 2001-08-31 2006-04-06 Avidex Ltd., Abingdon SOLUBLE T CELL RECEPTOR
US20050177884A1 (en) 2001-11-15 2005-08-11 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
ATE279441T1 (en) * 2001-12-22 2004-10-15 4Antibody Ag METHOD FOR PRODUCING GENETICALLY MODIFIED LYMPHOCYTE PRECURSOR CELLS OF VERTEBRATE ANIMALS AND THEIR USE FOR THE PRODUCTION OF HETEROLOGUE BINDING PROTEINS
NZ534205A (en) 2001-12-22 2006-04-28 Antibody A 4 Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins
DE10244457A1 (en) 2002-09-24 2004-04-01 Johannes-Gutenberg-Universität Mainz Process for the rational mutagenesis of alpha / beta T-cell receptors and corresponding mutated MDM2 protein-specific alpha / beta T-cell receptors
NZ539225A (en) 2002-10-09 2006-09-29 Avidex Ltd Single chain recombinant T cell receptors
AU2003279820A1 (en) * 2002-10-30 2004-06-07 The Wistar Institute Of Anatomy And Biology Mouse model for autoimmune disorders
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
DK2767161T3 (en) 2004-10-19 2018-05-07 Regeneron Pharma Method of generating an animal homozygous for genetic modification
US20090304657A1 (en) 2006-05-03 2009-12-10 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Chimeric t cell receptors and related materials and methods of use
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
US9388425B2 (en) 2006-10-20 2016-07-12 Trustees Of Boston University Tunable genetic switch for regulating gene expression
JP2008159109A (en) 2006-12-21 2008-07-10 Matsushita Electric Ind Co Ltd Data transfer unit
TWI476280B (en) 2008-03-07 2015-03-11 Regeneron Pharma Es-cell-derived mice from diploid host embryo injection
US20090328240A1 (en) 2008-06-24 2009-12-31 Sing George L Genetically modified mice as predictors of immune response
WO2010107400A1 (en) 2009-03-20 2010-09-23 Agency For Science, Technology And Research Genetically modified animal and method of obtaining the same
HUE055817T2 (en) * 2009-07-08 2021-12-28 Kymab Ltd Animal models and therapeutic molecules
GB0917090D0 (en) 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
WO2011044186A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
US9557323B2 (en) 2010-09-24 2017-01-31 The United States Of America As Represented By The Secretary Of The Navy Humanized transgenic mouse model
CN105950654B (en) 2010-11-27 2020-03-20 朱坚 Humanized transgenic animal
AU2012327204B2 (en) * 2011-10-28 2016-01-21 Regeneron Pharmaceuticals, Inc. Genetically modified T cell receptor mice
MX2017012829A (en) 2015-04-06 2018-02-23 Regeneron Pharma Humanized t cell mediated immune responses in non-human animals.

Also Published As

Publication number Publication date
EP3424947B1 (en) 2020-11-25
EP2771357A1 (en) 2014-09-03
KR102148387B1 (en) 2020-08-26
SG10201914043XA (en) 2020-03-30
PL3424947T3 (en) 2021-06-14
AU2012327204A1 (en) 2013-05-23
HK1198171A1 (en) 2015-03-13
SI3424947T1 (en) 2021-04-30
KR20200102001A (en) 2020-08-28
AU2016202512B2 (en) 2018-03-29
AU2018204700C1 (en) 2021-10-14
EP2771357B1 (en) 2018-07-18
BR112014009203A2 (en) 2020-10-27
NZ623147A (en) 2016-03-31
CN107858332A (en) 2018-03-30
KR102397961B1 (en) 2022-05-13
KR20190037354A (en) 2019-04-05
CN104011071B (en) 2017-11-07
BR112014009203B1 (en) 2023-02-28
US20130109053A1 (en) 2013-05-02
US9113616B2 (en) 2015-08-25
AU2021203192A1 (en) 2021-06-10
CN114891798A (en) 2022-08-12
JP6706311B2 (en) 2020-06-03
CA2853707A1 (en) 2013-05-02
IL232098B (en) 2020-06-30
KR20210133325A (en) 2021-11-05
PT2771357T (en) 2018-11-09
CN114891797A (en) 2022-08-12
US11528895B2 (en) 2022-12-20
KR102542272B1 (en) 2023-06-13
IL232098A0 (en) 2014-05-28
HUE053444T2 (en) 2021-06-28
JP2014532413A (en) 2014-12-08
RU2661106C2 (en) 2018-07-11
IL274914B2 (en) 2024-02-01
AU2018204700A1 (en) 2018-07-19
US20220386575A1 (en) 2022-12-08
MX353134B (en) 2017-12-20
JP6532924B2 (en) 2019-06-19
JP2019033770A (en) 2019-03-07
AU2016202512C1 (en) 2018-10-11
RU2014121160A (en) 2015-12-10
MX2014004894A (en) 2014-09-12
US20210051930A1 (en) 2021-02-25
IL274914A (en) 2020-07-30
KR101964776B1 (en) 2019-04-04
RS57893B1 (en) 2019-01-31
JP7305840B2 (en) 2023-07-10
IL274914B1 (en) 2023-10-01
AU2016202512A1 (en) 2016-05-12
CN107858333A (en) 2018-03-30
US20160021856A1 (en) 2016-01-28
PT3424947T (en) 2021-03-01
JP2023024744A (en) 2023-02-16
HRP20181626T1 (en) 2018-12-14
DK2771357T3 (en) 2018-10-29
SI2771357T1 (en) 2018-11-30
ES2858978T3 (en) 2021-09-30
AU2021203192B2 (en) 2024-04-11
JP6254528B2 (en) 2017-12-27
KR102321909B1 (en) 2021-11-05
JP2024019646A (en) 2024-02-09
KR20220066197A (en) 2022-05-23
AU2012327204B2 (en) 2016-01-21
DK3424947T3 (en) 2021-02-22
IL305550A (en) 2023-10-01
JP2018007696A (en) 2018-01-18
ES2691475T3 (en) 2018-11-27
KR20140077219A (en) 2014-06-23
JP2020146045A (en) 2020-09-17
CN107858333B (en) 2022-05-27
LT2771357T (en) 2018-10-25
WO2013063361A1 (en) 2013-05-02
AU2018204700B2 (en) 2021-04-01
CY1123831T1 (en) 2022-05-27
CN104011071A (en) 2014-08-27
JP2022093637A (en) 2022-06-23
EP3424947A1 (en) 2019-01-09
CY1120945T1 (en) 2019-12-11
EP3795587A1 (en) 2021-03-24
HRP20210256T1 (en) 2021-04-02
RS61455B1 (en) 2021-03-31
SG11201401030WA (en) 2014-04-28
PL2771357T3 (en) 2018-12-31
LT3424947T (en) 2021-03-10

Similar Documents

Publication Publication Date Title
IN2014CN03890A (en)
AU2019264610A1 (en) Genetically modified animals and methods for making the same
HK1252351A1 (en) Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues
IN2014CN03892A (en)
MX2013008375A (en) Anti - il1rap antibodies and their use for treating human.
HK1205191A1 (en) Aav vector compositions and methods for gene transfer to cells, organs and tissues aav
MY178723A (en) Genetically modified major histocompatibility complex mice
HK1212731A1 (en) Single -cell cultivation method
BR112015001543A2 (en) cooling jacket, jacket for cooling jacket, sealing means for jacket cooling, electric machine and method for producing a jacket cooling
SG10201808935WA (en) Targeted modification of rat genome
IN2012DN00568A (en)
WO2012098537A8 (en) Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells
ZA201104931B (en) Bioreactor for the cultivation of mammalian cells
WO2011159770A3 (en) Methods and compositions for promoting hair growth
HK1166100A1 (en) Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies
GB201100180D0 (en) Tumour cell and tissue culture
EP2443231A4 (en) Generation of induced pluripotent stem cells from cord blood
IN2012DN03404A (en)
WO2012094193A3 (en) Methods for enhancing the delivery of gene-transduced cells
EP2534251A4 (en) In vivo gene regulation by the combination of knock- in-teto sequence into the genome and tetracycline-controlled trans-suppressor (tts) protein
NZ708061A (en) Methods for generating genetically superior animals
WO2013188462A3 (en) Regulatory elements and uses thereof
WO2010148140A3 (en) Stable plasmid expression vector for bacteria
高蕾 et al. Human umbilical cord blood-derived stromal cells: multifaceted regulators of megakaryocytopoiesis
NZ621037A (en) Genes and proteins for alkanoyl-coa synthesis