CN107849104B - Tau结合抗体 - Google Patents

Tau结合抗体 Download PDF

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Publication number
CN107849104B
CN107849104B CN201680039795.4A CN201680039795A CN107849104B CN 107849104 B CN107849104 B CN 107849104B CN 201680039795 A CN201680039795 A CN 201680039795A CN 107849104 B CN107849104 B CN 107849104B
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tau
ser
gly
thr
binding
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CN107849104A (zh
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D·E·O·奈特
T·S·贝克
D·J·麦克米兰
R·A·格里芬
G·麦雷特-科罗
P·唐尼
J-P·库拉德
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UCB Biopharma SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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CN201680039795.4A 2015-07-06 2016-07-05 Tau结合抗体 Active CN107849104B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15175522 2015-07-06
EP15175522.0 2015-07-06
PCT/EP2016/065813 WO2017005734A1 (en) 2015-07-06 2016-07-05 Tau-binding antibodies

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CN107849104A CN107849104A (zh) 2018-03-27
CN107849104B true CN107849104B (zh) 2021-08-27

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US (4) US10287343B2 (https=)
EP (2) EP3319983B1 (https=)
JP (3) JP6630426B2 (https=)
KR (2) KR102770650B1 (https=)
CN (1) CN107849104B (https=)
AR (1) AR105267A1 (https=)
AU (1) AU2016289755C1 (https=)
CA (1) CA2991451A1 (https=)
CL (1) CL2018000043A1 (https=)
CO (1) CO2017012971A2 (https=)
EA (1) EA037092B1 (https=)
EC (1) ECSP18000887A (https=)
ES (1) ES3060419T3 (https=)
HR (1) HRP20260348T1 (https=)
IL (1) IL256685B (https=)
MA (2) MA41670A1 (https=)
MD (1) MD3319983T2 (https=)
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PE (1) PE20180481A1 (https=)
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SG (1) SG10202010735PA (https=)
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TN (1) TN2017000539A1 (https=)
TW (1) TWI745295B (https=)
UA (1) UA124616C2 (https=)
UY (1) UY36773A (https=)
WO (1) WO2017005734A1 (https=)
ZA (1) ZA201800027B (https=)

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UA128383C2 (uk) 2016-12-07 2024-07-03 Дженентек, Інк. Антитіло до тау-білка та спосіб його застосування
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
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JP2018139530A (ja) 2017-02-27 2018-09-13 帝人ファーマ株式会社 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤
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CN115335406B (zh) 2020-02-12 2026-01-30 伊莱利利公司 抗体或抗原-结合片段的结晶
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CO2017012971A2 (es) 2018-03-09
TWI745295B (zh) 2021-11-11
MA41670A1 (fr) 2018-05-31
US20190284267A1 (en) 2019-09-19
EA201890172A1 (ru) 2018-10-31
JP2020055849A (ja) 2020-04-09
KR20180025962A (ko) 2018-03-09
TN2017000539A1 (en) 2019-04-12
EA037092B1 (ru) 2021-02-04
MY193677A (en) 2022-10-25
AU2016289755B2 (en) 2020-12-03
TW201713689A (zh) 2017-04-16
CL2018000043A1 (es) 2018-05-18
US20230416350A1 (en) 2023-12-28
EP3319983A1 (en) 2018-05-16
PE20180481A1 (es) 2018-03-07
IL256685B (en) 2022-02-01
US10287343B2 (en) 2019-05-14
PH12017502207A1 (en) 2018-06-11
ZA201800027B (en) 2019-06-26
US20180201666A1 (en) 2018-07-19
EP3319983B1 (en) 2026-01-28
ES3060419T3 (en) 2026-03-26
PH12017502207B1 (en) 2022-08-10
BR112017028102A2 (en) 2018-09-04
UA124616C2 (uk) 2021-10-20
HK1246804A1 (zh) 2018-09-14
ECSP18000887A (es) 2018-03-31
NZ738058A (en) 2021-07-30
SMT202600068T1 (it) 2026-03-09
AU2016289755A1 (en) 2018-01-04
MD3319983T2 (ro) 2026-03-31
US10889640B2 (en) 2021-01-12
EP3319983C0 (en) 2026-01-28
UY36773A (es) 2017-01-31
SG10202010735PA (en) 2020-11-27
CA2991451A1 (en) 2017-01-12
JP6630426B2 (ja) 2020-01-15
JP2018524001A (ja) 2018-08-30
IL256685A (en) 2018-03-29
JP7100008B2 (ja) 2022-07-12
US20210115121A1 (en) 2021-04-22
HRP20260348T1 (hr) 2026-04-24
CN107849104A (zh) 2018-03-27
AR105267A1 (es) 2017-09-20
JP2022141689A (ja) 2022-09-29
WO2017005734A1 (en) 2017-01-12
KR20250027278A (ko) 2025-02-25
MA42377A (fr) 2018-05-16
EP4729538A2 (en) 2026-04-22
JP7413448B2 (ja) 2024-01-15
KR102770650B1 (ko) 2025-02-19
AU2016289755C1 (en) 2021-08-19
US11732034B2 (en) 2023-08-22
MX2017015817A (es) 2018-04-10

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