KR102770650B1 - 타우 결합 항체 - Google Patents

타우 결합 항체 Download PDF

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Publication number
KR102770650B1
KR102770650B1 KR1020187003689A KR20187003689A KR102770650B1 KR 102770650 B1 KR102770650 B1 KR 102770650B1 KR 1020187003689 A KR1020187003689 A KR 1020187003689A KR 20187003689 A KR20187003689 A KR 20187003689A KR 102770650 B1 KR102770650 B1 KR 102770650B1
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ser
gly
tau
thr
lys
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KR20180025962A (ko
Inventor
데이비드 에드워드 오르몬드 나이트
테런스 슈어드 베이커
데이비드 제임스 맥밀런
로버트 앤서니 그리핀
조르쥬 메레-코엘로
패트릭 다우니
장-필립 쿠라드
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유씨비 바이오파마 에스알엘
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Application filed by 유씨비 바이오파마 에스알엘 filed Critical 유씨비 바이오파마 에스알엘
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
KR1020187003689A 2015-07-06 2016-07-05 타우 결합 항체 Active KR102770650B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257004988A KR20250027278A (ko) 2015-07-06 2016-07-05 타우 결합 항체

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15175522 2015-07-06
EP15175522.0 2015-07-06
PCT/EP2016/065813 WO2017005734A1 (en) 2015-07-06 2016-07-05 Tau-binding antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257004988A Division KR20250027278A (ko) 2015-07-06 2016-07-05 타우 결합 항체

Publications (2)

Publication Number Publication Date
KR20180025962A KR20180025962A (ko) 2018-03-09
KR102770650B1 true KR102770650B1 (ko) 2025-02-19

Family

ID=53524640

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020187003689A Active KR102770650B1 (ko) 2015-07-06 2016-07-05 타우 결합 항체
KR1020257004988A Pending KR20250027278A (ko) 2015-07-06 2016-07-05 타우 결합 항체

Family Applications After (1)

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KR1020257004988A Pending KR20250027278A (ko) 2015-07-06 2016-07-05 타우 결합 항체

Country Status (29)

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US (4) US10287343B2 (https=)
EP (2) EP3319983B1 (https=)
JP (3) JP6630426B2 (https=)
KR (2) KR102770650B1 (https=)
CN (1) CN107849104B (https=)
AR (1) AR105267A1 (https=)
AU (1) AU2016289755C1 (https=)
CA (1) CA2991451A1 (https=)
CL (1) CL2018000043A1 (https=)
CO (1) CO2017012971A2 (https=)
EA (1) EA037092B1 (https=)
EC (1) ECSP18000887A (https=)
ES (1) ES3060419T3 (https=)
HR (1) HRP20260348T1 (https=)
IL (1) IL256685B (https=)
MA (2) MA41670A1 (https=)
MD (1) MD3319983T2 (https=)
MX (1) MX2017015817A (https=)
MY (1) MY193677A (https=)
PE (1) PE20180481A1 (https=)
PH (1) PH12017502207B1 (https=)
SG (1) SG10202010735PA (https=)
SM (1) SMT202600068T1 (https=)
TN (1) TN2017000539A1 (https=)
TW (1) TWI745295B (https=)
UA (1) UA124616C2 (https=)
UY (1) UY36773A (https=)
WO (1) WO2017005734A1 (https=)
ZA (1) ZA201800027B (https=)

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MX2019006330A (es) 2016-12-07 2019-09-26 Genentech Inc Anticuerpos anti-tau y metodos de uso.
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CO2017012971A2 (es) 2018-03-09
TWI745295B (zh) 2021-11-11
MA41670A1 (fr) 2018-05-31
US20190284267A1 (en) 2019-09-19
EA201890172A1 (ru) 2018-10-31
JP2020055849A (ja) 2020-04-09
KR20180025962A (ko) 2018-03-09
TN2017000539A1 (en) 2019-04-12
EA037092B1 (ru) 2021-02-04
MY193677A (en) 2022-10-25
AU2016289755B2 (en) 2020-12-03
TW201713689A (zh) 2017-04-16
CL2018000043A1 (es) 2018-05-18
US20230416350A1 (en) 2023-12-28
EP3319983A1 (en) 2018-05-16
PE20180481A1 (es) 2018-03-07
IL256685B (en) 2022-02-01
US10287343B2 (en) 2019-05-14
PH12017502207A1 (en) 2018-06-11
ZA201800027B (en) 2019-06-26
US20180201666A1 (en) 2018-07-19
EP3319983B1 (en) 2026-01-28
ES3060419T3 (en) 2026-03-26
PH12017502207B1 (en) 2022-08-10
BR112017028102A2 (en) 2018-09-04
UA124616C2 (uk) 2021-10-20
HK1246804A1 (zh) 2018-09-14
ECSP18000887A (es) 2018-03-31
NZ738058A (en) 2021-07-30
SMT202600068T1 (it) 2026-03-09
AU2016289755A1 (en) 2018-01-04
MD3319983T2 (ro) 2026-03-31
US10889640B2 (en) 2021-01-12
EP3319983C0 (en) 2026-01-28
UY36773A (es) 2017-01-31
SG10202010735PA (en) 2020-11-27
CA2991451A1 (en) 2017-01-12
JP6630426B2 (ja) 2020-01-15
JP2018524001A (ja) 2018-08-30
IL256685A (en) 2018-03-29
JP7100008B2 (ja) 2022-07-12
US20210115121A1 (en) 2021-04-22
HRP20260348T1 (hr) 2026-04-24
CN107849104A (zh) 2018-03-27
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AR105267A1 (es) 2017-09-20
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WO2017005734A1 (en) 2017-01-12
KR20250027278A (ko) 2025-02-25
MA42377A (fr) 2018-05-16
EP4729538A2 (en) 2026-04-22
JP7413448B2 (ja) 2024-01-15
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US11732034B2 (en) 2023-08-22
MX2017015817A (es) 2018-04-10

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