CN107802515A - One kind is exempted to inject micro- whole eye cream and preparation method thereof - Google Patents
One kind is exempted to inject micro- whole eye cream and preparation method thereof Download PDFInfo
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- CN107802515A CN107802515A CN201711286680.8A CN201711286680A CN107802515A CN 107802515 A CN107802515 A CN 107802515A CN 201711286680 A CN201711286680 A CN 201711286680A CN 107802515 A CN107802515 A CN 107802515A
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- eye
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
Exempt to inject micro- whole eye cream and preparation method thereof the invention discloses one kind, the eye cream is made of emulsifying agent, moisturizing grease, NMF, macromolecule thickener, micro-capsule parcel hyaluronic acid, the instant Firm agent of plant, caffeine silica alkanol, acetyl fourth peptide 5, preservative, aromatic and deionized water.Use eye cream of the present invention, the skin of eye relaxation can be tightened up immediately, dispel ocular edema, lift the elasticity of eye skin, fill skin bottom, improve eye skin comprehensively, for consumer provide one kind more comprehensively, safely, effectively, quick eye-care, consumer's eye is called forth one's youthful vigor again, exempt from micro- whole and reach the effect of micro- whole.Product of the present invention will not produce allergic reaction to user, safe to use；Product of the present invention has significant effect on the eye product for exempting to inject micro- whole anti-wrinkle Firm.
Description
【Technical field】
Exempt to inject micro- whole eye cream and preparation method thereof the present invention relates to one kind, belong to cosmetic technical field.
【Background technology】
It as the saying goes, the eyes are the windows of the mind.Most schoolgirls want the electric eye for possessing a pair of attractive.However,
Eye skin is most tender and lovely skin, is the position for being easiest to aging.Found by market survey, the worried eye of consumer
In problem, wrinkle, pouch, black eye enclose front three.Typically from after 25 years old, eye circumference skin begins to various problems occur, institute
To prevent and nurse particularly significant.It is at a relatively high that the number ratio of eye-care product is used, has exceeded half.It is when asking
Not no when should use eye-care product, more than ninety percent interviewee thinks have this necessary.Although it is believed that it is necessary to use eye
Nursing product, but actually think that the interviewee of DeGrain is in this embarrassed really now close to half, eye-care product
Urgent situation.Most eye-care product using effects can not reach the expection of consumer, and want quick solution eye problems, mesh
Some preceding cosmetic surgery hospitals remove to reach short-term crease-resistant tightening effect by injecting sodium hyaluronate or clostridium botulinum, but this method is not only
It is expensive, while its security is controversial always.Therefore, it is a kind of more comprehensively, safe and efficient exempt to inject micro- whole eye cream
Invention will be by market extensive concern and accreditation.
【The content of the invention】
The invention aims to the danger for making up the deficiencies in the prior art He evading microneedle injection, there is provided a kind of more complete
Face, safe and efficient exempt to inject micro- whole eye cream.
It is another object of the present invention in order to provide the preparation method of micro- whole eye cream.
One kind is exempted to inject micro- whole eye cream, it is characterised in that contains following components in percentage by weight：
A phases：
Emulsifying agent 1.0~3.0%
Moisturizing grease 3.0~10.0%
B phases：
NMF 3.0~8.0%
Macromolecule thickener 0.2~1.5%
Deionized water surplus
C phases：
D phases：
Preservative 0.2~1.0%
Aromatic 0.01~0.1%,
Each phase component percentage by weight sum meets 100% above.
More than 50% all it is hyaluronic acid in human body skin, as the important composition composition of skin corium, hyaluronic acid can be with
Skin smooth and plentiful is kept, but the horizontal of hyaluronic acid contents can be gradually lowered with advancing age, and this is due to
Caused by imbalance between synthesis and degraded.Hyaluronic acid quantity inside the people of 50 years old is detected only their youths
When half.Because the molecular weight of hyaluronic acid is big, being only applied to skin surface can not be by dermal absorption.And used in the present invention
Micro-capsule parcel hyaluronic acid (Hyalusphere) (hyaluronic acid of the spherolite parcel of French SOLIANCE companies production) is one
The high molecular weight hyaluronic acid (1~1.4 ten thousand dalton) that kind quantifies.It is to be arrived in aqueous solution interface with nonionic spherolite parcel
Hyaluronic acid, hyaluronic acid is wrapped up by multilayer spherolite technique for packing, spherolite can be deep into deep skin, deep in skin
Layer controls the release time of hyaluronic acid and is that long duration is effective by the continuous opening on spherolite top layer, true so as to increase
Hyaluronic acid contents in skin trigger the exuberant effect to fill wrinkle, help skin to return to the volume and plentiful of itself, with
Reach the visual effect of micro- whole filling.It is preferred that the hyaluronic acid of the spherolite parcel of French SOLIANCE companies production.
The instant Firm agent (Easyliance) of plant in the present invention is French SOLIANCE companies production by Africa
The polymer with synergy of two kinds of gum arabic and hydrolysis rhizobium glue naturally.Easyliance is in skin surface exhibition
Open form reticulates structure, when polymer film forming exsiccation, will shrink and unfold skin.Due to two kinds of polymer structural particularity,
Easyliance can smooth out skin by mechanism, allow skin to possess instant and obvious lifting effect of compacting.
Caffeine silica alkanol (Cafeisilane C) in the present invention is a kind of water-soluble of French Ai Ximei companies production
Property organosilicon derivates, there is very abundant hydroxyl functional, and obtain by being condensed some individual, so it is
With the biological function of itself, there is specific function caused by the root that those are made up of natural goods again.In caffeine silanol
On, main root is caffeine, while also has sweet dew alditol.Caffeine silanol not only works in terms of fat is solved, while again
Worked in terms of rebuilding skin histology and increasing real compact skin, and anti-inflammatory.Therefore it is widely used in weight reducing (solution fat, anti-cellulite knit inflammation)
In product, body and skin of face consolidation product and pouch product of dispelling.
Acetyl group tetrapeptide -5 (Eyeseryl) in the present invention is the raw material of Li Putai companies of Spain production, and this raw material obtains
Obtain C＆T and HBA and combine the optimal new technology prize issued.One of mechanism that pouch is formed is influenceed, is due to that hypertension causes
Poor blood circulation.Therefore, an effective pouch component of dispelling, which should have, improves sanguimotor antihypertensive function.Pass through
Research shows that Eyeseryl acetyl group tetrapeptides -5 can suppress I type angiotensin converting enzyme and glycosylation, improves vascular permeability,
Adhere to acting on regard to significant antioedematous and pouch of dispelling can be shown using more than 15 days, while can also improve due to ocular blood
Livid ring around eye problem caused by circulation is not good at.
The present invention exempts to inject the compounding of micro- whole eye cream four kinds of components more than, and the eye skin relaxation of energy comprehensively solve has wrinkle
Line, pouch and black-eyed problem.Exempt to inject micro- whole eye cream by smearing the present invention, while be equipped with rational massage manipulation, can
Reach instant visible wrinkle and subtract micro- whole anti-wrinkle that light, skin compacts and dispel the effect of microgroove, adhere to that long-term use can make eye deep
Layer skin recover again elasticity, reach dispel eye wrinkle-removing, mitigate pouch, black-eyed true effect, realize as it is micro- it is whole as
Miraculous effects.This breakthrough combination solves eye cream DeGrain in the market also unabiding deficiency, also removes from
Consumer goes the high expense and operation risk that cosmetic surgery hospital treats.
The present invention exempts to inject the preparation method of micro- whole eye cream, it is characterised in that comprises the following steps：
A, by A phases (i.e.：Oil phase) each component is put into oil cauldron stirring and is warming up to 80~85 DEG C；
B, by B phases (i.e.：Aqueous phase) each component is put into kettle stirring and is warming up to 80~85 DEG C；
C, first kettle raw material filtering be pumped into emulsification pot in, then slowly filtering suction oil cauldron raw material, then high speed homogenization 8~
10min, vacuum heat-preserving stirring 10-20min defoaming sterilizings；
D, 45 DEG C are cooled to, C phase each components is sequentially added, stirs；
E, 40 DEG C are cooled to, D phase components is sequentially added, stirs, filtering and discharging is examined.
The present invention exempts to inject in the preparation method of micro- whole eye cream, and the big speed for producing high speed homogenization is because of the emulsification of different size
Pot and difference, laboratory high speed homogenization speed are generally 8000-10000rpm.
Finished product is filtered into the filtering of 100 mesh in preparation method of the present invention.
Compared with existing product, the present invention has advantages below：
The micro-capsule parcel hyaluronic acid used in the present invention, is permeable to deep skin, then progressively slowly discharges transparent
Matter acid, skin supplement hyaluronic acid is continuously, skin is realized the full flexible of long period, reaches the micro- whole of long period
Effect；The instant Firm agent of plant, it has the effect of instant take-up slack skin, that is, can see the micro- whole effect got instant result
Fruit.Caffeine silica alkanol not only works in terms of fat is solved, while is rebuilding the real compact skin of skin histology increasing again, makes eye skin
Again elasticity is recovered；Acetyl group tetrapeptide -5, it is the tetrapeptide that there is antioedematous to act on, the formation of pouch can be prevented, and reduce swelling
Pouch.The eye cream of the compounding of four kinds of functional components more than, can tighten up the skin of eye relaxation immediately, dispel eye
Oedema, the elasticity of eye skin is lifted, fill skin bottom, improve eye skin comprehensively, provided for consumer a kind of more complete
Face, safely, effectively, quick eye-care, consumer's eye is called forth one's youthful vigor again, exempt from micro- whole and reach micro- whole work(
Effect.
Product of the present invention will not produce allergic reaction to user, safe to use；Product of the present invention is exempting to inject micro- whole dispel
There is significant effect on the eye product of wrinkle Firm.
【Embodiment】
With reference to specific embodiment, the invention will be further described：
Embodiment 1：
A phases：
B phases：
C phases：
D phases：
Preservative qs
Appropriate aromatic.
The preparation method of embodiment 1 is：
A, A phase each components are put into stirring in oil cauldron and are warming up to 80~85 DEG C；
B, B phase each components are put into stirring in kettle and are warming up to 80~85 DEG C；
C, first kettle raw material filtering be pumped into emulsification pot in, then slowly filtering suction oil cauldron raw material, then high speed homogenization 8~
10min, vacuum heat-preserving stirring 10-20min defoaming sterilizings；
D, 45 DEG C are cooled to, C phase each components is sequentially added, stirs；
E, 40 DEG C are cooled to, D phase each components is sequentially added, stirs, the discharging of 100 mesh filter-cloth filterings is examined.
Embodiment 2：
A phases：
B phases：
AVC 1.0%
Butanediol 5.0%
Deionized water surplus
C phases：
D phases：
Preservative qs
Appropriate essence.
The preparation method of embodiment 2 is the same as embodiment 1.
Embodiment 3：
A phases：
B phases：
C phases：
D phases：
Preservative qs
Appropriate essence.
The preparation method of embodiment 3 is the same as embodiment 1.
Embodiment 4：
A phases：
B phases：
C phases：
D phases：
Preservative qs
Appropriate essence.
The preparation method of embodiment 4 is the same as embodiment 1.
Embodiment 5：
A phases：
B phases：
C phases：
D phases：
Preservative qs
Appropriate essence.
The preparation method of embodiment 5 is the same as embodiment 1.
Some testing performance indexes are done to embodiment 1-5 micro- whole eye cream of exempting to inject, its test result is as follows：
1. outward appearance：The fine and smooth cream of white
2.pH values：5.0-7.0
3. heat-resistant stability investigates (48 DEG C × 48H)：It is qualified
4. cold-resistant study on the stability (- 15 DEG C × 48H)：It is qualified
In order to prove the performance of product of the present invention, following experiment has been carried out：
First, skin irritation test：
2.5~3kg healthy rabbits 100 are selected, arbitrarily extract 40, the symmetrical shaving 2.5cm in every rabbit back2,
Carried out with own control test method(s), apply every time 0.5g embodiment of the present invention product (embodiment 1 and the respectively test 20 of embodiment 2) or
Bare substrate, twice daily, left side or right side are administered at random, observe and record the reacting phenomenon of skin after 24h, 72h.
As a result show：Applying the embodiment of the present invention 1,2, (embodiment 1,2 is the minimum of application claims and the production of maximum magnitude
Product) product 24h, 72h after have no the local excitations such as rubefaction, dermexanthesis, water lump react, illustrate that the present invention exempts to inject micro- whole eye
Cream cosmetic is to be perfectly safe, without any adverse reaction.
2nd, efficacy test
1st, Subject Population：Totally 60, it is divided to two groups, every group of 30 people, respectively using the product of embodiment 1 and embodiment 2.
1. age range：Minimum 20 years old, maximum 42 years old, 25-30 year section accounts for 85%；
2. experimenter can be coordinated well, regularity in one's life can be kept during research；
3. eye problems feed back：Wrinkle, pouch, livid ring around eye, fatigue
2nd, method of testing：
Specification subject or care-giver adhere to using daily sooner or later, an ophthalmically acceptable test sample, and another eye is only using clear
Water wipes.Carry out follow-up within 2 weeks, 4 weeks after experiment starts, test using product and changed using the wrinkle depth of clear water, eye respectively
Bag change and livid ring around eye change, the test of same volunteer are completed by same survey crew.
3rd, search time
Entirely 28 days by a definite date researchers of research carried out clinical test results assessment the 0th day, 14 days, 28 days.
4th, testing standard
1. skin elasticity
Skin elasticity passes through skin quality elasticity measurement instrumentTo detect.In flexibility test, produced by machine
Low pressure by way of air-breathing by skin suck probe gap in, the depth for being inhaled into probe is measured by optical sensor
Degree.The amount of recovery (millimeter numerical value) of skin reflects its elasticity.Elasticity represents skin deformation and reaches recovery after maximum
Degree, its value is between 0 to 1 (maximum flexibility).
2. anti-livid ring around eye effect
High-resolution photo is obtained under polarized light, is then studied with chromascope (chromametry).
, can be to the color of skin according to the value of ITA ° (Individual Typological Angle, individual type angle)
Pool is classified as follows：Brown<10°<Sepia<28°<Reference colour<41°<Light color<55°<It is very light.
ITA ° of value, which is dramatically increased (+3%) and shows to be had using product, improves black-eyed effect.
3. the change of pouch
Subject feels, and reduces and is scored for pouch：
1-- does not reduce
2-- somewhat reduces
Reduction fairly good 3--
The extraordinary reductions of 4--
5th, test data
Using the said goods 2 weeks, clinical test results are carried out the 0th week, 2 weeks, 4 weeks and assess as shown in table 1, test is made even
Average.
Table 1：
6th, experimental result
From above-mentioned test result, micro- whole eye cream of exempting to inject in the present invention has increase skin elasticity, anti-livid ring around eye
And reduce the multi-efficiencies such as pouch.
Above-described embodiment is only currently preferred case study on implementation, it is impossible to limits present invention model claimed with this
Enclose, any unsubstantiality and replacement that those skilled in the art is done on the basis of the present invention belongs to application claims
The scope of protection.
Claims (5)
1. one kind is exempted to inject micro- whole eye cream, it is characterised in that contains following components in percentage by weight：
A phases：
Emulsifying agent 1.0~3.0%
Moisturizing grease 3.0~10.0%
B phases：
NMF 3.0~8.0%
Macromolecule thickener 0.2~1.5%
Deionized water surplus
C phases：
D phases：
Preservative 0.2~1.0%
Aromatic 0.001~0.1%,
Each phase component percentage by weight sum meets 100% above.
2. one kind according to claim 1 is exempted to inject micro- whole eye cream, it is characterised in that the instant Firm agent of described plant is
The polymer with synergy being made up of the gum arabic and hydrolysis rhizobium glue in Africa.
3. exempt to inject the preparation method of micro- whole eye cream described in a kind of claim 1 or 2, it is characterised in that comprise the following steps：
A, A phase each components are put into stirring in oil cauldron and are warming up to 80~85 DEG C；
B, B phase each components are put into stirring in kettle and are warming up to 80~85 DEG C；
C, first kettle raw material filtering be pumped into emulsification pot in, then slowly filtering suction oil cauldron raw material, then high speed homogenization 8~
10min, vacuum heat-preserving stirring 30min defoaming sterilizings；
D, 45 DEG C are cooled to, C phase each components is sequentially added, stirs；
E, 40 DEG C are cooled to, sequentially adds adjuvant component, is stirred, filtering and discharging is examined.
A kind of 4. preparation method for exempting to inject micro- whole eye cream according to claim 3, it is characterised in that the speed of high speed homogenization
Spend by production when institute use emulsification pot mark maximum homogeneous speed 85-100%.
5. a kind of preparation method for exempting to inject micro- whole eye cream according to claim 3, it is characterised in that be filtered into step e
100 mesh filter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711286680.8A CN107802515A (en) | 2017-12-07 | 2017-12-07 | One kind is exempted to inject micro- whole eye cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711286680.8A CN107802515A (en) | 2017-12-07 | 2017-12-07 | One kind is exempted to inject micro- whole eye cream and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107802515A true CN107802515A (en) | 2018-03-16 |
Family
ID=61579263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711286680.8A Pending CN107802515A (en) | 2017-12-07 | 2017-12-07 | One kind is exempted to inject micro- whole eye cream and preparation method thereof |
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| CN (1) | CN107802515A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223596A (en) * | 2018-09-18 | 2019-01-18 | 栗丽 | A kind of promoting blood circulation maintenance frost and preparation method thereof |
Citations (2)
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|---|---|---|---|---|
| FR2941377A1 (en) * | 2009-01-29 | 2010-07-30 | Soliance | COSMETIC COMPOSITIONS COMPRISING CETOGLUCONIC ACID DERIVATIVES |
| CN105943448A (en) * | 2016-06-17 | 2016-09-21 | 广州丹奇日用化工厂有限公司 | Black eye removal instant eyelift cream |
-
2017
- 2017-12-07 CN CN201711286680.8A patent/CN107802515A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2941377A1 (en) * | 2009-01-29 | 2010-07-30 | Soliance | COSMETIC COMPOSITIONS COMPRISING CETOGLUCONIC ACID DERIVATIVES |
| CN105943448A (en) * | 2016-06-17 | 2016-09-21 | 广州丹奇日用化工厂有限公司 | Black eye removal instant eyelift cream |
Non-Patent Citations (4)
| Title |
|---|
| JHTSKY: "《CosDNA》", 18 October 2017 * |
| S00122382: "《豆丁网》", 18 February 2016 * |
| 蓝昊等: "《魔肽帝国》", 30 June 2014, 作家出版社 * |
| 黄霏莉等: "《实用美容中药学》", 30 September 2001, 辽宁科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223596A (en) * | 2018-09-18 | 2019-01-18 | 栗丽 | A kind of promoting blood circulation maintenance frost and preparation method thereof |
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Application publication date: 20180316 |