CN107929115A - A kind of Chinese medicine composition and its preparation method and application - Google Patents
A kind of Chinese medicine composition and its preparation method and application Download PDFInfo
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- CN107929115A CN107929115A CN201710661559.2A CN201710661559A CN107929115A CN 107929115 A CN107929115 A CN 107929115A CN 201710661559 A CN201710661559 A CN 201710661559A CN 107929115 A CN107929115 A CN 107929115A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The invention discloses a kind of Chinese medicine composition and its preparation method and application, the Chinese medicine composition is mainly prepared by the following raw material by weight percentage：Chinese mesona herb 1 50%, centella 1 50%, radix scutellariae 1 50%, wild chrysanthemum 1 50% and glycyrrhiza glabra 1 50%, wherein the sum of percentage by weight of the Chinese medicine composition each component raw material is 100%.The Chinese medicine composition of the present invention has stronger hyaluronic acid enzyme inhibition rate, and being added in skin care item has effects that easy absorption, anti-inflammatory, maintenance of releiving, lifting skin resist power.Raw material of the present invention are natural component of releiving, gentle, non-stimulated to skin, have good application prospect and market prospects.
Description
Technical field
The invention belongs to cosmetic field, is related to a kind of Chinese medicine composition and its preparation method and application, and in particular to one
Kind have effects that to releive Chinese medicine composition of maintenance and its preparation method and application.
Background technology
In recent years, the skin problem of China resident increases increasingly, and it is obscure, dark to show as dry water shortage, sensitive fragility, spot
Sore acne etc., these skin problems are mainly irradiated by ultraviolet, air pollution, endocrine disorder, fungal infection, cosmetics make
Caused by the factor such as improper, and the city haze frequently occurred recently has also further aggravated the burden of skin.L'Oreal exists
Shanghai Chongming island and Xujiahui two places have chosen 349 consumers and carried out comparative study with regard to 4 skin indexs, the results show that
Air pollution causes greasy 3 times of the degree increase of skin, dry aggravation 14%, and atopic reaction increases by 7 times, squalene, protein mistake
Degree oxidation aggravation 150%, vitamin E is lost in seriously, and fibrocyte is also destroyed.
Skin allergy be influence skin health an important factor for one of, inflammatory factor, inflammatory mediator skin siberian crabapple
Immune cell activated, induction immunocyte produce antibody in system, cause blood vessel dilatation and vascular permeability increase, cause skin to go out
The problems such as existing erythema, fever, shouting pain.Therefore, skin allergy situation can be effectively improved by reducing the content of inflammatory factor.For example,
It can suppress allergic reaction by preventing histamine release of mast cell, or be prevented by suppressing the activity of hyaluronidase
Histamine is combined with acceptor.
201310449238.8 disclose a kind of adjusting cutaneous immunisation power, the external use skin care of delay skin aging, including
It is oligopeptides -1, ginsenoside, glycyrrhiza glabra root extract, Artemisia capillaris flower extract, radix scutellariae root extract, Gotu Kola P.E, auxiliary
Enzyme Q10 wrappages, flat peach Cactus Pedicel extract and other compositions, the skin care item have reduce wrinkle, reduce skin roughness,
The effect of even skin tone, firm skin, but there is no significant effect in terms of antiallergy.
201510226733.1 disclosing a kind of multiple-effect without preservative repairs Essence and preparation method thereof, including product
The careless extract 0.12-0.4% of snow, giant knotweed root extract 0.01-0.4%, radix scutellariae root extract 0.01-0.4%, tea extract
0.01-0.4%, glycyrrhiza glabra root extract 0.01-0.4%, german chamomile flower extract 0.01-0.4%, Rosmarinus officinalis extract
0.01-0.4% and other compositions, the multiple-effect repair Essence and are free of preservative, and nonirritant, moistening effect is good, antiphlogistic effects
Significantly, but do not have anti-allergic effects.
201610151147.X discloses a kind of quiet type makeup remover and preparation method thereof of releiving containing plant petals, wherein
Anti-sensitizer include dipotassium glycyrrhizinate, peony root extractive, allantoin, purslane extract, Gotu Kola P.E, scutellariae,radix carry
Thing, giant knotweed root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, Rosmarinus officinalis extract are taken, but should
How the antiallergic effect of makeup remover does not discuss.
Therefore it provides a kind of have effects that notable antiallergic, releive, the Chinese medicine of maintenance using natural Chinese medicinal herb as primary raw material
Composition, has great importance and vast market prospect in cosmetic field.
The content of the invention
The present invention is in the market correlation skin care item releive in maintenance and other effects the defects of, there is provided a kind of Chinese medicine composition
And its preparation method and application, the Chinese medicine composition using natural Chinese medicinal herb as primary raw material, have antiallergic, releive, maintenance, guarantor
Wet, moisturizing etc. acts on, suitable for sensitive skin.
In a first aspect, the present invention provides a kind of Chinese medicine composition, the Chinese medicine composition by weight percentage mainly by
The following raw material is prepared：Chinese mesona herb 1-50%, centella 1-50%, radix scutellariae 1-50%, wild chrysanthemum 1-50% and glycyrrhiza glabra
1-50%, wherein the sum of percentage by weight of the Chinese medicine composition each component raw material is 100%.
The nature and flavor and effect of each Chinese medicine of the present invention are as follows：
Chinese mesona herb：Nickname Mesona chinensis Benth, it is property slightly sweet flavor, cool, there is the effect of clearing heat and promoting diuresis, cool blood relieving summer-heat, mainly as in
Medicine component is used to treat the diseases such as hot summer weather, dysentery, diabetes, vascular hypertension, muscle arthrosis pain, acute nephritis, at present, not yet
There is report of the Chinese mesona herb as cosmetic industry component.
Centella：It is bitter, pungent, it is cold in nature, there is clearing heat and promoting diuresis, the efficacy of removing toxicity for detumescence effect.
Radix scutellariae：It is bitter in taste, tremble with fear, be loaded in《Wu Pu Bencao》, there is the effect of heat-clearing and damp-drying drug, cool blood tocolysis, removing toxic substances.
Wild chrysanthemum：It is bitter, pungent, cool, first recorded in《All officials》, there is clearing heat and detoxicating, wind-dispelling heat-dissipating, anti-inflammatory, dissipate the stasis of blood, detumescence,
The effect of sterilization.
Glycyrrhiza glabra：Sweet in flavor, mild-natured, returns spleen, stomach, lung channel, have the effect of clearing heat and detoxicating, anti-inflammatory, anti-oxidant.
Chinese medicine composition provided by the invention carries out the side's of sending use based on theory of traditional Chinese medical science, according to the principle of monarch
Medicine.Prescription can increase the fine and smooth degree of skin using Chinese mesona herb as monarch drug in a prescription, bring refrigerant, net saturating skin impression；With centella
For ministerial drug, the resistance of skin epidermis can be increased, promote in dermal layer of the skin the formation of collagen and fibrinous
Regeneration, has the function of the effect of consolidating skin barrier, asiaticosid auxiliary Chinese mesona herb therein plays heat-clearing, cooling, skin toner；
Using radix scutellariae and wild chrysanthemum as adjutant, monarch drug in a prescription, ministerial drug is coordinated to play effect, the wherein baicalin in radix scutellariae has anti-inflammatory, resistance state
Effect, by suppressing the release of allergic reaction medium, suppresses anaphylactoid generation；Wild chrysanthemum is natural sedative, can be with
Alleviate the allergic symptom of skin, there is anti-inflammatory, antibacterial, calmness；Using glycyrrhiza glabra as medicine is made, have and repair impaired flesh
The effect of all medicines in skin, comprehensively regulating skin, reconciliation side, five kinds of components coordinate jointly, synergistic effect so that Chinese medicine composition has
Play the role of lifting skin resilience, comprehensively regulating skin state.
Preferably, the percentage by weight of the Chinese mesona herb is 1-50%, for example, can be 1%, 2%, 5%, 8%, 10%,
12%th, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48% or
50%, it is preferably 20-50%, more preferably 25-40%.
Preferably, the percentage by weight of the centella is 1-50%, for example, can be 1%, 2%, 5%, 8%, 10%,
12%th, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48% or
50%, it is preferably 15-40%, more preferably 20-25%.
Preferably, the percentage by weight of the radix scutellariae is 1-50%, for example, can be 1%, 2%, 5%, 8%, 10%,
12%th, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48% or
50%, it is preferably 10-30%, more preferably 15-20%.
Preferably, the percentage by weight of the wild chrysanthemum is 1-50%, for example, can be 1%, 2%, 5%, 8%, 10%,
12%th, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%, 48% or
50%, it is preferably 10-30%, more preferably 10-20%.
Preferably, the percentage by weight of the glycyrrhiza glabra is 1-50%, for example, can be 1%, 2%, 5%, 8%,
10%th, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 32%, 35%, 38%, 40%, 42%, 45%,
48% or 50%, it is preferably 10-30%, more preferably 10-15%.
Preferably, the Chinese medicine composition is mainly prepared by the following raw material by weight percentage：Chinese mesona herb 20-
50%th, centella 15-40%, radix scutellariae 10-30%, wild chrysanthemum 10-30% and glycyrrhiza glabra 10-30%, wherein the Chinese medicine group
The sum of percentage by weight of compound each component is 100%.
Preferably, the Chinese medicine composition is mainly prepared by the following raw material by weight percentage：Chinese mesona herb 25-
40%th, centella 20-25%, radix scutellariae 15-20%, wild chrysanthemum 10-20% and glycyrrhiza glabra 10-15%, wherein the Chinese medicine group
The sum of percentage by weight of compound each component is 100%.
Preferably, the Chinese medicine composition is mainly prepared by the following raw material by weight percentage：Chinese mesona herb 25%, product
Snow grass 25%, radix scutellariae 20%, wild chrysanthemum 20% and glycyrrhiza glabra 10%.
Second aspect, the present invention provides a kind of method for preparing Chinese medicine composition as described in relation to the first aspect, including with
Lower step：
(1) pre-process：Chinese medicine composition each component raw material is crushed, is uniformly mixed after sieving；
(2) homogeneous extracts：Chinese medicinal granule after crushing is placed in high pressure homogenizer, adds deionized water, it is high-pressure homogeneous
Extraction；
(3) after extracting solution is centrifuged, concentrated with micro-filtrate membrane filtration, then with reverse osmosis membrane, after adding solvent dissolving
Filtering, that is, be prepared the Chinese medicine composition.
Preferably, the mesh number of step (1) described sieving is 10-100 mesh, for example, can be 10 mesh, 15 mesh, 20 mesh, 25 mesh,
30 mesh, 35 mesh, 40 mesh, 45 mesh, 50 mesh, 55 mesh, 60 mesh, 65 mesh, 70 mesh, 75 mesh, 80 mesh, 85 mesh, 90 mesh, 95 mesh or 100 mesh,
Preferably 80 mesh.
Preferably, step (2) Chinese medicinal granule and the feed liquid mass ratio of the deionized water are 1:(5-30), such as can
To be 1:5、1:8、1:10、1:12、1:15、1:18、1:20、1:22、1:25、1:28 or 1:30, it is preferably 1:25.
Preferably, the high-pressure homogeneous extraction time described in step (2) is 5-25min, for example, can be 5min, 8min,
10min, 12min, 15min, 18min, 20min, 22min or 25min, are preferably 20min.
Preferably, the high-pressure homogeneous extraction pressure described in step (2) is 5-60Mpa, for example, can be 5Mpa, 10Mpa,
15Mpa, 20Mpa, 25Mpa, 30Mpa, 35Mpa, 40Mpa, 45Mpa, 50Mpa, 55Mpa or 60Mpa, are preferably 45Mpa.
Preferably, the aperture of the microfiltration membranes described in step (3) is 100-600nm, for example, can be 100nm, 150nm,
200nm, 250nm, 300nm, 350nm, 400nm, 450nm, 500nm, 550nm or 600nm, are preferably 250nm.
Preferably, the Chinese medicine composition each component raw material of the quality of the extracting solution after step (3) described concentration and step (1)
The mass ratio of gross mass be (0.5-10):1, such as can be 0.5:1、1.0:1、1.5:1、2.0:1、2.5:1、3.0:1、
3.5:1、4.0:1、4.5:1、5.0:1、5.5:1、6.0:1、6.5:1、7.0:1、7.5:1、8.0:1、8.5:1、9.0:1、9.5:1
Or 10.0:1, it is preferably 1:1.
Preferably, the solvent described in step (3) is butanediol and/or propane diols.
Preferably, the amount of step (3) described solvent and the mass ratio of the amount of the extracting solution are (0.5-10):1, such as can
To be 0.5:1、1.0:1、1.5:1、2.0:1、2.5:1、3.0:1、3.5:1、4.0:1、4.5:1、5.0:1、5.5:1、6.0:1、
6.5:1、7.0:1、7.5:1、8.0:1、8.5:1、9.0:1、9.5:1 or 10.0:1, it is preferably 1:1.
The third aspect, is used to prepare the present invention provides a kind of Chinese medicine composition as described in relation to the first aspect and is repaiied with releiving
Protect the cosmetics of effect.
Preferably, the additive amount of the Chinese medicine composition is 0.1-40.0%, for example, can be 0.1%, 1.0%,
2.0%th, 3.0%, 4.0%, 5.0%, 6.0%, 7.0%, 8.0%, 9.0%, 10.0%, 11.0%, 12.0%, 13.0%,
14.0%th, 15.0%, 16.0%, 17.0%, 18.0%, 19.0%, 20.0%, 21.0%, 22.0%, 23.0%, 24.0%,
25.0%th, 26.0%, 27.0%, 28.0%, 29.0%, 30.0%, 31.0%, 32.0%, 33.0%, 34.0%, 35.0%,
36.0%th, 37.0%, 38.0%, 39.0% or 40.0%, it is preferably 10.0-15.0%.
Preferably, the formulation of the cosmetics includes：It is any in aqua, emulsion, spray, cream, elite or facial mask
It is a kind of or at least two combination, be preferably aqua and/or emulsion.
Compared with prior art, the present invention has the advantages that：
(1) antiallergic：The hyaluronic acid inhibiting rate of Chinese medicine composition prepared by the present invention is more than 80%, up to
90.05%, there is the effect of improving skin exquisiteness degree, enhancing skin resistance, Reduce allergy symptom, salubrious skin；
(2) it is nonirritant：The L/D values of Chinese medicine composition prepared by the present invention are equal>100, in nonirritant；
(3) prosthetic：Have added with the skin care item of Chinese medicine composition prepared by the present invention significantly releive, maintenance, town
Quiet effect, can substantially desalinate erythema, red and swollen phenomenon, have lifting skin resilience, the work of comprehensively regulating skin state
With.
Brief description of the drawings
Fig. 1 tests representative graph for skin closure patch, wherein, Fig. 1 (a) is the normal skin of subject, and Fig. 1 (b) is
SDS stimulates the skin after 5h, and Fig. 1 (c) is to use the skin after skin care item 48h.
Embodiment
The technological means and its effect taken for the present invention is further explained, with reference to embodiments with attached drawing to this hair
It is bright to be further described.It is understood that the specific embodiments described herein are used only for explaining the present invention, rather than
Limitation of the invention.
In the examples where no specific technique or condition is specified, according to the described technology of document in the art or condition,
Or carried out according to product description.Reagents or instruments used without specified manufacturer, be can be by regular channel commercially available from
The conventional products of acquisition.
The preparation of 1 Chinese medicine composition of embodiment (I)
The Chinese medicine of Chinese mesona herb 25%, centella 25%, radix scutellariae 20%, wild chrysanthemum 20% and glycyrrhiza glabra 10% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 80 mesh sieve, is 1 by feed liquid mass ratio:25 add
Enter deionized water, high pressure homogenization method 20min, extracts pressure 45Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 250nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Butanediol dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 2 Chinese medicine composition of embodiment (II)
The Chinese medicine of Chinese mesona herb 30%, centella 25%, radix scutellariae 15%, wild chrysanthemum 15% and glycyrrhiza glabra 15% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 85 mesh sieve, is 1 by feed liquid mass ratio:28 add
Enter deionized water, high pressure homogenization method 22min, extracts pressure 50Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 300nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Propane diols dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 3 Chinese medicine composition of embodiment (III)
The Chinese medicine of Chinese mesona herb 30%, centella 20%, radix scutellariae 20%, wild chrysanthemum 20% and glycyrrhiza glabra 10% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 75 mesh sieve, is 1 by feed liquid mass ratio:22 add
Enter deionized water, high pressure homogenization method 18min, extracts pressure 40Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 200nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Propane diols and butanediol mixed liquor dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 4 Chinese medicine composition of embodiment (IV)
The Chinese medicine of Chinese mesona herb 40%, centella 25%, radix scutellariae 15%, wild chrysanthemum 10% and glycyrrhiza glabra 10% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 90 mesh sieve, is 1 by feed liquid mass ratio:30 add
Enter deionized water, high pressure homogenization method 25min, extracts pressure 55Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 350nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Butanediol dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 5 Chinese medicine composition of embodiment (V)
The traditional Chinese medicine composite powder of Chinese mesona herb 20%, centella 40%, radix scutellariae 10% and wild chrysanthemum 30% will be included
It is broken, it is uniformly mixed, is placed in high pressure homogenizer after being sieved with 70 mesh sieve, is 1 by feed liquid mass ratio:20 add deionized water,
High pressure homogenization method 15min, extracts pressure 35Mpa, after extracting solution is centrifuged, with the micro-filtrate membrane filtration of 150nm, then with instead
Permeable membrane concentrates, and the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, it is molten to add the propane diols identical in quality with extracting solution
Solution, filtering, are made the extract of Chinese medicine composition.
The preparation of 6 Chinese medicine composition of embodiment (VI)
The traditional Chinese medicine composite powder of Chinese mesona herb 45%, centella 15%, radix scutellariae 30% and wild chrysanthemum 10% will be included
It is broken, it is uniformly mixed, is placed in high pressure homogenizer after being sieved with 95 mesh sieve, is 1 by feed liquid mass ratio:18 add deionized water,
High pressure homogenization method 12min, extracts pressure 60Mpa, after extracting solution is centrifuged, with the micro-filtrate membrane filtration of 400nm, then with instead
Permeable membrane concentrates, and the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add the propane diols identical in quality with extracting solution and fourth
Mixed liquor dissolving, the filtering of glycol, are made the extract of Chinese medicine composition.
The preparation of 7 Chinese medicine composition of embodiment (VII)
The Chinese medicine of Chinese mesona herb 30%, centella 20%, radix scutellariae 10%, wild chrysanthemum 10% and glycyrrhiza glabra 30% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 60 mesh sieve, is 1 by feed liquid mass ratio:15 add
Enter deionized water, high pressure homogenization method 10min, extracts pressure 30Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 100nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Butanediol dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 8 Chinese medicine composition of embodiment (VIII)
The Chinese medicine of Chinese mesona herb 50%, centella 19%, radix scutellariae 15%, wild chrysanthemum 15% and glycyrrhiza glabra 1% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 50 mesh sieve, is 1 by feed liquid mass ratio:12 add
Enter deionized water, high pressure homogenization method 8min, extracts pressure 25Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 450nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Propane diols dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 9 Chinese medicine composition of embodiment (IX)
The Chinese medicine of Chinese mesona herb 1%, centella 50%, radix scutellariae 19%, wild chrysanthemum 15% and glycyrrhiza glabra 15% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 40 mesh sieve, is 1 by feed liquid mass ratio:10 add
Enter deionized water, high pressure homogenization method 5min, extracts pressure 20Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 500nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Propane diols and butanediol mixed liquor dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 10 Chinese medicine composition of embodiment (X)
The Chinese medicine of Chinese mesona herb 15%, centella 1%, radix scutellariae 50%, wild chrysanthemum 19% and glycyrrhiza glabra 15% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 30 mesh sieve, is 1 by feed liquid mass ratio:8 add
Enter deionized water, high pressure homogenization method 5min, extracts pressure 15Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 550nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Butanediol dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 11 Chinese medicine composition of embodiment (XI)
The Chinese medicine of Chinese mesona herb 15%, centella 15%, radix scutellariae 1%, wild chrysanthemum 50% and glycyrrhiza glabra 19% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 20 mesh sieve, is 1 by feed liquid mass ratio:5 add
Enter deionized water, high pressure homogenization method 5min, extracts pressure 10Mpa, after extracting solution is centrifuged, with the microfiltration membranes of 600nm
Filtering, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
Propane diols dissolving, filtering, be made Chinese medicine composition extract.
The preparation of 12 Chinese medicine composition of embodiment (XII)
The Chinese medicine of Chinese mesona herb 19%, centella 15%, radix scutellariae 15%, wild chrysanthemum 1% and glycyrrhiza glabra 50% will be included
Composition material crushes, and is uniformly mixed, is placed in high pressure homogenizer after being sieved with 10 mesh sieve, is 1 by feed liquid mass ratio:5 add
Enter deionized water, high pressure homogenization method 5min, extracts pressure 5Mpa, after extracting solution is centrifuged, with the microfiltration membranes mistake of 600nm
Filter, then concentrated with reverse osmosis membrane, the mass ratio for being concentrated into extracting solution and Chinese medicine is 1:1, add identical in quality with extracting solution
The dissolving of the mixed liquor of propane diols and butanediol, filtering, are made the extract of Chinese medicine composition.
Comparative example 1
Compared with Example 1, in addition to not containing Chinese mesona herb, Chinese medicine composition include centella 45%, radix scutellariae 21%,
Wild chrysanthemum 17% and glycyrrhiza glabra 17%, other preparation process are same as Example 1.
Comparative example 2
Compared with Example 1, in addition to not containing centella, Chinese medicine composition include Chinese mesona herb 17%, radix scutellariae 45%,
Wild chrysanthemum 21% and glycyrrhiza glabra 17%, other preparation process are same as Example 1.
Comparative example 3
Compared with Example 1, in addition to not containing radix scutellariae, Chinese medicine composition include Chinese mesona herb 17%, centella 17%,
Wild chrysanthemum 45% and glycyrrhiza glabra 21%, other preparation process are same as Example 1.
Comparative example 4
Compared with Example 1, in addition to not containing wild chrysanthemum, Chinese medicine composition includes Chinese mesona herb 21%, centella
17%th, radix scutellariae 17% and glycyrrhiza glabra 45%, other preparation process are same as Example 1.
Comparative example 5
Compared with Example 1, in addition to not containing glycyrrhiza glabra, Chinese medicine composition includes Chinese mesona herb 45%, centella
21%th, radix scutellariae 17% and wild chrysanthemum 17%, other preparation process are same as Example 1.
Comparative example 6
Chinese mesona herb 100% is taken to prepare Chinese medical extract, specific preparation process is same as Example 1.
Comparative example 7
Centella 100% is taken to prepare Chinese medical extract, specific preparation process is same as Example 1.
Comparative example 8
Radix scutellariae 100% is taken to prepare Chinese medical extract, specific preparation process is same as Example 1.
Comparative example 9
Wild chrysanthemum 100% is taken to prepare Chinese medical extract, specific preparation process is same as Example 1.
Comparative example 10
Glycyrrhiza glabra 100% is taken to prepare Chinese medical extract, specific preparation process is same as Example 1.
Comparative example 11
Extracting liquorice acid dipotassium powder is soluble in water, is configured to 1% dipotassium glycyrrhizinate solution.
The external research for suppressing hyaluronidase activity
Hyaluronidase is the principal element to cause allergic reaction.At the beginning of anaphylactogen during subintrusion body, body can produce anti-
Body IgE, when anaphylactogen invades body again, meeting be combined with the IgE antibody of mast cell surface, so as to start activation signals, released
Histamine is put, histamine produces allergic reaction under the activation of hyaluronidase.Therefore the activity for suppressing hyaluronidase can be with
Effectively prevent anaphylactoid generation.Hyaluronidase has strong correlation with inflammatory reaction, allergic reaction.
The external experiment for suppressing hyaluronidase activity uses Elson-Morgan methods, comprises the following steps that：
By the 2.5mmol/L CaCl of 0.1mL2Add in the hyaluronidase (600U/mL) of 0.5mL, 37 DEG C of insulations
20min；Add sample liquid 0.5mL, 37 DEG C of insulation 20min；Add 0.4mg/mL Sodium Hyaluronates 2mL, 37 DEG C of insulation 40min；
Acetylacetone,2,4-pentanedione solution 1mL is added, is placed in boiling water bath and heats 15min, cools down 5mim with frozen water immediately；It is eventually adding Ehrlich
Reagent 1.0mL, room temperature place 60min colour developings, absorbance are measured at 530nm.
Sample is to the measure and calculation formula of hyaluronic acid enzyme inhibition rate：
Hyaluronic acid enzyme inhibition rate (%)=[(A-B)-(C-D)]/(A-B) × 100%
A is represented in formula：The absorbance (replacing sample liquid with acetate buffer solution) of contrast solution；B is represented：Compare blank solution
Absorbance (replacing sample liquid and enzyme liquid with acetate buffer solution)；C is represented：The absorbance of sample liquid；D is represented：Sample blank liquid
Absorbance (replacing enzyme liquid with hac buffer).
Experimental result is as shown in table 1：
Influence of 1 sample of table to hyaluronidase activity
From embodiment 1-12 contrast from the point of view of, when Chinese medicine composition include Chinese mesona herb 25%, centella 25%, radix scutellariae 20%,
When wild chrysanthemum 20% and glycyrrhiza glabra 10%, there is highest hyaluronic acid inhibiting rate, up to 90.05%, centella, radix scutellariae,
Under the assisting of wild chrysanthemum and glycyrrhiza glabra, the effect of Chinese mesona herb can play optimal clearing heat and promoting diuresis, cool blood relieving summer-heat, make skin
Resistance strengthens, and allergic symptom is alleviated.Each embodiment reaches more than 80% to the inhibiting rate of hyaluronidase, hence it is evident that excellent
In comparative example 1-11.
In the case where extraction process is identical, compared with Example 1, monarch drug in a prescription Chinese mesona herb is lacked in comparative example 1, remaining four kinds
Component significantly reduces the inhibiting rate of hyaluronidase, and only 48.58%, antiallergic hydraulic performance decline, illustrates in this Chinese medicine composition
Middle Chinese mesona herb plays important antiallergic effect；Comparative example 2-5 lacks centella, radix scutellariae, wild chrysanthemum and glycyrrhiza glabra respectively, prepares
Chinese medicine composition the inhibiting rate of hyaluronidase is substantially reduced；Comparative example 6-11 only includes unit traditional Chinese medicinal components, to transparent
The inhibiting rate of matter acid enzyme is less than 60%, illustrates that this five kinds of Chinese traditional medicine compositions have synergistic effect together, can more preferably play antiallergic work(
Effect.It follows that the component of the Chinese medicine composition is indispensable, the traditional Chinese medicine of the five flavours of compounding, which cooperates, plays optimal antiallergic
Maintenance effect.
Erythrocyte hemolysis is tested
Erythrocyte hemolysis experiment is the alternative of lagophthalmos stimulation test (Draize test), and basic principle is to pass through survey
Determine hemoglobin stripping quantity and denaturation degrees carry out damage of the evaluating chemical product to ocular tissue's cell.Mainly pass through red blood cell in the world
Hemolytic experiment evaluates the irritation of cosmetics and its raw material to eye.
The Chinese medicine composition that this experiment prepares embodiment 1-12 carries out erythrocyte hemolysis experiment, and according to European alternative
The test method and grade scale (ECVAM.ECVAM DB-ALM of the erythrocyte hemolysis experiment of method authentication center (ECVAM):
INVITOX Protocol,Red blood cells test system.INVITOX No.37.Ispra.Italy:ECVAM,
1994) irritation of Chinese medicine composition is evaluated.Table 2 is ECVAM to the irritating grade scale of cosmetics.
The irritating grade scale of cosmetics of 2 ECVAM of table
| L/D | Classification |
| ＞ 100 | It is nonirritant |
| 10 ＜ L/D≤100 | Microstimulation |
| 1 ＜ L/D≤10 | Slight stimulation |
| 0.1 ＜ L/D≤1 | Moderate irritation |
| L/D≤0.1 | Severe irritation |
Table 3 is the erythrocyte hemolysis experimental result of each sample.
The erythrocyte hemolysis experimental result of 3 each sample of table
| Numbering | L/D | Evaluation |
| Embodiment 1 | 783.72 | It is nonirritant |
| Embodiment 2 | 721.55 | It is nonirritant |
| Embodiment 3 | 717.23 | It is nonirritant |
| Embodiment 4 | 702.82 | It is nonirritant |
| Embodiment 5 | 655.49 | It is nonirritant |
| Embodiment 6 | 642.59 | It is nonirritant |
| Embodiment 7 | 638.24 | It is nonirritant |
| Embodiment 8 | 594.83 | It is nonirritant |
| Embodiment 9 | 585.42 | It is nonirritant |
| Embodiment 10 | 579.63 | It is nonirritant |
| Embodiment 11 | 571.26 | It is nonirritant |
| Embodiment 12 | 566.35 | It is nonirritant |
As can be seen from Table 3, the L/D values of embodiment 1-12 are equal>100, illustrate Chinese medicine composition in nonirritant.Therefore,
The Chinese medicine composition is safe, non-stimulated to skin, belongs to natural, non-stimulated raw material, can trust addition in cosmetics.
13 Shu Min toners of embodiment and preparation method thereof
Table 4 show the Shu Min toner formulas containing Chinese medicine composition (I).
4 Shu Min toner formulas of table
| Material title | Mass fraction/% |
| Deionized water | Surplus |
| EDETATE SODIUM | 0.02 |
| Glycerine | 2.00 |
| Xanthans | 0.05 |
| Sodium Hyaluronate | 0.05 |
| Allantoin | 0.20 |
| Panthenol | 0.50 |
| Dipotassium glycyrrhizinate | 0.10 |
| Butanediol | 3.00 |
| Aloe extract | 1.00 |
| 1,2- hexylene glycols | 1.50 |
| Chinese medicine composition (I) | 10.00 |
The preparation method of Shu Min toners is as follows：
(1) xanthans, Sodium Hyaluronate are added in glycerine, are uniformly dispersed, it is spare；
(2) by EDETATE SODIUM, panthenol, allantoin, glycerine, xanthans, Sodium Hyaluronate, butanediol, 1,2- hexylene glycols, sweet
Oxalic acid dipotassium puts into water phase pot successively, is heated to 80 DEG C, stirring cools down to being completely dissolved；
(3) it is cooled to 40 DEG C, adds Chinese medicine composition (I), stirring is to being completely dissolved；
(4) after temperature is down to 35 DEG C, vacuum defoamation, examines the physical and chemical indexes such as color, smell, appearance, after the assay was approved
200 mesh filtering and dischargings.
14 Shu Min milky lotion of embodiment and preparation method thereof
Table 5 show the Shu Min milky lotion formulas containing Chinese medicine composition (II).
5 Shu Min milky lotion formulas of table
The preparation method of Shu Min milky lotion is as follows：
(1) oil phase raw material is put into oil phase pot, is warming up to 85 DEG C, stirring is to being completely dissolved；
(2) hyaluronic acid and xanthans are disperseed in advance in glycerine, aqueous phase substance is then put into water phase pot, is warming up to
85 DEG C, stirring is to being completely dissolved；
(3) lasting stirring, oil phase is slowly added in water phase, then with the speed emulsifying 5-10 of 4000-6000rpm
Minute, persistently stirred with the speed of 1000-2000rpm after emulsification and start to cool down；
(4) treat that temperature is cooled to 45 DEG C, add addition phase, with the speed emulsifying 2 minutes of 4000-6000rpm；
(5) after temperature is down to 35 DEG C, vacuum defoamation, examines the physical and chemical indexes such as color, smell, appearance, after the assay was approved
200 mesh filtering and dischargings.
Embodiment 15
Compared with embodiment 13, the additive amount of Chinese medicine composition (I) is 0.10%, and other conditions are identical with embodiment 13.
Embodiment 16
Compared with embodiment 14, the additive amount of Chinese medicine composition (II) is 40.00%, other conditions and 14 phase of embodiment
Together.
Skin closure patch test
The Shu Min skin care item of Example 13-16 and competing product (the commercially available milky lotion with antiallergic maintenance) carry out skin
Closure patch test.The female volunteers that 60 ages are chosen in the sensitive skin quality of 20-45 Sui carry out human efficiency's evaluation.
Volunteer's inner forearm draws 3 circles of patch device size respectively from top to bottom, and numbering is No. 1, No. 2, No. 3 respectively, and is taken pictures
Record.Filter paper is placed in spot examination device, suitable 10% SDS (lauryl sodium sulfate) is added dropwise, is pasted on No. 1 and No. 2
Place, No. 3 are control wells, place physiological saline.It is tested 5 it is small when after, remove patch, change of skin observed after half an hour, and take pictures
Record.The filter paper that dropwise addition there are the competing product of about 0.020mL is attached to No. 1 position, there are about 0.020mL embodiment skin care item by being added dropwise
Filter paper is attached to No. 2 positions, and No. 3 are blank control wells, places physiological saline.Light pressure is allowed to equably be pasted on subject's forearm
Inner side, continues 48h, removes patch, change of skin is observed after half an hour, and photograph to record.
Valuation officer evaluates repairing effect, and wherein highest is divided into 5, represents that obvious erythema, redness occurs in tested position
Phenomena such as, it is minimum to be divided into 1, represent that tested position recovers normal.
Experimental result is as shown in table 6：
6 subjects skin's reaction result of table
| Numbering | After SDS stimulates 5h | After sample repairs 48h |
| Embodiment 13 | 4.8 | 1.9 |
| Embodiment 14 | 4.7 | 1.8 |
| Embodiment 15 | 4.8 | 2.2 |
| Embodiment 16 | 4.9 | 2.3 |
| Competing product | 4.8 | 3.5 |
As seen from the results in Table 6, the Shu Min skin care item of embodiment 13-16 are substantially excellent to repair ability, the antiphlogistic effects of skin
Yu Jingpin.
Fig. 1 tests representative graph for skin closure patch, wherein, Fig. 1 (a) is the normal skin of subject, and Fig. 1 (b) is
SDS stimulates the skin after 5h, it can be seen that No. 1 and No. 2 obvious erythema of position skins appearance, No. 3 position skins it is normal；Fig. 1
(c) to be repaired using the skin after skin care item 48h, No. 1 position using competing product, erythema is still more apparent, and No. 2 positions use real
The Shu Min skin care item for applying example 14 are repaired, and erythema is substantially desalinated, and No. 3 position skins are normal.It follows that the addition present invention
The milky lotion of Chinese medicine composition has the maintenance effect of releiving better than commercial product, skin resilience can be lifted, to skin
Play a protective role.
In conclusion Chinese medicine composition prepared by the present invention has：(1) antiallergic：The Chinese medicine composition of preparation it is transparent
Matter acid inhibiting rate is more than 80%, and up to 90.05%, having improves skin exquisiteness degree, enhancing skin resistance, alleviates
The effect of allergic symptom, salubrious skin；(2) it is nonirritant：Tested by erythrocyte hemolysis, the Chinese medicine composition prepared
L/D values are equal>100, in nonirritant；(3) prosthetic：The skin care item of the Chinese medicine composition prepared added with the present invention have notable
Releive, maintenance, the effect of calmness, can substantially desalinate erythema, red and swollen phenomenon, there is lifting skin resilience, comprehensive adjust
Manage the effect of skin state.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., all fall within protection scope of the present invention and the open scope.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that the Chinese medicine composition is mainly prepared by the following raw material by weight percentage
Obtain：Chinese mesona herb 1-50%, centella 1-50%, radix scutellariae 1-50%, wild chrysanthemum 1-50% and glycyrrhiza glabra 1-50%, wherein institute
The sum of percentage by weight of Chinese medicine composition each component raw material is stated as 100%.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition is main by weight percentage
It is prepared by the following raw material：Chinese mesona herb 20-50%, centella 15-40%, radix scutellariae 10-30%, wild chrysanthemum 10-30% and light
Fruit radix glycyrrhizae 10-30%, wherein the sum of percentage by weight of the Chinese medicine composition each component raw material is 100%.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that the Chinese medicine composition is by weight percentage
Mainly it is prepared by the following raw material：Chinese mesona herb 25-40%, centella 20-25%, radix scutellariae 15-20%, wild chrysanthemum 10-20%
With glycyrrhiza glabra 10-15%, wherein the sum of percentage by weight of the Chinese medicine composition each component raw material be 100%.
4. Chinese medicine composition according to any one of claim 1-3, it is characterised in that the Chinese medicine composition is by weight
Percentage is mainly prepared by the following raw material：Chinese mesona herb 25%, centella 25%, radix scutellariae 20%, wild chrysanthemum 20% and light fruit
Radix glycyrrhizae 10%.
A kind of 5. method for preparing the Chinese medicine composition as any one of claim 1-4, it is characterised in that including following step
Suddenly：
(1) pre-process：Chinese medicine composition each component raw material is crushed, is uniformly mixed after sieving；
(2) homogeneous extracts：Chinese medicinal granule after crushing is placed in high pressure homogenizer, adds deionized water, high pressure homogenization method；
(3) after extracting solution is centrifuged, concentrate with micro-filtrate membrane filtration, then with reverse osmosis membrane, filtered after adding solvent dissolving,
The Chinese medicine composition is prepared.
6. according to the method described in claim 5, it is characterized in that, the mesh number of step (1) described sieving is 10-100 mesh, preferably
For 80 mesh.
7. the method according to claim 5 or 6, it is characterised in that step (2) Chinese medicinal granule and the deionized water
Feed liquid mass ratio be 1:(5-30), is preferably 1:25；
Preferably, the high-pressure homogeneous extraction time is 5-25min, is preferably 20min；
Preferably, the high-pressure homogeneous extraction pressure is 5-60Mpa, is preferably 45Mpa.
8. according to claim 5-7 any one of them methods, it is characterised in that the aperture of step (3) described microfiltration membranes is
100-600nm, is preferably 250nm；
Preferably, the quality of the extracting solution after the concentration and the gross mass of the Chinese medicine composition each component raw material of step (1)
Mass ratio is (0.5-10):1, it is preferably 1:1；
Preferably, the solvent is butanediol and/or propane diols；
Preferably, the amount of the solvent and the mass ratio of the amount of the extracting solution are (0.5-10):1, it is preferably 1:1.
9. a kind of Chinese medicine composition as any one of claim 1-4 is used to prepare the makeup for the maintenance that has effects that to releive
Product；
Preferably, the additive amount of the Chinese medicine composition is 0.1-40.0%, is preferably 10.0-15.0%.
10. cosmetics according to claim 9, it is characterised in that the formulation of the cosmetics includes：Aqua, emulsion, spray
In mist agent, cream, elite or facial mask any one or at least two combination, be preferably aqua and/or emulsion.
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| CN113288835A (en) * | 2021-05-20 | 2021-08-24 | 科丝美诗(中国)化妆品有限公司 | Traditional Chinese medicine composition for relieving and repairing and preparation method and application thereof |
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| CN114099390B (en) * | 2021-12-22 | 2023-05-16 | 广东工业大学 | Mask liquid containing mesona chinensis benth extract and preparation method thereof |
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Address after: No.18, Nanyun 1st Road, Guangzhou Development Zone, Guangdong 510000 Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: No.18, Nanyun 1st Road, Guangzhou Development Zone, Guangdong 510000 Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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