CN107793478A - 一种抗cd19抗体及其制备方法和用途 - Google Patents
一种抗cd19抗体及其制备方法和用途 Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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Abstract
Description
克隆号 | EC50(A268) |
3G11 | 0.07 |
阳性对照(FMC63WT) | 7.14 |
阴性对照(SS1WT) | 19.44 |
克隆 | A268 |
3G11 | 6.92 |
阳性对照(FMC63WT) | 71.44 |
阴性对照(SS1WT) | 77.76 |
克隆号 | EC50(A268) | Emax(最大抑制率) |
3G11 | 1.26 | 53% |
阳性对照(FMC63WT) | >5.4 | 20% |
阴性对照(SS1WT) | >5.4 | 19% |
WT | 3G11 | |
Koff(1/s) | 1.06×10-3 | 1.21×10-3 |
克隆号 | 扩增倍数 | 感染效率 |
WT | 23 | 25% |
3G11 | 35 | 26% |
细胞因子变化倍数 | CTL019+Raji/CTL019 | 3G11+Raji/3G11 |
IFNγ | 13.96 | 59.29 |
TNFα | 39 | 44 |
IL6 | 6 | 4 |
IL2 | 103.75 | 104.80 |
WT | 3G11 | |
EC50 | 1.758 | 1.791 |
Claims (16)
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CN202310233184.5A Pending CN117024588A (zh) | 2016-09-06 | 2017-05-19 | 抗cd19抗体在制备白血病治疗药物中的用途 |
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