CN107737297A - 一种治疗腰椎骨质增生的药物及其制备方法 - Google Patents
一种治疗腰椎骨质增生的药物及其制备方法 Download PDFInfo
- Publication number
- CN107737297A CN107737297A CN201711344718.2A CN201711344718A CN107737297A CN 107737297 A CN107737297 A CN 107737297A CN 201711344718 A CN201711344718 A CN 201711344718A CN 107737297 A CN107737297 A CN 107737297A
- Authority
- CN
- China
- Prior art keywords
- grams
- root
- impurity
- dry
- picked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
本发明公开了一种治疗腰椎骨质增生的药物及其制备方法,其主要是由白芍、甘草、木瓜、威灵仙、桃仁、红花、续断、桑寄生、牛膝、当归、川芎、赤芍、熟地黄、桂枝、乌蛇、乳香、没药、丹参、苏木、鸡血藤、赤芍、砂仁、独活、刺蒺藜按一定重量配比制备而成,本发明药物具有祛风通络,消痰散癖,活血通经,去瘀止痛,补肝肾,强筋骨的功能,用于治疗腰椎骨质增生见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗腰椎骨质增生的药物及其制备方法,属中药领域。
背景技术
腰椎骨质增生主要病因与关节软骨的退行性病变有关,腰椎的骨质增生是因为中年以后,腰椎骨质增生随着年龄的增大,机体各组织细胞的生理功能也逐渐衰退老化,退化的椎间盘逐渐失去水份,椎间隙变窄,纤维环松弛向周边膨出,椎体不稳,纤维环在椎体边缘外发生撕裂,导致髓核之突出,将后纵韧带的骨膜顶起,其下面产生新骨,形成骨刺或骨质增生。也有人认为椎间盘退变萎缩后,椎体向前倾斜,椎体前缘在中线为前纵韧带所阻,两侧骨膜掀起,骨膜下形成新骨。另外,局部的受压因素也是引起骨质增生的主要因素。由于西药治疗副作用大,因此人们对有效治疗腰椎骨质增生的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗腰椎骨质增生的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗腰椎骨质增生的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择白芍、甘草、木瓜、威灵仙、桃仁、红花、续断、桑寄生、牛膝、当归、川芎、赤芍、熟地黄、桂枝、乌蛇、乳香、没药、丹参、苏木、鸡血藤、赤芍、砂仁、独活、骨碎补、淫羊藿、肉苁蓉、莱菔子、刺蒺藜进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗腰椎骨质增生。其中选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用木瓜是因为其性味酸,温,入肝、脾经,有平肝和胃,去湿舒筋的功能,治吐泻转筋,湿痹,脚气,水肿,痢疾。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用续断是因为其性味苦辛,微温,入肝、肾经,有补肝肾,续筋骨,调血脉的功能,治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。选用桑寄生是因为其性味苦甘,平,入肝、肾经,有补肝肾,强筋骨,除风湿,通经络,益血,安胎的功能,治腰膝酸痛,筋骨痿弱,偏枯,脚气,风寒湿痹,胎漏血崩,产后乳汁不下。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肥拘挛,痿痹。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用乌蛇是因为其性味甘咸,平,入肺、脾二经,有祛风湿,通经络的功能,治风湿顽痹,肌肤不仁,骨、关节结核,风疹疥癣,麻风,破伤风,小儿麻痹症。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用苏木是因为其性味甘、咸、平,有行血,破瘀,消肿,止痛的功能,治妇人血气心腹痛,经闭,产后瘀血,胀痛喘急,痢疾,破伤风。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用砂仁是因为其性味辛,温,入脾、胃经,有行气调中,和胃、醒脾的功能,治腹痛痞胀,胃呆食滞,噎隔呕吐,寒泻冷痢,妊娠胎动。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。选用骨碎补是因为其性味苦,温,入肝、肾经,有补肾,活血,止血的功能,治肾虚久泻及腰痛,风湿痹痛,齿痛,耳鸣,跌打闪挫、骨伤,阑尾炎,斑秃,鸡眼。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用肉苁蓉是因为其性味甘酸咸,温,入肾、大肠经,有补肾,益精,润燥,清肠的功能,治男子阳痿,女子不孕,带下,血崩,腰膝冷痛,血枯便秘。选用莱菔子是因为其性味辛甘,平,入肺、胃经,有下气定喘,消食化痰的功能,治咳嗽痰喘,食积气滞,胸闷腹胀,下痢后重。选用刺蒺藜是因为其性味苦辛,温,入肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿翳,胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
白芍15-20克,甘草5-15克,木瓜5-15克,威灵仙10-20克,桃仁5-15克,红花5-15克,续断5-15克,桑寄生25-35克,牛膝10-20克,当归10-20克,川芎5-15克,赤芍10-14克,熟地黄10-14克,桂枝5-15克,乌蛇5-15克,乳香4-8克,没药5-15克,丹参10-20克,苏木4-8克,鸡血藤10-20克,赤芍5-15克,砂仁10-20克,独活10-20克,骨碎补15-25克,淫羊藿10-20克,肉苁蓉10-20克,莱菔子10-20克,刺蒺藜10-20克。
优选为:
白芍18克,甘草10克,木瓜10克,威灵仙15克,桃仁10克,红花10克,续断10克,桑寄生30克,牛膝15克,当归15克,川芎10克,赤芍12克,熟地黄12克,桂枝10克,乌蛇10克,乳香6克,没药10克,丹参15克,苏木6克,鸡血藤15克,赤芍10克,砂仁15克,独活15克,骨碎补20克,淫羊藿15克,肉苁蓉15克,莱菔子15克,刺蒺藜15克。
本发明药物的制备方法如下
一、备料
1、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
2、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
3、木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,趁热切片,日晒夜露,以由红转紫黑色为止;
4、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
5、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
6、红花:拣净杂质,除去茎叶、蒂头,晒干;
7、续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
8、桑寄生:用水洗净,润透,切段,晒干;
9、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
10、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
11、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
12、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
13、熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
14、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
15、乌蛇:乌蛇砍去头,用黄酒闷透后,取出,除去皮骨晒干,每乌蛇100斤,用黄酒20-25斤;
16、乳香:拣去砂子杂质;
17、没药:拣去杂质,打成碎块;
18、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
19、苏木:取原药材,锯成短段,再劈成碎片或镑片;
20、鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
21、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
22、砂仁:拣去杂质及果壳,捣碎;
23、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
24、骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
25、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
26、肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次,如系咸苁蓉,泡尽盐分,润透,纵向切片,晒干;
27、莱菔子:簸去杂质,漂净泥土,捞出,晒干,用时捣碎;
28、刺蒺藜:漂去泥沙,除净残留的硬刺。
二、制备
1、将所述重量的白芍、甘草、木瓜、威灵仙、桃仁、红花、续断、桑寄生、牛膝、当归、川芎、赤芍、熟地黄、桂枝、乌蛇、乳香、没药、丹参、苏木、鸡血藤、赤芍、砂仁、独活、骨碎补、淫羊藿、肉苁蓉、莱菔子、刺蒺藜放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中威灵仙有祛风湿,通经络,消痰涎,散癖积的功能为君药;红花有活血通经,去瘀止痛的功能;桑寄生有补肝肾,强筋骨,除风湿,通经络的功能,二者为臣药,三味药共同发挥祛风通络,消痰散癖,活血通经,去瘀止痛,补肝肾,强筋骨的作用,治疗腰椎骨质增生效力全面,且以祛风通络,消痰散癖,活血通经,去瘀止痛为主可治本,川芎有行气开郁,祛风燥湿,活血止痛的功能为佐药,乌蛇有祛风湿,通经络的功能为使药,与下余诸药是治标。
本发明药物具有祛风通络,消痰散癖,活血通经,去瘀止痛,补肝肾,强筋骨的功能,用于治疗腰椎骨质增生,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治腰椎骨质增生门诊患者共33例。
2、诊断标准
腰椎骨质增生是一种慢性、进展性关节病变,以腰三、腰四最为常见。如压迫坐骨神经可引起坐骨神经炎,出现患肢剧烈麻痛、灼痛、抽痛、串痛、向整个下肢放射。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用5个疗程。
4、疗效评定标准
显效:腰椎骨质增生症状消失,体质恢复正常,随访一年无复发;
好转:腰椎剧痛、灼痛、串痛减轻,骨质增生症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗腰椎骨质增生患者33例,结果显效28例,显效率为84.8%,好转3例,好转率为9.1%,无效2例,总有效率为93.9%。
Claims (3)
1.一种治疗腰椎骨质增生的药物,其特征在于:它是由下列重量范围内的原料药制成:
白芍15-20克,甘草5-15克,木瓜5-15克,威灵仙10-20克,桃仁5-15克,红花5-15克,续断5-15克,桑寄生25-35克,牛膝10-20克,当归10-20克,川芎5-15克,赤芍10-14克,熟地黄10-14克,桂枝5-15克,乌蛇5-15克,乳香4-8克,没药5-15克,丹参10-20克,苏木4-8克,鸡血藤10-20克,赤芍5-15克,砂仁10-20克,独活10-20克,骨碎补15-25克,淫羊藿10-20克,肉苁蓉10-20克,莱菔子10-20克,刺蒺藜10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
白芍18克,甘草10克,木瓜10克,威灵仙15克,桃仁10克,红花10克,续断10克,桑寄生30克,牛膝15克,当归15克,川芎10克,赤芍12克,熟地黄12克,桂枝10克,乌蛇10克,乳香6克,没药10克,丹参15克,苏木6克,鸡血藤15克,赤芍10克,砂仁15克,独活15克,骨碎补20克,淫羊藿15克,肉苁蓉15克,莱菔子15克,刺蒺藜15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(2)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(3)木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,趁热切片,日晒夜露,以由红转紫黑色为止;
(4)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(5)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(6)红花:拣净杂质,除去茎叶、蒂头,晒干;
(7)续断:洗净泥沙,除去残留根头,润透后切片晒干,筛去屑;
(8)桑寄生:用水洗净,润透,切段,晒干;
(9)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(10)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(11)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(12)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(13)熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
(14)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(15)乌蛇:乌蛇砍去头,用黄酒闷透后,取出,除去皮骨晒干,每乌蛇100斤,用黄酒20-25斤;
(16)乳香:拣去砂子杂质;
(17)没药:拣去杂质,打成碎块;
(18)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(19)苏木:取原药材,锯成短段,再劈成碎片或镑片;
(20)鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
(21)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(22)砂仁:拣去杂质及果壳,捣碎;
(23)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(24)骨碎补:去净泥砂杂质,洗净,稍浸泡,润透,切片,晒干;
(25)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(26)肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次,如系咸苁蓉,泡尽盐分,润透,纵向切片,晒干;
(27)莱菔子:簸去杂质,漂净泥土,捞出,晒干,用时捣碎;
(28)刺蒺藜:漂去泥沙,除净残留的硬刺;
(二)制备
(1)将所述重量的白芍、甘草、木瓜、威灵仙、桃仁、红花、续断、桑寄生、牛膝、当归、川芎、赤芍、熟地黄、桂枝、乌蛇、乳香、没药、丹参、苏木、鸡血藤、赤芍、砂仁、独活、骨碎补、淫羊藿、肉苁蓉、莱菔子、刺蒺藜放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711344718.2A CN107737297A (zh) | 2017-12-15 | 2017-12-15 | 一种治疗腰椎骨质增生的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711344718.2A CN107737297A (zh) | 2017-12-15 | 2017-12-15 | 一种治疗腰椎骨质增生的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107737297A true CN107737297A (zh) | 2018-02-27 |
Family
ID=61240029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711344718.2A Withdrawn CN107737297A (zh) | 2017-12-15 | 2017-12-15 | 一种治疗腰椎骨质增生的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107737297A (zh) |
-
2017
- 2017-12-15 CN CN201711344718.2A patent/CN107737297A/zh not_active Withdrawn
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102805843B (zh) | 一种治疗胃痛的药物及其制备方法 | |
CN106924476A (zh) | 一种治疗视网膜中央静脉阻塞的药物及其制备方法 | |
CN107737297A (zh) | 一种治疗腰椎骨质增生的药物及其制备方法 | |
CN106902343A (zh) | 一种治疗坐骨神经痛的药物及其制备方法 | |
CN106620363A (zh) | 一种治疗阑尾炎的药物及其制备方法 | |
CN106492125A (zh) | 一种治疗冠心病的药物及其制备方法 | |
CN106798837A (zh) | 一种治疗虹膜睫状体炎的药物及其制备方法 | |
CN105288422A (zh) | 一种用于治疗腹绞痛综合征的中药制剂及制备方法 | |
CN105535869A (zh) | 一种可有效治疗噎嗝病的中药组合物及其制备方法 | |
CN107737293A (zh) | 一种治疗女性不孕症的药物及其制备方法 | |
CN106619995A (zh) | 一种治疗腰椎间盘突出症的药物及其制备方法 | |
CN107496897A (zh) | 一种治疗肾盂肾炎的药物及其制备方法 | |
CN106798910A (zh) | 一种治疗痛经的药物及其制备方法 | |
CN107693749A (zh) | 一种治疗四肢冰冷的药物及其制备方法 | |
CN108452258A (zh) | 一种治疗心绞痛的药物及其制备方法 | |
CN107823530A (zh) | 一种治疗遗精的药物及其制备方法 | |
CN108355094A (zh) | 一种治疗肾癌的药物及其制备方法 | |
CN106880791A (zh) | 一种治疗女性不孕症的药物及其制备方法 | |
CN108420947A (zh) | 一种治疗乳腺癌的药物及其制备方法 | |
CN106822791A (zh) | 一种治疗甲亢的药物及其制备方法 | |
CN108524867A (zh) | 一种治疗肝癌的药物及其制备方法 | |
CN107961304A (zh) | 一种治疗老年白内障的药物及其制备方法 | |
CN107715021A (zh) | 一种治疗前列腺肥大的药物及其制备方法 | |
CN108785607A (zh) | 一种治疗类风湿关节炎的药物及其制备方法 | |
CN106620545A (zh) | 一种治疗胆结石的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180227 |
|
WW01 | Invention patent application withdrawn after publication |