CN107737252A - A kind of Chinese medicine composition for treating bile reflux gastritis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating bile reflux gastritis and preparation method thereof Download PDFInfo
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- CN107737252A CN107737252A CN201711281930.9A CN201711281930A CN107737252A CN 107737252 A CN107737252 A CN 107737252A CN 201711281930 A CN201711281930 A CN 201711281930A CN 107737252 A CN107737252 A CN 107737252A
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating bile reflux gastritis and preparation method thereof.The Chinese medicine composition is to be prepared from the following materials：The achene of Siberian cocklebur, rhizoma atractylodis, rhizoma Gastrodiae, calamus, semen brassicae, the root of kudzu vine, radix polygonati officinalis, Ligusticum wallichii, Chinese yam, reticulate millettia, champion bauhinia stem, the root of Dahurain angelica, peppermint oil, indigo naturalis.The Chinese medicine composition has good therapeutic effect to bile reflux gastritis.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating bile reflux gastritis and its preparation
Method.
Background technology
Bile reflux gastritis is the name of disease of modern medicine, its typical clinical manifestations, such as gastral cavity pain, swollen ruffian, heartburn, mouth
It is bitter, vomiting is bitter, heating, noisy, indigestion and loss of appetite, the even symptom feature such as melena, with " epigastric pain " in motherland medical science, " ruffian card ", " tell
The description such as acid ", " noisy ", " cholemesia ", " ehat in the gallbladder channel " has similar part more.It is various in the pathogenic process of bile reflux gastritis
Factor harasses liver and gall, or puzzlement stomach internal organs, causes liver-stomach disharmony, mechanism of qi superinverse, causes bile with mechanism of qi superinverse, in stomach, to be to cause
This pathogenetic most important pathomechanism.
It is damp and hot be its main pathological product because courage stomach Qi is inverse, weakness of the spleen and the stomach, transporting is powerless, and the defeated cloth of bringing about the spread of body fluid is not normal, stays
And metaplasia is wet turbid, with the passing of time change heat, heat symptoms caused by an exopathgen it is wet it is turbid accumulate burnt in resistance, stomach internal organs is stagnant full, and it is inverse that stomach takes courage, disease feel sick dislike bitter, gastral cavilty is scorching hot,
The damp-heat blocking in the body such as feeling of fullness as.Clinic observes that this patient has yellow or faint yellow bile sample duodenum by means of gastroscope
Liquid is interrupted from pylorus show bubble or spurting or continuously pours in gastral cavity.The muddy liquid holdup stomach of a large amount of yellow or yellow green
Chamber, the theory of traditional Chinese medical science for damp and hot retardance taste provide best evidence.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating bile reflux gastritis；
It is a further object of the present invention to provide a kind of Chinese medicine composition preparation method for treating bile reflux gastritis.
The purpose of the present invention is realized by following technical scheme：
The Chinese medicine composition for the treatment of bile reflux gastritis of the present invention, it is prepared by the raw material including following parts by weight
Form：
Achene of Siberian cocklebur 5-20 parts, rhizoma atractylodis 3-15 parts, rhizoma Gastrodiae 5-20 parts, calamus 20-40 parts, semen brassicae 5-20 parts, root of kudzu vine 15-30 parts,
Radix polygonati officinalis 5-20 parts, Ligusticum wallichii 15-30 parts, Chinese yam 5-20 parts, reticulate millettia 5-20 parts, champion bauhinia stem 15-30 parts, root of Dahurain angelica 20-40 parts, peppermint
Oily 5-20 parts, indigo naturalis 5-20 parts.
Preferably, it is to be prepared by the raw material including following parts by weight：
Achene of Siberian cocklebur 10-15 parts, rhizoma atractylodis 5-10 parts, rhizoma Gastrodiae 10-15 parts, calamus 25-35 parts, semen brassicae 10-15 parts, root of kudzu vine 20-25
Part, radix polygonati officinalis 10-15 parts, Ligusticum wallichii 20-25 parts, Chinese yam 10-15 parts, reticulate millettia 10-15 parts, champion bauhinia stem 20-25 parts, root of Dahurain angelica 25-35
Part, peppermint oil 10-15 parts, indigo naturalis 10-15 parts.
More excellent, it is to be prepared by the raw material including following parts by weight：
12 parts of the achene of Siberian cocklebur, 8 parts of rhizoma atractylodis, 12 parts of rhizoma Gastrodiae, 30 parts of calamus, 12 parts of semen brassicae, 23 parts of the root of kudzu vine, 12 parts of radix polygonati officinalis, Ligusticum wallichii 23
Part, 12 parts of Chinese yam, 12 parts of reticulate millettia, 23 parts of champion bauhinia stem, 30 parts of the root of Dahurain angelica, 12 parts of peppermint oil, 12 parts of indigo naturalis.
It is the crude drug source of Chinese medicine composition of the present invention below：
The achene of Siberian cocklebur, it is feverfew Siberian cocklebur Xanthium sibiricum Patr. fruit of the drying and ripening with involucre.Autumn
Harvest, dry during fruit maturation, remove the impurity such as stalk, leaf.Herb can also be used as medicine.It is pungent, bitter, temperature；It is poisonous.Return lung passes through.Wind-dispelling solution
Table, declare clearing the nasal passage, damp dispelling and pain relieving.For anemofrigid headache, nasosinusitis runny nose, rubella itch, arthritis with fixed pain caused by dampness contraction.Controlled in main expel pathogenic wind from the body surface
While main symptom, specially work in clearing the nasal passage, the obstinate accompanying symptoms in this exterior syndrome can be released, it can also damp dispelling and pain relieving, treat diseases caused by external factors
Chill and folder damp evil are stranded the card of resistance.
Rhizoma atractylodis：This product is feverfew Atractylis lancea Atractylodes lancea（Thunb.）Or Atractylis chinensis DC.
Atractylodes chinensis （DC.）Koidz. dry rhizome.Spring, the excavation of season in autumn two, remove silt, dry, hit
Remove fibrous root.【Nature and flavor】It is pungent, bitter, temperature.【Channel tropism】Returns spleen, stomach, Liver Channel.【Major function】It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.With
In abdominal fullness and distention, diarrhea, oedema, tinea pedis Wei lame, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia.
Rhizoma Gastrodiae, it is orchid rhizoma Gastrodiae Gastrodia elata Blume. dry tuber.It is sweet, put down.Return liver warp.It is flat
Liver Inflammation Zhijing.For dizziness of having a headache, extremity numbness, child convulsion, epilepsy clonus, lockjaw.
Calamus：Latin literary fame Acorus calamus. plant kingdoms；Angiospermae；Monocotyledonae；Arales；
Araeceae；Acorus；Calamus kind.Can for ward off it is dirty have one's ideas straightened out, a surname's gas is by phlegm, removing toxic substances, desinsection.Control demented, frightened epilepsy, coma due to phlegm syncope,
Wind-cold-dampness arthralgia, a mouthful fulminant dysentery of keeping silent, external application ulcer mange.Have one's ideas straightened out, resolving sputum, stomach invigorating.For epilepsy, phlegm febrile convulsion, that chest and abdomen are swollen is vexed, chronic
Bronchitis.
Semen brassicae：Alias hot food, Latin literary fame Semen sinapis. 1 year or biennial plant sinapsis alba Sinapis
Alba L. dry mature seed.《Book on Chinese herbal medicine must be matched somebody with somebody》：" enter meridian of Hand-TAI YIN." warm lung slit phlegm profit gas, dissipating bind are removed obstruction in channels to relieve pain.Cure mainly
Reduces phlegm by drink；Mass dissipating and swelling eliminating.Main cough and phlegm；Fullness in the chest and hypochondriac pain；Extremity numbness；Painful swelling of joints；Multiple abscess with damp phlegm；Cloudy subcutaneous ulcer pyogenic infections.Control
Acute mastitis, breast cancer, mammary gland pain, tuberculosis, phlegm and retained fluid cough and asthma, fullness in chest and hypochondrium pain, gastric disorder causing nausea vomiting, aphasia from apoplexy, limbs numbness pain is numb,
Tinea pedis, cloudy subcutaneous ulcer, pyogenic infections, treating swelling and pain by traumatic injury.For asthma due to excessive phlegm cough of trembling with fear, distending pain in the chest and hypochondrium, the stagnant channels and collaterals of phlegm, joint numbness, pain, phlegm wet stream
Note, cloudy subcutaneous ulcer pyogenic infections.
The root of kudzu vine is legume pueraria lobata Pueraria lobata（Willd.）Ohwi or sweet kudzu Pueraria
Thomsonii Benth. dry root.It is sweet, pungent, it is cool in nature.Returns spleen, stomach.The root of kudzu vine has relieving muscles diaphoresis, treating measles, solution
Heat is promoted the production of body fluid, the effect of Shengyang Zhixie.For fever caused by exogenous pathogens headache, Xiang Qiang, thirsty, measles without adequate eruption, diarrhea, hypertension neck pain
Deng disease.
Radix polygonati officinalis is liliaceous plant radix polygonati officinalis Polygonatum odoratum (Mill.) Druce dry rhizome.Taste
It is sweet, it is slightly cold, it is mild-natured.Return lung；Stomach.Nourishing yin to moisten dryness, promote the production of body fluid to quench thirst.Hinder for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, interior heat
Quench one's thirst.
Ligusticum wallichii, it is samphire Ligusticum wallichii Ligusticum chuanxiong Hort.（Or Ligusticum
wallichii Franch.）Dry rhizome.It is pungent, temperature.Return liver, courage, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menstruation
It is uncomfortable, closed dysmenorrhea, abdominal mass stomachache, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Chinese yam is Dioscoreaceae plant Chinese yam Dioscorea opposita Thumb. dry rhizome.It is sweet, put down.Returns spleen,
Lung, kidney channel.Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, band
Under, frequent micturition, abnormal heat is quenched one's thirst.
Reticulate millettia, it is legume spatholobus suberectus（Sargentodoxa cuneata, smoothfruit ventilago root and stem, three leaf reticulate millettias, nine layers of wind）Spatholobus
Suberectus Dunn drying rattan.It is bitter, sweet, temperature.Return liver and kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, blood
Empty sallow, paralysis and numbness, arthralgia pain due to rheumatism.
Champion bauhinia stem, it is the stem of legume Bauhinia champloni.Toil, put down, it is nontoxic.Wind-dispelling, stasis eliminatings, analgesic.Treating rheumatic ostealgia is controlled, is fallen
Play synthetism.
The root of Dahurain angelica, it is umbellate form section plant root of Dahurain angelica Angelica dahurica（Fisch.ex Hoffm.） Benth. et
Or Radix angelicae dahuricae Angelica dahurica Hook.f.（Fisch.ex Hoffm.） Benth.et Hook.f.
var.formosana（Boiss.）Shan et Yuan dry root.It is pungent, temperature.Return stomach, large intestine, lung channel.Wind dehumidifying is dissipated, it is sensible
Analgesic, detumescence and apocenosis.For cold headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, sore swell and ache curative.
Peppermint oil is the fresh cauline leaf of labiate peppermint or family peppermint through distillable aromatic oil.It is pungent, it is cool, it is nontoxic.
Dispelling wind, heat-clearing.Control affection of exogenous wind-heat, headache and hot eyes, pharyngalgia, dentalgia, skin pruritus.
Indigo naturalis, it is acanthaceous vegetable acanthaceous indigo Baphicacanthus cusia（Nees）Bremek., polygonaceae plant indigo plant
Polygonum tinctorium Ait. or cruciferae isatis Isatis indigotica Fort. leaf or cauline leaf
Processed obtained dried powder or agglomerate.It is salty, tremble with fear.Return liver warp.It is clearing heat and detoxicating, cool blood, arresting convulsion.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and this method is to use
It is prepared using the extraction of the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes.Specific preparation method is as follows：
Scheme one：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, 6- of each amount of water equivalent to medicinal material gross weight
12 times, each extraction time is 1-3 hours, merges extract solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C
1.15-1.20 clear cream, produces active component.
Scheme two：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is medicinal material
4-10 times of total amount, extraction time are 1-4 hours, merge extract solution, filtering, relative density is when filtrate is concentrated into 70-80 DEG C
1.15-1.20 clear cream, produces active component.
Scheme three：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times, each extraction time is 1-3 hours, merge extract solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C
1.15-1.20 clear cream, ethanol is added, it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, filtrate is concentrated into 70-80
DEG C when relative density be 1.10-1.25 medicinal extract, produce active component.
The Chinese medicine for the treatment of bile reflux gastritis of the present invention, can also match somebody with somebody with pharmaceutically acceptable carrier
Close, various oral formulations, such as tablet, capsule, oral liquid, syrup, mixture are made.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following：
Oral formulations：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1：Tablet
Scheme one is taken to add tablet and often use auxiliary material one of to the gained active component of scheme three, routinely production method is prepared into
Invention tablet.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 1：Capsule
Scheme one is taken to add capsule and often use auxiliary material, routinely production method is prepared into one of to the gained active component of scheme three
Capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 3：Syrup
Scheme one is taken to add syrup and often use auxiliary material, routinely production method is prepared into one of to the gained active component of scheme three
Syrup of the present invention.
Above-mentioned syrup often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
Method 4：Mixture
Scheme one is taken to add mixture and often use auxiliary material one of to the gained active component of scheme three, routinely production method is prepared into
Invention mixture.
Above-mentioned mixture often includes one of flavouring, preservative or whole with auxiliary material.
Method 5：Oral liquid
Scheme one is taken dissolving after-purification, concentration, to add oral liquid and often use auxiliary material, by normal one of to the gained active component of scheme three
Rule production method is prepared into oral liquid of the present invention.
Above-mentioned oral liquid often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
The applicant refers to modern pharmacological research achievement on the basis of Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation is studied, by for many years
Experiment, multiple formulations are screened, have found the Chinese medicine preparation that can effectively treat bile reflux gastritis.
Chinese medicine composition active ingredient disclosed in this invention is by the achene of Siberian cocklebur, rhizoma atractylodis, rhizoma Gastrodiae, calamus, semen brassicae, Pueraria lobota
Root, radix polygonati officinalis, Ligusticum wallichii, Chinese yam, reticulate millettia, champion bauhinia stem, the root of Dahurain angelica, peppermint oil, indigo naturalis are prepared.The mutually collaboration of full side, has and dredges
Courage and stomach, the effect of regulating functional activities of qi, have good therapeutic effect to bile reflux gastritis.
A kind of Chinese medicine composition for treating bile reflux gastritis provided by the invention has advantages below：
1st, composite preparation provided by the invention is safe and effective, has the function that thin courage and stomach, regulating functional activities of qi, to bile reflux
Gastritis has good therapeutic effect.
2nd, clinical tests prove that, patient is after traditional Chinese medicine composition for treating of the present invention, patients with bile reflux gastritis
Clinical symptoms have clear improvement, it is efficient up to 95.5%.
3rd, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, in good taste, and cost is low.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate
The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
The oral liquid of embodiment 1
Achene of Siberian cocklebur 0.5kg, rhizoma atractylodis 0.3kg, rhizoma Gastrodiae 0.5kg, calamus 2kg, semen brassicae 0.5kg, root of kudzu vine 1.5kg, radix polygonati officinalis 0.5kg,
Ligusticum wallichii 1.5kg, Chinese yam 0.5kg, reticulate millettia 0.5kg, champion bauhinia stem 1.5kg, root of Dahurain angelica 2kg, peppermint oil 0.5kg, indigo naturalis 0.5kg.Take
Whole medicinal materials, extracting in water 2 times, amount of water is respectively 10 times of medicinal material gross weight, 8 times twice, and extraction time is respectively 2 twice
Hour, 1 hour, merge extract solution, filtration, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, is added in medicinal extract
Auxiliary material mannitol, sorbic acid, water stir, and packing, oral liquid are made.
The tablet of embodiment 2
Achene of Siberian cocklebur 2kg, rhizoma atractylodis 1.5kg, rhizoma Gastrodiae 2kg, calamus 4kg, semen brassicae 2kg, root of kudzu vine 3kg, radix polygonati officinalis 2kg, Ligusticum wallichii 3kg, mountain
Medicine 2kg, reticulate millettia 2kg, champion bauhinia stem 3kg, root of Dahurain angelica 4kg, peppermint oil 2kg, indigo naturalis 2kg.Whole medicinal materials are taken, with 40% alcohol reflux
Extraction 3 times, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, 4 times, extraction time distinguish 3 hours, 2 hours, it is 1 small
When, merge extract solution, filtering, relative density is 1.25 medicinal extract when filtrate concentrates 60 DEG C, adds supplementary product starch, ethanol, talcum
Powder, tablet is made.
The granule of embodiment 3
Achene of Siberian cocklebur 1kg, rhizoma atractylodis 0.5kg, rhizoma Gastrodiae 1kg, calamus 2.5kg, semen brassicae 1kg, root of kudzu vine 2kg, radix polygonati officinalis 1kg, Ligusticum wallichii 2kg,
Chinese yam 1kg, reticulate millettia 1kg, champion bauhinia stem 2kg, root of Dahurain angelica 2.5kg, peppermint oil 1kg, indigo naturalis 1kg.Take whole medicinal materials, extracting in water 3
Secondary, amount of water is respectively equivalent to 12 times of medicinal material gross weight, 8 times, 6 times three times, each extraction time distinguish 3 hours, 2 hours, 1
Hour, merge extract solution, filtration, relative density is 1.20 clear cream when filtrate is concentrated into 70 DEG C, adds ethanol, makes the alcohol content be
40%, stand 24 hours, filtration, filtrate is concentrated into the medicinal extract that relative density when filtrate is concentrated into 70 DEG C is 1.10, add starch,
Dextrin, granulation, dry, whole grain produce.
The capsule of embodiment 4
Achene of Siberian cocklebur 1.5kg, rhizoma atractylodis 1kg, rhizoma Gastrodiae 1.5kg, calamus 3.5kg, semen brassicae 1.5kg, root of kudzu vine 2.5kg, radix polygonati officinalis 1.5kg,
Ligusticum wallichii 2.5kg, Chinese yam 1.5kg, reticulate millettia 1.5kg, champion bauhinia stem 2.5kg, root of Dahurain angelica 3.5kg, peppermint oil 1.5kg, indigo naturalis 1.5kg.
Whole medicinal materials are taken, are extracted 2 times with alcohol reflux, each concentration of alcohol is respectively 80%, 60%, and each ethanol consumption is respectively medicinal material
10 times, 8 times of total amount, extraction time are respectively 4 hours, 3 hours, merge extract solution, filtering, filtrate is concentrated into relative at 80 DEG C
Density is 1.10 medicinal extract, and supplementary product starch, ethanol, dextrin, magnesium stearate are added in medicinal extract, capsule is made according to a conventional method
Agent.
The tablet of embodiment 5
Achene of Siberian cocklebur 1.2kg, rhizoma atractylodis 0.8kg, rhizoma Gastrodiae 1.2kg, calamus 3kg, semen brassicae 1.2kg, root of kudzu vine 2.3kg, radix polygonati officinalis 1.2kg,
Ligusticum wallichii 2.3kg, Chinese yam 1.2kg, reticulate millettia 1.2kg, champion bauhinia stem 2.3kg, root of Dahurain angelica 3kg, peppermint oil 1.2kg, indigo naturalis 1.2kg.Take
Whole medicinal materials, amount of water is respectively 12 times of medicinal material gross weight, 8 times, 6 times three times, three times extraction time be respectively 3 hours, it is 2 small
When, 1 hour, merge extract solution, filtration, when filtrate is concentrated into 70 DEG C relative density be 1.25 clear cream, add supplementary product starch, second
Alcohol, talcum powder, tablet is made.
The granule of embodiment 6
Achene of Siberian cocklebur 1.5kg, rhizoma atractylodis 0.6kg, rhizoma Gastrodiae 1kg, calamus 2.8kg, semen brassicae 1.4kg, root of kudzu vine 2.8kg, radix polygonati officinalis 1.6kg,
Ligusticum wallichii 2kg, Chinese yam 1.8kg, reticulate millettia 1.2kg, champion bauhinia stem 2.8kg, root of Dahurain angelica 3.3kg, peppermint oil 1kg, indigo naturalis 0.6kg, Niu great
Power 2.5kg, arrowleaf abelmoschus root 2kg.Whole medicinal materials are taken, each amount of water is respectively equivalent to 12 times of medicinal material gross weight, 10 times, every time
Extraction time is respectively 3 hours, 2 hours, merges extract solution, filtration, filtrate be concentrated into relative density at 80 DEG C be 1.05 it is clear
Cream, ethanol is added, it is 70% to make alcohol content, stands 12 hours, filtration, and relative density is 1.25 leaching when filtrate is concentrated into 70 DEG C
Cream, adds starch, dextrin, and granulation, dry, whole grain produce.
The syrup of embodiment 7
Achene of Siberian cocklebur 0.8kg, rhizoma atractylodis 0.4kg, rhizoma Gastrodiae 0.6kg, calamus 2.3kg, semen brassicae 0.8kg, root of kudzu vine 1.8kg, radix polygonati officinalis
0.6kg, Ligusticum wallichii 2.6kg, Chinese yam 0.7kg, reticulate millettia 1.5kg, champion bauhinia stem 2.8kg, root of Dahurain angelica 3.2kg, peppermint oil 1.8kg, indigo naturalis
0.8kg.Whole medicinal materials are taken, amount of water is respectively 10 times of medicinal material gross weight, 8 times twice, and extraction time is respectively 2 small twice
When, 1 hour, merge extract solution, filtration, when filtrate is concentrated into 80 DEG C relative density be 1.10 medicinal extract.Sugar is added in medicinal extract
Slurry agent auxiliary material sucrose, sorbic acid, water stir, and syrup is made.
The mixture of embodiment 8
Achene of Siberian cocklebur 1.6kg, rhizoma atractylodis 0.6kg, rhizoma Gastrodiae 1.7kg, calamus 3.5kg, semen brassicae 1.7kg, root of kudzu vine 2.8kg, radix polygonati officinalis
0.8kg, Ligusticum wallichii 2kg, Chinese yam 1.6kg, reticulate millettia 1.4kg, champion bauhinia stem 3kg, root of Dahurain angelica 2.4kg, peppermint oil 0.6kg, indigo naturalis
1.8kg.Whole medicinal materials are taken, amount of water is respectively equivalent to 12 times of medicinal material gross weight, 8 times, 6 times three times, each extraction time point
Other 3 hours, 2 hours, 1 hour, merge extract solution, filtration, filtrate concentration ad pond om is 3 times of medicinal material gross weight, filling, is added
Enter mixture auxiliary material sucrose, ethyl ester, water, sorbic acid to stir, mixture is made.
Embodiment 9
Capsule prepared by the embodiment of the present invention 4, it is oral to give patients with bile reflux gastritis, 2 tablets each time, 3 times a day, faces
Bed data are as follows：
| Disorder class | Illness number of cases | The course of disease | Treatment time | Efficiently individual quantity | Total effective rate |
| Bile reflux gastritis | 134 | - 1 month 5 days | 5-7 days | 128 | 95.5% |
Embodiment 10
Mr. Wang, female, 38 years old.Uncomfortable more than 2 years, exacerbation 1 week is burnt in gastral cavilty portion of main suit.Before 2 years, there is gastral cavilty portion burning without obvious inducement
Burn discomfort, with sour regurgitation, belch, when have gastral cavilty portion pain.Examine for：Bile reflux gastritis.Give the embodiment of the present invention 4 to treat, 3
Burn feeling disappears after it, continues to take one month, clinical symptoms disappear substantially.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (8)
1. a kind of Chinese medicine composition for treating bile reflux gastritis, it is characterised in that it is the raw material by including following parts by weight
It is manufactured：
Achene of Siberian cocklebur 5-20 parts, rhizoma atractylodis 3-15 parts, rhizoma Gastrodiae 5-20 parts, calamus 20-40 parts, semen brassicae 5-20 parts, root of kudzu vine 15-30 parts,
Radix polygonati officinalis 5-20 parts, Ligusticum wallichii 15-30 parts, Chinese yam 5-20 parts, reticulate millettia 5-20 parts, champion bauhinia stem 15-30 parts, root of Dahurain angelica 20-40 parts, peppermint
Oily 5-20 parts, indigo naturalis 5-20 parts.
2. as claimed in claim 1 treatment bile reflux gastritis Chinese medicine composition, it is characterised in that it be by including with
Made of the raw material of lower parts by weight：
Achene of Siberian cocklebur 10-15 parts, rhizoma atractylodis 5-10 parts, rhizoma Gastrodiae 10-15 parts, calamus 25-35 parts, semen brassicae 10-15 parts, root of kudzu vine 20-25
Part, radix polygonati officinalis 10-15 parts, Ligusticum wallichii 20-25 parts, Chinese yam 10-15 parts, reticulate millettia 10-15 parts, champion bauhinia stem 20-25 parts, root of Dahurain angelica 25-35
Part, peppermint oil 10-15 parts, indigo naturalis 10-15 parts,.
3. as claimed in claim 1 treatment bile reflux gastritis Chinese medicine composition, it is characterised in that it be by including with
Made of the raw material of lower parts by weight：
12 parts of the achene of Siberian cocklebur, 8 parts of rhizoma atractylodis, 12 parts of rhizoma Gastrodiae, 30 parts of calamus, 12 parts of semen brassicae, 23 parts of the root of kudzu vine, 12 parts of radix polygonati officinalis, Ligusticum wallichii 23
Part, 12 parts of Chinese yam, 12 parts of reticulate millettia, 23 parts of champion bauhinia stem, 30 parts of the root of Dahurain angelica, 12 parts of peppermint oil, 12 parts of indigo naturalis.
4. the Chinese medicine composition of the treatment bile reflux gastritis as described in claim any one of 1-3, it is characterised in that it
Active component is prepared using the extraction of the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes.
5. the Chinese medicine composition for the treatment of bile reflux gastritis as claimed in claim 4, it is characterised in that its active component
It is prepared by the following method and forms：Take whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water equivalent to
6-12 times of medicinal material gross weight, each extraction time are 1-3 hours, merge extract solution, filtration, when filtrate is concentrated into 70-80 DEG C
Relative density is 1.15-1.20 clear cream, produces active component.
6. the Chinese medicine composition for the treatment of bile reflux gastritis as claimed in claim 4, it is characterised in that its active component
It is prepared by the following method and forms：Whole medicinal materials are taken, 40-80% alcohol refluxs extraction 2-3 times are used after mixing, every time
Ethanol consumption is 4-10 times of medicinal material total amount, and extraction time is 1-4 hours, merges extract solution, filtering, and filtrate is concentrated into 70-80
DEG C when relative density be 1.15-1.20 clear cream, produce active component.
7. as claimed in claim 4 treatment bile reflux gastritis Chinese medicine composition, it is characterised in that it activity into
Divide to be prepared by the following method and form：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is suitable
In 6-12 times of medicinal material gross weight, each extraction time is 1-3 hours, merges extract solution, filtration, and filtrate is concentrated into 70-80 DEG C
When relative density be 1.15-1.20 clear cream, add ethanol, it be 40-70% to make alcohol content, stand 12-24 hours, filter, filtrate
Relative density is 1.10-1.25 medicinal extract when being concentrated into 70-80 DEG C, produces active component.
A kind of 8. Chinese medicine composition for treating bile reflux gastritis, as the treatment bile any one of claim 1-3
The Chinese medicine composition of reflux gastritis is prepared with pharmaceutically acceptable carrier combination.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895381A (en) * | 2012-11-13 | 2013-01-30 | 李新欣 | Traditional Chinese medicine for treating bile reflux gastritis |
| CN103638293A (en) * | 2013-12-07 | 2014-03-19 | 王纯治 | Chinese medicine mixture for treating bile reflux gastritis |
| CN103721174A (en) * | 2012-10-15 | 2014-04-16 | 青岛信立德中药技术研究开发有限公司 | Traditional Chinese medicine composition used for treating chronic reflux gastrItIs |
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2017
- 2017-12-07 CN CN201711281930.9A patent/CN107737252A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721174A (en) * | 2012-10-15 | 2014-04-16 | 青岛信立德中药技术研究开发有限公司 | Traditional Chinese medicine composition used for treating chronic reflux gastrItIs |
| CN102895381A (en) * | 2012-11-13 | 2013-01-30 | 李新欣 | Traditional Chinese medicine for treating bile reflux gastritis |
| CN103638293A (en) * | 2013-12-07 | 2014-03-19 | 王纯治 | Chinese medicine mixture for treating bile reflux gastritis |
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| 魏睦新等: "《医治消化病的大医之法》", 30 June 2015, 科学技术文献出版社 * |
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Application publication date: 20180227 |