CN104524535B - It is a kind of to treat Chinese medicine composition of chronic cor pulmonale and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for treating chronic cor pulmonale, it is made up of Chinese ephedra, cassia twig, rhizoma zingiberis, asarum, the tuber of pinellia, the fruit of Chinese magnoliavine, the root of herbaceous peony, blackberry lily, lepidium seed, the Radix Astragali, Radix Angelicae Sinensis, rhodiola root, gekko, agalloch eaglewood, peach kernel, safflower, Ligusticum wallichii, the red sage root, spina gleditsiae, Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, honey-fried licorice root according to certain weight proportion, have effects that eliminating dampness dissolving phlegm, freeing lung and relieving asthma, nourishing blood and tranquilization, nourishing generate fluid, can effectively treat chronic cor pulmonale.

Description

It is a kind of to treat Chinese medicine composition of chronic cor pulmonale and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, and in particular to a kind of Chinese traditional medicine composition for treating chronic cor pulmonale Thing.The invention further relates to the preparation method of the Chinese medicine composition.

Background technology

Chronic cor pulmonale be by the chronic disease of lung tissue, pulmonary arterial vascular or thorax cause lung tissue structure and Dysfunction, causes pulmonary vascular resistance to increase, and pulmonary artery pressure increases, and makes right cardiectasis, hypertrophy, companion or not with right heart failure Heart disease, is common disease, frequently-occurring disease.The ill age is more more than 40 years old, and with age growth, illness rate increases, cold district, Highlands, rural area illness rate are high, and its protopathy is most common with chronic bronchitis, pulmonary emphysema, and acute attack is more with winter-spring season See, lung, cardiac insufficiency are often induced because of respiratory tract infection.Clinical manifestation is mainly：The symptom of lung primary disease, pulmonary emphysema With the sign and pulmonary encephalopathy of right heart insufficiency etc., have difficulty in breathing and aggravate during serious attack, limitation of activity, loss of appetite, very To there is respiratory failure, right heart failure and threat to life.

Chronic cor pulmonale belongs to the categories such as traditional Chinese medical science dyspnea, phlegm and retained fluid, the lung-distension, oedema.Pathological change first consists in body Positive unsaturated vapor, lower for the resistance, perverse trend invasion and attack human body, lung is first by it, and lung qi a surname's drop mistake department sends out to breath with cough.If experiencing repeatedly evil Gas then feel frustrated weak by lung, and phlegm and retained fluid is detained, and with the passing of time healthy tendency must decline, and it is all dirty further to involve the heart, spleen, kidney.Lung wound with the passing of time must and in the heart, The heart qi deficiency be difficult to promote then cause the stagnation of the heart blood and see palpitaition, chest door, suppress breathe heavily, cyanosis, tongue it is dim；The spleen has the function to transport and transform nutrients, the dysfunction of the spleen in transport, water paddy Do not change, life in phlegm wet, above the criminal's of gushing lung, and see that the amount of coughing up phlegm is more；The main water of kidney, kidney deficiency is difficult water processed, water pathogen attacking heart, then aggravate palpitaition, Shortness of breath；Kidney is again main to receive gas, the main breathing of lung, lung qi answer it is descending return kidney, kidney qi is taken the photograph again receives lung qi, if kidney qi deficiency can not be taken the photograph Receive lung qi, then send out and breathed heavily for void.Therefore, the generation of pulmonary heart disease, is lung, the heart, spleen, the dirty functional disturbance of kidney four.

At present, treatment pulmonary heart disease does not have a specific drug, it is most with anti-inflammatory, cough-relieving, relieving asthma or entered with cardiopathic medicine is treated Row treatment, if necessary can also be using diuresis, expansion blood vessel medicine and cardiotonic, and to improve the treatment such as ventilation, but effect is very undesirable, Easily recur and the death rate is high, the use of antibiotic can only play interim symptom management, alleviate the interim threat being in a bad way, no Disease can fundamentally be treated.

The content of the invention

It is an object of the invention to provide a kind of Chinese medicine composition, the Chinese medicine composition is for treatment chronic cor pulmonale It is cheap with evident in efficacy, it is with strong points, have no toxic side effect, the characteristics of uneasy to recur.

It is a further object of the present invention to provide the preparation method of the Chinese medicine preparation of the treatment chronic cor pulmonale.

Inventor is in clinical treatment practice for many years, it was observed that the pain that chronic cor pulmonale is brought to patient, According to the combination principle of the rule of development of the illness, and Chinese medicine, and by substantial amounts of clinical verification, Exploration and conclusion goes out one repeatedly Kind treat the new formula of the Chinese medicine preparation of chronic cor pulmonale, present invention selection Chinese ephedra, cassia twig, rhizoma zingiberis, asarum, the tuber of pinellia, The fruit of Chinese magnoliavine, the root of herbaceous peony, blackberry lily, lepidium seed, the Radix Astragali, Radix Angelicae Sinensis, rhodiola root, gekko, agalloch eaglewood, peach kernel, safflower, Ligusticum wallichii, the red sage root, gleditsia sinensis Thorn, Radix Codonopsis, rhizoma atractylodis macrocephalae, Poria cocos, honey-fried licorice root are combined, and cause each efficacy of drugs to produce synergy these drug regimens, With eliminating dampness dissolving phlegm, freeing lung and relieving asthma, nourishing blood and tranquilization, nourishing generate fluid effect, so as to effectively treatment chronic pulmonary Heart disease.

The effect of medicine in the present invention：

Wherein：

Chinese ephedra：For Ephedraceae plant ephedra sinica Ephedra sinica Stapf, epheday intermedia Ephedra intermedia Schrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge. drying herbaceous stem stem.Nature and flavor：It is pungent, micro- Hardship, temperature.Return lung, bladder warp.Effect：Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema.It is uncomfortable in chest to breath with cough for anemofrigid cold, geomantic omen Edema；Bronchial astehma.Chinese ephedra it is warm-natured it is pungent dissipate, can sweating cold dispelling and inducing diaphoresis, wind promoting eruption can be dissipated again.With control catch cold it is caused Fever with chilliness, the disease such as lossless, often play the role of inducing sweat and dispelling exogenous evils with cassia twig mutual reinforcement between to use.Measles without adequate eruption is such as controlled, has concurrently and coughs During symptom out of breath of coughing, can be drunk in promoting eruptions with acrid-cool drugs medicine plus Chinese ephedra, because of lung governing skin and hair, this product can facilitaing lung, and can dissipate, can receive Rash, the effect relievingd asthma.

Cassia twig：For canella Chinese cassia tree Cinnamomum cassia Presl dry twig.Nature and flavor：Acrid, sweet, warm.Return The heart, lung, bladder warp.Effect：Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.Cure mainly exterior syndrome due to wind-cold；Numbness and ache of cold dampness； Wei lump in the abdomen is lumpd；The obstruction of qi in the chest；Palpitaition；Phlegm and retained fluid.《Changsha medicine solution》Carry：" enter liver man and promoting circulation of blood point determine channels and collaterals and reach Rong Yu.Kind solution ailment said due to cold or exposure, Most adjust wood gas.The detrapping of sending up the lucid YANG, drop turbid yin rushes inverse, the urgency contraction of relaxing muscles and tendons arteries and veins；The heap soil or fertilizer over and around the roots resistance in sharp joint, dissipates and suppresses, relieve pain Chu, lead to Channels and collaterals, it is puckery to open numbness, very goes raw.Only run quickly globefish, more pacify palpitation with fear." modern medicine study confirm, cassia twig can effectively expand blood vessel, rush Enter sweating, contained cinnaldehydrum, natrium cinnamicum have antipyretic, analgesia, calm, anticonvulsant action, in addition cassia twig also have antibacterial, it is disease-resistant Effect of poison.Cassia twig is warm-natured, the kind gas that activates yang, and can change cold sensation of the genitalia, temperature three-way meridian, for all pain cards of congealing cold with blood stasis.

Rhizoma zingiberis：For zingiber Zingiber officinale Rosc. dry rhizome.Nature and flavor：Pungent, heat.Returns spleen, Stomach, the heart, lung channel.Effect：Warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm, Wenfei of drink.For coldness and pain in the epigastrium, vomiting and diarrhea, limb Cold weak pulse, sputum cough.

Asarum：For aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt Var.mandshuricum (Maxim.) Kitag., Seoul asarum Asarum sieboldii Miq.var.seoulense Nakai or asarum sieboldii Asarum sieboldii Miq. drying herb.Nature and flavor are pungent；Temperature；Mild toxicity.Return lung warp, kidney channel, the heart channel of Hang-Shaoyin, Liver Channel, gallbladder channel, the spleen channel.Effect：Mass dissipating and swelling eliminating；Relieving exterior syndrome and dispelling cold；Wind-expelling pain-stopping；Wenfei of drink；Lower gas eliminating the phlegm, it is sensible.It is antibacterial, anti- Virus function kakuol preserved material, volatile oil etc. have certain external suppression to make to gram positive bacteria, hay bacillus and typhoid bacillus With decoction also has inhibitory action to tubercle bacillus and typhoid bacillus.Herba Asari volatile oil is to a variety of fungies such as Aspergillus flavus, aspergillus niger Bacterium, Candida albicans etc. have inhibitory action, and the active ingredient of antibacterial is safrole.

The tuber of pinellia：For in the Southern Star section plant tuber of pinellia (Pinellia ternata (Thunb.) Breit.) stem tuber.Nature and flavor are pungent, Temperature, it is poisonous.Enter spleen, stomach.Effect：It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.The pungent scattered temperate-dryness of the product is poisonous, and it is simultaneous that master enters taste Enter lung, energy water-filling is wet, lowering the adverse flow of qi, and kind taste damp phlegm of dispelling.Water is wet to be gone, and spleen is strong and sputum drops then stomach and and feeling of fullness from disappearing against gas Vomiting stops certainly, therefore is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both the abundant expectoration cough and asthma circulation of vital energy in the wrong direction of spleen damp phlegm heap soil or fertilizer over and around the roots had been cured mainly, again Control the dizziness palpitaition insomnia of criminal in damp phlegm.《Haigoushen》：Dissolving phlegm saliva, Appetizing spleen-tonifying, anti-nausea, go in the heart phlegm expire, lower lung qi is main Cough knot.

The fruit of Chinese magnoliavine：For magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or Central China five tastes Sub- Schisandra sphenanthera Rehd.et Wils. dry mature fruit.Nature and flavor：It is warm, sour, sweet.Return lung, the heart, Kidney channel.Function：Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathed heavily for void of coughing long, emission, enuresis frequent micturition, endless diarrhea, Spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.

The root of herbaceous peony：For dicotyledon ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall. dry root.Nature and flavor： Cool, picric acid is slightly cold.Effect：Enrich blood soft liver, smooth liver and relieve pain, hold back and cloudy receive sweat.Research shows：The Paeoniflorin contained in the root of herbaceous peony has anti- Bacterium, antipyretic, anti-inflammatory, increase coronary flow, improvement myocardial nutritional flow, expansion blood vessel, confrontation acute myocardial ischemia, suppression Platelet aggregation, calmness, analgesia, spasmolysis, antiulcer, the effect for adjusting blood glucose.Root of herbaceous peony decoction can suppress shigella dysenteriae, pneumonia chain Coccus, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc..This product energy nourishing the liver blood, hold back liver-yin, suppression liver-yang, dredge Irritability, and contraction urgency can be delayed, relieved the pain bitterly, to treat the good medicine of the various pain of Liver Channel.

Blackberry lily：For irides blackberry lily Belamcanda chinensis (L.) DC. dry rhizome.Nature and flavor：Hardship, It is cold.Return lung is passed through.Effect：It is clearing heat and detoxicating, dissolving phlegm, relieving sore-throat.For heat toxin convulsive seizure due to phlegm-fire pent-up, abscess of throat, accumulation and obstruction of sputum, gas of coughing Breathe heavily.Except with addition to for dissolving phlegm, the medicine of relieving sore-throat, also to eliminating mass lump in the abdomen, except malaria is female, stimulates the menstrual flow and closes in biejiajian pills.Alias is crow Fan.With great burdock achene or radix scutellariae, then clearing heat, relieving sore-throat；Such as match somebody with somebody Chinese ephedra, then dispelling phlegm to stop asthma.《Bencao Jingshu》：" blackberry lily, hardship can be let out down, therefore Kind drop；And it is pungent, thus it is kind scattered.Therefore main cough with dyspnea, larynx numbness pharyngalgia, must not message, dissipating bind gas is evil inverse in the heart.Both dropped and dissipated, benefit with It is slightly cold, therefore the big heat of staple food drink.

Lepidium seed：For crucifer Lepidium apetalum Lepidium apetalum Willd. or Descurainia sophia Descurainia sophia (L.) Webb ex prantl dry mature seed.Nature and flavor：Pungent, hardship, Great Cold.Return lung, bladder Through.Effect：Removing heat from lung and relieving asthma, line water detumescence.For sputum stop up lung, dyspnea and cough with excessive sputum, fullness in chest and hypochondrium, must not prostration, chest and abdomen oedema is small Just it is unfavorable；Cor pulmonale oedema.《Bencao Jingshu》：Roripa montana, is the positive medicine of meridian of Hand-TAI YIN, therefore Zhong Jing purging the lung of pathogenic fire soup uses it, also enters Hand sun is bright, meridian of Foot-TAI YANG.The lung belonging to metal, main fur, bladder belongs to water, hides body fluid, obstruction of lung-QI then bladder with here, the upper orifices of example is closed then Lower orifices are obstructed, and lower orifices are obstructed, then water it is wet overflow for breathe heavily it is full, be swelling, be accumulation, a variety of diease occurrences.Pungent to dissipate, hardship can be let out, Great Cold heavy cloudy energy is descending to relieve oedema or abdominal distension through diuresis or purgation, therefore can treat《This warp》Lead all diseases.

The Radix Astragali：For legume astragalus mongolicus Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membranacus Astragalus membranaceus (Fisch.) Bge.'s Dry root.Nature and flavor：It is sweet, tepor.Return lung, spleen, liver and kidney channel.Effect：Tonifying Qi and lifting yang, solid table arrest sweating, inducing diuresis for removing edema, torr sore apocenosis, Regulating fluid apssage.This product is in vitro to Shigella shigae, bacillus anthracis, α-hemolytic streptococcus, hemolytic hammer Bacterium, corynebacterium diphtheriae, bacillus pseudodiphthericus, Diplococcus pneumopniae, staphylococcus aureus, Staphylococcus citreus, hay bacillus etc. are There is inhibitory action.

Radix Angelicae Sinensis：For umbelliferae angelica Angelica sinensis (Oliv.) Diels dry root.Nature and flavor are sweet, pungent, Hardship, temperature.Return liver, the heart, the spleen channel.Effect：Enrich blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.Radix Angelicae Sinensis Central nervous system has suppression Effect, volatile oil has the effect such as calmness, hypnosis, analgesia, anesthesia." Radix Astragali and Radix Angelicae Sinensis have the reason of mutual reinforcement between." the big tonifying lung spleen of the Radix Astragali it Gas, there is admittedly outer energy；Radix Angelicae Sinensis benefit blood and battalion, are blood man gas medicines, are used with pungent elevator behavior, using gentle Xin Run as work(.Two tastes close it, Just can Yin grows while yang is generating, therefore traumatology disease is damaged in medical treatment wound, no matter Qi and blood deficiency, whether there is heating, it is multi-purpose return, stilbene matching.For Blood deficiency chlorosis, dizziness palpitaition, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.According to《Book on Chinese herbal medicine is just》Carry：" its it is sweet and Weight, therefore can specially enrich blood, and its gas is light and pungent, thus again can promoting circulation of blood, can support nutrition blood, tonifying Qi production of sperm, five viscera settling, strengthen body, beneficial mind, All tangible deficient diseases, it is omni-benefiting." modern medicine study confirms that Radix Angelicae Sinensis has antibacterial, antiinflammation.

Rhodiola root：For Crassulaceae Rhodida plant rhodiola root Rhodiola saera (Prain) Fu, with all herbal medicine. Nature and flavor：It is sweet, puckery, tremble with fear.Effect：Tonifying Qi clearing lung-heat；Intelligence development nourishing heart；Controlling of bleeding with astringents；Eliminating stasis to subdue swelling.Main deficiency of vital energy and physically weak；Chilly after being ill；Gas It is short weak；Cough with lung heat；Spitting of blood；Leukorrhea is suffered from diarrhoea；Traumatic injury；Burn and scald；Neurosis；Altitude sickness.

Gekko：For Gekkonidae animal gekko Gekko gecko Linnaeus hirudo leech.Nature and flavor：It is salty, put down.Return lung, kidney Through.Effect：Invigorate the lung and the kidney, receive gas Dingchuan, supporing yang strengthening the essence.Breathed rush, overstrain cough hemoptysis, impotence and seminal emission for void.《Bencao Jingshu》： Gekko, it is led long lung impairment and cough, drenches drip person, and all lung kidneys are disease, labor pole then lung kidney deficiency and heat, therefore exopathogen is easily invaded, internal evidence and hair .Gekko category is cloudy, source on energy moisturizing, then lung kidney is all obtained and supported, and labor heat cough is removed certainly；The convergence of vessels in the lung, regulating fluid apssage.Under it is defeated Bladder.Normal lung-QI, therefore it is certainly logical to drench draining road.

Agalloch eaglewood：Contain the timber of resin for Isolated From Thymelaeaceae Species suspension culture of Aquilaria sinensis Aquilaria sinensis (Lour.) Gilg.Property Taste：Pungent, hardship, tepor.Returns spleen, stomach, kidney channel.Effect：Promoting qi circulation and relieving pain, warming middle energizer to arrest vomiting, gas of receiving is relievingd asthma.For the swollen vexed pain of chest and abdomen, Gastrofrigid vomiting hiccup, the kidney deficiency circulation of vital energy in the wrong direction breathes heavily urgency.《Medicineization justice》：Agalloch eaglewood, it is pure sun and rises, body weight and sink, it is pungent to wander away, gas hero horizontal stroke OK, thus have exceedingly high ability work(, control all carbuncles of thoracic dorsal four limbs and skin pruritus.And the fragrant foster internal organs of energy temperature, protect and defend gas.If cold-dampness is stagnant In bottom, helped and relaxed through medicine with this, be apt to expulsion perverse trend；If injury from falling down, helped and blood medicine, energy scattered stasis pain with this；If strange all diseases, Helped with this and attack phlegm medicine, energy sending down abnormally ascending is calmed the nerves.In a word, dredging the channel, blood turns with gas row, phlegm with gas, all category sufferings, and know invariably more.

Peach kernel：For rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) Franch. dry mature seed.Nature and flavor：Bitter, sweet, flat.The thoughts of returning home, liver, large intestine channel.Effect：Promoting blood circulation, ease constipation Defaecation, it is relieving cough and asthma.The power of peach kernel dissolving stasis is stronger, also known as stasis-breaking drug, for treating blood stasis, wei lumps in the abdomen, often with safflower, Radix Angelicae Sinensis.Peach Benevolence blocks blood flow, blood obstacle has improvement result, each internal organs each group can be made to knit functional recovery normal.

Safflower：For feverfew safflower Carthamus tinctorius L. tubular corolla.Nature and flavor：Temperature, it is pungent.The thoughts of returning home, Liver Channel.Effect：Invigorate blood circulation, blood stasis removing analgesic.The pungent scattered temperature of safflower is led to, and specially enters blood system, can promoting blood circulation, stimulate the menstrual flow tune arteries and veins, Chang Yutao The mutual reinforcements between such as benevolence, Radix Angelicae Sinensis, Ligusticum wallichii are use.Safflower has expansion blood vessel function.Carthamin yellow can be obviously prolonged blood plasma recalcification time, coagulate Blood zymogen time and clotting time.《A supplement to augmented materia medica》：" safflower, it is broken to stay blood, blood-nourishing.Multi-purpose then blood-breaking is few to use then blood-nourishing.” Crude extract from carthamus tinctorius L. with water plays the role of slight excited heart, increase coronary flow, has mitigation effect to myocardial ischemia, and subtract heart rate Slowly, the amplitude that electrocardiogram S-T segment is raised is remarkably decreased, and also suppresses platelet aggregation and increase fibrinolysis activity.

Ligusticum wallichii：For samphire Ligusticum wallichii Ligusticum chuanxiong Hort. dry rhizome.Nature and flavor：It is pungent, Temperature.Return liver, courage, the heart channel of Hang-Shaoyin.Effect：Blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent scattered temperature of this product is led to, the up mountain peak top of energy, assigns the sea of blood, outer thorough Fur, bypasses four limbs, can invigorate blood circulation again can promoting the circulation of qi, former times people meaning Ligusticum wallichii is the gas medicine in blood, nearly say its pungent scattered, Xie Yu that resides, it is sensible, The functions such as analgesic.If heart arteries and veins stasis blocking, chest impediment and cardialgia is then often equal with cassia twig, the red sage root and used.This product, which contains ligustrazine, can suppress blood vessel Smooth muscle contraction, coronary artery dilator increases coronary blood flow, improves myocardial anoxia situation and Mesentery microcirculation, increases brain And limb blood flow amount, reduce peripheral vascular resistance, moreover it is possible to suppress platelet aggregation, can pre- preventing thrombosis formation, to cardiovascular and cerebrovascular Disease has good curative effect.

The red sage root：For dicotyledon Labiatae Labiatae salvia reds sage root Salvia/miltiorrhizaBge Drying root and rhizome.Nature and flavor：Hardship, is slightly cold.Channel tropism：Enter the heart, Liver Channel.Effect：Promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, clearly Heart relieving restlessness, nourishing blood and tranquilization.For sternal rib hypochondriac pain, arthralgia pain due to rheumatism, abdominal mass caking.Modern medicine is it is demonstrated experimentally that the red sage root is also with anti- The function of platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of regulation is a kind of safety and reliable treatment thrombus disease The natural traditional Chinese medicine of disease.

Spina gleditsiae：For legume Chinese honey locust Gleditsia sinensis Lam. drying quil.Nature and flavor：It is pungent, temperature.Return Lung, Liver Channel.Effect：Detumescence and apocenosis, promoting blood circulation by removing wind.Its decoction of modern pharmacology research is burrowed method with flat board, to golden yellow grape Coccus and micrococcus catarrhalis have inhibitory action.Spina gleditsiae can draw that all medicines are up, the kind disease for controlling the part of the body cavity above the diaphragm housing the heart and lungs.

Radix Codonopsis：For Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., codonopsis pilosula var. modesta Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis Tangshen Oliv. dry root.Nature and flavor：It is sweet, flat.Returns spleen, lung channel.Effect：Help spleen and lung, nourishes blood and promotes the production of body fluid.It is empty for spleen and lung Weak, shortness of breath, palpitaition, anorexia and loose stool, virtual asthma cough, Heat Diabetes etc..Acid mucopolysaccharide in Radix Codonopsis has anti-freezing, can reduce blood Fat and reduction blood viscosity and plasma viscosity, and with lowering blood pressure and blood fat, anti-oxidant, anti-aging, improve the immune of human body Power.Remote myocardial infarction and cerebral thrombosis recovery phase are made moderate progress, with purifying the blood, preventing hypertension, cardiovascular and cerebrovascular disease Effect.

Rhizoma atractylodis macrocephalae：For feverfew bighead atractylodes rhizome Atractylodes macrocephala Koidz. dry rhizome.Nature and flavor： It is bitter, sweet, temperature.Returns spleen, stomach.Effect：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis is antiabortive, the bighead atractylodes rhizome can air making-up and spleen enlivening, and can eliminating dampness Li Shui, is the key medicine of invigorating the spleen to dry.In the sweet temperature compensation of the bighead atractylodes rhizome, can air making-up and spleen enlivening, can also strengthening exterior and reducing sweat, and the Radix Astragali, radix pseudostellariae compatibility, The work(of tonifying spleen lung is played altogether.It is same to control consumptive disease, the weak person of overstrain.Bighead atractylodes rhizome antibacterial action is obvious：Infusion is in vitro to Epidermophvton Tinea bacterium, star nocardia have inhibitory action.Decoction also has inhibitory action to meningococcus.The bighead atractylodes rhizome, which also has, promotes hematopoiesis Function.

Poria cocos：For On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia.Nature and flavor：Sweet, light, It is flat.The thoughts of returning home, lung, spleen, kidney channel.Effect：Clearing damp and promoting diuresis, invigorating the spleen calming heart.Sweet provide additional supplies of this product is oozed, and has not only been mended but also sharp, and effect is gentle, mild-natured And it is partially without fever and chills, it is the key medicine of clearing damp and promoting diuresis.Poria cocos decoction has obvious sedation.《Modality》：" cure mainly Ji Rou Shun muscle of throbbing with fear Cautious, a dizzy agitation is controlled on side." this product by heart-spleen boosting tranquilizing mind.Be used for the insufficiency of heart and spleen, insufficiency of vital energy and blood it is confused and worried.

Honey-fried licorice root：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza Inflata Bat. or glycyrrhiza glabra Glycyrrhiza Glabra L. drying root and rhizome.Honey-fried licorice root dries for the honey of radix glycyrrhizae Processed goods processed.Nature and flavor are sweet, put down.The thoughts of returning home, lung, spleen, stomach.Effect：Tonifying spleen and stomach, Yiqi and vein recovery.《Japan hanako materia medica》：Pacify soul to determine Soul.General debility is mended, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, strengthening the essence is fostered the spirit of nobility, strengthened the bone, and is solved cold and hot.

The present invention square solution be：Square epheday intermedia, cassia twig sweating cold dispelling, freeing lung and relieving asthma, rhizoma zingiberis eliminating dampness dissolving phlegm, Wenfei of drink, Asarum Wenfei of drink, lower gas eliminating the phlegm, the tuber of pinellia is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, and the above five tastes are altogether monarch drug in a prescription, from the at all enterprising of disease Row is eliminating dampness and eliminating phlegm, freeing lung and relieving asthma, sweating cold dispelling so that pulmonary circulation is strengthened, and reduces pulmonary vascular resistance, so that it is high to mitigate pulmonary artery The phenomenon of pressure.Fruit of Chinese magnoliavine nourishing generate fluid, kidney calming, the root of herbaceous peony enrich blood soft liver, hold back it is cloudy receive sweat, blackberry lily is clearing heat and detoxicating, dissolving phlegm relieving sore-throat, Lepidium seed removing heat from lung and relieving asthma, line water detumescence, the Radix Astragali, Chinese angelica blood supplementing promoting blood circulation, tonifying Qi and lifting yang, above Six-element are ministerial drug altogether, on the one hand auxiliary Assistant monarch drug in a prescription freeing lung and relieving asthma, another aspect replenishing and activating blood, kidney calming, treatment chronic cor pulmonale caused by pained, shortness of breath, Cardio palmus shape, and the body of patient is carried out taking a tonic or nourishing food to build up one's health conditioning, strengthen patient's constitution, promote patient to recover.Rhodiola root tonifying Qi Clearing lung-heat, intelligence development nourishing heart, gekko invigorated the lung and the kidney, receive gas Dingchuan, and agalloch eaglewood promoting qi circulation and relieving pain, gas of receiving are relievingd asthma, peach kernel, safflower invigorate blood circulation, Blood stasis removing analgesic, Ligusticum wallichii blood-activating and qi-promoting, wind-expelling pain-stopping, red sage root stasis-dispelling and pain-killing, nourishing blood and tranquilization, spina gleditsiae promoting blood circulation by removing wind, Radix Codonopsis help Spleen and lung, nourishes blood and promotes the production of body fluid, rhizoma atractylodis macrocephalae, Poria cocos clearing damp and promoting diuresis, invigorating the spleen calming heart, several tastes of the above are adjutant altogether, alleviate the chronic pulmonary heart Other complication that popular name for is brought, and play the role of anti-inflammation, invigorate blood circulation, get through pulmonary artery, the blood vessel near heart Stasis blocking, is that blood operation is smooth, so as to reach the purpose for the treatment of chronic cor pulmonale, honey-fried licorice root priming channel tropism, mediation are all Medicine, to make medicine.This side's all medicines share, the monarch and his subjects pull together, assistant make it is auxiliary altogether, with eliminating dampness dissolving phlegm, freeing lung and relieving asthma, nourishing blood and tranquilization, QI invigorating The effect promoted the production of body fluid, can effectively treat chronic cor pulmonale.

Medicine material consumption of the present invention largely is groped to summarize through inventor's progress to be drawn, each raw material dosage is following Parts by weight scope all has preferable curative effect：3-9 parts of Chinese ephedra, 7-17 parts of cassia twig, 7-17 parts of rhizoma zingiberis, 1-5 parts of asarum, tuber of pinellia 4-14 It is part, 5-15 parts of the fruit of Chinese magnoliavine, 7-17 parts of the root of herbaceous peony, 7-17 parts of blackberry lily, 4-14 parts of lepidium seed, 13-23 parts of the Radix Astragali, 10-20 parts of Radix Angelicae Sinensis, red 7-17 parts of red-spotted stonecrop, 3-9 parts of gekko, 1-5 parts of agalloch eaglewood, 7-17 parts of peach kernel, 4-14 parts of safflower, 7-17 parts of Ligusticum wallichii, 13-23 parts of the red sage root, 10-20 parts of spina gleditsiae, 10-20 parts of Radix Codonopsis, 13-23 parts of rhizoma atractylodis macrocephalae, 7-17 parts of Poria cocos, 3-9 parts of honey-fried licorice root.

Wherein it is preferably：6 parts of Chinese ephedra, 12 parts of cassia twig, 12 parts of rhizoma zingiberis, 3 parts of asarum, 9 parts of the tuber of pinellia, 10 parts of the fruit of Chinese magnoliavine, the root of herbaceous peony 12 parts, 12 parts of blackberry lily, 9 parts of lepidium seed, 18 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of rhodiola root, 6 parts of gekko, 3 parts of agalloch eaglewood, peach kernel 12 Part, 9 parts of safflower, 12 parts of Ligusticum wallichii, 18 parts of the red sage root, 15 parts of spina gleditsiae, 15 parts of Radix Codonopsis, 18 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, honey-fried licorice root 6 Part.

Medicine of the present invention can be prepared into any conventional oral preparations using the conventional method of Chinese medicine preparation, such as pill, dissipate Agent, tablet, oral liquid etc..These bulk drugs can for example be smashed and well mixed powder is made take after mixing it with water；Decocting can be used, Through filtering to get filtrate, add preservative and oral liquid is made；Decoction can also be directly taken if necessary.

Currently preferred preparation method is decoction, and its preparation method is as follows：

Step one：By weight proportion of the present invention, the fruit of Chinese magnoliavine, lepidium seed are first bundled into pack with gauze, is put in water and soaks About 45 minutes, filtering was standby；

Step 2：By weight proportion of the present invention, gekko, peach kernel, rhizoma atractylodis macrocephalae, Poria cocos are ground to 200 mesh sieves, it is standby With；

Step 3：By weight proportion of the present invention, by rhizoma zingiberis, the root of herbaceous peony, blackberry lily, the Radix Astragali, Radix Angelicae Sinensis, agalloch eaglewood, Ligusticum wallichii, the red sage root, party Parametric amplifier enter in marmite plus step one in soak after remaining cold water, more than 3~6 centimetres of powder, after being fried boiling with high heat, then with being cooked by slow fire 20~30 minutes, filtering, obtain filtrate, the water of 3 cms added in the remaining dregs of a decoction, then add Chinese ephedra, asarum, the tuber of pinellia, Pack in rhodiola root, spina gleditsiae and step one is decocted about 30 minutes, and cassia twig, safflower, honey-fried licorice root are added afterwards and decocts 15 points Clock is filtered, and obtains filtrate, merges filtrate twice, and filtering, waste, the powder added in step 2 is well mixed, both institute of the present invention The traditional Chinese herbal decoction stated, once in the morning and once at night, warmly takes.

Medicine eliminating dampness dissolving phlegm of the present invention, freeing lung and relieving asthma, nourishing blood and tranquilization, nourishing generate fluid the effects such as, and evident in efficacy, price is low It is honest and clean, it is with strong points, have no toxic side effect, uneasy to recur, the Chinese medicine preparation is treated by the way of can reduce Western medicine to patient liver The damage of renal function, fundamentally carries out conditioning body, recuperating to cure the disease is combined, and accelerates the improvement of the state of an illness, according to clinical 196 Patient view counts, using total effective rate 89.8% after one course for the treatment of of medicine of the present invention, total effective rate 96% after two courses for the treatment of.

Embodiment

Embodiment one, 3 parts of Chinese ephedra, 7 parts of cassia twig, 7 parts of rhizoma zingiberis, 1 part of asarum, 4 parts of the tuber of pinellia, 5 parts of the fruit of Chinese magnoliavine, 7 parts of the root of herbaceous peony, penetrate Dry 7 parts, 4 parts of lepidium seed, 13 parts of the Radix Astragali, 10 parts of Radix Angelicae Sinensis, 7 parts of rhodiola root, 3 parts of gekko, 1 part of agalloch eaglewood, 7 parts of peach kernel, 4 parts of safflower, 7 parts of Ligusticum wallichii, 13 parts of the red sage root, 10 parts of spina gleditsiae, 10 parts of Radix Codonopsis, 13 parts of rhizoma atractylodis macrocephalae, 7 parts of Poria cocos, 3 parts of honey-fried licorice root.

Embodiment two, 6 parts of Chinese ephedra, 12 parts of cassia twig, 12 parts of rhizoma zingiberis, 3 parts of asarum, 9 parts of the tuber of pinellia, 10 parts of the fruit of Chinese magnoliavine, the root of herbaceous peony 12 Part, 12 parts of blackberry lily, 9 parts of lepidium seed, 18 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of rhodiola root, 6 parts of gekko, 3 parts of agalloch eaglewood, 12 parts of peach kernel, 9 parts of safflower, 12 parts of Ligusticum wallichii, 18 parts of the red sage root, 15 parts of spina gleditsiae, 15 parts of Radix Codonopsis, 18 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 6 parts of honey-fried licorice root.

Embodiment three, 9 parts of Chinese ephedra, 17 parts of cassia twig, 17 parts of rhizoma zingiberis, 5 parts of asarum, 14 parts of the tuber of pinellia, 15 parts of the fruit of Chinese magnoliavine, the root of herbaceous peony 17 Part, 17 parts of blackberry lily, 14 parts of lepidium seed, 23 parts of the Radix Astragali, 20 parts of Radix Angelicae Sinensis, 17 parts of rhodiola root, 9 parts of gekko, 5 parts of agalloch eaglewood, 17 parts of peach kernel, 14 parts of safflower, 17 parts of Ligusticum wallichii, 23 parts of the red sage root, 20 parts of spina gleditsiae, 20 parts of Radix Codonopsis, 23 parts of rhizoma atractylodis macrocephalae, 17 parts of Poria cocos, 9 parts of honey-fried licorice root.

Here is clinical statisticses data of the patient using medicine of the present invention：

First, general information

Accept out-patient 392 for medical treatment.Patient is randomly divided into observation group and control group, wherein male 200, women 192 Example, M-F 1: 04.1, max age 81 years old, minimal ages 40 years old, course of disease time, two groups of patient ages, sex, diseases The items basic document such as journey is essentially identical, no significant difference (P ＞ 0.05).

2nd, treatment method：

1st, observation group weighs bulk drug (agent on the one according to Medications Example two of the present invention, and preferred preparation method Amount), filter and remove residue after decocting, once a dose sooner or later, warmly takes.It is within 15 days a course for the treatment of.

2nd, control group according in CN 102961699A treat chronic cor pulmonale Chinese medicine composition, twice daily, It is within 15 days an observation cycle.

3rd, efficacy assessment standard

1st, cure：Each clinical symptom disappearance of chronic cor pulmonale, auscultation of lung dry and wet rale disappears, electrocardiogram and chest Portion's x-ray inspection recovers normal.

2nd, take a turn for the better：Each clinical symptoms of chronic cor pulmonale substantially mitigate, and constitution is progressively recovered, electrocardiogram and chest X Ray examination is obviously improved, edema extinction.

3rd, it is not cured：Chronic cor pulmonale clinical symptoms do not have any improvement.

4th, observation group's result is counted

Control group result is counted

Wherein：Total effective rate=cure rate+improvement rate

Use the situation of effect comparison of two groups of patients after two courses for the treatment of

Group	Number of cases	Cure [n (%)]	Take a turn for the better [n (%)]	It is not cured [n (%)]	Total effective rate (%)
						Observation group	196	134(68.4)	54(27.6)	8(4)	96.0
Control group	196	63(32)	88(45)	45(23)	77.0

It can be found that observation group, apparently higher than control group, thus illustrates by the treatment total effective rate for contrasting two groups of patients, Chinese medicine of the present invention has good clinical effectiveness in treatment chronic cor pulmonale, can effectively improve the cure rate for the treatment of, is worth Obtain and promoted in clinical practice.

Model case and curative effect：

Case one, Lee, female, 59 years old, patient's constitution was bad always, with chronic cor pulmonale, and with chronic Obstructive lung disease, cough, expectoration phenomenon is more than, has the phenomenon breathed heavily and suppressed through often gasping for breath after activity every time, using relievining asthma And some anti-infectious drug therapies, effect is undesirable always, can not be discontinued at all, and later here is gone to a doctor, using the present invention Made decoction in embodiment two, patient is taken after two courses for the treatment of, and cough, expectoration phenomenon substantially mitigate, and is breathed heavily after activity and is suppressed phenomenon and obtain To alleviation, palpitaition, edema of lower extremity phenomenon also disappear, to consolidate curative effect, continued taking the two courses, patient clinical symptom disappears completely Lose, activity is freely, hence it is evident that feel that constitution is also strengthened, the state of mind is also improved, follow-up half a year, no relapse recovery from illness.

Case two, Bai, man, 64 years old, cough, shortness of breath, feeling of distension and oppression over the chest were felt substantially to aggravate when cough and asthma, fatigue, sometimes can Substantially feel cardio palmus shape, remove examination in hospital, be diagnosed as chronic cor pulmonale, carry out here treatment, using of the invention real Made decoction in example two is applied, patient is taken after two courses for the treatment of, and sensory symptoms substantially mitigates, breathe smooth, do not cough and do not breathe heavily, palpitaition, Phenomenon uncomfortable in chest is also eased, and the state of mind is improved, and continues to take a course for the treatment of, patient clinical symptom is wholly absent, Constitution is also improved, and freely, without other malaise symptoms, follow-up half a year, no relapse is fully recovered for activity.

Case three, in certain, man, 69 years old, patient respiratory was difficult, palpitaition, and with puffiness of face, appetite is poor, cough and asthma is out of breath, When the symptoms, especially evening such as appetite difference, sleep quality degradation, constitution worse and worse, is diagnosed as chronic pulmonary Heart disease, takes some medicines such as relieving asthma, and effect always not substantially, go to a doctor, using institute in the embodiment of the present invention two by later here Decoction processed, takes after three courses for the treatment of, and symptom feels obvious and mitigated that shortness of breath phenomenon uncomfortable in chest is also eased, and nocturnal cough substantially subtracts Gently, sleep quality is improved, to consolidate curative effect, and patient continues taking the two courses, patient feel breathing it is smooth, without discomfort Sense, palpitaition, phenomenon uncomfortable in chest are wholly absent, and other clinical symptoms also disappear, follow-up half a year, no relapse, recovery from illness.

Claims (3)

1. a kind of Chinese medicine composition for treating chronic cor pulmonale, it is characterised in that the Chinese medicine composition is by following heavy Measure the medicine composition of part：3-9 parts of Chinese ephedra, 7-17 parts of cassia twig, 7-17 parts of rhizoma zingiberis, 1-5 parts of asarum, 4-14 parts of the tuber of pinellia, fruit of Chinese magnoliavine 5- 15 parts, 7-17 parts of the root of herbaceous peony, 7-17 parts of blackberry lily, 4-14 parts of lepidium seed, 13-23 parts of the Radix Astragali, 10-20 parts of Radix Angelicae Sinensis, 7-17 parts of rhodiola root, 3-9 parts of gekko, 1-5 parts of agalloch eaglewood, 7-17 parts of peach kernel, 4-14 parts of safflower, 7-17 parts of Ligusticum wallichii, 13-23 parts of the red sage root, spina gleditsiae 10-20 Part, 10-20 parts of Radix Codonopsis, 13-23 parts of rhizoma atractylodis macrocephalae, 7-17 parts of Poria cocos, 3-9 parts of honey-fried licorice root.

2. the Chinese medicine composition of the treatment chronic cor pulmonale according to claims 1, it is characterised in that by following The medicine composition of parts by weight：6 parts of Chinese ephedra, 12 parts of cassia twig, 12 parts of rhizoma zingiberis, 3 parts of asarum, 9 parts of the tuber of pinellia, 10 parts of the fruit of Chinese magnoliavine, the root of herbaceous peony 12 Part, 12 parts of blackberry lily, 9 parts of lepidium seed, 18 parts of the Radix Astragali, 15 parts of Radix Angelicae Sinensis, 12 parts of rhodiola root, 6 parts of gekko, 3 parts of agalloch eaglewood, 12 parts of peach kernel, 9 parts of safflower, 12 parts of Ligusticum wallichii, 18 parts of the red sage root, 15 parts of spina gleditsiae, 15 parts of Radix Codonopsis, 18 parts of rhizoma atractylodis macrocephalae, 12 parts of Poria cocos, 6 parts of honey-fried licorice root.

3. the Chinese medicine preparation for the treatment of chronic cor pulmonale according to claim 1 or 2, it is characterised in that：In described Medicine preparation is decoction.