CN107669550A - Organic baby moistening frost and preparation method thereof - Google Patents
Organic baby moistening frost and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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Abstract
The invention discloses a kind of organic baby moistening frost and preparation method thereof, organic baby moistening frost includes following raw materials：Parleam, glycerine, butanediol, german chamomile extract, pot marigold extract, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride, dimethyl silicone polymer, cetostearyl alcohol, cetanol, stearine, the stearates of PEG 75, tocopherol acetate, panthenol, Sodium Hyaluronate, ceteth 20, stereth 20, Sepigel EG, EDETATE SODIUM, xanthans, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, deionized water.Organic baby moistening frost of the present invention and preparation method thereof, natural organic component is added, formula is reasonable, moderate performance, non-stimulated, has good moist moistening effect, the tender and lovely skin of the obtained suitable baby of organic baby moistening frost.
Description
Technical field
The invention belongs to daily chemical product technical field, and in particular to a kind of organic baby moistening frost and preparation method thereof.
Background technology
Skin cream, moisture content needed for skin can be supplemented rapidly, makes skin full, so as to prevent the appearance of microgroove and dry line,
The skin that the calm water shortage of effectively releiving is dried.Help skin to keep moistening, maintain skin ideal water balance, make the tender light of skin
It is sliding.Skin cream, moisture content needed for rapid supplement skin, makes skin full, so as to prevent the appearance of microgroove and dry line, town of effectively releiving
Determine the skin of water shortage drying.Help skin to keep moistening, maintain skin ideal water balance, make skin tender smooth.
The skin of baby only has 1/10th thickness of adult skin, and epidermis is cell monolayer, and it is multi-layer cellular to be grown up；Very
Collagenous fibres are few in skin, thus lack flexibility, it is easy to are permeated and rubbed impaired by foreign object.The more delicate softness of infant skin,
Sebum is thin.And skin care item of being grown up are the physilogical characteristics developments according to adult skin, the comparison of ingredients of central addition is complicated.Baby's skin
Based on moisturizing moisturizing, adult's skin care item easily cause to bear to baby's skin, it is possible to can cause the skin of baby for the nursing of skin
Skin allergy.Therefore, the daily skin care item that baby's design is aimed to Baby Care selection are advisable.
Baby skin protection product refer to specifically for infant skin development, for baby's daily cleaning, protect the nursing of skin to produce
Product.Baby skin protection product primary efficacy is moisturizing, moistened.Baby can not produce grease, it is necessary to which daily smearing moisturizing produces due to itself
Product are to protect tender and lovely skin.For baby moistening product, not only need it that there is good soothing effect, also to reach its profit
In absorption, non-greasy, more want composition naturally gentle, it is non-stimulated.
The content of the invention
For above-mentioned technical problem, the present invention provides a kind of organic baby moistening frost and preparation method thereof, and addition naturally has
Machine component, it is moderate performance, non-stimulated, there is good moist moistening effect, the obtained suitable baby of organic baby moistening frost spoils
Tender skin.
The invention provides a kind of organic baby moistening frost, including following raw materials：Parleam, glycerine, butanediol,
German chamomile extract, pot marigold extract, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride, poly dimethyl silicon
Oxygen alkane, cetostearyl alcohol, cetanol, stearine, PEG-75 stearates, tocopherol acetate, panthenol, hyaluronic acid
Sodium, ceteth -20, stereth -20, Sepigel EG, EDETATE SODIUM, xanthans, methyl hydroxybenzoate, Nipasol,
Phenoxyethanol, deionized water.
Preferably, organic baby moistening frost, the raw material of following weight parts is included：It is Parleam 5-10 parts, sweet
Oily 5-10 parts, butanediol 2-5 parts, german chamomile extract 2-5 parts, pot marigold extract 2-5 parts, Butyrospermum parkii fruit fat 1-3 parts, oily olive
Olive fruit oil 1-3 parts, caprylic/capric triglyceride 1-3 parts, dimethyl silicone polymer 1-2 parts, cetostearyl alcohol 1-2 parts, cetanol
1-2 parts, stearine 0.5-1.5 parts, PEG-75 stearate 0.5-1.5 parts, tocopherol acetate 0.1-1 parts, panthenol
0.1-1 parts, Sodium Hyaluronate 0.1-1 parts, ceteth -200.1-1 parts, stereth -200.1-1 parts, Sepigel
EG 0.1-1 parts, EDETATE SODIUM 0.01-0.1 parts, xanthans 0.01-0.1 parts, methyl hydroxybenzoate 0.01-0.03 parts, Nipasol
0.01-0.02 parts, Phenoxyethanol 0.01-0.02 parts, deionized water 45-65 parts.
The german chamomile extract is german chamomile flower extract or Flos Chrysanthemi base of leaf extract.
Preferably, the german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes；
(2) alcohol extracting；
(3) water extraction；
(4) mix.
Preferably, the preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes；
(2) ferment；
(3) microwave；
(4) alcohol extracting；
(5) water extraction；
(6) mix.
It is highly preferred that the preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, it is small to be placed in 40-60 DEG C of drying box dry 18-24
When, crush as 60-100 mesh, obtain Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：(0.1-0.5)：(1-5) is mixed,
Leavening is obtained, uniformly sprays leavening in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is Flos Chrysanthemi base of leaf silty amount
5-15%, then be sealed by fermentation 2-5 days at 25-35 DEG C, obtain the Flos Chrysanthemi base of leaf that ferments；
(3) microwave：The water of 1-3 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtains mixed liquor,
Mixed liquor stands 20-40 minutes at 20-30 DEG C, and it is close to be put into microwave treatment 100-300 seconds, microwave power in microwave vacuum equipment
8-12W/g is spent, vacuum 0.03-0.06MPa, obtains microwave treatment mixture；
(4) alcohol extracting：The ethanol of 10-18 times of Flos Chrysanthemi cauline leaf silty amount will be added in microwave treatment mixture, at 45-55 DEG C
Refluxing extraction 3-5 hours, using 300 mesh filter-cloth filterings, filtrate A and filter residue are obtained, filtrate A is concentrated under reduced pressure at 45-55 DEG C
The 20-30% of filtrate A mass, concentrate is obtained, the water that 3-5 times of concentrate quality is added in concentrate is uniformly dispersed, at 45-55 DEG C
It is 1.2-1.3 (50 DEG C) to be concentrated under reduced pressure into relative density, obtains alcohol extract；
(5) water extraction：The water of 5-10 times of filter residue quality will be added in the filter residue of step (4), 1-3 hours is incubated at 45-55 DEG C,
Using 300 mesh filter-cloth filterings, liquor B is obtained, adds the water of 5-10 times of filter residue quality, 1-3 hours is incubated at 45-55 DEG C, adopts
With 300 mesh filter-cloth filterings, liquor C, merging filtrate B and liquor C are obtained, obtains filtrate D, filtrate D is concentrated under reduced pressure into phase at 45-55 DEG C
It is 1.2-1.3 (50 DEG C) to density, obtains water extract；
(6) mix：Water extract and alcohol extract are mixed, with 100-200 revs/min of stirring 5-10 minute, obtain german chamomile floral leaf
Stem extraction.
The preparation method of the german chamomile flower extract comprises the following steps：
(1) Flos Chrysanthemi pre-processes：Fresh Flos Chrysanthemi is gathered, is placed in 40-60 DEG C of drying box and dries 18-24 hours, is crushed
For 60-100 mesh, german chamomile pollen is obtained；
(2) leavening is prepared：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：(0.1-0.5)：(1-5)
Mixing, with 60-100 revs/min of stirring 8-12 minute, leavening is obtained, uniformly sprays leavening, wherein leavening in german chamomile pollen
Dosage be Flos Chrysanthemi silty amount 5-15%, then 25-35 DEG C be sealed by fermentation 2-5 days, obtain ferment Flos Chrysanthemi；
(3) microwave：The water of 1-3 times of Flos Chrysanthemi silty amount will be added in the Flos Chrysanthemi that ferments, obtain mixed liquor, mixed liquor
20-40 minutes are stood at 20-30 DEG C, are put into microwave treatment 100-300 seconds in microwave vacuum equipment, Microwave Power Density 10-
13W/g, vacuum 0.03-0.06MPa, obtain microwave treatment mixture；
(4) alcohol extracting：The ethanol of 10-18 times of Flos Chrysanthemi silty amount will be added in microwave treatment mixture, in 45-55 DEG C of backflow
3-5 hours are extracted, using 300 mesh filter-cloth filterings, filtrate A and filter residue is obtained, filtrate A is concentrated under reduced pressure into filtrate A at 45-55 DEG C
The 20-30% of quality, concentrate is obtained, the water that 3-5 times of concentrate quality is added in concentrate is uniformly dispersed, in 45-55 DEG C of decompression
It is 1.2-1.3 (50 DEG C) to be concentrated into relative density, obtains alcohol extract；
(5) water extraction：The water of 5-10 times of filter residue quality will be added in the filter residue of step (4), 1-3 hours is incubated at 45-55 DEG C,
Using 300 mesh filter-cloth filterings, liquor B is obtained, adds the water of 5-10 times of filter residue quality, 1-3 hours is incubated at 45-55 DEG C, adopts
With 300 mesh filter-cloth filterings, liquor C, merging filtrate B and liquor C are obtained, obtains filtrate D, filtrate D is concentrated under reduced pressure into phase at 45-55 DEG C
It is 1.2-1.3 (50 DEG C) to density, obtains water extract；
(6) mix：Water extract and alcohol extract are mixed, with 100-200 revs/min of stirring 5-10 minute, Flos Chrysanthemi is obtained and carries
Take thing.
The fermentation accelerant is chitosan oligosaccharide and/or lactitol.
Preferably, the fermentation accelerant is the mixture of chitosan oligosaccharide and lactitol, the matter of the chitosan oligosaccharide and lactitol
It is (3-8) to measure ratio：1.
Present invention also offers a kind of preparation method of organic baby moistening frost, comprise the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, Sepigel EG are added in reactor, and 75- is heated with stirring under 20-30 revs/min
85 DEG C, and oil phase is obtained with 20-30 revs/min of stirring 15-25 minute at 75-85 DEG C；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, in 20-
30 revs/min are heated with stirring to 75-85 DEG C, and obtain aqueous phase at 75-85 DEG C with 20-30 revs/min of stirring 15-25 minute；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, 3-5 minutes are stirred with 30-50 revs/min at 75-85 DEG C,
Homogenizer is opened, is emulsified 10 minutes with 2000-4000 revs/min, then 45-55 DEG C is cooled to 30-50 revs/min of stirring, is added successively
Enter panthenol, german chamomile extract, pot marigold extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, with 30-50
Rev/min stirring 20-30 minutes, obtain organic baby moistening frost.
Organic baby moistening frost of the present invention and preparation method thereof, natural organic component being added, formula is reasonable, moderate performance,
It is non-stimulated, there is good moist moistening effect, the tender and lovely skin of the obtained suitable baby of organic baby moistening frost.
Embodiment
The present invention is expanded on further with reference to specific embodiment.It should be appreciated, however, that these embodiments are only used for
It is bright the present invention and be not meant to limit the scope of the invention.The test method of unreceipted actual conditions in the following example, generally
According to normal condition, or according to the condition proposed by manufacturer.
Parleam, No. CAS：68937-10-0, also known as synthesize saualane, NOF Corp's production.
Glycerine, No. CAS：56-81-5.
Butanediol, i.e. 1,3-BDO, No. CAS：107-88-0, Japanese Daicel production.
Caprylic/capric triglyceride, No. CAS：65381-09-1, the production of this reagent Co., Ltd of Adama.
Dimethyl silicone polymer, No. CAS：9006-65-9, the production of Guangzhou Ka Fen bio tech ltd.
Cetostearyl alcohol, No. CAS：67762-27-0, buy from this hundred full chemistries (Shanghai) Co., Ltd..
Cetanol, No. CAS：36653-82-4, Chemical Reagent Co., Ltd., Sinopharm Group's production.
Stearine, No. CAS：85666-92-8, buy from Nanjing Si Baike biochemistry Industrial Co., Ltd..
PEG-75 stearates, No. CAS：9004-99-3, buy from Guangzhou Bi Sheng trade Co., Ltds, the trade mark：DUS
SPEG 80。
Tocopherol acetate, No. CAS：7695-91-2, German BASF production.
Panthenol, No. CAS：16485-10-2, the production of Jining Heng Tai Chemical Co., Ltd.s.
Sodium Hyaluronate, No. CAS：9067-32-7, the production of Shaanxi Pa Nier bio tech ltd.
Ceteth -20, No. CAS：9004-95-9, Chemical Reagent Co., Ltd., Sinopharm Group's production.
Stereth -20, No. CAS：9005-00-9.Shanghai Aladdin biochemical technology limited company produces.
Sepigel EG, chemical name：PAA/sodium acryloyldimethyl taurate copolymers (and) isohexadecane
(and) Polyoxyethylene Sorbitan Monooleate, the production of match BIC Corp of France.
EDETATE SODIUM, No. CAS：6381-92-6, the HX-30 of Dutch Aksu production.
Xanthans, No. CAS：11138-66-2, the production of Xi'an Bai Chuan bio tech ltd.
Methyl hydroxybenzoate, No. CAS：99-76-3, Xi'an Ze Long bio tech ltd.
Nipasol, No. CAS：94-13-3, Wuhan Yi Meite bio tech ltd.
Phenoxyethanol, No. CAS：122-99-6, the Phenoxethol PE of BASF production.
Saccharomycete, buy from Chinese industrial Microbiological Culture Collection administrative center, bacterial strain deposit number CICC 1001, it is living
Bacteria concentration is 1011CFU/g.
German chamomile (CHAMOMILLA RECUTITA), also known as chamomile, there is antiallergy, anti-oxidant, antipruritic, moisturizing, calmness
Etc. function, it is particularly suitable for dryness and allergic skin, also with clearing heat and detoxicating, eliminating stasis to resolve swelling, bactericidal antiphlogistic, relieving itching and removing dandruff function,
Gently keep the skin wet, skin of releiving.German chamomile cauline leaf flower plucks sub- Zhenxiong County Mu Xiang towns wax gourd tree farmer industry life in the embodiment of the present invention
State garden.
Pot marigold (CALENDULA OFFICINALIS) extract, using Anhui Kun great biotechnologies Co., Ltd
The cosmetics-stage pot marigold extract solution of production.Pot marigold extract solution is rich in a variety of nutrition such as vitamin A and vitamin C, mineral matter
Composition, external preparation for skin has anti-inflammatory, sterilization anti-mildew, convergence, the anti-effect festered, and can mitigate sunburn, burn and scald etc. and town
Determine skin, improve sensitive skin quality and other effects.Its flavones active component being rich in has anti-oxidant, antiangiogenic, resistance should
Property and antiviral effect.
Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit fat, i.e. shea butter, it is to refine institute from the African wooden fruit of breast
It is natural light yellow or connect subdiaphanous cream solid grease, suitable for skincare products such as cream, emulsion, soap.Newborn wood
Fruit oil secretes the indices of grease very close to containing abundant non-saponified composition, be easily absorbed by the human body, not only with human sebaceous
Season cracking can be prevented, moreover it is possible to further recover and keep the natural elasticity of skin, there is deep layer to moisten effect.The present invention is implemented
Using the Butyrospermum parkii fruit fat of Xi'an Hua Geng bio tech ltd production in example.
Olive (OLEA EUROPAEA) fruit oil, i.e., organic olive oil, be by the fresh direct cold press of olive fruit and
Into remaining natural nutrient component, olive oil is one of most popular grease of skin care item, has moisturizing and skin care etc.
Effect.Using the cosmetics-stage olive oil of Spain Maeva productions in the embodiment of the present invention.
Microwave vacuum equipment, the microwave vacuum low-temperature drying instrument produced using Nanjing Xian Ou instrument manufacturings Co., Ltd, type
Number：ATPI0-1000W.
The detection of german chamomile extract antioxidation activity：
Choose the kunming mice (buying from Shanghai Si Laike experimental animals company) of 150 6 week old cleaning grades, male and female half and half
(male and female difference cage), the adaptability of 7 days by a definite date is carried out in the zoopery sterile barrier area that 28 DEG C of relative humidity (RH) are 60%
After raising, 10 groups are randomly divided into, and is respectively labeled as blank group, model group, embodiment 1-8 groups, every group 15.Except blank group
Outside, continuously injection is declined other each group mouse for six weeks daily by 150mg/kg dose subcutaneous injection of d-galactose with manufacturing mouse
Old model.Blank group then injects the sterile saline of corresponding dosage.After injection of d-galactose two weeks, start gavage, experimental group
The german chamomile extract as corresponding to filling 500mg/kg dosage, blank group and model group are filled mouse by 500mg/kg dosage daily daily
Physiological saline, continuous gavage surrounding.
(contain fasting 12h) after 24h is administered in last time, weigh mouse weight, eyeball takes blood, and vertebra dislocation is put to death.Solution
Cut open mouse and neatly take out its liver is intact.The residual of liver surface is killed in a large scale only with physiological saline, after filter paper suck dry moisture, claimed
Measure liver weight and accurately cut 0.1000g and be placed in numbered 2mL centrifuge tubes, often pipe plus 0.9mL physiological saline, use tissue
Carefully the mouse liver even slurry liquid that volume ratio is 10% is made in grinding to mill, is placed in standby in 4 DEG C of refrigerators.The blood taken is in 37
30min is heated in DEG C water-bath, after abundant blood coagulation, 1h is stood in 4 DEG C of refrigerators.With refrigerated centrifuge 4 DEG C with 4000r/min from
Heart 10min, takes supernatant to produce serum.The above-mentioned serum made is placed in 4 DEG C of refrigerators and saved backup., will when taking serum
Liquid level tilts, and liquid-transfering gun pipette tips patch tube wall slowly suctions out, and avoids reaching pipette tips in blood plasma.
With SOD and MDA kits detection mice serum SOD activity and liver MDA content.Specific method reference reagent box is said
Bright book.SOD determines kit and the purchase of MDA kits builds up Science and Technology Ltd. from Nanjing.
Moisture retention determines：The german chamomile extract of each embodiment is dried under vacuum to constant weight at 45-55 DEG C, obtains drying mother
Chrysanthemum extract.
It is accurate weigh the german chamomile extract sample (each three Duplicate Samples of embodiment) that 0.5g has been dried be placed in it is a diameter of
In 25mm measuring cup, and the deionized water of dry german chamomile extract sample quality 40% is added into each bottle, slowly rock title
Measuring bottle, after sample fully absorbs moisture, it is placed in the drier that bottom dries discoloration silica gel equipped with 200g, is placed in 20 DEG C
Biochemical cultivation case in.Measuring cup is taken out after 12 hours and weighed, calculates moisturizing rate.
Moisturizing rate=mn/mo× 100%；
moContain water quality, m to put to preceding samplenFor place 12 hours after sample contain water quality.
Embodiment 1
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) alcohol extracting：The ethanol of 14 times of Flos Chrysanthemi base of leaf silty amount will be added in Flos Chrysanthemi base of leaf powder, in 50 DEG C of refluxing extractions
4 hours, using 300 mesh filter-cloth filterings, filtrate A and filter residue are obtained, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains alcohol extract；
(3) water extraction：The water of 7 times of filter residue quality will be added in (2) filter residue of step, 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtains liquor B, adds the water of 7 times of filter residue quality, and 2 hours are incubated at 50 DEG C, using 300 mesh filter-cloth filterings,
Obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature is 50 DEG C and is concentrated under reduced pressure
It is 1.25 (50 DEG C) to relative density, obtains water extract；
(4) mix：Water extract and alcohol extract are mixed, stirred 8 minutes with 150 revs/min, obtains the extraction of Flos Chrysanthemi base of leaf
Thing.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, SepigelEG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Embodiment 2
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 10% of Flos Chrysanthemi base of leaf silty amount, then 30
DEG C be sealed by fermentation 3 days, obtain ferment Flos Chrysanthemi base of leaf；
(3) alcohol extracting：The Flos Chrysanthemi base of leaf that ferments is added to the ethanol of 14 times of Flos Chrysanthemi base of leaf silty amount, in 50 DEG C of refluxing extractions
4 hours, using 300 mesh filter-cloth filterings, filtrate A and filter residue are obtained, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains alcohol extract；
(4) water extraction：The water of 7 times of filter residue quality will be added in the filter residue of step (3), 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtains liquor B, adds the water of 7 times of filter residue quality, and 2 hours are incubated at 50 DEG C, using 300 mesh filter-cloth filterings,
Obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature is 50 DEG C and is concentrated under reduced pressure
It is 1.25 (50 DEG C) to relative density, obtains water extract；
(5) mix：Water extract and alcohol extract are mixed, stirred 8 minutes with 150 revs/min, obtains the extraction of Flos Chrysanthemi base of leaf
Thing.
The fermentation accelerant is chitosan oligosaccharide.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, Sepigel EG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Embodiment 3
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 10% of Flos Chrysanthemi base of leaf silty amount, then 30
DEG C be sealed by fermentation 3 days, obtain ferment Flos Chrysanthemi base of leaf；
(3) microwave：The water of 2 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtain mixed liquor, mix
Close feed liquid and stand 30 minutes at 25 DEG C, be put into microwave treatment 150 seconds in microwave vacuum equipment, Microwave Power Density 10W/g, vacuum
0.05MPa is spent, obtains microwave treatment mixture；
(4) alcohol extracting：The ethanol of 14 times of Flos Chrysanthemi cauline leaf silty amount will be added in microwave treatment mixture, carried in 50 DEG C of backflows
Take 4 hours, using 300 mesh filter-cloth filterings, obtain filtrate A and filter residue, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains alcohol extract；
(5) water extraction：The water of 7 times of filter residue quality will be added in the filter residue of step (4), 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtains liquor B, adds the water of 7 times of filter residue quality, and 2 hours are incubated at 50 DEG C, using 300 mesh filter-cloth filterings,
Obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature is 50 DEG C and is concentrated under reduced pressure
It is 1.25 (50 DEG C) to relative density, obtains water extract；
(6) mix：Water extract and alcohol extract are mixed, stirred 8 minutes with 150 revs/min, obtains the extraction of Flos Chrysanthemi base of leaf
Thing.
The fermentation accelerant is chitosan oligosaccharide.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, Sepigel EG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Embodiment 4
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 10% of Flos Chrysanthemi base of leaf silty amount, then 30
DEG C be sealed by fermentation 3 days, obtain ferment Flos Chrysanthemi base of leaf；
(3) microwave：The water of 2 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtain mixed liquor, mix
Close feed liquid and stand 30 minutes at 25 DEG C, be put into microwave treatment 150 seconds in microwave vacuum equipment, Microwave Power Density 10W/g, vacuum
0.05MPa is spent, obtains microwave treatment mixture；
(4) alcohol extracting：The ethanol of 28 times of Flos Chrysanthemi cauline leaf silty amount will be added in microwave treatment mixture, carried in 50 DEG C of backflows
Take 4 hours, using 300 mesh filter-cloth filterings, obtain filtrate A and filter residue, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains Flos Chrysanthemi base of leaf extract.
The fermentation accelerant is chitosan oligosaccharide.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, Sepigel EG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Embodiment 5
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, 0.5 part of ceteth -20, stearyl alcohol gather
- 200.5 parts of ether, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, oxybenzene third
0.015 part of ester, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 10% of Flos Chrysanthemi base of leaf silty amount, then 30
DEG C be sealed by fermentation 3 days, obtain ferment Flos Chrysanthemi base of leaf；
(3) microwave：The water of 2 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtain mixed liquor, mix
Close feed liquid and stand 30 minutes at 25 DEG C, be put into microwave treatment 150 seconds in microwave vacuum equipment, Microwave Power Density 10W/g, vacuum
0.05MPa is spent, obtains microwave treatment mixture；
(4) water extraction：The water of 14 times of Flos Chrysanthemi base of leaf silty amount will be added in microwave treatment mixture, it is small in 50 DEG C of insulations 2
When, using 300 mesh filter-cloth filterings, liquor B is obtained, adds the water of 14 times of filter residue quality, 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature 50
It is 1.25 (50 DEG C) DEG C to be concentrated under reduced pressure into relative density, obtains Flos Chrysanthemi base of leaf extract.
The fermentation accelerant is chitosan oligosaccharide.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, Sepigel EG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Embodiment 6
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is german chamomile flower extract.
The preparation method of the german chamomile flower extract comprises the following steps：
(1) Flos Chrysanthemi pre-processes：Fresh Flos Chrysanthemi (colored part) is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours,
Crush as 80 mesh, obtain german chamomile pollen；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in german chamomile pollen, the dosage of wherein leavening is the 10% of Flos Chrysanthemi silty amount, then in 30 DEG C of sealing hairs
Ferment 3 days, obtain the Flos Chrysanthemi that ferments；
(3) microwave：The water of 2 times of Flos Chrysanthemi silty amount will be added in the Flos Chrysanthemi that ferments, obtain mixed liquor, mixed liquor exists
25 DEG C stand 30 minutes, are put into microwave treatment 150 seconds in microwave vacuum equipment, Microwave Power Density 10W/g, vacuum
0.05MPa, obtain microwave treatment mixture；
(4) alcohol extracting：The ethanol of 14 times of Flos Chrysanthemi silty amount will be added in microwave treatment mixture, in 50 DEG C of refluxing extractions 4
Hour, using 300 mesh filter-cloth filterings, filtrate A and filter residue are obtained, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains alcohol extract；
(5) water extraction：The water of 7 times of filter residue quality will be added in the filter residue of step (4), 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtains liquor B, adds the water of 7 times of filter residue quality, and 2 hours are incubated at 50 DEG C, using 300 mesh filter-cloth filterings,
Obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature is 50 DEG C and is concentrated under reduced pressure
It is 1.25 (50 DEG C) to relative density, obtains water extract；
(6) mix：Water extract and alcohol extract are mixed, is stirred 8 minutes with 150 revs/min, obtains german chamomile flower extract.
The fermentation accelerant is chitosan oligosaccharide.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, Sepigel EG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Embodiment 7
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 10% of Flos Chrysanthemi base of leaf silty amount, then 30
DEG C be sealed by fermentation 3 days, obtain ferment Flos Chrysanthemi base of leaf；
(3) microwave：The water of 2 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtain mixed liquor, mix
Close feed liquid and stand 30 minutes at 25 DEG C, be put into microwave treatment 150 seconds in microwave vacuum equipment, Microwave Power Density 10W/g, vacuum
0.05MPa is spent, obtains microwave treatment mixture；
(4) alcohol extracting：The ethanol of 14 times of Flos Chrysanthemi cauline leaf silty amount will be added in microwave treatment mixture, carried in 50 DEG C of backflows
Take 4 hours, using 300 mesh filter-cloth filterings, obtain filtrate A and filter residue, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains alcohol extract；
(5) water extraction：The water of 7 times of filter residue quality will be added in the filter residue of step (4), 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtains liquor B, adds the water of 7 times of filter residue quality, and 2 hours are incubated at 50 DEG C, using 300 mesh filter-cloth filterings,
Obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature is 50 DEG C and is concentrated under reduced pressure
It is 1.25 (50 DEG C) to relative density, obtains water extract；
(6) mix：Water extract and alcohol extract are mixed, stirred 8 minutes with 150 revs/min, obtains the extraction of Flos Chrysanthemi base of leaf
Thing.
The fermentation accelerant is lactitol.
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, SepigelEG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Obtained german chamomile extract inoxidizability test result：SOD in serum 129.52U/mL, liver MDA 5.317nmol/
MgProt, moisturizing rate 68.16%.
Embodiment 8
Organic baby moistening frost raw material (parts by weight)：8 parts of Parleam, 8 parts of glycerine, 4 parts of butanediol, german chamomile extraction
4 parts of thing, 4 parts of pot marigold extract, 2 parts of Butyrospermum parkii fruit fat, 2 parts of olive oil, 2 parts of caprylic/capric triglyceride, poly- two
1.5 parts of methylsiloxane, 1.5 parts of cetostearyl alcohol, 1.5 parts of cetanol, 1 part of stearine, PEG-75 stearates 1
Part, 0.5 part of tocopherol acetate, 0.5 part of panthenol, 0.5 part of Sodium Hyaluronate, -200.5 parts of ceteth, stereth -
200.5 parts, 0.5 part of Sepigel EG, 0.03 part of EDETATE SODIUM, 0.02 part of xanthans, 0.02 part of methyl hydroxybenzoate, Nipasol
0.015 part, 0.015 part of Phenoxyethanol, 56.4 parts of deionized water.
The german chamomile extract is Flos Chrysanthemi base of leaf extract.
The preparation method of the Flos Chrysanthemi base of leaf extract comprises the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 50 DEG C of drying boxes and dries 21 hours, powder
Broken is 80 mesh, obtains Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：0.3：3 mixing, obtain leavening,
Leavening is uniformly sprayed in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 10% of Flos Chrysanthemi base of leaf silty amount, then 30
DEG C be sealed by fermentation 3 days, obtain ferment Flos Chrysanthemi base of leaf；
(3) microwave：The water of 2 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtain mixed liquor, mix
Close feed liquid and stand 30 minutes at 25 DEG C, be put into microwave treatment 150 seconds in microwave vacuum equipment, Microwave Power Density 10W/g, vacuum
0.05MPa is spent, obtains microwave treatment mixture；
(4) alcohol extracting：The ethanol of 14 times of Flos Chrysanthemi cauline leaf silty amount will be added in microwave treatment mixture, carried in 50 DEG C of backflows
Take 4 hours, using 300 mesh filter-cloth filterings, obtain filtrate A and filter residue, filtrate A is concentrated under reduced pressure into filtrate A mass at 50 DEG C
25%, obtain concentrate, the water that 4 times of concentrate quality is added in concentrate is uniformly dispersed, vacuum be 0.08MPa, temperature be
It is 1.25 (50 DEG C) that 50 DEG C, which are concentrated under reduced pressure into relative density, obtains alcohol extract；
(5) water extraction：The water of 7 times of filter residue quality will be added in the filter residue of step (4), 2 hours are incubated at 50 DEG C, using 300
Mesh filter-cloth filtering, obtains liquor B, adds the water of 7 times of filter residue quality, and 2 hours are incubated at 50 DEG C, using 300 mesh filter-cloth filterings,
Obtain liquor C, merging filtrate B and liquor C, obtain filtrate D, filtrate D vacuum be 0.08MPa, temperature is 50 DEG C and is concentrated under reduced pressure
It is 1.25 (50 DEG C) to relative density, obtains water extract；
(6) mix：Water extract and alcohol extract are mixed, stirred 8 minutes with 150 revs/min, obtains the extraction of Flos Chrysanthemi base of leaf
Thing.
The fermentation accelerant is the mixture of chitosan oligosaccharide and lactitol, and the mass ratio of the chitosan oligosaccharide and lactitol is 5：
1。
The preparation method of organic baby moistening frost, comprises the following steps：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride,
Dimethyl silicone polymer, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, whale
Ceryl alcohol polyethers -20, stereth -20, SepigelEG are added in reactor, are heated with stirring to 80 DEG C under 25 revs/min, and
Stirred 20 minutes with 25 revs/min at 80 DEG C, obtain oil phase；
(2) prepared by aqueous phase：Deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans are added in reactor, 25
80 DEG C rev/min are heated with stirring to, and is stirred 20 minutes with 25 revs/min at 80 DEG C, obtains aqueous phase；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, is stirred 4 minutes with 40 revs/min at 80 DEG C, opens homogeneous
Device, is emulsified 10 minutes with 3000 revs/min, then is cooled to 50 DEG C with 40 revs/min of stirrings, sequentially adds panthenol, german chamomile extract, gold
Small cup flower extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, are stirred 25 minutes with 40 revs/min, obtained organic
Baby moistening frost.
Obtained german chamomile extract inoxidizability test result：SOD in serum 134.68U/mL, liver MDA 4.926nmol/
MgProt, moisturizing rate 70.87%.
Test case 1
The inoxidizability of the moisturizing rate of the german chamomile extract obtained to embodiment 1-6 is tested.Concrete outcome is shown in Table 1.
Table 1：The inoxidizability test result table of german chamomile extract
| SOD in serum (U/mL) | Liver MDA (nmol/mgProt) | |
| Embodiment 1 | 115.45 | 6.324 |
| Embodiment 2 | 126.31 | 5.581 |
| Embodiment 3 | 129.93 | 5.406 |
| Embodiment 4 | 123.06 | 5.988 |
| Embodiment 5 | 119.26 | 6.192 |
| Embodiment 6 | 124.65 | 5.647 |
| Model group | 87.192 | 7.622 |
| Blank group | 115.71 | 4.202 |
The accumulation of D- galactose contents is excessive to cause Mice Body intracellular metabolite disorderly, and free radical is largely accumulated, had a strong impact on small
The oxidation level and oxidation resistance of mouse liver, significantly reduce the rise of mouse liver MDA contents, blood SOD vigor.
Embodiment 2 is first fermented Flos Chrysanthemi base of leaf to be extracted again, and the inoxidizability of obtained german chamomile extract is better than real
Apply example 1.This is that the activity extract content of fermented stepmother's chrysanthemum base of leaf improves, while fermentation process produces metabolite and had
Inoxidizability.
Embodiment 3 is extracted again using microwave vacuum processing fermentation Flos Chrysanthemi base of leaf, and obtained german chamomile extract resists
Oxidisability is better than embodiment 2.
Embodiment 3 first uses water extraction again using alcohol extracting, and the inoxidizability of obtained german chamomile extract is better than embodiment 4 and reality
Apply example 5.
The german chamomile extract of embodiment 3 is Flos Chrysanthemi base of leaf extract, and the inoxidizability of obtained organic baby moistening frost is excellent
German chamomile flower extract is used in embodiment 6.
Test case 2
The moisturizing rate of the german chamomile extract obtained to embodiment 1-6 is tested.Concrete outcome is shown in Table 2.
The moisturizing rate test result table of the german chamomile extract of table 2
| Moisturizing rate, % | |
| Embodiment 1 | 52.48 |
| Embodiment 2 | 65.19 |
| Embodiment 3 | 68.84 |
| Embodiment 4 | 58.17 |
| Embodiment 5 | 54.83 |
| Embodiment 6 | 63.25 |
Test case 3
Organic baby moistening frost that embodiment 1-8 is obtained carries out multiple skin irritation test.
Animal prepares：The similar adult of body weight, health, the rabbit 28 of skin zero damage, male and female half and half.Single cage is raised,
The 3d times have been adapted in experimental animal room environment before experiment.24h before experiment, in the case of not damaging epidermis, rabbit is carried on the back
The hair of portion backbone both sides skin is cut short, left and right each one piece, scope about 3 × 3cm.A, B, C, D are divided into Skin-test.
Test method：If to smear organic baby moistening frost area, left side C areas and right side D areas make for left side A areas and right side B areas
For blank control.Take tested material 0.5g to be applied to cropping area, smear scope 2.5cm × 2.5cm, 2 times a day, needed before smearing every time
Cropping is continuous to smear 7 days to ensure that tested material is abundant with skin contact.Observe and record the stimulate the reaction situation for smearing position.
After off-test, find each group rabbit smear position without oedema, without erythema, non-pigment it is calm, without diseases such as bleedings
Shape, while observe that experiment is normal with rabbit vital movement rule, the state of mind without exception.Test result indicates that preparation has
Machine baby moistening frost is nonirritant to rabbit normal skin.
Claims (10)
1. a kind of organic baby moistening frost, it is characterised in that including following raw materials：Parleam, glycerine, butanediol, mother
Chrysanthemum extract, pot marigold extract, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride, polydimethylsiloxanes
Alkane, cetostearyl alcohol, cetanol, stearine, PEG-75 stearates, tocopherol acetate, panthenol, hyaluronic acid
Sodium, ceteth -20, stereth -20, Sepigel EG, EDETATE SODIUM, xanthans, methyl hydroxybenzoate, Nipasol,
Phenoxyethanol, deionized water.
2. organic baby moistening frost as claimed in claim 1, it is characterised in that the raw material including following weight parts：Hydrogenation is poly- different
Butylene 5-10 parts, glycerine 5-10 parts, butanediol 2-5 parts, german chamomile extract 2-5 parts, pot marigold extract 2-5 parts, Butyrospermum parkii
Fruit fat 1-3 parts, olive oil 1-3 parts, caprylic/capric triglyceride 1-3 parts, dimethyl silicone polymer 1-2 parts, cetearyl alcohol
Alcohol 1-2 parts, cetanol 1-2 parts, stearine 0.5-1.5 parts, PEG-75 stearate 0.5-1.5 parts, tocopheryl acetate
Ester 0.1-1 parts, panthenol 0.1-1 parts, Sodium Hyaluronate 0.1-1 parts, ceteth -200.1-1 parts, stereth -
200.1-1 parts, Sepigel EG 0.1-1 parts, EDETATE SODIUM 0.01-0.1 parts, xanthans 0.01-0.1 parts, methyl hydroxybenzoate
0.01-0.03 parts, Nipasol 0.01-0.02 parts, Phenoxyethanol 0.01-0.02 parts, deionized water 45-65 parts.
3. organic baby moistening frost as claimed in claim 2, it is characterised in that the german chamomile extract be german chamomile flower extract or
Flos Chrysanthemi base of leaf extract.
4. organic baby moistening frost as claimed in claim 3, it is characterised in that the german chamomile extract extracts for Flos Chrysanthemi base of leaf
Thing.
5. organic baby moistening frost as claimed in claim 4, it is characterised in that the preparation method of the Flos Chrysanthemi base of leaf extract
Comprise the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes；
(2) alcohol extracting；
(3) water extraction；
(4) mix.
6. organic baby moistening frost as claimed in claim 5, it is characterised in that the preparation method of the Flos Chrysanthemi base of leaf extract
Comprise the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes；
(2) ferment；
(3) microwave；
(4) alcohol extracting；
(5) water extraction；
(6) mix.
7. organic baby moistening frost as claimed in claim 6, it is characterised in that the preparation method of the Flos Chrysanthemi base of leaf extract
Comprise the following steps：
(1) Flos Chrysanthemi base of leaf pre-processes：Fresh Flos Chrysanthemi base of leaf is gathered, is placed in 40-60 DEG C of drying box and dries 18-24 hours,
Crush as 60-100 mesh, obtain Flos Chrysanthemi base of leaf powder；
(2) ferment：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：(0.1-0.5)：(1-5) is mixed, and is obtained
Leavening, uniform sprinkling leavening in Flos Chrysanthemi base of leaf powder, the dosage of wherein leavening is the 5- of Flos Chrysanthemi base of leaf silty amount
15%, then be sealed by fermentation 2-5 days at 25-35 DEG C, obtain the Flos Chrysanthemi base of leaf that ferments；
(3) microwave：The water of 1-3 times of Flos Chrysanthemi base of leaf silty amount will be added in the Flos Chrysanthemi base of leaf that ferments, obtain mixed liquor, mix
Feed liquid stands 20-40 minutes at 20-30 DEG C, is put into microwave treatment 100-300 seconds in microwave vacuum equipment, Microwave Power Density 8-
12W/g, vacuum 0.03-0.06MPa, obtain microwave treatment mixture；
(4) alcohol extracting：The ethanol of 10-18 times of Flos Chrysanthemi cauline leaf silty amount will be added in microwave treatment mixture, in 45-55 DEG C of backflow
3-5 hours are extracted, using 300 mesh filter-cloth filterings, filtrate A and filter residue is obtained, filtrate A is concentrated under reduced pressure into filtrate A at 45-55 DEG C
The 20-30% of quality, concentrate is obtained, the water that 3-5 times of concentrate quality is added in concentrate is uniformly dispersed, in 45-55 DEG C of decompression
It is 1.2-1.3 to be concentrated into relative density, obtains alcohol extract；
(5) water extraction：The water of 5-10 times of filter residue quality will be added in the filter residue of step (4), be incubated 1-3 hours at 45-55 DEG C, use
300 mesh filter-cloth filterings, obtain liquor B, add the water of 5-10 times of filter residue quality, 1-3 hours are incubated at 45-55 DEG C, using 300
Mesh filter-cloth filtering, liquor C, merging filtrate B and liquor C are obtained, obtain filtrate D, filtrate D is concentrated under reduced pressure into relatively close at 45-55 DEG C
Spend for 1.2-1.3, obtain water extract；
(6) mix：Water extract and alcohol extract are mixed, with 100-200 revs/min of stirring 5-10 minute, Flos Chrysanthemi base of leaf is obtained and carries
Take thing.
8. organic baby moistening frost as claimed in claim 3, it is characterised in that the preparation method of the german chamomile flower extract includes
Following steps：
(1) Flos Chrysanthemi pre-processes：Fresh Flos Chrysanthemi is gathered, is placed in 40-60 DEG C of drying box and dries 18-24 hours, crush as 60-
100 mesh, obtain german chamomile pollen；
(2) leavening is prepared：By deionized water, saccharomycete, fermentation accelerant in mass ratio 100：(0.1-0.5)：(1-5) is mixed
Close, with 60-100 revs/min of stirring 8-12 minute, obtain leavening, uniform sprinkling leavening in german chamomile pollen, wherein leavening
Dosage is the 5-15% of Flos Chrysanthemi silty amount, then is sealed by fermentation 2-5 days at 25-35 DEG C, obtains the Flos Chrysanthemi that ferments；
(3) microwave：The water of 1-3 times of Flos Chrysanthemi silty amount will be added in the Flos Chrysanthemi that ferments, obtain mixed liquor, mixed liquor exists
20-30 DEG C of standing 20-40 minute, it is put into microwave treatment 100-300 seconds in microwave vacuum equipment, Microwave Power Density 10-13W/
G, vacuum 0.03-0.06MPa, obtain microwave treatment mixture；
(4) alcohol extracting：The ethanol of 10-18 times of Flos Chrysanthemi silty amount will be added in microwave treatment mixture, in 45-55 DEG C of refluxing extraction
3-5 hours, using 300 mesh filter-cloth filterings, filtrate A and filter residue are obtained, filtrate A is concentrated under reduced pressure into filtrate A mass at 45-55 DEG C
20-30%, obtain concentrate, the water that 3-5 times of concentrate quality is added in concentrate is uniformly dispersed, and is concentrated under reduced pressure at 45-55 DEG C
It is 1.2-1.3 to relative density, obtains alcohol extract；
(5) water extraction：The water of 5-10 times of filter residue quality will be added in the filter residue of step (4), be incubated 1-3 hours at 45-55 DEG C, use
300 mesh filter-cloth filterings, obtain liquor B, add the water of 5-10 times of filter residue quality, 1-3 hours are incubated at 45-55 DEG C, using 300
Mesh filter-cloth filtering, liquor C, merging filtrate B and liquor C are obtained, obtain filtrate D, filtrate D is concentrated under reduced pressure into relatively close at 45-55 DEG C
Spend for 1.2-1.3, obtain water extract；
(6) mix：Water extract and alcohol extract are mixed, with 100-200 revs/min of stirring 5-10 minute, obtain german chamomile flower extract.
9. the organic baby moistening frost as described in claim 7 or 8, it is characterised in that the fermentation accelerant be chitosan oligosaccharide and/or
Lactitol.
10. the preparation method of organic baby moistening frost as described in claim any one of 1-9, it is characterised in that including following step
Suddenly：
(1) prepared by oil phase：By Parleam, Butyrospermum parkii fruit fat, olive oil, caprylic/capric triglyceride, poly- two
Methylsiloxane, cetostearyl alcohol, cetanol, tocopherol acetate, stearine, PEG-75 stearates, cetanol
Polyethers -20, stereth -20, SepigelEG are added in reactor, and 75-85 DEG C is heated with stirring under 20-30 revs/min,
And oil phase is obtained with 20-30 revs/min of stirring 15-25 minute at 75-85 DEG C；
(2) prepared by aqueous phase：By deionized water, glycerine, butanediol, EDETATE SODIUM, xanthans add reactor in, 20-30 turn/
Divide and be heated with stirring to 75-85 DEG C, and aqueous phase is obtained with 20-30 revs/min of stirring 15-25 minute at 75-85 DEG C；
(3) emulsify：Oil phase and aqueous phase are sequentially added into emulsification pot, at 75-85 DEG C with 30-50 revs/min of stirring 3-5 minute, opened
Homogenizer, is emulsified 10 minutes with 2000-4000 revs/min, then is cooled to 45-55 DEG C with 30-50 revs/min of stirring, is sequentially added general
Alcohol, german chamomile extract, pot marigold extract, Sodium Hyaluronate, methyl hydroxybenzoate, Nipasol, Phenoxyethanol, with 30-50 revs/min
20-30 minutes are stirred, obtain organic baby moistening frost.
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| CN108309875A (en) * | 2018-05-07 | 2018-07-24 | 杨恒智 | Moisten moisturizing face cream and preparation method thereof |
| CN108721150A (en) * | 2018-08-28 | 2018-11-02 | 广州市华晟健康产业有限公司 | A kind of baby containing olive extract moistens frost again |
| CN108904388A (en) * | 2018-08-30 | 2018-11-30 | 广州市华晟健康产业有限公司 | A kind of baby's Hydra Zen containing pot marigold |
| CN109125190A (en) * | 2018-11-01 | 2019-01-04 | 广州市华晟健康产业有限公司 | A kind of multiple-effect infant moisture surge treatment formula |
| CN110974726A (en) * | 2019-12-31 | 2020-04-10 | 福建省梦娇兰日用化学品有限公司 | Infant skin cream based on ultrasonic assistance |
| CN112156058A (en) * | 2020-09-25 | 2021-01-01 | 深圳全棉时代科技有限公司 | Infant moisturizing lotion and preparation method thereof |
| CN113304186A (en) * | 2021-05-26 | 2021-08-27 | 上海橙果生物工程有限公司 | Skin cream capable of relieving joint pain and improving joint vitality as well as preparation method and using method thereof |
| CN113855610A (en) * | 2021-10-25 | 2021-12-31 | 合肥工业大学智能制造技术研究院 | Method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309875A (en) * | 2018-05-07 | 2018-07-24 | 杨恒智 | Moisten moisturizing face cream and preparation method thereof |
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| CN108904388A (en) * | 2018-08-30 | 2018-11-30 | 广州市华晟健康产业有限公司 | A kind of baby's Hydra Zen containing pot marigold |
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| CN110974726A (en) * | 2019-12-31 | 2020-04-10 | 福建省梦娇兰日用化学品有限公司 | Infant skin cream based on ultrasonic assistance |
| CN112156058A (en) * | 2020-09-25 | 2021-01-01 | 深圳全棉时代科技有限公司 | Infant moisturizing lotion and preparation method thereof |
| CN113304186A (en) * | 2021-05-26 | 2021-08-27 | 上海橙果生物工程有限公司 | Skin cream capable of relieving joint pain and improving joint vitality as well as preparation method and using method thereof |
| CN113855610A (en) * | 2021-10-25 | 2021-12-31 | 合肥工业大学智能制造技术研究院 | Method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream |
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