KR20050081550A - Hypoallergenic cosmetics formulation containing botanical extracts for acne skin - Google Patents

Abstract

The present invention is 5 of Magnolia obovata bark extract, Camellia sinensis leaf extract, Grapefruit seed extract, Grapefruit seed extract, Ginger root extract, Phellodendron amurense bark extract The present invention relates to an antibacterial composition for acne skin, which contains a natural plant extract of a species, and has excellent skin hypo-allergenic properties and a fundamental improvement effect of acne. In particular, the composition of the present invention suggests safe application to various types of cosmetic compositions that function as a skin sebum control effect and acne relief effect.

Description

Hypoallergenic cosmetics formulation containing botanical extracts for acne skin

The present invention comprises Magnolia obovata bark extract, Camellia sinensis leaf extract, Grapefruit seed extract, Grapefruit seed extract, Ginger root extract, Phellodendron amurense bark extract The present invention relates to a cosmetic composition containing a mixed extract, and more particularly, to a cosmetic composition having an effect of treating or preventing skin diseases such as acne by a stronger antibacterial action of the extract.

There are various microorganisms on the skin. These microorganisms cause various skin diseases. Staphylococcus aureus, which causes purulent skin, includes Staphylococcus epidermis, Acne bacteria (Propionibacterium acnes), Oily skin infections (oval patirosporum bacteria, Pity ovale) These bacteria decompose sebum or sweat secreted on the skin and produce odors. In addition, the degradation products irritate and irritate the skin. In particular, acne bacteria (Propionibacterium acnes) breaks down sebum by using a fatty acid degrading enzyme lipase (lipase) to produce free fatty acids. These free fatty acids not only irritate the skin but also cause inflammatory lesions such as papules, pustules and nodules, which are red rashes found in acne.

Dermatophytes invade the stratum corneum of the hair and skin, causing superficial mycosis. The skin filaments that cause superficial mycosis include Microsporum, Trichophyton, and Epidermophyton, and fungi represent ringworm. Candida albicans causes cutaneous candidiasis and chronic mucosal candidiasis. These fungi represent superficial mycosis, in which the fungus parasitic in the keratinous tissue of the skin and multiplies and causes lesions. Another cause of granulomatous lesions in skin and subcutaneous tissue is Sporotrix schenckii.

In order to treat such acne, attempts have been made to have a therapeutic effect by smoothing the secretion of sebum through exfoliation of pores using salicylic acid or vitamin A derivatives, or by using benzoyl peroxide. Attempts have been made to cure through removal and strong antimicrobial action. However, salicylic acid preparations can cause skin redness, swelling or skin repellency, as well as poor therapeutic effects, while retinoic acid preparations have the effect of inhibiting hyperkeratosis, but contact dermatitis, erythema, skin drying and peeling may occur. In addition, benzoyl peroxide preparations have been reported to cause side effects such as allergic contact dermatitis, scarring and severe erythema.

In view of these problems, the present inventors have studied to develop cosmetics that are excellent in the prevention and treatment effect of acne and excellent in the safety of the skin even for a long time use. As a result, Magnolia obovata bark extract and Camellia sinensis leaf extracts, grapefruit seed extract, ginger root extract, and Phellodendron amurense bark extract were used to combine the extracts. Could know.

Accordingly, it is an object of the present invention to provide a cosmetic composition containing a natural extract blending component having an effect of treating or preventing skin diseases such as acne with a stronger antibacterial action and having excellent safety of skin hypoallergenic aspects.

An object of the present invention is a gnocchi extract (Magnolia obovata bark extract), Camellia sinensis extract (Camelllia sinensis leaf extract), grapefruit seed extract (Grpaefruit seed extract), Ginger root extract (Ginger root extract), yellow white extract (Phellodendron amurense bark extract It is achieved by a cosmetic composition containing a vegetable extract mixing component (hereinafter referred to as a mixed extract component) consisting of five mixed extracts of the compounds.

Magnolia Bark is the bark of stems and branches of Magnolia officinalis Rehder et Wilson and Magnolia obovata Thunberg. It is a raw material used mainly in herbal medicine to warm the inside, lower the energy, and control the humidity, wall, and enemy. When the stomach and chest are full and painful, it has been used for indications such as vomiting, diarrhea and dysentery. The thick gourd extract component serves to soothe acne and regulate sebum when applied to the skin, and the thick gourd extract is preferably 0.1-50% by weight based on the total mixed extract component. If it is less than 0.1% by weight, the effect is insignificant. If it is more than 50%, the irritation of the skin may be increased.

Camellia sinensis leaf extract may be prepared from various organs (flowers, fruits, stems, roots, leaves, etc.) of the camellia, but is preferably extracted from the leaves of the camellia. Camellia extract soothes acne skin and plays a role in skin healing of acne wounds, and the content is preferably 0.1-50% by weight based on the total mixture extract. If the amount is less than 0.1% by weight, the effect is insignificant, and if it is 50% or more, it may not be suitable for the excessive sebum skin condition, and the side of skin fit decreases when applied to the cosmetic composition.

Grapefruit seed extract is obtained from grapefruit fruit, which is a fruit of the grapefruit tree belonging to the citrus (Citrus). Grapefruit seed extract is an extract of the active ingredient by drying the grapefruit seeds, the main component is vitamin C and naringin. Of these, naringin is known as vitamin P, a flavonoid, which has excellent bacteriostatic action to stop the growth of microorganisms and microbial sterilization. The grapefruit seed extract is preferably 0.1 to 70% by weight based on the total mixed extract component. If it is less than 0.1% by weight, the effect is insignificant, and if it is 70% or more, it may increase the degree of irritation on the skin.

Ginger root extract (Ginger rroot extract) is used as a medicine called health (말린) dried root stem in oriental medicine, it is effective for digestive dysentery diarrhea, promotes blood circulation, anti-inflammatory and analgesic effect. When applied to the acne site has an acne anti-inflammatory action and pain relief effect, the ginger root extract is preferably 0.1-40% by weight relative to the total mixed extract ingredients. If it is less than 0.1% by weight, the effect is insignificant. If it is more than 40%, the irritation of the skin may be increased.

Phellodendron amurense bark extract used in the present invention is obtained from the baekbaekpi, the bark of the baekbaek stem, which is native to Korea, and a representative example of baekbaek is Phellodendron amurense RUPRECHT. . His varieties include var. Latifoliolatum NAKAI, var. Japonicum OHWI, P. insulare NAKAI, and Pelodendron wheel Nagai. Nakai), P. sachalinense Sarg. Yellow and white skin contains yellow or tan pigment and 1.5 to 4.5% of the alkaloids. The main component of alkaloids is berberine. In addition, there are palmatine, magnoflorine, guanidine, guatedine, jateorrizine, phellodendrine, candicine, and menisperine. High-density compounds are known to contain obakunone, obakulactone, and the like. These ingredients have strong antibacterial action, blood pressure lowering action, central nerve suppression action, acetylcholine enhancement action and anti-inflammatory action and have been used for bone disease and jaundice in herbal or medicinal wood. It is also effective for typhoid fever, cholera, dry stomach, and intestinal tract, and their bark has been used for gastroenteritis, abdominal pain, jaundice, and the like as a high-density agent, a formal agent, and an anti-inflammatory astringent drug.

In particular, the Phellodendron amurense bark extract of the present invention performs a function of removing any one of the 'acne generation mechanism', for example, 'acne bacteria'. Usually, the yellowish white extract is disclosed in, for example, Korean Patent Publication No. 1999-75521 'Cosmetic Ingredients Containing Herbal Extracts with Wrinkle Improvement Effect', Korean Patent Publication No. 2001-10368 'Skin Control Cosmetic Composition for Skin', Korean Patent As described in Korean Patent Publication No. 2001-18655, 'Cosmetic Composition Containing Rhubarb Extract', etc., it has excellent 'skin adaptability', and US Patent Publication No. 5080900 'Dermatitis Containing Red Oak Sap Extract. As shown in 'Treatment of skin ulcers with an aqueous extract of oak bark ash', it is known that it has excellent antibacterial function. (Magnolia obovata bark extract), Camellia sinensis leaf extract, Grapefruit seed extract, Ginger root extract (Gi nger root extract) and the like, and mixed with the composition for acne treatment, through which, for example, by promoting the removal of acne bacteria residing in the hair follicles (Hair follicle) of the skin, the final composition according to the present invention is' Sebum excessive secretion suppression function, and 'skin inflammation removal function', along with excellent 'acne bacteria removal function' will be induced at the same time. The sulfur white extract is preferably 0.1 to 80% by weight based on the total mixed extract component. If it is less than 0.1% by weight, the effect is insignificant, and if it is more than 80%, irritation may be increased on the skin.

In the cosmetic composition for acne skin of the present invention, Magnolia obovata bark extract, Camellia sinensis leaf extract, Grapefruit seed extract, Ginger root extract, Ginger root extract, Phellodendron The amount of the mixed extract composed of five plant extracts of amurense bark extract is preferably 0.1-50% by weight based on the total cosmetic composition, and when the amount is less than 0.1% by weight, the acne improvement effect that can be achieved is too weak. In the case of exceeding 50% by weight, the increase in the effect of the increase of the content becomes smaller, which causes a problem in that the efficiency in terms of effectiveness versus content is reduced.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to the mixed extraction component as an active ingredient, and include conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. And carriers.

The composition for acne skin of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing It may be formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Example 1 and Comparative Example 1-6.

Skin lotion containing mixed extract containing 15%, 15%, 20%, 25%, 25% by weight of hickory extract, camellia extract, grapefruit seed extract, ginger root extract, and white bean extract, respectively. Prescription example of) is as follows.

Table 1. Prescription example of skin lotion (skin lotion) according to the present invention (unit: weight%)

number Raw material Example 1 Comparative Example 1 One  Thick Extract, Camellia Extract, Grapefruit Seed Extract, Ginger Root Extract, Yellow White Extract Mixed Extract 10.0 - 2 glycerin 2.0 2.0 3 Butylene Glycol 3.0 3.0 4 Propylene glycol 2.0 2.0 5 Polyoxyethylene (60) Cured Castor Oil 1.00 1.0 6 ethanol 8.0 8.0 7 Triethanolamine 0.1 0.1 8 antiseptic 0.005 0.005 9 Pigment 0.003 0.003 10 Spices 0.002 0.002 11 Purified water Remaining amount Remaining amount

<Manufacturing method>

Example 1: Raw material No. 11, raw materials 2, 3, 4, and 8 were sequentially added and stirred to dissolve. The raw material No. 5 was heated and dissolved about 55 ° C., and raw material No. 10 was added and stirred. Input to raw material No. 11. Finally, the raw materials 1, 6, 7, and 9 were added and sufficiently stirred before passing through a microfluidizer and aged.

Comparative Example 1: Raw material No. 11, raw materials 2, 3, 4, and 8 were sequentially added and stirred to dissolve. Then, raw material No. 5 was heated and dissolved about 55 ° C., and raw material No. 10 was added and stirred. Input to raw material No. 11. Finally, the raw materials 6, 7, and 9 are added and sufficiently stirred before passing through a microfluidizer and aged.

Comparative Example 2: The same as Example 1, but using only the pak extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 3 Same as Example 1, but using only Camellia extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 4 The same as Example 1, but using only grapefruit seed extract instead of a mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 5 The same as Example 1, but using only the ginger root extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 6: The same as Example 1, but using only the white extract extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Example 2 and Comparative Example 7-12.

Formulation of nutritional lotion containing mixed extract containing 20%, 20%, 25%, 25% and 10% by weight of hickory extract, camellia extract, grapefruit seed extract, ginger root extract, and yellow white extract, respectively An example follows.

Table 2. Prescription example of nutrition lotion according to the present invention (unit: weight%)

number Raw material Example 2 Comparative Example 7 One Thick Extract, Camellia Extract, Grapefruit Seed Extract, Ginger Root Extract, Yellow White Extract Mixed Extract 10.0 - 2 Cytostolol 1.90 1.90 3 Polyglyceryl 2-oleate 1.30 1.30 4 Ceramide 0.7 0.7 5 Ceteares-4 1.2 1.2 6 cholesterol 1.4 1.4 7 Dicetylphosphate 0.5 0.5 8 Concentrated glycerin 6.0 6.0 9 Sunflower oil 8.0 8.0 10 Carboxy Vinyl Polymer 0.2 0.2 11 Xanthan Gum 0.3 0.3 12 antiseptic 0.003 0.003 13 Spices 0.002 0.002 14 Purified water Remaining amount Remaining amount

<Manufacturing method>

Example 2 Raw materials 2, 3, 4, 5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1, 7, 8, and 14 are mixed and homogenized at a constant temperature to pass through a microfluidizer, and then the raw material 9 is gradually added at a constant temperature to homogenize and then microfluda again. Pass it through again. Then, the raw materials 10, 11, 12, 13 are added to disperse to stabilize and mature.

Comparative Example 7: The raw materials 2, 3, 4, 5, and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipids and the raw materials 7, 8 and 14 are mixed and homogenized at a constant temperature and passed through a microfluidizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then again added to the microfluidizer. Pass it again. Then, the raw materials 10, 11, 12, 13 are added to disperse to stabilize and mature.

Comparative Example 8: The same as Example 1, but using only the raw extract extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 9: Same as Example 1, but using only Camellia extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 10: The same as Example 1, but using only the grapefruit seed extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 11: The same as Example 1, but using only the ginger root extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow white extract for the raw material 1

Comparative Example 12: The same as Example 1, but using only the white extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow white extract for raw material 1

Example 3 and Comparative Example 13-18

Of nourishing cream in cosmetics containing a mixed extract containing 10%, 30%, 20%, 25%, and 15% by weight of hickory extract, camellia extract, grapefruit seed extract, ginger root extract, and yellowish white extract, respectively A prescription example is as follows.

Table 3. Prescription example of nutrition cream according to the present invention (unit: weight%)

number Raw material Example 3 Comparative Example 13 One Thick Extract, Camellia Extract, Grapefruit Seed Extract, Ginger Root Extract, Yellow White Extract Mixed Extract 10.0 - 2 Cytostolol 4.0 4.0 3 Polyglyceryl 2-oleate 3.0 3.0 4 Ceramide 0.7 0.7 5 Ceteares-4 2.0 2.0 6 cholesterol 3.0 3.0 7 Dicetylphosphate 0.4 0.4 8 Concentrated glycerin 5.0 5.0 9 Sunflower oil 22.0 22.0 10 Carboxy Vinyl Polymer 0.5 0.5 11 Triethanolamine 0.5 0.5 12 antiseptic 0.005 0.005 13 Spices 0.003 0.003 14 Purified water Remaining amount Remaining amount

(Manufacturing method)

Example 3: Raw materials 2, 3, 4, 5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1, 7, 8, and 14 are mixed and homogenized at a constant temperature to pass through a microfluidizer, and then the raw material 9 is gradually added at a constant temperature to homogenize and then microfluda again. Pass it through again. Then, the raw materials 10, 11, 12, 13 are added to disperse to stabilize and mature.

Comparative Example 13: The raw materials 2, 3, 4, 5, and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipids and the raw materials 7, 8 and 14 are mixed and homogenized at a constant temperature and passed through a microfluidizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then again added to the microfluidizer. Pass it again. Then, the raw materials 10, 11, 12, 13 are added to disperse to stabilize and mature.

Comparative Example 14: The same as Example 1, but using only the pak extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 15: The same as Example 1, but using only Camellia extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 16: The same as Example 1, but using only grapefruit seed extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 17: The same as Example 1, but using only the ginger root extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 18 The same as the Example 1, but using only the white extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow white extract for the raw material 1

Example 4 and Comparative Examples 19-24

Prescription examples of massage creams in cosmetics containing 20% by weight, 10% by weight, 25% by weight, 25% by weight and 20% by weight of hickory extract, camellia extract, grapefruit seed extract, ginger root extract, respectively same.

Table 4. Prescription example of massage cream according to the present invention (unit: weight%)

number Raw material Example 4 Comparative Example 19 One Thick Extract, Camellia Extract, Grapefruit Seed Extract, Ginger Root Extract, Yellow White Extract Mixed Extract 10.0 - 2 Beeswax 10.0 10.0 3 Polysorbate 60 1.5 1.5 4 Sorbitan sesquioleate 0.8 0.8 5 Liquid paraffin 38.0 38.0 6 Squalane 6.0 6.0 7 Caprylic / Capric Triglycerides 4.0 4.0 8 Carboxy Vinyl Polymer 0.2 0.2 9 glycerin 6.0 6.0 10 Butylene glycol 3.0 3.0 11 Propylene glycol 3.0 3.0 12 Triethanolamine 0.2 0.2 13 antiseptic 0.005 0.005 14 Pigment 0.002 0.002 15 Spices 0.002 0.002 16 Purified water Remaining amount Remaining amount

<Manufacturing method>

Example 4 The raw materials 8, 9, 10, 11, 13, and 16 are heated to 80-85 ° C. with mixing and stirring, and then put into the manufacturing unit, and then the emulsifier is activated and the raw materials 2, 3, 4, 5, 6, 7, 12 is heated to between 80-85 ° C and emulsified. After emulsification, cool down to 50 ℃ while stirring using a stirrer, add raw material No. 14, cool to 45 ℃, add raw material No. 15, and cool to 35 ℃. It is cooled to 25 ° C. and aged.

Comparative Example 19: Mixing and stirring the raw materials 8, 9, 10, 11, 13, 16 and heated to 80-85 ℃ to put into the manufacturing unit and then actuated emulsifier and raw materials 2, 3, 4, 5, 6, 7, 12 is heated to between 80-85 ° C and emulsified. After emulsification, the mixture is cooled to 50 ° C. while stirring using a stirrer, and the raw material No. 14 is added and cooled to 45 ° C., then the raw material No. 15 is added, cooled to 35 ° C., and aged.

Comparative Example 20: The same as Example 1, but using only the pak extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 21: The same as Example 1, but using only Camellia extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 22: The same as Example 1, but using only the grapefruit seed extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 23: The same as Example 1, but using only the ginger root extract instead of the mixed extract consisting of five kinds of raw materials extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract for the raw material 1

Comparative Example 24: The same as Example 1, but using only the white extract extract instead of the mixed extract consisting of five kinds of raw material extract, camellia extract, grapefruit seed extract, ginger root extract, yellow white extract for the raw material 1

Acne antibacterial test

The antimicrobial effect of Example 1-4 and Comparative Example 1-24 was measured as follows.

After incubating each strain for 1 day, 200 µl was plated in a petri dish, 1 g of each extract was dissolved in 2 ml of 50% 1, 3-butylene glycol aqueous solution, and 30 µl of the mixed solution was taken. Each strain was inoculated on a paper disc and cultured under the following conditions (Table 5).

Table 5. Culture conditions of strains for measuring the antimicrobial effect of natural extracts according to the present invention

number Strains Medium Time, temperature type One Candida albicans (ATCC 10259) Nutrient agar 48 hours, 37 ℃ Exhalation 2 Escherichia coli (ATCC 25922) Tryticase soy agar 48 hours, 37 ℃ Exhalation 3 Streptococcus aureus (Staphylococcus aureus ATCC 29737) Nutrient agar 48 hours, 37 ℃ Exhalation 4 Bacillus subtilis ATCC 6633 Nutrient agar 48 hours, 37 ℃ Exhalation 5 Streptococcus mutans ATCC 25175 Brain heart infusion 24 hours, 37 ℃ Exhalation 6 Staphylococcus epidermidis ATCC 12228 Nutrient agar 48 hours, 27 ℃ Exhalation 7 Acne Bacteria (Propionibacterium acne ATCC 6919) Reinforced clostridial agar medium 72 hours, 37 ℃ anaerobe

The results are shown in Table 13 to measure the diameter of the clear zone appearing around the paper disc (paper disc).

Table 6. Experimental results for the examples and comparative examples using a mixed extract consisting of five kinds of extracts, camellia extract, grapefruit seed extract, ginger root extract, yellow white extract

       (Clean area diameter unit: mm)

sample Clean area sample Clean area sample Clean area sample Clean area Example 1 23 Example 2 21 Example 3 22 Example 4 23 Comparative Example 1 0 Comparative Example 7 0 Comparative Example 13 0 Comparative Example 19 0 Comparative Example 2 15 Comparative Example 8 13 Comparative Example 14 14 Comparative Example 20 15 Comparative Example 3 9 Comparative Example 9 8 Comparative Example 15 9 Comparative Example 21 10 Comparative Example 4 14 Comparative Example 10 13 Comparative Example 16 13 Comparative Example 22 14 Comparative Example 5 17 Comparative Example 11 16 Comparative Example 17 16 Comparative Example 23 18 Comparative Example 6 15 Comparative Example 12 14 Comparative Example 18 15 Comparative Example 24 16

As a result of the acne antimicrobial test, the examples containing the mixed extract component consisting of five kinds of gourd extract, camellia extract, grapefruit seed extract, ginger root extract, and yellowish white extract contain only a single component among the five components. It was confirmed that the results showing better antimicrobial activity compared to the comparative examples that do not contain any one of the comparative examples or five components.

Measure improvement for acne

In order to confirm the effect of acne treatment of the present invention, 122 men and women aged 18-35 years old were divided into two groups of 61 persons each, and in the same manner as the routine lotion use for each three weeks, 61 persons of the lotion of Example 2 Another 61 people were allowed to use the lotion of Comparative Example 7, and the degree of improvement was determined according to the opinion of the user.

Table 7. Sebum secretion effect (unit: number of people)

Example 2 Comparative Example 7 Very effective 18 0 It works 36 One is average 5 7 It does not work One 21 No effect at all One 32

Table 8. Acne improvement effect (unit: number of people)

Example 2 Comparative Example 7 Very effective 19 0 It works 33 2 is average 5 5 It does not work 3 24 No effect at all One 30

Human closed patch test

The human patch test is widely used as a method to search for primary irritants (Matsumura et al , 1995), but dermatologically, it refers to a diagnostic patch test for the diagnosis of allergic contact dermatitis. do.

In the back of each healthy adult male and female, 40 μl was put in a kit (Finn chamber), which was fixed to the skin with a tape (scanpore tape). After 24 hours it was removed from the skin and after 4 hours the results were determined. The degree of erythema and edema is indicated numerically. The criteria for acceptance were in accordance with the criteria of the International Contact Dermatitis Research Group (ICDRG) (Wooding et al , 1967; Rietschell, 1982; Fischer & Maibach, 1984; Aberer et al , 1993).

(Criteria)

0 = no redness

1 = erythema

2 = redness and papules

3 = redness, papules and vesicles

4 = severe edema and vesicles

Stimulus (%) = (responsiveness of positive response / response of self population) × 100

Table 9. Stimulus of closed patch test

Stimulus of closed patch test (%) Example 1  2.02 Example 2  1.83 Example 3  2.03 Example 4  1.92 Comparative Example 1  2.08 Comparative Example 7  1.75 Comparative Example 13  1.93 Comparative Example 19  1.88

As a result of the above experiment, the case containing the mixed extract component consisting of five kinds of pakbak extract, camellia extract, grapefruit seed extract, ginger root extract, and yellowish white extract is more sebum than the comparative example containing no five components at all. The control properties and acne improvement properties showed excellent results, especially in the case of the embodiment containing a mixed extract consisting of five kinds of extract, camellia extract, grapefruit seed extract, ginger root extract, yellow-white extract in terms of skin irritation The skin irritation properties, which are almost similar to the comparative examples that do not contain the five components at all, exhibit stable hypoallergenic properties in terms of skin irritation.

Skin cosmetic composition containing a mixed extract consisting of the five extracts of the extract, camellia extract, grapefruit seed extract, ginger root extract, yellowish white extract of the present invention has a strong antibacterial effect and has excellent ability to improve acne skin and at the same time Also excellent in polar properties, the cosmetic composition of the present invention proposes the use as a safe cosmetic composition for treating or preventing skin diseases such as acne.

Claims (3)

A cosmetic composition for acne skin having a strong antibacterial effect, which contains a mixed extract consisting of five kinds of pear extract, camellia extract, grapefruit seed extract, ginger root extract, and yellowish white extract. The cosmetic composition according to claim 1, wherein the content ratio of each of the plant extracts to the total mixed extract component consisting of the five species is adjusted to the following weight ratio. 1) Thicken extract: 0.1-50% by weight 2) Camellia Extract: 0.1-50% by weight 3) Grapefruit Seed Extract: 0.1-70% by weight 4) Ginger Root Extract: 0.1-40% by weight 5) Yellow White Extract: 0.1-80% by weight The cosmetic according to any one of claims 1 to 2, wherein the cosmetic composition has a formulation such as softening cream (skin lotion), nutritious cream (milk lotion), nutrition cream, massage cream, essence, pack, emulsified foundation, or the like. Composition.