CN108309875A - Moisten moisturizing face cream and preparation method thereof - Google Patents
Moisten moisturizing face cream and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The invention discloses a kind of moist moisturizing face cream and preparation method thereof, the moist moisturizing face cream includes that following raw materials are prepared：Glycerine, saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, Fructus Jujubae extract, grape seed extract, chitosan oligosaccharide, stabilizer, Sodium Hyaluronate, tocopherol acetate, usnic acid, water.The present invention moistens moisturizing face cream and preparation method thereof, adds natural plant extracts, and obtained moist moisturizing face cream is safe to use, stable quality is easy to skin absorption, continues water lock, permanent moisturizing has good performance of keeping humidity and anti-light sensitivity, can effectively moisturize the skin.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of moist moisturizing face cream and preparation method thereof.
Background technology
With the civilization and progress of society, the continuous improvement of living standards of the people and quality, people more focus on cosmetics original
The quality and safety of material, it is desirable to use the green natural raw material being harmful to human health simultaneously with cosmetology effect.
Material for cosmetics ask have the characteristics that stability it is good and to human skin without allergic reaction.The master of countries in the world cosmetics
It is " advocating nature " to want development trend, makes every effort to use natural plant raw material in cosmetics.There is manufacture in China and using natural
Vast territory and abundant resources for the long history of plant cosmetics, abundant practical experience and technical advantage, and China, in its unique geography
Under environment and weather conditions, many natural plants with their own characteristics are grown.These plants are because of its different characteristic, for a long time
For beauty, there is moisturizing, the effect for preventing extraneous various adverse factors from being injured to skin.
However, in the prior art face cream cannot long-acting moisturizing, and additive types are various, are used for a long time and are caused to skin
Injury.
Invention content
Aiming at the above shortcomings existing in the prior art, technical problem to be solved by the invention is to provide one kind moistening guarantor
Wet face cream and preparation method thereof adds natural plant extracts, and obtained moist moisturizing face cream is safe to use, stable quality, easily
It is absorbed in skin, continues water lock, permanent moisturizing has good performance of keeping humidity and anti-light sensitivity, can effectively moisturize the skin.
Purpose of the present invention is to what is be achieved through the following technical solutions：
A kind of moist moisturizing face cream, including the raw material of following weight parts are prepared：5-10 parts of glycerine, 3-6 parts of saualane,
3-6 parts of camellia seed oil, 1-3 parts of olive oil, 1-5 parts of isopropyl myristate, 1-3 parts of molecular distillation monoglyceride, Fructus Jujubae extract
1-3 parts, 2-6 parts of grape seed extract, 1-3 parts of chitosan oligosaccharide, 1-3 parts of stabilizer, 0.1-0.5 parts of Sodium Hyaluronate, tocopherol second
0.1-0.5 parts of acid esters, 0.001-0.01 parts of usnic acid, 30-50 parts of water.
Preferably, a kind of moist moisturizing face cream, including the raw material of following weight parts are prepared：5-10 parts of glycerine, spiny dogfish
3-6 parts of alkane, 3-6 parts of camellia seed oil, 1-3 parts of olive oil, 1-5 parts of isopropyl myristate, 1-3 parts of molecular distillation monoglyceride, ocean
1-3 parts of Flos Sophorae extract, 1-3 parts of Fructus Jujubae extract, 2-6 parts of grape seed extract, 1-3 parts of chitosan oligosaccharide, 1-3 parts of stabilizer, thoroughly
0.1-0.5 parts of bright matter acid sodium, 0.1-0.5 parts of tocopherol acetate, 0.001-0.01 parts of usnic acid, 30-50 parts of water.
It is highly preferred that a kind of moist moisturizing face cream, is prepared by the raw material of following weight parts：5-10 parts of glycerine, spiny dogfish
3-6 parts of alkane, 3-6 parts of camellia seed oil, 1-3 parts of olive oil, 1-5 parts of isopropyl myristate, 1-3 parts of molecular distillation monoglyceride, ocean
1-3 parts of Flos Sophorae extract, 1-3 parts of Fructus Jujubae extract, 2-6 parts of grape seed extract, modified 1-3 parts of chitosan oligosaccharide, stabilizer 1-3
Part, 0.1-0.5 parts of Sodium Hyaluronate, 0.1-0.5 parts of tocopherol acetate, 0.001-0.01 parts of usnic acid, 30-50 parts of water.
The stabilizer is sodium alginate and/or lithium magnesium silicate.
Preferably, the stabilizer is the mixture of sodium alginate and lithium magnesium silicate, the sodium alginate and lithium magnesium silicate
Mass ratio be (2-5)：1.
The preparation method of the modified chitosan oligosaccharide includes the following steps that described part is parts by weight：
(1) glacial acetic acid aqueous solution that 2-4 parts of chitosan oligosaccharides and 80-100 parts of mass fractions are 4% is mixed, 40-60 DEG C with
After 200-400 revs/min is stirred 8-12 minutes, 0.4-0.6 parts of n-hydroxysuccinimides are added, continuation is stirred with 200-400 revs/min
It mixes 15-25 minutes, adds 0.5-0.8 parts of 1- (3- dimethylamino-propyls) -3- ethyl carbodiimides, stirred with 200-400 revs/min
It mixes 10-20 minutes, adds 0.4-0.8 parts of arginine, continue to stir 10-20 hours with 200-400 revs/min at 40-60 DEG C, obtain
To mixed liquor；
(2) above-mentioned mixed liquor is fitted into bag filter, is dialysed 24-36 hours with distilled water, single flash was changed every 8 hours
Water, then dialyse 12-24 hours in the Aqueous Solutions of Polyethylene Glycol that mass fraction is 18%, a dialyzate was changed every 6 hours, it will
Mixed liquor in bag filter pours into culture dish, is dried to perseverance under the conditions of temperature is 55-65 DEG C, vacuum degree is 60-100Pa
Weight obtains modified chitosan oligosaccharide.
The acacia flower extract is prepared by following methods：Robiniae,flos are 1-2 hours dry at 50-60 DEG C, it obtains
Dry robiniae,flos, dry robiniae,flos and water in mass ratio 1：(6-10) is mixed, and 30-50 minutes is kept the temperature at 80-90 DEG C, with 300 mesh
Filter-cloth filtering collects filtrate A and filter residue；The water that dry 4-8 times of robiniae,flos quality is added in filter residue keeps the temperature 20- at 80-90 DEG C
40 minutes, with 300 mesh filter-cloth filtering wastes, liquor B, merging filtrate A and liquor B are obtained, is in vacuum degree 0.06MPa, temperature
It is concentrated under reduced pressure at 55 DEG C, it is 1.10-1.20g/mL to be concentrated under reduced pressure into 55 DEG C of density, obtains acacia flower extract.
A kind of preparation method of moist moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 75-85 DEG C with 30-50 revs/min, and at 75-85 DEG C with 30-50 revs/min
Stirring 10-30 minutes, obtains oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, modified chitosan oligosaccharide are sequentially added in reaction kettle, with 30-50 revs/min
It is heated with stirring to 75-85 DEG C, and is stirred 10-30 minutes with 30-50 revs/min at 75-85 DEG C, water phase is obtained；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, stirred 5-10 minutes with 30-50 revs/min at 75-85 DEG C
Afterwards, with 2000-4000 revs/min of homogeneous 8-12 minutes, then with 30-50 revs/min of stirring it is cooled to 45-55 DEG C, sequentially added transparent
Matter acid sodium, acacia flower extract, Fructus Jujubae extract, grape seed extract, usnic acid are stirred 20-40 minutes with 30-50 revs/min,
It obtains moistening moisturizing face cream.
The present invention moistens moisturizing face cream and preparation method thereof, adds natural plant extracts, obtained moist moisturizing face cream
Safe to use, stable quality is easy to skin absorption, continues water lock, and permanent moisturizing has good performance of keeping humidity and anti-light quick
Property, it can effectively moisturize the skin.
Specific implementation mode
In the present invention, if not refering in particular to, all devices and raw material is commercially available or the industry is common are following
Method in embodiment is unless otherwise instructed this field conventional method.
Glycerine, Shanghai Mike's woods biochemical technology Co., Ltd, product identification：G6201.
Saualane, the natural saualane that 101 Chemical Co., Ltd. of Jining provides.
Camellia seed oil, Jishui County Lian Xing spice oils Co., Ltd provide.
Olive oil, Jishui County Lian Xing spice oils Co., Ltd provide.
Isopropyl myristate, this biochemical technology Co., Ltd of Tianjin Skien provide, product identification：I-37201.
Molecular distillation monoglyceride, this biochemical technology Co., Ltd of Tianjin Skien provide, product identification：S-62181.
Grape seed extract, the Xi'an bio tech ltd Tong Ze provide, withdrawal ratio 10:1.
Sodium Hyaluronate, Xi'an Hao Yuan Bioisystech Co., Ltd provide.
Tocopherol acetate, Wuhan Jing Xiu scientific researches bio tech ltd provide.
Usnic acid, the Xi'an four seasons, bio tech ltd provided.
Sodium alginate, Qingdao Mingyue Marine Alga Group Corp., Ltd. provide.
Lithium magnesium silicate, hundred benefit of Nanjing can new material Science and Technology Ltd. provide, cosmetics-stage.
Glacial acetic acid, Beijing sky Co., Ltd of Kang Hong chemical industry class provide, purity 99%.
Chitosan oligosaccharide, the production of Shaanxi Sen Lang biochemical industries Co., Ltd, molecular weight 2000, deacetylation 90.5%.
N-hydroxysuccinimide, Shanghai Aladdin biochemical technology limited liability company provide, product identification：H109330.
1- (3- dimethylamino-propyls) -3- ethyl carbodiimides, Shanghai Mike's woods biochemical technology Co., Ltd provide, product
Number：N807578.
Arginine, No. CAS：74-79-3, Shanghai Mike's woods biochemical technology Co., Ltd provide, product identification：A6286.
Polyethylene glycol, molecular weight 20000, Shanghai Aladdin biochemical technology limited liability company provide.
Jujube is the fruit of Rhamnaceae plant jujube (Ziziphus jujuba).In the embodiment of the present invention Fructus Jujubae extract by
Hubei Yuancheng Saichuang Technology Co., Ltd. provides, withdrawal ratio 10:1.
Robiniae,flos, Classification system：SophorajaponicaLinn is provided by Anguo City Jian Ren medicinal materials Co., Ltd.
Bag filter, the bag filter provided using upper Haier's force Industrial Co., Ltd., specification：49mm (MD77), molecular weight
MV1000。
Moisture retention is tested：Select women of the age between 20-35 Sui, health, rule of life, no skin disease and mistake
Quick history totally 90 people, is randomly divided into 6 groups, and every group of 15 people survey embodiment 1-5 and the comparative example 1 moist moisturizing face cream prepared
Examination.
Test method：Test environment temperature is 25 DEG C, relative humidity 50-65%, by the left forearm of examinee before measuring
It cleans, dries, balanced 30 minutes in test environment, while examinee being allowed to keep tranquil.Marked on left forearm 1 3cm ×
The square Experimental Area of 3cm is tested as the test section for smearing the moist moisturizing face cream of the present invention using CM825 moisture of skin
Instrument (German CK companies) measures the skin moisture content of test area, and each region takes three positions, is averaged as test
Value, record result are A0；According to 0.1g/cm2Dosage smear after this money Essence is gently massaged into absorption, 2 hours, it is 4 small
When, 8 hours when using moisture of skin tester test skin moisture content, each region takes three positions, is averaged conduct
Test value, record result are A1, calculate：Moisture of skin incrementss=[(A1-A0)/A0] × 100% evaluates the moisture retention of product.
Anti- light sensitivity test：Select women of the age between 20-35 Sui, health, rule of life, no skin disease and
Allergies 5 People, the moist moisturizing face cream prepared to embodiment 2 and comparative example 1 are tested.Specific test method is imitated with reference to beam
Elder generation, Liu Shubao etc.《Natural plants are to skin efficacy study》Side in (fragrance flavor and cosmetic, the 6th phase in 2003) in 1.6.1
Method is tested, and 3 positions is chosen in the forearm of subject, respectively as 2 trial zone of embodiment, 1 trial zone of comparative example, control
Position, according to the method for bibliography, erythema numerical value when testing 24 hours is calculated by the following formula out UV-induced
The percentage of the reduction of skin irritatin：
Fungistatic effect is tested：The moist moisturizing face cream Brown Glass Brown glass bottles and jars only that embodiment 1-5 and comparative example 1 will be prepared
It is filling, 30 days in the environment that opening is placed on 25 DEG C of temperature, relative humidity is 80%, then according to the Master's thesis of Li Wanying
《The refined and application in cosmetics of pine-seed oil》5.2.2 section in method test total number of bacteria.
Embodiment 1
Moisten moisturizing face cream raw material (parts by weight)：8 parts of glycerine, 4 parts of saualane, 4 parts of camellia seed oil, 2 parts of olive oil, Pork and beans
3 parts of cool isopropyl propionate, 2 parts of Fructus Jujubae extract, 4 parts of grape seed extract, 2 parts of chitosan oligosaccharide, is stablized 2 parts of molecular distillation monoglyceride
2 parts of agent, 0.3 part of Sodium Hyaluronate, 0.3 part of tocopherol acetate, 0.005 part of usnic acid, 40 parts of water.
The stabilizer is sodium alginate.
The preparation method for moistening moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 80 DEG C with 40 revs/min, and stirred 20 minutes with 40 revs/min at 80 DEG C, obtains
To oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, chitosan oligosaccharide are sequentially added in reaction kettle, with 40 revs/min of agitating and heatings
It is stirred 20 minutes with 40 revs/min to 80 DEG C, and at 80 DEG C, obtains water phase；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 80 DEG C are stirred 8 minutes with 40 revs/min, with 3000
Rev/min homogeneous 10 minutes, then 50 DEG C are cooled to 40 revs/min of stirrings, sequentially add Sodium Hyaluronate, Fructus Jujubae extract, grape
Seed extract, usnic acid are stirred 30 minutes with 40 revs/min, obtain moistening moisturizing face cream.
Embodiment 2
Moisten moisturizing face cream raw material (parts by weight)：8 parts of glycerine, 4 parts of saualane, 4 parts of camellia seed oil, 2 parts of olive oil, Pork and beans
3 parts of cool isopropyl propionate, 2 parts of molecular distillation monoglyceride, 2 parts of acacia flower extract, 2 parts of Fructus Jujubae extract, grape seed extract 4
Part, 2 parts of chitosan oligosaccharide, 2 parts of stabilizer, 0.3 part of Sodium Hyaluronate, 0.3 part of tocopherol acetate, 0.005 part of usnic acid, water 40
Part.
The stabilizer is sodium alginate.
The acacia flower extract is prepared by following methods：Robiniae,flos are 1 hour dry at 55 DEG C, obtain dry ocean
Sophora flower, dry robiniae,flos and water in mass ratio 1：8 mixing, 40 minutes are kept the temperature at 85 DEG C, with 300 mesh filter-cloth filterings, collect filtrate A
And filter residue；The water that 6 times of dry robiniae,flos quality is added in filter residue is kept the temperature 30 minutes at 85 DEG C, is abandoned with 300 mesh filter-cloth filterings
Slag obtains liquor B, merging filtrate A and liquor B, is concentrated under reduced pressure at being 55 DEG C in vacuum degree 0.06MPa, temperature, decompression is dense
It is 1.10g/mL to be reduced to 55 DEG C of density, obtains acacia flower extract.
The preparation method for moistening moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 80 DEG C with 40 revs/min, and stirred 20 minutes with 40 revs/min at 80 DEG C, obtains
To oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, chitosan oligosaccharide are sequentially added in reaction kettle, with 40 revs/min of agitating and heatings
It is stirred 20 minutes with 40 revs/min to 80 DEG C, and at 80 DEG C, obtains water phase；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 80 DEG C are stirred 8 minutes with 40 revs/min, with 3000
Rev/min homogeneous 10 minutes, then be cooled to 50 DEG C with 40 revs/min of stirrings sequentially adds Sodium Hyaluronate, acacia flower extract, big
Jujube extract, grape seed extract, usnic acid are stirred 30 minutes with 40 revs/min, obtain moistening moisturizing face cream.
Comparative example 1
Moisten moisturizing face cream raw material (parts by weight)：8 parts of glycerine, 4 parts of saualane, 4 parts of camellia seed oil, 2 parts of olive oil, Pork and beans
3 parts of cool isopropyl propionate, 2 parts of molecular distillation monoglyceride, 2 parts of acacia flower extract, 2 parts of chitosan oligosaccharide, 2 parts of stabilizer, hyaluronic acid
0.3 part of sodium, 0.3 part of tocopherol acetate, 0.005 part of usnic acid, 40 parts of water.
The stabilizer is sodium alginate.
The acacia flower extract is prepared by following methods：Robiniae,flos are 1 hour dry at 55 DEG C, obtain dry ocean
Sophora flower, dry robiniae,flos and water in mass ratio 1：8 mixing, 40 minutes are kept the temperature at 85 DEG C, with 300 mesh filter-cloth filterings, collect filtrate A
And filter residue；The water that 6 times of dry robiniae,flos quality is added in filter residue is kept the temperature 30 minutes at 85 DEG C, is abandoned with 300 mesh filter-cloth filterings
Slag obtains liquor B, merging filtrate A and liquor B, is concentrated under reduced pressure at being 55 DEG C in vacuum degree 0.06MPa, temperature, decompression is dense
It is 1.10g/mL to be reduced to 55 DEG C of density, obtains acacia flower extract.
The preparation method for moistening moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 80 DEG C with 40 revs/min, and stirred 20 minutes with 40 revs/min at 80 DEG C, obtains
To oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, chitosan oligosaccharide are sequentially added in reaction kettle, with 40 revs/min of agitating and heatings
It is stirred 20 minutes with 40 revs/min to 80 DEG C, and at 80 DEG C, obtains water phase；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 80 DEG C are stirred 8 minutes with 40 revs/min, with 3000
Rev/min homogeneous 10 minutes, then 50 DEG C are cooled to 40 revs/min of stirrings, sequentially add Sodium Hyaluronate, acacia flower extract, pine
Trailing plants acid, is stirred 30 minutes with 40 revs/min, obtains moistening moisturizing face cream.
Embodiment 3
Moisten moisturizing face cream raw material (parts by weight)：8 parts of glycerine, 4 parts of saualane, 4 parts of camellia seed oil, 2 parts of olive oil, Pork and beans
3 parts of cool isopropyl propionate, 2 parts of molecular distillation monoglyceride, 2 parts of acacia flower extract, 2 parts of Fructus Jujubae extract, grape seed extract 4
Part, modified 2 parts of chitosan oligosaccharide, 2 parts of stabilizer, 0.3 part of Sodium Hyaluronate, 0.3 part of tocopherol acetate, 0.005 part of usnic acid, water
40 parts.
The stabilizer is sodium alginate.
The preparation method of the modified chitosan oligosaccharide includes the following steps that described part is parts by weight：
(1) glacial acetic acid aqueous solution that 3 parts of chitosan oligosaccharides and 90 parts of mass fractions are 4% is mixed, at 50 DEG C with 300 revs/min
After ten minutes, 0.5 part of n-hydroxysuccinimide is added in stirring, continues to stir 20 minutes with 300 revs/min, adds 0.6 part of 1-
(3- dimethylamino-propyls) -3- ethyl carbodiimides are stirred 15 minutes with 300 revs/min, add 0.6 part of arginine, are continued
50 DEG C are stirred 15 hours with 300 revs/min, obtain mixed liquor；
(2) above-mentioned mixed liquor is fitted into bag filter, is dialysed 32 hours with distilled water, first water was changed every 8 hours,
It dialyses 18 hours in the Aqueous Solutions of Polyethylene Glycol that mass fraction is 18% again, a dialyzate was changed every 6 hours, by bag filter
In mixed liquor pour into culture dish, dried to constant weight under the conditions of temperature is 60 DEG C, vacuum degree is 80Pa, it is few to obtain modified shell
Sugar.
The acacia flower extract is prepared by following methods：Robiniae,flos are 1 hour dry at 55 DEG C, obtain dry ocean
Sophora flower, dry robiniae,flos and water in mass ratio 1：8 mixing, 40 minutes are kept the temperature at 85 DEG C, with 300 mesh filter-cloth filterings, collect filtrate A
And filter residue；The water that 6 times of dry robiniae,flos quality is added in filter residue is kept the temperature 30 minutes at 85 DEG C, is abandoned with 300 mesh filter-cloth filterings
Slag obtains liquor B, merging filtrate A and liquor B, is concentrated under reduced pressure at being 55 DEG C in vacuum degree 0.06MPa, temperature, decompression is dense
It is 1.10g/mL to be reduced to 55 DEG C of density, obtains acacia flower extract.
The preparation method for moistening moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 80 DEG C with 40 revs/min, and stirred 20 minutes with 40 revs/min at 80 DEG C, obtains
To oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, modified chitosan oligosaccharide are sequentially added in reaction kettle, stirred with 40 revs/min
80 DEG C are heated to, and is stirred 20 minutes with 40 revs/min at 80 DEG C, water phase is obtained；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 80 DEG C are stirred 8 minutes with 40 revs/min, with 3000
Rev/min homogeneous 10 minutes, then be cooled to 50 DEG C with 40 revs/min of stirrings sequentially adds Sodium Hyaluronate, acacia flower extract, big
Jujube extract, grape seed extract, usnic acid are stirred 30 minutes with 40 revs/min, obtain moistening moisturizing face cream.
Embodiment 4
Moisten moisturizing face cream raw material (parts by weight)：8 parts of glycerine, 4 parts of saualane, 4 parts of camellia seed oil, 2 parts of olive oil, Pork and beans
3 parts of cool isopropyl propionate, 2 parts of molecular distillation monoglyceride, 2 parts of acacia flower extract, 2 parts of Fructus Jujubae extract, grape seed extract 4
Part, modified 2 parts of chitosan oligosaccharide, 2 parts of stabilizer, 0.3 part of Sodium Hyaluronate, 0.3 part of tocopherol acetate, 0.005 part of usnic acid, water
40 parts.
The stabilizer is lithium magnesium silicate.
The preparation method of the modified chitosan oligosaccharide includes the following steps that described part is parts by weight：
(1) glacial acetic acid aqueous solution that 3 parts of chitosan oligosaccharides and 90 parts of mass fractions are 4% is mixed, at 50 DEG C with 300 revs/min
After ten minutes, 0.5 part of n-hydroxysuccinimide is added in stirring, continues to stir 20 minutes with 300 revs/min, adds 0.6 part of 1-
(3- dimethylamino-propyls) -3- ethyl carbodiimides are stirred 15 minutes with 300 revs/min, add 0.6 part of arginine, are continued
50 DEG C are stirred 15 hours with 300 revs/min, obtain mixed liquor；
(2) above-mentioned mixed liquor is fitted into bag filter, is dialysed 32 hours with distilled water, first water was changed every 8 hours,
It dialyses 18 hours in the Aqueous Solutions of Polyethylene Glycol that mass fraction is 18% again, a dialyzate was changed every 6 hours, by bag filter
In mixed liquor pour into culture dish, dried to constant weight under the conditions of temperature is 60 DEG C, vacuum degree is 80Pa, it is few to obtain modified shell
Sugar.
The acacia flower extract is prepared by following methods：Robiniae,flos are 1 hour dry at 55 DEG C, obtain dry ocean
Sophora flower, dry robiniae,flos and water in mass ratio 1：8 mixing, 40 minutes are kept the temperature at 85 DEG C, with 300 mesh filter-cloth filterings, collect filtrate A
And filter residue；The water that 6 times of dry robiniae,flos quality is added in filter residue is kept the temperature 30 minutes at 85 DEG C, is abandoned with 300 mesh filter-cloth filterings
Slag obtains liquor B, merging filtrate A and liquor B, is concentrated under reduced pressure at being 55 DEG C in vacuum degree 0.06MPa, temperature, decompression is dense
It is 1.10g/mL to be reduced to 55 DEG C of density, obtains acacia flower extract.
The preparation method for moistening moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 80 DEG C with 40 revs/min, and stirred 20 minutes with 40 revs/min at 80 DEG C, obtains
To oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, modified chitosan oligosaccharide are sequentially added in reaction kettle, stirred with 40 revs/min
80 DEG C are heated to, and is stirred 20 minutes with 40 revs/min at 80 DEG C, water phase is obtained；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 80 DEG C are stirred 8 minutes with 40 revs/min, with 3000
Rev/min homogeneous 10 minutes, then be cooled to 50 DEG C with 40 revs/min of stirrings sequentially adds Sodium Hyaluronate, acacia flower extract, big
Jujube extract, grape seed extract, usnic acid are stirred 30 minutes with 40 revs/min, obtain moistening moisturizing face cream.
Embodiment 5
Moisten moisturizing face cream raw material (parts by weight)：8 parts of glycerine, 4 parts of saualane, 4 parts of camellia seed oil, 2 parts of olive oil, Pork and beans
3 parts of cool isopropyl propionate, 2 parts of molecular distillation monoglyceride, 2 parts of acacia flower extract, 2 parts of Fructus Jujubae extract, grape seed extract 4
Part, modified 2 parts of chitosan oligosaccharide, 2 parts of stabilizer, 0.3 part of Sodium Hyaluronate, 0.3 part of tocopherol acetate, 0.005 part of usnic acid, water
40 parts.
The stabilizer is the mixture of sodium alginate and lithium magnesium silicate, the mass ratio of the sodium alginate and lithium magnesium silicate
It is 3：1.
The preparation method of the modified chitosan oligosaccharide includes the following steps that described part is parts by weight：
(1) glacial acetic acid aqueous solution that 3 parts of chitosan oligosaccharides and 90 parts of mass fractions are 4% is mixed, at 50 DEG C with 300 revs/min
After ten minutes, 0.5 part of n-hydroxysuccinimide is added in stirring, continues to stir 20 minutes with 300 revs/min, adds 0.6 part of 1-
(3- dimethylamino-propyls) -3- ethyl carbodiimides are stirred 15 minutes with 300 revs/min, add 0.6 part of arginine, are continued
50 DEG C are stirred 15 hours with 300 revs/min, obtain mixed liquor；
(2) above-mentioned mixed liquor is fitted into bag filter, is dialysed 32 hours with distilled water, first water was changed every 8 hours,
It dialyses 18 hours in the Aqueous Solutions of Polyethylene Glycol that mass fraction is 18% again, a dialyzate was changed every 6 hours, by bag filter
In mixed liquor pour into culture dish, dried to constant weight under the conditions of temperature is 60 DEG C, vacuum degree is 80Pa, it is few to obtain modified shell
Sugar.
The acacia flower extract is prepared by following methods：Robiniae,flos are 1 hour dry at 55 DEG C, obtain dry ocean
Sophora flower, dry robiniae,flos and water in mass ratio 1：8 mixing, 40 minutes are kept the temperature at 85 DEG C, with 300 mesh filter-cloth filterings, collect filtrate A
And filter residue；The water that 6 times of dry robiniae,flos quality is added in filter residue is kept the temperature 30 minutes at 85 DEG C, is abandoned with 300 mesh filter-cloth filterings
Slag obtains liquor B, merging filtrate A and liquor B, is concentrated under reduced pressure at being 55 DEG C in vacuum degree 0.06MPa, temperature, decompression is dense
It is 1.10g/mL to be reduced to 55 DEG C of density, obtains acacia flower extract.
The preparation method for moistening moisturizing face cream, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, life
It educates phenol acetic acid esters to be added in reaction kettle, is heated with stirring to 80 DEG C with 40 revs/min, and stirred 20 minutes with 40 revs/min at 80 DEG C, obtains
To oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, modified chitosan oligosaccharide are sequentially added in reaction kettle, stirred with 40 revs/min
80 DEG C are heated to, and is stirred 20 minutes with 40 revs/min at 80 DEG C, water phase is obtained；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 80 DEG C are stirred 8 minutes with 40 revs/min, with 3000
Rev/min homogeneous 10 minutes, then be cooled to 50 DEG C with 40 revs/min of stirrings sequentially adds Sodium Hyaluronate, acacia flower extract, big
Jujube extract, grape seed extract, usnic acid are stirred 30 minutes with 40 revs/min, obtain moistening moisturizing face cream.
Test case 1
The moisture retention of embodiment 1-5 and the comparative example 1 moist moisturizing face cream being prepared is tested, specific test knot
Fruit is shown in Table 1.
1 skin moisture-keeping test result table of table
Test case 2
The anti-light sensitivity for the moist moisturizing face cream that embodiment 2 and comparative example 1 are prepared is tested, specific test knot
Fruit is shown in Table 2.
2 anti-light sensitivity test result table of table
| Skin irritatin is reduced, % | |
| Embodiment 2 | 88% |
| Comparative example 1 | 53% |
Test case 3
The fungistatic effect of embodiment 1-5 and the comparative example 1 moist moisturizing face cream being prepared is tested, it is specific to test
It the results are shown in Table 3.
3 fungistatic effect test result table of table
| Total plate count, cfu/g | |
| Embodiment 1 | 42 |
| Embodiment 2 | 33 |
| Comparative example 1 | 51 |
| Embodiment 3 | 24 |
| Embodiment 4 | 27 |
| Embodiment 5 | 19 |
Acacia flower extract is added in embodiment 2, the moisture retention and biocidal property of moist moisturizing face cream can be obviously improved.
Due to containing photosensitive material in robiniae,flos, acacia flower extract is separately added to moisten guarantor by comparative example 1
In wet face cream, the anti-light sensitivity of skin reduces, and jujube extraction is added in the embodiment of the present invention 2 while acacia flower extract is added
Object and grape seed extract have been obviously improved the anti-light sensitivity of skin.
Embodiment 3 uses modification of chitosan, the moisture retention and biocidal property of obtained moist moisturizing face cream to be better than embodiment 2.
This may be because modified chitosan hydrophilic is more preferable, and to promote moisture retention, modified chitosan biological activity carries
Height, to improve biocidal property.
Claims (8)
1. a kind of moist moisturizing face cream, which is characterized in that the raw material including following weight parts is prepared：5-10 parts of glycerine, angle
3-6 parts of shark alkane, 3-6 parts of camellia seed oil, 1-3 parts of olive oil, 1-5 parts of isopropyl myristate, 1-3 parts of molecular distillation monoglyceride,
1-3 parts of Fructus Jujubae extract, 2-6 parts of grape seed extract, 1-3 parts of chitosan oligosaccharide, 1-3 parts of stabilizer, Sodium Hyaluronate 0.1-0.5
Part, 0.1-0.5 parts of tocopherol acetate, 0.001-0.01 parts of usnic acid, 30-50 parts of water.
2. a kind of moist moisturizing face cream, which is characterized in that the raw material including following weight parts is prepared：5-10 parts of glycerine, angle
3-6 parts of shark alkane, 3-6 parts of camellia seed oil, 1-3 parts of olive oil, 1-5 parts of isopropyl myristate, 1-3 parts of molecular distillation monoglyceride,
1-3 parts of acacia flower extract, 1-3 parts of Fructus Jujubae extract, 2-6 parts of grape seed extract, 1-3 parts of chitosan oligosaccharide, 1-3 parts of stabilizer,
0.1-0.5 parts of Sodium Hyaluronate, 0.1-0.5 parts of tocopherol acetate, 0.001-0.01 parts of usnic acid, 30-50 parts of water.
3. a kind of moist moisturizing face cream, which is characterized in that be prepared by the raw material of following weight parts：5-10 parts of glycerine, spiny dogfish
3-6 parts of alkane, 3-6 parts of camellia seed oil, 1-3 parts of olive oil, 1-5 parts of isopropyl myristate, 1-3 parts of molecular distillation monoglyceride, ocean
1-3 parts of Flos Sophorae extract, 1-3 parts of Fructus Jujubae extract, 2-6 parts of grape seed extract, modified 1-3 parts of chitosan oligosaccharide, stabilizer 1-3
Part, 0.1-0.5 parts of Sodium Hyaluronate, 0.1-0.5 parts of tocopherol acetate, 0.001-0.01 parts of usnic acid, 30-50 parts of water.
4. moistening moisturizing face cream as described in any one of claim 1-3, which is characterized in that the stabilizer is sodium alginate
And/or lithium magnesium silicate.
5. moist moisturizing face cream as claimed in claim 4, which is characterized in that the stabilizer is sodium alginate and lithium magnesium silicate
Mixture.
6. moist moisturizing face cream as claimed in claim 3, which is characterized in that the preparation method of the modified chitosan oligosaccharide include with
Lower step, described part are parts by weight：
(1) glacial acetic acid aqueous solution that 2-4 parts of chitosan oligosaccharides and 80-100 parts of mass fractions are 4% is mixed, 8- is stirred at 40-60 DEG C
After 12 minutes, 0.4-0.6 parts of n-hydroxysuccinimides are added, continues stirring 15-25 minutes, adds 0.5-0.8 parts of 1- (3-
Dimethylamino-propyl) -3- ethyl carbodiimides, stir 10-20 minutes, add 0.4-0.8 parts of arginine, continue in 40-60
DEG C stirring 10-20 hours, obtain mixed liquor；
(2) above-mentioned mixed liquor is fitted into bag filter, is dialysed 24-36 hours with distilled water, first water was changed every 8 hours,
It dialyses 12-24 hours in the Aqueous Solutions of Polyethylene Glycol that mass fraction is 18% again, a dialyzate was changed every 6 hours, it will be saturating
Mixed liquor in analysis bag pours into culture dish, is dried under the conditions of temperature is 55-65 DEG C, vacuum degree is 60-100Pa to constant weight,
Obtain modified chitosan oligosaccharide.
7. moist moisturizing face cream as claimed in claim 2 or claim 3, which is characterized in that the acacia flower extract is by following methods
It is prepared：Robiniae,flos are 1-2 hours dry at 50-60 DEG C, obtain dry robiniae,flos, dry robiniae,flos and water in mass ratio 1：
(6-10) is mixed, and 30-50 minutes are kept the temperature at 80-90 DEG C, with 300 mesh filter-cloth filterings, collects filtrate A and filter residue；Add again in filter residue
The water for entering dry 4-8 times of robiniae,flos quality keeps the temperature 20-40 minutes at 80-90 DEG C, with 300 mesh filter-cloth filtering wastes, obtains filtrate
B, merging filtrate A and liquor B, it is 1.10-1.20g/mL to be concentrated under reduced pressure into 55 DEG C of density, obtains acacia flower extract.
8. the preparation method of the moist moisturizing face cream as described in any one of claim 3-7, includes the following steps：
(1) prepared by oil phase：By saualane, camellia seed oil, olive oil, isopropyl myristate, molecular distillation monoglyceride, tocopherol
Acetic acid esters is added in reaction kettle, is heated with stirring to 75-85 DEG C with 30-50 revs/min, and stirred with 30-50 revs/min at 75-85 DEG C
10-30 minutes, obtain oil phase；
(2) prepared by water phase：Water, stabilizer, glycerine, modified chitosan oligosaccharide are sequentially added in reaction kettle, stirred with 30-50 revs/min
It is heated to 75-85 DEG C, and is stirred 10-30 minutes with 30-50 revs/min at 75-85 DEG C, water phase is obtained；
(3) it emulsifies：Oil phase and water phase are sequentially added into emulsification pot, after 75-85 DEG C is stirred 5-10 minutes with 30-50 revs/min, with
2000-4000 revs/min of homogeneous 8-12 minutes, then it is cooled to 45-55 DEG C with 30-50 revs/min of stirring, sequentially add hyaluronic acid
Sodium, acacia flower extract, Fructus Jujubae extract, grape seed extract, usnic acid are stirred 20-40 minutes with 30-50 revs/min, are obtained
Moisten moisturizing face cream.
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