CN113855610A - Method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream - Google Patents
Method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream Download PDFInfo
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- A61K8/67—Vitamins
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- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Abstract
A method for preparing proanthocyanidin rhizoma polygonati moisturizing cream comprises the following steps: (1) preparing a hydrolyzed procyanidine solution, (2) preparing a sealwort extracting solution, (3) preparing materials and (4) preparing. The moisturizing cream prepared by the invention is white paste, contains hydrolyzed procyanidin and rhizoma polygonati extract, is added with various vegetable oil components, locks water and moisturizes, and can relieve discomfort of skin caused by dryness and keep the skin elastic and moist.
Description
Technical Field
The invention belongs to the technical field of cosmetic preparation, and relates to a preparation method of proanthocyanidin and rhizoma polygonati moisturizing cream.
Background
The cosmetic is a chemical industrial product or a fine chemical product which is applied to any part of the surface of a human body, such as skin, hair, nails, lips and teeth, by smearing, spraying or the like, so as to achieve the purposes of cleaning, maintaining, beautifying, decorating and changing the appearance, or correcting the odor of the human body and keeping a good state. A moisturizing cream, also called a moisturizing cream, is a liquid cream cosmetic, is a kind of cream, and has the effects of supplementing skin moisture and improving skin surface texture and skin color uniformity.
Procyanidins, a generic term for a large group of polyphenols that are widely present in plants, have the common feature that anthocyanins can be produced by heating in an acidic medium, and are therefore called procyanidins. Procyanidins are a pigment component in plants and are widely present in various plants. The procyanidin has strong antioxidant and free radical scavenging effects, can effectively scavenge superoxide anion free radical and hydroxyl free radical, and also participates in metabolism of phosphoric acid and arachidonic acid and protein phosphorylation, and can protect lipid from peroxidation damage; is a powerful metal chelating agent which can chelate metal ions and form inert compounds in vivo; protect and stabilize vitamin C, and is helpful for the absorption and utilization of vitamin C.
Polygonatum sibiricum is a perennial herb of Polygonatum of Liliaceae, is an important traditional Chinese medicine and a medicine-food homologous article in China, and the extract thereof is listed in the catalogue of used cosmetic raw materials (2021 year edition). The existing research shows that the polygonatum extract is used for cosmetics, can enhance the metabolism of the dermis of the skin and has antioxidant activity; promoting proliferation of vascular endothelial cells, and strengthening and solidifying capillary vessels; has effects of whitening skin, and preventing and treating red blood streak.
Disclosure of Invention
The invention aims to provide a method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream.
In order to achieve the above objects and other related objects, the present invention provides the following technical solutions: a method for preparing proanthocyanidin polygonatum sibiricum moisturizing cream comprises the following steps:
step 1: crushing grape seeds to 80-120 meshes to obtain grape seed powder; mixing grape seed powder and deionized water at a mass ratio of 1:20-30, and heating and extracting for 60-90min to obtain an extracting solution; filtering the extracting solution, and collecting filtrate; then carrying out reduced pressure concentration on the filtrate to obtain a concentrated extract; mixing the concentrated extract with sulfurous acid at a mass ratio of 10-15:1, heating to 50-53 deg.C, maintaining stirring speed at 50-100r/min, processing for 10-15min, and cooling to room temperature to obtain hydrolyzed procyanidin solution;
step 2: cleaning rhizoma Polygonati raw material, and draining; carrying out microwave enzyme deactivation treatment on the sealwort; pulverizing rhizoma Polygonati after microwave enzyme deactivation treatment to 80-120 mesh to obtain rhizoma Polygonati fine material; mixing the fine rhizoma Polygonati material with deionized water at a mass ratio of 1:10-15, and extracting at 70-80 deg.C and stirring speed of 30-60r/min for 90-120min to obtain extractive solution; filtering the extracting solution, collecting filtrate, and concentrating the filtrate in vacuum to obtain rhizoma Polygonati extracting solution;
and step 3: preparing the following materials in parts by weight: 75-85 parts by weight of deionized water, 5-10 parts by weight of glycerol, 0.2-0.5 part by weight of caprylic/capric triglyceride, 0.1-0.5 part by weight of glyceryl acrylate/acrylic acid copolymer, 0.05-0.25 part by weight of propylene glycol, 0.05-0.25 part by weight of cetostearyl alcohol, 0.05-0.25 part by weight of squalene, 0.05-0.50 part by weight of butanediol, 0.1-0.25 part by weight of stearic acid, 0.05-0.25 part by weight of polydimethylsiloxane, 0.05-0.5 part by weight of glyceryl stearate, 0.05-0.15 part by weight of PEG-100 stearate, 0.05-0.5 part by weight of sodium stearoyl lactylate, 0.05-0.25 part by weight of sucrose polyoxometallate, 0.1-0.5 part by weight of sodium hyaluronate, 0.1-0.5 part by weight of extract, 0.1-0.5 part by weight of chamomile extract and 0.5 part by weight of gold Chamomile extract, 0.1-0.5 part by weight of camellia seed extract, 0.1-0.5 part by weight of licorice extract, 0.5-0.25 part by weight of ceramide 3, 0.5-0.25 part by weight of ceramide 6 II, 0.5-0.25 part by weight of ceramide 1, 0.5-0.25 part by weight of phytosphingosine, 0.5-0.25 part by weight of cholesterol, 0.1-0.5 part by weight of masson pine leaf extract, 0.1-1.5 parts by weight of hydrolytic solution, 0.1-1.5 parts by weight of sealwort extract, 0.1-0.5 part by weight of shea butter, 0.1-0.5 part by weight of jojoba seed oil, 0.05-0.25 part by weight of white beeswax, 0.05-0.25 part by weight of nicotinamide, 0.05-0.25 part by weight of p-hydroxyacetophenone, 0.05-0.25 part by weight of hexylene glycol, 0.05-0.25 part by weight of carbomer diol, 0.05-0.5 weight parts of arbutin, 0.1-0.5 weight parts of tocopherol acetate, 0.1-0.5 weight parts of xanthan gum, 0.1-0.5 weight parts of EDTA-disodium and 0.05-0.5 weight parts of sodium hydroxide;
and 4, step 4: the method comprises the following steps:
firstly, mixing p-hydroxyacetophenone, 1, 2-hexanediol and butanediol, and heating to 50-55 ℃ under the condition of stirring to form transparent liquid;
secondly, keeping the rotating speed of the deionized water at 50-100r/min and the heating state, and adding glycerol, xanthan gum and EDTA-disodium into the deionized water; heating to 82-85 deg.C, stirring at 3000-;
thirdly, mixing caprylic/capric triglyceride, cetearyl alcohol, glyceryl stearate, PEG-100 stearate, sucrose polyoxometalate and white beeswax, heating to 82-85 ℃, stirring until the mixture is completely melted into liquid, then adding tocopherol acetate, and stirring until the tocopherol acetate is completely dissolved;
fourthly, mixing the solution obtained in the second step with the solution obtained in the third step, putting the mixture into vacuum high-shear stirring equipment, and performing high-shear stirring for 5-10min at the rotation speed of 4000-;
fifthly, cooling the material obtained in the fourth step to 70-75 ℃, adding squalene, stearic acid, polydimethylsiloxane, sodium stearoyl lactylate, sodium hyaluronate, shea butter resin and jojoba seed oil, putting the mixture into a vacuum high-shear stirring device, and stirring the mixture for 1-2min at a high shear of 5000r/min at a rotation speed of 4000-;
sixthly, cooling the materials obtained in the fifth step to 55-60 ℃, adding the glycerin acrylate/acrylic acid copolymer and propylene glycol, putting the mixture into vacuum stirring equipment, and stirring for 5-15min at the rotating speed of 50-200r/min under the vacuum condition of vacuum gauge pressure of-0.09 to-0.10 MPa until the materials are uniformly mixed;
seventhly, cooling the materials obtained in the sixth step to 25-45 ℃, adding ceramide 3, ceramide 6 II, ceramide 1, phytosphingosine, cholesterol, wild chrysanthemum extract, golden chamomile extract, camellia seed extract, licorice extract, masson pine leaf extract, hydrolyzed procyanidine solution, sealwort extract, nicotinamide, carbomer and arbutin, putting into a vacuum stirring device, and stirring for 5-15min at the rotating speed of 100 and 200r/min under the vacuum of-0.09 to-0.10 MPa of vacuum gauge pressure until the materials are uniformly mixed;
step eight, mixing the material obtained in the step one and the material obtained in the step six, and adjusting the pH value of the mixed material to 6.5-7.0; putting the mixed materials into vacuum stirring equipment, and stirring for 5-15min at the rotating speed of 100-0.09 to-0.10 MPa in vacuum until the materials are uniformly mixed.
And step nine, filtering the material obtained in the step eight by using filtering equipment with the fineness of 200-mesh and 300-mesh, and collecting filtrate, namely the moisturizing cream.
The preferable technical scheme is as follows: the temperature of the material is less than or equal to 55 ℃ when the grape seeds are crushed.
The preferable technical scheme is as follows: the heating and extracting conditions of the grape seed powder are as follows: the reaction is carried out at the temperature of 50-53 ℃ and the stirring speed of 30-60 r/min.
The preferable technical scheme is as follows: the microwave enzyme deactivation conditions are as follows: placing the glass into a microwave environment, wherein the frequency is 2450MHz, and the radiation intensity is as follows: 0.25-0.50w/cm2Is processed for 150-200s in the vacuum microwave environment.
Due to the application of the technical scheme, compared with the prior art, the invention has the advantages that:
the moisturizing cream prepared by the invention is white paste, contains hydrolyzed procyanidin and rhizoma polygonati extract, is added with various vegetable oil components, locks water and moisturizes, and can relieve discomfort of skin caused by dryness and keep the skin elastic and moist.
Drawings
FIG. 1 is a diagram of a product produced by the present invention.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
Please refer to fig. 1. It should be understood that the structures, ratios, sizes, and the like shown in the drawings and described in the specification are for illustrative purposes only and are not intended to limit the scope of the present invention. The following examples are provided for a better understanding of the present invention, and are not intended to limit the invention. The experimental procedures in the following examples are conventional unless otherwise specified. The experimental materials used in the following examples were all purchased from a conventional biochemical reagent store unless otherwise specified.
Example 1: method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream
A method for preparing proanthocyanidin polygonatum sibiricum moisturizing cream is characterized by comprising the following steps.
(1) Preparation of hydrolyzed procyanidin solution
The raw material for preparing the hydrolyzed procyanidin is grape seeds, and the grape seeds are fresh, dry, free of mildew and insect pests and meet the production sanitary requirements of cosmetics.
And (4) crushing. Pulverizing grape seed into 80-120 mesh to obtain grape seed powder. Preferably, the crushing temperature of the grape seeds is not too high, when the temperature of the crusher exceeds 55 ℃, the temperature is temporarily reduced for a period of time, and the crushing production is continued after the temperature of the crusher is reduced.
And (4) extracting. Mixing grape seed powder and deionized water at a mass ratio of 1:25, placing into a heating stirring extraction device with a condensed water collection device, keeping the temperature at 52 deg.C and stirring at a rotation speed of 45r/min, and extracting for 75min to obtain an extractive solution.
And (5) filtering. Filtering the extractive solution with filter paper or filter screen with pore diameter of 50 μm, and collecting filtrate.
Vacuum concentrating under reduced pressure. Placing the filtrate into vacuum decompression concentration equipment, boiling and concentrating under the condition of vacuum gauge pressure of-0.095 MPa to 5-7.5% of the original volume to obtain concentrated extract for later use.
Acid hydrolysis. Mixing the concentrated extract and sulfurous acid at a mass ratio of 12:1, heating to 51 deg.C, maintaining stirring speed at 75r/min, treating for 12min, cooling to room temperature to obtain hydrolyzed procyanidin solution, and refrigerating at 3 deg.C for use. Preferably, the sulfurous acid is of analytical grade.
(2) Preparing rhizoma Polygonati extract
The rhizoma polygonati raw material is fresh rhizoma polygonati roots without root hairs, has no mildew or insect pests, and meets the production sanitary requirements of cosmetics.
And (5) microwave enzyme deactivation treatment. Cleaning rhizoma Polygonati raw material, and draining; putting rhizoma polygonati into a microwave environment, wherein the frequency is 2450MHz, and the radiation intensity is as follows: 0.35w/cm2The processing time is 180s in the vacuum microwave environment for standby.
And (4) crushing. Pulverizing rhizoma Polygonati after microwave enzyme deactivation treatment to 80-120 mesh to obtain rhizoma Polygonati fine material for use.
And (4) extracting. Mixing the fine sealwort and deionized water according to the mass ratio of 1:12, putting the mixture into heating and stirring extraction equipment with a condensed water collecting device, keeping the temperature at 75 ℃, stirring at the rotating speed of 45r/min, and extracting for 100min to obtain an extracting solution.
And (5) filtering. Filtering the extractive solution with filter paper or filter screen with aperture of 40 μm, and collecting filtrate.
Vacuum concentrating under reduced pressure. Placing the filtrate into vacuum decompression concentration equipment, boiling and concentrating under the condition of vacuum gauge pressure of-0.095 MPa to 6.5% of the original volume to obtain concentrated extract, namely rhizoma Polygonati extract, and refrigerating at 3 ℃ for later use.
(3) Stock preparation
The following materials were prepared according to the recipe: 80 parts by weight of deionized water, 7 parts by weight of glycerol, 0.3 part by weight of caprylic/capric triglyceride, 0.3 part by weight of glyceryl acrylate/acrylic acid copolymer, 0.15 part by weight of propylene glycol, 0.15 part by weight of cetostearyl alcohol, 0.15 part by weight of squalene, 0.25 part by weight of butylene glycol, 0.18 part by weight of stearic acid, 0.15 part by weight of polydimethylsiloxane, 0.25 part by weight of glyceryl stearate, 0.1 part by weight of PEG-100 stearate, 0.25 part by weight of sodium stearoyl lactylate, 0.15 part by weight of sucrose polyoxalate, 0.3 part by weight of sodium hyaluronate, 0.3 part by weight of wild chrysanthemum flower extract, 0.3 part by weight of Chrysanthemum indicum extract, 0.3 part by weight of camellia seed extract, 0.3 part by weight of licorice extract, 0.15 part by weight of ceramide 3, 0.15 part by weight of ceramide 6, 0.15 part by weight of ceramide II, 0.15 parts by weight of phytosphingosine, 0.15 parts by weight of cholesterol, 0.3 parts by weight of masson pine leaf extract, 0.8 parts by weight of hydrolyzed procyanidin solution in (1), 0.5 parts by weight of semen astragali extract in (2), 0.3 parts by weight of shea butter, 0.3 parts by weight of jojoba seed oil, 0.15 parts by weight of white beeswax, 0.15 parts by weight of nicotinamide, 0.15 parts by weight of p-hydroxyacetophenone, 0.15 parts by weight of 1, 2-hexanediol, 0.15 parts by weight of carbomer, 0.3 parts by weight of arbutin, 0.2 parts by weight of tocopherol acetate, 0.3 parts by weight of xanthan gum, 0.2 parts by weight of EDTA-disodium and 0.35 parts by weight of sodium hydroxide.
In particular, all materials should meet the requirements of the catalogue of used cosmetic raw materials.
(4) Blending
Step one, preparing the materials according to the step (3), mixing the p-hydroxyacetophenone, the 1, 2-hexanediol and the butanediol, stirring and heating to about 52 ℃, and completely dissolving the materials into transparent liquid for later use.
Secondly, keeping the rotating speed of the deionized water at 75r/min and the heating state, and adding glycerol, xanthan gum and EDTA-disodium into the deionized water; and after the solution is heated to 83 ℃, high-shear stirring is carried out for 8min at the rotation speed of 4000r/min until the solution is completely and uniformly dispersed.
Thirdly, mixing caprylic/capric triglyceride, cetostearyl alcohol, glyceryl stearate, PEG-100 stearate, sucrose polyoxometalate and white beeswax, heating to 83 ℃, stirring until the mixture is completely melted into liquid, and keeping the temperature for later use; adding the tocopherol acetate into the heat preservation solution, and stirring until the tocopherol acetate is completely dissolved for later use.
And fourthly, mixing the solution obtained in the second step and the solution obtained in the third step, putting the mixture into vacuum high-shear stirring equipment, and performing high-shear stirring for 7min at the rotating speed of 4500r/min under the vacuum condition of vacuum gauge pressure of-0.095 MPa until the materials are completely and uniformly emulsified. Preferably, the processing of the step is carried out by adopting a vacuum homogenizing emulsifying machine, the rotating speed can reach 4000-.
And fifthly, cooling the material obtained in the fourth step to 72 ℃, adding squalene, stearic acid, polydimethylsiloxane, sodium stearoyl lactylate, sodium hyaluronate shea butter and jojoba seed oil, putting into vacuum high-shear stirring equipment, and stirring for 1.5min at a high shear of 4500r/min under the vacuum of-0.095 MPa of vacuum gauge pressure until the material is completely emulsified and uniform. Preferably, the processing of the step is carried out by adopting a vacuum homogenizing emulsifying machine, the rotating speed can reach 4000-.
Sixthly, cooling the materials obtained in the fifth step to 58 ℃, adding the glycerin acrylate/acrylic acid copolymer and the propylene glycol, putting the mixture into a vacuum stirring device, and stirring for 10min at the rotating speed of 100r/min under the vacuum of the vacuum gauge pressure of-0.095 MPa until the materials are uniformly mixed.
Seventhly, cooling the materials obtained in the sixth step to 35 ℃, adding ceramide 3, ceramide 6 II, ceramide 1, phytosphingosine, cholesterol, wild chrysanthemum extract, golden chamomile extract, camellia seed extract, liquorice extract, masson pine leaf extract, (1) hydrolyzed procyanidine solution, (2) medium-yellow essence extract, nicotinamide, carbomer and arbutin, putting the mixture into a vacuum stirring device, and stirring for 10min at the rotating speed of 150r/min under the vacuum condition that the vacuum gauge pressure is minus 0.095MPa until the materials are uniformly mixed.
Eighthly, mixing the material obtained in the first step and the material obtained in the sixth step, properly adding sodium hydroxide, and adjusting the pH value of the mixed material to 6.8; and (3) putting the mixed materials into a vacuum stirring device, and stirring for 10min at the rotating speed of 150r/min under the vacuum of-0.095 MPa of vacuum gauge pressure until the materials are uniformly mixed.
And ninthly, filtering the material obtained in the eighth step by using a filtering device with the fineness of 200 meshes, and collecting filtrate, namely the moisturizing cream.
The moisturizing cream prepared by the invention is white paste, contains hydrolyzed procyanidin and rhizoma polygonati extract, is added with various vegetable oil components, locks water, moisturizes, can relieve discomfort of skin caused by dryness and keeps the skin elastic and moist.
The product of the invention is produced by the Huangshan lotus Xiu Biotechnology limited company in a test way, and executes the QB/T1857-.
The product is white paste, and the microbial and physical and chemical indexes meet the requirements of technical standards for cosmetic safety (2015 edition) detected by Hangzhou Hike detection technology limited company. The product diagram is shown in fig. 1.
Example 2: method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream
A method for preparing proanthocyanidin polygonatum sibiricum moisturizing cream comprises the following steps:
step 1: crushing grape seeds to 80 meshes to obtain grape seed powder; mixing grape seed powder and deionized water according to a mass ratio of 1:20, and heating and extracting for 60min to obtain an extracting solution; filtering the extracting solution, and collecting filtrate; then carrying out reduced pressure concentration on the filtrate to obtain a concentrated extract; mixing the concentrated extract with sulfurous acid at a mass ratio of 10:1, heating to 50 deg.C, maintaining stirring speed at 50r/min, treating for 10min, and cooling to room temperature to obtain hydrolyzed procyanidin solution;
step 2: cleaning rhizoma Polygonati raw material, and draining; carrying out microwave enzyme deactivation treatment on the sealwort; crushing the polygonatum subjected to microwave enzyme deactivation treatment to 80 meshes to obtain polygonatum fine materials; mixing the fine sealwort material with deionized water according to the mass ratio of 1:10, and extracting for 90min under the conditions that the temperature is 70 ℃ and the stirring speed is 30r/min to obtain an extracting solution; filtering the extracting solution, collecting filtrate, and concentrating the filtrate in vacuum to obtain rhizoma Polygonati extracting solution;
and step 3: preparing the following materials in parts by weight: 75 parts by weight of deionized water, 5 parts by weight of glycerol, 0.2 part by weight of caprylic/capric triglyceride, 0.1 part by weight of glyceryl acrylate/acrylic acid copolymer, 0.05 part by weight of propylene glycol, 0.05 part by weight of cetostearyl alcohol, 0.05 part by weight of squalene, 0.05 part by weight of butylene glycol, 0.1 part by weight of stearic acid, 0.05 part by weight of polydimethylsiloxane, 0.05 part by weight of glyceryl stearate, 0.05 part by weight of PEG-100 stearate, 0.05 part by weight of sodium stearoyl lactylate, 0.05 part by weight of sucrose polyoxalate, 0.1 part by weight of sodium hyaluronate, 0.1 part by weight of wild chrysanthemum flower extract, 0.1 part by weight of Chrysanthemum indicum extract, 0.1 part by weight of camellia seed extract, 0.1 part by weight of licorice extract, 0.5 part by weight of ceramide 3, 0.5 part by weight of ceramide 6 II, 0.5 part by weight of ceramide 1 part by weight of ceramide, 0.5 parts by weight of phytosphingosine, 0.5 parts by weight of cholesterol, 0.1 parts by weight of masson pine leaf extract, 0.1 parts by weight of hydrolyzed procyanidin solution, 0.1 parts by weight of polygonatum extract, 0.1 parts by weight of shea butter, 0.1 parts by weight of jojoba seed oil, 0.05 parts by weight of white beeswax, 0.05 parts by weight of nicotinamide, 0.05 parts by weight of p-hydroxyacetophenone, 0.05 parts by weight of 1, 2-hexanediol, 0.05 parts by weight of carbomer, 0.05 parts by weight of arbutin, 0.1 parts by weight of tocopheryl acetate, 0.1 parts by weight of xanthan gum, 0.1 parts by weight of EDTA-disodium and 0.05 parts by weight of sodium hydroxide;
and 4, step 4: the method comprises the following steps:
firstly, mixing p-hydroxyacetophenone, 1, 2-hexanediol and butanediol, and heating to 50 ℃ under the condition of stirring to form transparent liquid;
secondly, keeping the rotation speed of 50r/min and the heating state of deionized water, and adding glycerol, xanthan gum and EDTA-disodium into the deionized water; heating to 82 ℃, and stirring for 5min by high shear at a rotating speed of 3000r/min until the dispersion is uniform;
thirdly, mixing caprylic/capric triglyceride, cetearyl alcohol, glyceryl stearate, PEG-100 stearate, sucrose polyoxometalate and white beeswax, heating to 82 ℃, stirring until the mixture is completely melted into liquid, then adding tocopherol acetate, and stirring until the tocopherol acetate is completely dissolved;
fourthly, mixing the solution obtained in the second step with the solution obtained in the third step, putting the mixture into vacuum high-shear stirring equipment, and performing high-shear stirring for 5min at the rotation speed of 4000r/min under the condition that the vacuum gauge pressure is minus 0.09MPa until the materials are completely and uniformly emulsified;
fifthly, cooling the material obtained in the fourth step to 70 ℃, adding squalene, stearic acid, polydimethylsiloxane, sodium stearoyl lactylate, sodium hyaluronate, shea butter fruit resin and jojoba seed oil, putting the mixture into a vacuum high-shear stirring device, and stirring the mixture for 1min at a high shear of 4000r/min under the condition that the vacuum gauge pressure is-0.09 MPa until the material is completely and uniformly emulsified;
sixthly, cooling the materials obtained in the fifth step to 55 ℃, adding the glycerin acrylate/acrylic acid copolymer and propylene glycol, putting the mixture into a vacuum stirring device, and stirring the mixture for 55min at a rotating speed of 50r/min under the vacuum condition of vacuum gauge pressure of-0.09 MPa until the materials are uniformly mixed;
seventhly, cooling the materials obtained in the sixth step to 25 ℃, adding ceramide 3, ceramide 6 II, ceramide 1, phytosphingosine, cholesterol, wild chrysanthemum extract, golden chamomile extract, camellia seed extract, licorice extract, masson pine leaf extract, hydrolyzed procyanidine solution, sealwort extract, nicotinamide, carbomer and arbutin, putting into a vacuum stirring device, and stirring for 5min at the rotating speed of 100r/min under the vacuum of the vacuum gauge pressure of-0.09 MPa until the materials are uniformly mixed;
step eight, mixing the material obtained in the step one and the material obtained in the step six, and adjusting the pH value of the mixed material to 6.5; and (3) putting the mixed materials into a vacuum stirring device, and stirring for 5min at the rotating speed of 100r/min under the vacuum of-0.09 MPa of vacuum gauge pressure until the materials are uniformly mixed.
And ninthly, filtering the material obtained in the eighth step by using a filtering device with the fineness of 200 meshes, and collecting filtrate, namely the moisturizing cream.
The preferred embodiment is: the temperature of the material is less than or equal to 55 ℃ when the grape seeds are crushed.
The preferred embodiment is: the heating and extracting conditions of the grape seed powder are as follows: the reaction is carried out at the temperature of 50 ℃ and the stirring speed of 30-60 r/min.
The preferred embodiment is: the microwave enzyme deactivation conditions are as follows: placing the glass into a microwave environment, wherein the frequency is 2450MHz, and the radiation intensity is as follows: 0.25w/cm2Is processed for 150s in a vacuum microwave environment.
Example 3: method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream
A method for preparing proanthocyanidin polygonatum sibiricum moisturizing cream comprises the following steps:
step 1: crushing grape seeds to 120 meshes to obtain grape seed powder; mixing grape seed powder and deionized water according to the mass ratio of 1:30, and heating and extracting for 90min to obtain an extracting solution; filtering the extracting solution, and collecting filtrate; then carrying out reduced pressure concentration on the filtrate to obtain a concentrated extract; mixing the concentrated extract with sulfurous acid at a mass ratio of 15:1, heating to 53 ℃, keeping the stirring speed at 100r/min, treating for 15min, and then cooling to room temperature to obtain a hydrolyzed procyanidin solution;
step 2: cleaning rhizoma Polygonati raw material, and draining; carrying out microwave enzyme deactivation treatment on the sealwort; crushing the polygonatum subjected to microwave enzyme deactivation treatment to 120 meshes to obtain polygonatum fine materials; mixing the fine sealwort material with deionized water according to the mass ratio of 1:15, and extracting for 120min under the conditions that the temperature is 80 ℃ and the stirring speed is 60r/min to obtain an extracting solution; filtering the extracting solution, collecting filtrate, and concentrating the filtrate in vacuum to obtain rhizoma Polygonati extracting solution;
and step 3: preparing the following materials in parts by weight: 85 parts by weight of deionized water, 10 parts by weight of glycerol, 0.5 part by weight of caprylic/capric triglyceride, 0.5 part by weight of glyceryl acrylate/acrylic acid copolymer, 0.25 part by weight of propylene glycol, 0.25 part by weight of cetostearyl alcohol, 0.25 part by weight of squalene, 0.50 part by weight of butylene glycol, 0.25 part by weight of stearic acid, 0.25 part by weight of polydimethylsiloxane, 0.5 part by weight of glyceryl stearate, 0.15 part by weight of PEG-100 stearate, 0.5 part by weight of sodium stearoyl lactylate, 0.25 part by weight of sucrose polyoxalate, 0.5 part by weight of sodium hyaluronate, 0.5 part by weight of wild chrysanthemum flower extract, 0.5 part by weight of Chrysanthemum indicum extract, 0.5 part by weight of camellia seed extract, 0.5 part by weight of licorice extract, 0.25 part by weight of ceramide 3, 0.25 part by weight of ceramide 6 II, 0.25 part by weight of ceramide 1, 0.25 parts by weight of phytosphingosine, 0.25 parts by weight of cholesterol, 0.5 parts by weight of masson pine leaf extract, 1.5 parts by weight of hydrolyzed procyanidin solution, 1.5 parts by weight of polygonatum extract, 0.5 parts by weight of shea butter, 0.5 parts by weight of jojoba seed oil, 0.25 parts by weight of white beeswax, 0.25 parts by weight of nicotinamide, 0.25 parts by weight of p-hydroxyacetophenone, 0.25 parts by weight of 1, 2-hexanediol, 0.25 parts by weight of carbomer, 0.5 parts by weight of arbutin, 0.5 parts by weight of tocopheryl acetate, 0.5 parts by weight of xanthan gum, 0.5 parts by weight of EDTA-disodium and 0.5 parts by weight of sodium hydroxide;
and 4, step 4: the method comprises the following steps:
firstly, mixing p-hydroxyacetophenone, 1, 2-hexanediol and butanediol, and heating to 55 ℃ under the condition of stirring to form transparent liquid;
secondly, keeping the rotating speed of the deionized water at 100r/min and the heating state, and adding glycerol, xanthan gum and EDTA-disodium into the deionized water; heating to 85 deg.C, and high-shear stirring at 5000r/min for 10min to disperse uniformly;
thirdly, mixing caprylic/capric triglyceride, cetearyl alcohol, glyceryl stearate, PEG-100 stearate, sucrose polyoxometalate and white beeswax, heating to 85 ℃, stirring until the mixture is completely melted into liquid, then adding tocopheryl acetate, and stirring until the mixture is completely dissolved;
fourthly, mixing the solution obtained in the second step with the solution obtained in the third step, putting the mixture into vacuum high-shear stirring equipment, and performing high-shear stirring for 10min at the rotating speed of 5000r/min under the condition that the vacuum gauge pressure is minus 0.10MPa until the materials are completely and uniformly emulsified;
fifthly, cooling the material obtained in the fourth step to 75 ℃, adding squalene, stearic acid, polydimethylsiloxane, sodium stearoyl lactylate, sodium hyaluronate, shea butter fruit resin and jojoba seed oil, putting the mixture into a vacuum high-shear stirring device, and stirring the mixture for 2min at a high shear of 5000r/min under the condition that the vacuum gauge pressure is-0.10 MPa until the material is completely and uniformly emulsified;
sixthly, cooling the materials obtained in the fifth step to 60 ℃, adding the glycerol acrylate/acrylic acid copolymer and propylene glycol, putting the mixture into vacuum stirring equipment, and stirring for 15min at the rotating speed of 200r/min under the vacuum condition of vacuum gauge pressure of-0.10 MPa until the materials are uniformly mixed;
seventhly, cooling the materials obtained in the sixth step to 45 ℃, adding ceramide 3, ceramide 6 II, ceramide 1, phytosphingosine, cholesterol, wild chrysanthemum extract, golden chamomile extract, camellia seed extract, licorice extract, masson pine leaf extract, hydrolyzed procyanidine solution, sealwort extract, nicotinamide, carbomer and arbutin, putting into a vacuum stirring device, and stirring for 15min at the rotating speed of 200r/min under the vacuum of-0.10 MPa of vacuum gauge pressure until the materials are uniformly mixed;
step eight, mixing the material obtained in the step one and the material obtained in the step six, and adjusting the pH value of the mixed material to 7.0 by using sodium hydroxide; and (3) putting the mixed materials into a vacuum stirring device, and stirring for 15min at the rotating speed of 200r/min under the vacuum of-0.10 MPa of vacuum gauge pressure until the materials are uniformly mixed.
And ninthly, filtering the material obtained in the eighth step by using a filtering device with the fineness of 300 meshes, and collecting filtrate, namely the moisturizing cream.
The preferred embodiment is: the temperature of the material is less than or equal to 55 ℃ when the grape seeds are crushed.
The preferred embodiment is: the heating and extracting conditions of the grape seed powder are as follows: the reaction is carried out at the temperature of 53 ℃ and the stirring speed of 30-60 r/min.
The preferred embodiment is: the microwave enzyme deactivation conditions are as follows: placing the glass into a microwave environment, wherein the frequency is 2450MHz, and the radiation intensity is as follows: 0.50w/cm2The vacuum microwave environment is processed for 200 s.
The foregoing is illustrative of the preferred embodiment of the present invention and is not to be construed as limiting thereof in any way, and any modifications or variations thereof that fall within the spirit of the invention are intended to be included within the scope thereof.
Claims (4)
1. A method for preparing proanthocyanidin and rhizoma polygonati moisturizing cream is characterized by comprising the following steps: comprises the following steps:
step 1: crushing grape seeds to 80-120 meshes to obtain grape seed powder; mixing grape seed powder and deionized water at a mass ratio of 1:20-30, and heating and extracting for 60-90min to obtain an extracting solution; filtering the extracting solution, and collecting filtrate; then carrying out reduced pressure concentration on the filtrate to obtain a concentrated extract; mixing the concentrated extract with sulfurous acid at a mass ratio of 10-15:1, heating to 50-53 deg.C, maintaining stirring speed at 50-100r/min, processing for 10-15min, and cooling to room temperature to obtain hydrolyzed procyanidin solution;
step 2: cleaning rhizoma Polygonati raw material, and draining; carrying out microwave enzyme deactivation treatment on the sealwort; pulverizing rhizoma Polygonati after microwave enzyme deactivation treatment to 80-120 mesh to obtain rhizoma Polygonati fine material; mixing the fine rhizoma Polygonati material with deionized water at a mass ratio of 1:10-15, and extracting at 70-80 deg.C and stirring speed of 30-60r/min for 90-120min to obtain extractive solution; filtering the extracting solution, collecting filtrate, and concentrating the filtrate in vacuum to obtain rhizoma Polygonati extracting solution;
and step 3: preparing the following materials in parts by weight: 75-85 parts by weight of deionized water, 5-10 parts by weight of glycerol, 0.2-0.5 part by weight of caprylic/capric triglyceride, 0.1-0.5 part by weight of glyceryl acrylate/acrylic acid copolymer, 0.05-0.25 part by weight of propylene glycol, 0.05-0.25 part by weight of cetostearyl alcohol, 0.05-0.25 part by weight of squalene, 0.05-0.50 part by weight of butanediol, 0.1-0.25 part by weight of stearic acid, 0.05-0.25 part by weight of polydimethylsiloxane, 0.05-0.5 part by weight of glyceryl stearate, 0.05-0.15 part by weight of PEG-100 stearate, 0.05-0.5 part by weight of sodium stearoyl lactylate, 0.05-0.25 part by weight of sucrose polyoxometallate, 0.1-0.5 part by weight of sodium hyaluronate, 0.1-0.5 part by weight of extract, 0.1-0.5 part by weight of chamomile extract and 0.5 part by weight of gold Chamomile extract, 0.1-0.5 part by weight of camellia seed extract, 0.1-0.5 part by weight of licorice extract, 0.5-0.25 part by weight of ceramide 3, 0.5-0.25 part by weight of ceramide 6 II, 0.5-0.25 part by weight of ceramide 1, 0.5-0.25 part by weight of phytosphingosine, 0.5-0.25 part by weight of cholesterol, 0.1-0.5 part by weight of masson pine leaf extract, 0.1-1.5 parts by weight of hydrolytic solution, 0.1-1.5 parts by weight of sealwort extract, 0.1-0.5 part by weight of shea butter, 0.1-0.5 part by weight of jojoba seed oil, 0.05-0.25 part by weight of white beeswax, 0.05-0.25 part by weight of nicotinamide, 0.05-0.25 part by weight of p-hydroxyacetophenone, 0.05-0.25 part by weight of hexylene glycol, 0.05-0.25 part by weight of carbomer diol, 0.05-0.5 weight parts of arbutin, 0.1-0.5 weight parts of tocopherol acetate, 0.1-0.5 weight parts of xanthan gum, 0.1-0.5 weight parts of EDTA-disodium and 0.05-0.5 weight parts of sodium hydroxide;
and 4, step 4: the method comprises the following steps:
firstly, mixing p-hydroxyacetophenone, 1, 2-hexanediol and butanediol, and heating to 50-55 ℃ under the condition of stirring to form transparent liquid;
secondly, keeping the rotating speed of the deionized water at 50-100r/min and the heating state, and adding glycerol, xanthan gum and EDTA-disodium into the deionized water; heating to 82-85 deg.C, stirring at 3000-;
thirdly, mixing caprylic/capric triglyceride, cetearyl alcohol, glyceryl stearate, PEG-100 stearate, sucrose polyoxometalate and white beeswax, heating to 82-85 ℃, stirring until the mixture is completely melted into liquid, then adding tocopherol acetate, and stirring until the tocopherol acetate is completely dissolved;
fourthly, mixing the solution obtained in the second step with the solution obtained in the third step, putting the mixture into vacuum high-shear stirring equipment, and performing high-shear stirring for 5-10min at the rotation speed of 4000-;
fifthly, cooling the material obtained in the fourth step to 70-75 ℃, adding squalene, stearic acid, polydimethylsiloxane, sodium stearoyl lactylate, sodium hyaluronate, shea butter resin and jojoba seed oil, putting the mixture into a vacuum high-shear stirring device, and stirring the mixture for 1-2min at a high shear of 5000r/min at a rotation speed of 4000-;
sixthly, cooling the materials obtained in the fifth step to 55-60 ℃, adding the glycerin acrylate/acrylic acid copolymer and propylene glycol, putting the mixture into vacuum stirring equipment, and stirring for 5-15min at the rotating speed of 50-200r/min under the vacuum condition of vacuum gauge pressure of-0.09 to-0.10 MPa until the materials are uniformly mixed;
seventhly, cooling the materials obtained in the sixth step to 25-45 ℃, adding ceramide 3, ceramide 6 II, ceramide 1, phytosphingosine, cholesterol, wild chrysanthemum extract, golden chamomile extract, camellia seed extract, licorice extract, masson pine leaf extract, hydrolyzed procyanidine solution, sealwort extract, nicotinamide, carbomer and arbutin, putting into a vacuum stirring device, and stirring for 5-15min at the rotating speed of 100 and 200r/min under the vacuum of-0.09 to-0.10 MPa of vacuum gauge pressure until the materials are uniformly mixed;
step eight, mixing the material obtained in the step one and the material obtained in the step six, and adjusting the pH value of the mixed material to 6.5-7.0; putting the mixed materials into vacuum stirring equipment, and stirring for 5-15min at a rotation speed of 100-0.09 to-0.10 MPa in vacuum under the vacuum gauge pressure of-0.09 to-0.10 MPa until the materials are uniformly mixed;
and step nine, filtering the material obtained in the step eight by using filtering equipment with the fineness of 200-mesh and 300-mesh, and collecting filtrate, namely the moisturizing cream.
2. The method for preparing proanthocyanidin and polygonatum sibiricum moisturizing cream according to claim 1, wherein the method comprises the following steps: the temperature of the material is less than or equal to 55 ℃ when the grape seeds are crushed.
3. The method for preparing proanthocyanidin and polygonatum sibiricum moisturizing cream according to claim 1, wherein the method comprises the following steps: the heating and extracting conditions of the grape seed powder are as follows: the reaction is carried out at the temperature of 50-53 ℃ and the stirring speed of 30-60 r/min.
4. The method for preparing proanthocyanidin and polygonatum sibiricum moisturizing cream according to claim 1, wherein the method comprises the following steps: the microwave enzyme deactivation conditions are as follows: put into a microwave environment, and has the frequency of 2450MHz and strong radiationDegree: 0.25-0.50w/cm2Is processed for 150-200s in the vacuum microwave environment.
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