CN104523500A - Composition containing double-effect plant active ingredients and preparation method for composition - Google Patents
Composition containing double-effect plant active ingredients and preparation method for composition Download PDFInfo
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- CN104523500A CN104523500A CN201410773756.XA CN201410773756A CN104523500A CN 104523500 A CN104523500 A CN 104523500A CN 201410773756 A CN201410773756 A CN 201410773756A CN 104523500 A CN104523500 A CN 104523500A
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Abstract
The invention relates to a composition containing double-effect plant active ingredients and a preparation method of the composition. The composition containing double-effect plant active ingredients consists of the following components in parts by weight: 0.5-5 parts of antioxidantive active peptides and 0.1-5 parts of plant extract, wherein the molecular weight of the antioxidant active peptides is smaller than 1000 Da, the plant extract is selected from one or more of saussurea involucrate extract, rhodiola rosea extract, salviae miltiorrhizae extract, rhodiola rosea or tea polyphenol. According to the composition containing double-effect plant active ingredients disclosed by the invention, the antioxidant active peptides with molecular weight lower than 1000 Da, which can penetrate through a skin barrier, and the plant extract with antioxidant activity are selected as the functional ingredients of the antioxidant composition, so that a synergistic effect is achieved. The product provided by the invention has a remarkable antioxidant effect and a function of delaying skin ageing, and is suitable for skin external application.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of compositions and the preparation technology thereof that contain economic benefits and social benefits active components of plants.
Background technology
Antioxidation active peptides refers to that a class has the protein peptide of antioxidation, common are the degradation product of glutathion, carnosine and some functional proteins.Wherein:
Glutathion is present in each cell of almost health, can help to keep normal immune function, and has antioxidation, in functional food extensive uses such as slow down aging, enhancing immunity, antitumor.
Carnosine (Carnosin) has significant oxidation resistance, can Scavenging active oxygen remove the alpha-beta unsaturated aldehyde that fatty acid peroxidase on cell membrane formed, carnosine also has function (the Aggarwal BB promoting skin healing in addition, Shishodia S, et al, Ann N Y Acad Sci 1030,434 – 41; KimHY, Park EJ, Joe E-H, Jou I, J Immunol 171,6072 – 9).
Collagen tripeptide is called for short CTP, it is collagen hydrolysate, structure can be expressed as " Gly-X-Y " simply, mean molecule quantity is about 280, research shows that CTP can significantly improve body endoperoxide dismutase (SOD) vigor, reduction mda content (Yang Guoyan, etc., food and machinery, (2010) 26:75-78).
Synthesis tripeptides (Phe-lys-Leu) can strengthen the ability to express (Gu Longjian, South China Science & Engineering University's Master's thesis, 2013) of cell SOD and catalase (CAT).
Bee pollen is at the pollen formed after storage and fermentation in Nidus Vespae, has unique natural health effect and medical treatment and its cosmetic values, can delay skin aging, its effect be familiar with by increasing people.Bee pollen main composition is protein, and content accounts for the 25-30% of bee pollen dry weight.Bee pollen protein degradation is become little peptide, the peptide with antioxidant activity can be obtained, the preparation method of this product is shown in CN200710097715.3 (publication number is CN101058600A), and can increase the utilization rate of bee pollen protein, the sensitization of reduction bee pollen albumen.
Some Chinese herbal medicine that Chinese medicine is used, as the plant such as Radix Rhodiolae, Herba Saussureae Involueratae, its extract has good antioxidation, radioprotective characteristic.Wherein:
Radix Rhodiolae extract, can by removing ultra-oxygen anion free radical, hydroxyl radical free radical, fat oxygen-derived free radicals 1,1-diphenyl-2-trinitrophenyl-hydrazine free radical (DPPH) etc., chelated metal ions, anti-lipid peroxidation, improve crucial enzyme (superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) etc.) in endogenous Free-radical ring opening polymerization active, thus reduce cytolipin extent of peroxidation, reduce the injury that unnecessary free radical causes.
Herba Saussureae Involueratae water extract has very powerful scavenging action to the hydroxy radical that ionizing radiation produces, and obviously can suppress the occurrence frequency of the human peripheral lymphocyte chromosomal aberration caused by ionizing radiation; And can by regulating cell cycle after radiation damage occurs, namely the G1 phase blocks, the S phase postpones to make cell have the sufficient time to carry out normal repair, or the apoptosis that induced damage seriously cannot be repaired (Gao Bo, University Of Suzhou's Master's thesis, calendar year 2001).Herba Saussureae Involueratae ethanol extract, Radical Metabolism and energy metabolism level by regulating hypoxia mice improve the ability of anti-hypoxia, its main mechanism may be the body injury degree by alleviating because the toxicant such as reactive oxygen free radical and MDA causes, strengthen the effect of glycolysis production capacity, ensure the energy needed for body existence, particularly strengthen the energy supply to major organs, alleviate the tissue breakdown that body occurs because energy is under-supply, thus improve the ability (Ma Huiping of body anti-hypoxia further, Jiao Yang, Gao Rongmin, Deng, Chinese crude drug, 2014 (37) 99-103).
Tea polyphenols has removing toxic substances and radiation resistance, radioactive substance effectively can be stoped to invade bone marrow, and strontium 90 and Co 60 can be made to excrete rapidly, be described as " radiation jinx " by healthy and medical circle.
TANSHINONES (Tanshione) is the effective ingredient in salviamiltiorrhizabung, can promote that antioxidant reductase synthesizes, make catalase in blood (CAT), glutathion peroxidase (GSH-Px) vigor, in skin, SOD vigor strengthens, improve cell clearance H2O2 and O2-) ability, Cell protection from radical damage, and can make fibroblasts strengthen, collagen protein synthesis increases, and slow down aging process; TANSHINONES has Ca again
2+antagonist action, can stop Ca
2+enter in cell, suppress xanthine dehydrogenase to change to xanthine oxidase, reduce free radical and produce; In addition, TANSHINONES has again slight estrogen action, is also improved effect to skin aging.
About the report that antioxidation active peptides and plant extract share, as follows:
CN201310172301.8 (CN103330213A) relates to a kind of tea polyphenol liposoluble microcapsule and preparation method thereof, the core of described tea polyphenol liposoluble microcapsule is made up of tea polyphenols and reduced glutathion, and the mass ratio of described tea polyphenols and glutathion is 95-99:1 ~ 5.
CN201410295928.7 (CN104027293A) discloses a kind of skin-lightening cosmetic and preparation method thereof.The present invention be with various plants compositions for primary raw material, mainly contain rice bran extract, Radix Rhodiolae extract, Folium Ginkgo extract, tea polyphenols, Fructus Citri Limoniae juice concentrated solution, chitosan, Radix Puerariae extract, konjaku powder, floral disc of sunflower extract, Semen Helianthi core extract, Fructus Gleditsia core, hemicellulose, Mel; In addition, also containing a small amount of glycerol, 1,3-PD, squalane, hyaluronate sodium, carbomer, triethanolamine, allantoin, nano titanium oxide, collagen protein powder, antibacterial, the different monooctyl ester of ferulic acid and glutathion.
CN201410145784.7 (CN103860453A) discloses a kind of face of living and to compact emollient cream and preparation method thereof, emollient cream of the present invention with the antioxidant network system of VCE, Vitamin E acetate, thioctic acid, glutathion, coenzyme Q10 composition for main active.
At present, there is not yet the report that anti-oxidation peptide of the present invention and plant extract share.
Summary of the invention
The object of this invention is to provide a kind of compositions containing economic benefits and social benefits active components of plants.
The first object of the present invention is to provide a kind of compositions containing economic benefits and social benefits active components of plants, is grouped into: antioxidation active peptides 0.5-5 part, plant extract 0.1-5 part by the one-tenth of following weight portion.
In above-mentioned composition:
Described antioxidant activity peptide molecular weight is less than 1000Da (dalton); Particularly, described antioxidation active peptides is selected from one or more in carnosine, glutathion, synthesis tripeptides (Phe-Lys-leucine, Phe-lys-Leu), collagen tripeptide or low-molecular-weight bee pollen protein peptide.
Described plant extract is selected from one or more in Herba Saussureae Involueratae extract, Radix Rhodiolae extract, Radix Salviae Miltiorrhizae extract, rhodioside or tea polyphenols, and said extracted thing all can by commercially available purchase, and described extract is water extract.
Present invention also offers the cosmetics containing above-mentioned composition, it is made up of compositions and adjuvant.
Described adjuvant is selected from one or more in glycerol, almond oil, propylene glycol, silicone oil, PEG-100 stearate, lanoline, hexadecanol, vaseline, American Avocado Tree oil, polyglycerol acrylate, castor oil hydrogenated, Cera Flava, caprylic/capric glyceride or diglycol monostearate.
As the preferred version of cosmetics, described cosmetics are grouped into by the one-tenth of following weight portion: glutathion 0.1-2 part, carnosine 0.1-2 part, Herba Saussureae Involueratae water extract 0.1-1.5 part, Radix Rhodiolae water extract 0.1-1.5 part, glycerol 3-8 part, above composition water are mended to 100 parts, almond oil 0.5-5 part, silicone oil 2-4 part, PEG-100 stearate 0.5-1.5 part, hexadecanol 2-4 part, vaseline 4-8 part.
As another preferred version of cosmetics, described cosmetics are grouped into by the one-tenth of following weight portion: low-molecular-weight bee pollen protein peptide 0.5-2 part, carnosine 0.1-2 part, collagen tripeptide 0.1-0.5 part, tea polyphenols 0.2-2 part, radix Salviae Miltiorrhizae water extract 0.1-1 part, glycerol 1-15 part, above composition water are mended to 100 parts, American Avocado Tree oil 0.5-5 part, polyglycerol acrylate 2-4 part, castor oil hydrogenated 0.5-1.5 part, Cera Flava 2-4 part and caprylic/capric glyceride 4-8 part.
As another preferred version of cosmetics, described cosmetics (antioxidant effect better, long shelf-life) are grouped into by the one-tenth of following weight portion: low-molecular-weight bee pollen protein peptide 0.5-2 part, glutathion 0.1-2 part, synthesis tripeptides 0.1-0.5 part, rhodioside 0.5-1.5 part, tea polyphenols 0.5-1.5 part, propylene glycol 1-5 part, above composition water are mended to 100 parts, caprylic/capric glyceride 0.5-5 part, lanoline 5-10 part, hexadecanol 0.5-1.5 part, diglycol monostearate 2-10 part.
Further preferably, described cosmetics (antioxidant effect the best, long shelf-life) are grouped into by the one-tenth of following weight portion: low-molecular-weight bee pollen protein peptide 1 part, glutathion 0.5 part, synthesis tripeptides 0.5 part, rhodioside 0.5 part, tea polyphenols 1.5 parts, propylene glycol 1.5 parts, 91 parts, water, caprylic/capric glyceride 2 parts, lanoline 5 parts, hexadecanol 1.5 parts, diglycol monostearate 3 parts.
Present invention also offers the preparation method of above-mentioned cosmetics, the method comprises the following steps:
1) take low-molecular-weight bee pollen protein peptide, glutathion, synthesis tripeptides, rhodioside, tea polyphenols, propylene glycol and water according to proportioning, be mixed with solution;
2) by caprylic/capric glyceride, lanoline, hexadecanol and diglycol monostearate Hybrid Heating to 70-85 DEG C, solid content is disperseed completely, stirs and be cooled to 30-40 DEG C, add step 1) in the solution that obtains, homogenizing process.
Compositions containing economic benefits and social benefits active components of plants provided by the invention and preparation technology thereof have the following advantages:
1, select can through skin barrier in the present invention, molecular weight lower than 1000 daltonian antioxidation active peptides, with the plant extract with antioxidant activity, as the functional components of antioxidant composition, meet international antioxidant network theoretical, to the synergistic requirement of multiple antioxidant.
2, cosmetics provided by the invention, have significant antioxidant effect, are suitable for external preparation for skin, have the function of delaying skin aging.
3, cosmetics provided by the invention greatly can improve cell viability, and are better than prior art.
4, find through experiment investigation, the product of prior art also has good effect, but after being above 12 months, character changes, and can not maintain the ability removing DPPH; Product provided by the invention all has good removing DPPH ability, and preserve 18 months, its elimination effect still keeps good effect.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
Embodiment 1: the compositions containing economic benefits and social benefits active components of plants and cosmetics thereof
1, form
2, preparation method:
1) by recipe quantity, configuration component A solution;
2) by B component Hybrid Heating to 70 DEG C, solid content is disperseed completely, stir be cooled to 40 DEG C, add component A solution, homogenizing process.
Embodiment 2: the compositions containing economic benefits and social benefits active components of plants and cosmetics thereof
1, form
2, preparation method:
1) by recipe quantity, configuration component A solution;
2) by B component Hybrid Heating to 80 DEG C, solid content is disperseed completely, stir be cooled to 40 DEG C, add component A solution, homogenizing process.
Embodiment 3: the compositions containing economic benefits and social benefits active components of plants and cosmetics thereof
1, form
2, preparation method:
1) by recipe quantity, configuration component A solution;
2) by B component Hybrid Heating to 80 DEG C, solid content is disperseed completely, stir be cooled to 40 DEG C, add component A solution, homogenizing process.
Embodiment 4: the compositions containing economic benefits and social benefits active components of plants and cosmetics thereof
1, form
2, preparation method:
1) by recipe quantity, configuration component A solution;
2) by B component Hybrid Heating to 75 DEG C, solid content is disperseed completely, stir be cooled to 35 DEG C, add component A solution, homogenizing process.
Embodiment 5: the compositions containing economic benefits and social benefits active components of plants and cosmetics thereof
1, form
2, preparation method:
1) by recipe quantity, configuration component A solution;
2) by B component Hybrid Heating to 70 DEG C, solid content is disperseed completely, stir be cooled to 30 DEG C, add component A solution, homogenizing process.
Comparative example 1:
With reference to the embodiment 1 of CN201310172301.8 (CN103330213A), proportioning by tea polyphenols and glutathion is 95:5, then molecular weight bee pollen protein peptide, glutathion, synthesis tripeptides, rhodioside and the tea polyphenols tea polyphenols in the embodiment of the present invention 3 and glutathion are replaced, total consumption is 4g, namely the consumption of tea polyphenols and glutathion is respectively: 3.8g and 0.2g, and all the other adjuvants, preparation method are with embodiments of the invention 3.
Comparative example 2:
With reference to the embodiment 2 of CN201410295928.7 (CN104027293A), it specifically forms and preparation method refers to this patent documentation.
Experimental example 1: free radical scavenging is tested
1, test principle: DPPH is a kind of stable free radical in organic solvent, and its lone pair electrons have strong absorption (aobvious darkviolet) near 517nm.When organic scavenger exists, lone pair electrons are paired, and absorb and disappear or weaken, and by measuring the degree absorbing and weaken, can evaluate the activity of free radical scavenger.
2, laboratory sample:
Sample 1-5: the embodiment 1-5 cosmetics prepared;
Reference substance 1,2: comparative example 1,2.
Reference substance 3: only retain low-molecular-weight bee pollen protein peptide in embodiment 3, delete glutathion, synthesis tripeptides, rhodioside and tea polyphenols, its consumption is 10g, all the other compositions and consumption reference example 4g;
Reference substance 4: retain the synthesis tripeptides in embodiment 3, delete low-molecular-weight bee pollen protein peptide, glutathion, rhodioside and tea polyphenols, its consumption is revised as 1g.
3, test method: extracting sample solution 2mL and concentration are that the DPPH solution 2mL of 100 μm of oL/L successively adds in same tool plug test tube, shake up; Left at room temperature 30min, working sample absorbance under 517nm wavelength.
Suppression ratio: K%=[1-(Ai-Aj)/Ac] × 100%
The absorbance of Ai:2mLDPPH solution+2mL product to be tested solution
The absorbance of Aj:2mL product to be tested solution+2mL solvent
The absorbance of Ac:2mLDPPH solution+2mL solvent
Detected at 0 month, 12 months, 18 months respectively.
Sample preservation is: sealing is preserved, and forbids direct sunlight.
4, experimental result:
4.1 0 months clearance rate to DPPH: in table 1.
The different sample of table 1 is to the clearance rate (%) of DPPH
Table 1 result shows: respectively compared with reference substance 1-4, the clearance rate of sample 1-5 to DPPH has increase in various degree.
4.2 12 months clearance rate to DPPH: in table 2.
The different sample of table 2 is to the clearance rate (%) of DPPH
Table 2 result shows: respectively compared with reference substance 1-4, sample 1-5 increases the clearance rate star of DPPH, and wherein the clearance rate of sample 3-5 significantly increases.
4.3 18 months clearance rate to DPPH: in table 3.
The different sample of table 3 is to the clearance rate (%) of DPPH
Table 3 result shows: respectively compared with reference substance 1-4, sample 1-5 increases the clearance rate star of DPPH, and the clearance rate of sample 3-5 significantly increases.
Result shows: the product of prior art also has good effect, but after being above 12 months, character changes, and can not maintain the ability removing DPPH; Product provided by the invention all has good removing DPPH ability, and preserve 18 months, its elimination effect still keeps good effect.
Experimental example 2:MTT activity test
1, laboratory sample: with experimental example 1.Increase blank group.
2, experimental technique: the human epidermal cell HEK-n of trophophase of taking the logarithm, according to 1 × 10
5the concentration of cells/mL inoculates 96 orifice plates, every pore volume 200 μ L, after normal cultivation 24h; to in protection group cell culture fluid; add sample 1-5, reference substance 1-4, blank group (only adding isopyknic PBS) respectively, after 5min, adopt 1mM H respectively
2o
2carry out oxidative damage process 6h.After oxidative damage process terminates, take out 96 well culture plates, abandon supernatant, after carefully rushing 2-3 time with PBS, then add the fresh medium of 200 μ L containing 0.5mg/mLMTT, continue at 37 DEG C, 5%CO
24h is cultivated under condition.After cultivation terminates, discard MTT solution, every hole adds 100 μ LDMSO, vibration mixing, surveys each hole absorbance (A490) that wavelength is 490nm, calculates cell survival rate.
3, experimental result: in table 4
Table 4:MTT activity test
Table 4 result shows, and compared with blank group, reference substance significantly can increase cell survival rate, and sample 1-5 extremely significantly can increase cell survival rate; Respectively compared with reference substance 1-4, sample 1-5 obviously can increase cell survival rate.
Result shows: cosmetics provided by the invention greatly can improve cell viability, and are better than prior art.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. the compositions containing economic benefits and social benefits active components of plants, is grouped into by the one-tenth of following weight portion: antioxidation active peptides 0.5-5 part, plant extract 0.1-5 part.
2. compositions according to claim 1, is characterized in that, described antioxidant activity peptide molecular weight is less than 1000Da.
3. compositions according to claim 2, is characterized in that, described antioxidation active peptides is selected from one or more in carnosine, glutathion, synthesis tripeptides, collagen tripeptide or low-molecular-weight bee pollen protein peptide.
4. compositions according to claim 1, is characterized in that, described plant extract is selected from one or more in Herba Saussureae Involueratae extract, Radix Rhodiolae extract, Radix Salviae Miltiorrhizae extract, rhodioside or tea polyphenols.
5. containing the cosmetics of compositions described in any one of claim 1-4, it is characterized in that, these cosmetics are made up of compositions and adjuvant, and described adjuvant is selected from one or more in glycerol, almond oil, propylene glycol, silicone oil, PEG-100 stearate, lanoline, hexadecanol, vaseline, American Avocado Tree oil, polyglycerol acrylate, castor oil hydrogenated, Cera Flava, water, caprylic/capric glyceride or diglycol monostearate.
6. cosmetics according to claim 5, it is characterized in that, described cosmetics are grouped into by the one-tenth of following weight portion: glutathion 0.1-2 part, carnosine 0.1-2 part, Herba Saussureae Involueratae water extract 0.1-1.5 part, Radix Rhodiolae water extract 0.1-1.5 part, glycerol 3-8 part, above composition water are mended to 100 parts, almond oil 0.5-5 part, silicone oil 2-4 part, PEG-100 stearate 0.5-1.5 part, hexadecanol 2-4 part, vaseline 4-8 part.
7. cosmetics according to claim 5, it is characterized in that, described cosmetics are grouped into by the one-tenth of following weight portion: low-molecular-weight bee pollen protein peptide 0.5-2 part, carnosine 0.1-2 part, collagen tripeptide 0.1-0.5 part, tea polyphenols 0.2-2 part, radix Salviae Miltiorrhizae water extract 0.1-1 part, glycerol 1-15 part, above composition water are mended to 100 parts, American Avocado Tree oil 0.5-5 part, polyglycerol acrylate 2-4 part, castor oil hydrogenated 0.5-1.5 part, Cera Flava 2-4 part and caprylic/capric glyceride 4-8 part.
8. cosmetics according to claim 5, it is characterized in that, described cosmetics are grouped into by the one-tenth of following weight portion: low-molecular-weight bee pollen protein peptide 0.5-2 part, glutathion 0.1-2 part, synthesis tripeptides 0.1-0.5 part, rhodioside 0.5-1.5 part, tea polyphenols 0.5-1.5 part, propylene glycol 1-5 part, above composition water are mended to 100 parts, caprylic/capric glyceride 0.5-5 part, lanoline 5-10 part, hexadecanol 0.5-1.5 part, diglycol monostearate 2-10 part.
9. cosmetics according to claim 8, it is characterized in that, described cosmetics are grouped into by the one-tenth of following weight portion: low-molecular-weight bee pollen protein peptide 1 part, glutathion 0.5 part, synthesis tripeptides 0.5 part, rhodioside 0.5 part, tea polyphenols 1.5 parts, propylene glycol 1.5 parts, 91 parts, water, caprylic/capric glyceride 2 parts, lanoline 5 parts, hexadecanol 1.5 parts, diglycol monostearate 3 parts.
10. the preparation method of the cosmetics described in claim 8 or 9, is characterized in that, the method comprises the following steps:
1) take low-molecular-weight bee pollen protein peptide, glutathion, synthesis tripeptides, rhodioside, tea polyphenols, propylene glycol and water according to proportioning, be mixed with solution;
2) by caprylic/capric glyceride, lanoline, hexadecanol and diglycol monostearate Hybrid Heating to 70-85 DEG C, solid content is disperseed completely, stirs and be cooled to 30-40 DEG C, add step 1) in the solution that obtains, homogenizing process.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157838A (en) * | 2017-06-05 | 2017-09-15 | 云南摩尔农庄生物科技开发有限公司 | A kind of antioxidant composition containing walnut peel extract |
| CN107296768A (en) * | 2017-07-25 | 2017-10-27 | 四川吉晟生物医药有限公司 | A kind of whitening cosmetics combined containing gadol extract and active peptides |
| CN110179735A (en) * | 2019-07-10 | 2019-08-30 | 湖北省吉美化妆品有限公司 | Have effects that Vitamin K, the plant composition for eye pouch of dispelling and its application in external use skin care |
| CN110357954A (en) * | 2019-07-11 | 2019-10-22 | 余雪平 | Easily absorb the collagen and its preparation process for improving skin |
| CN116637107A (en) * | 2022-02-15 | 2023-08-25 | 四川大学 | Natural antioxidant-loaded antitumor nano-drug and load proportion screening method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073566A (en) * | 2006-05-19 | 2007-11-21 | 秦长青 | Production and use for tanshinone component injection |
| CN101214200A (en) * | 2008-01-21 | 2008-07-09 | 丁克祥 | Skin externally-applied liquid state and solid state kreotoxin (liushengtai) composite nano emulsion and preparation thereof |
| CN103860453A (en) * | 2014-04-11 | 2014-06-18 | 六安市丹皇生物科技有限责任公司 | Energizing and firming cream and preparation method thereof |
| CN103933541A (en) * | 2014-05-12 | 2014-07-23 | 潘宏涛 | Glutathione anti-cancer composition |
| CN104027293A (en) * | 2014-06-27 | 2014-09-10 | 王忠良 | Whitening cosmetic and preparation method thereof |
-
2014
- 2014-12-12 CN CN201410773756.XA patent/CN104523500A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073566A (en) * | 2006-05-19 | 2007-11-21 | 秦长青 | Production and use for tanshinone component injection |
| CN101214200A (en) * | 2008-01-21 | 2008-07-09 | 丁克祥 | Skin externally-applied liquid state and solid state kreotoxin (liushengtai) composite nano emulsion and preparation thereof |
| CN103860453A (en) * | 2014-04-11 | 2014-06-18 | 六安市丹皇生物科技有限责任公司 | Energizing and firming cream and preparation method thereof |
| CN103933541A (en) * | 2014-05-12 | 2014-07-23 | 潘宏涛 | Glutathione anti-cancer composition |
| CN104027293A (en) * | 2014-06-27 | 2014-09-10 | 王忠良 | Whitening cosmetic and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157838A (en) * | 2017-06-05 | 2017-09-15 | 云南摩尔农庄生物科技开发有限公司 | A kind of antioxidant composition containing walnut peel extract |
| CN107157838B (en) * | 2017-06-05 | 2020-12-08 | 云南摩尔农庄生物科技开发有限公司 | Antioxidant composition containing walnut green husk extract |
| CN107296768A (en) * | 2017-07-25 | 2017-10-27 | 四川吉晟生物医药有限公司 | A kind of whitening cosmetics combined containing gadol extract and active peptides |
| CN110179735A (en) * | 2019-07-10 | 2019-08-30 | 湖北省吉美化妆品有限公司 | Have effects that Vitamin K, the plant composition for eye pouch of dispelling and its application in external use skin care |
| CN110357954A (en) * | 2019-07-11 | 2019-10-22 | 余雪平 | Easily absorb the collagen and its preparation process for improving skin |
| CN116637107A (en) * | 2022-02-15 | 2023-08-25 | 四川大学 | Natural antioxidant-loaded antitumor nano-drug and load proportion screening method thereof |
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Application publication date: 20150422 |