CN107648095A - Fructus Momordicae fructoside mouthwash and preparation method thereof - Google Patents
Fructus Momordicae fructoside mouthwash and preparation method thereof Download PDFInfo
- Publication number
- CN107648095A CN107648095A CN201710825423.0A CN201710825423A CN107648095A CN 107648095 A CN107648095 A CN 107648095A CN 201710825423 A CN201710825423 A CN 201710825423A CN 107648095 A CN107648095 A CN 107648095A
- Authority
- CN
- China
- Prior art keywords
- fructus momordicae
- momordicae fructoside
- mouthwash
- raw material
- fructoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The invention belongs to oral disinfecting product technical field, and in particular to a kind of Fructus Momordicae fructoside mouthwash and preparation method thereof.Fructus Momordicae fructoside mouthwash is made up of the following raw material：Chlorhexidine gluconate, surfactant, sodium fluoride, xylitol, tea extract, Fructus Momordicae fructoside, Purified Water.The present invention is free of ethanol, using natural plant extracts, complex glucose acid chlorohexidene, bactericidal effect can be reached, the addition of Fructus Momordicae fructoside can solve the problem that the problem of mouthfeel is bitter simultaneously, lingering fragrance is left after gargling, is adapted to require mouthfeel higher people, product has simultaneously removes oral peculiar smell, the function of anti-caries.
Description
Technical field
The invention belongs to oral disinfecting product technical field, and in particular to a kind of Fructus Momordicae fructoside mouthwash and its preparation side
Method.
Background technology
At present, the domestic rinse product for oral hygiene is a lot, and the advantages of simple, easy to carry is used because it has,
Therefore commercially it is popular.Mouthwash can solve many problems, such as periodontitis, carious tooth, oral peculiar smell, oral inflammation
Problem.Traditional mouthwash contains more alcohol, there is certain injury to tooth.It is main component as chlorhexidine gluconate
Mouthwash, due to sterilization, continuing the effect of antibacterial, many people were write similar to patent, but due to chlorohexidene taste
It is very poor, it is bitter during gargling, hardship after still having after gargling, cause many people to inspire awe even from distance.Though current producer is carried with various plants
Thing is taken to cover bitter taste, but still can not improve mouthfeel well.Therefore a kind of new mouthwash is needed to be asked to solve this
Topic.
In general sweetener, based on saccharin sodium, xylitol, glucose, but sweetening effect is limited, if substantial increase,
The easy breed bacteria of system can be caused again.Fructus Momordicae fructoside is that content and the higher composition of sugariness, its sugariness are in Momordica grosvenori
300 times of sucrose, category is low in calories, non-energy, the sweetener of non-fermented type.
Fructus Momordicae fructoside, sweet taste can be not only improved, also with following functions：
Eliminating the phlegm, antitussive effect；
Anti-inflammatory, antibacterial acts on；
Remove free radical and antioxidation.
On the premise of solving sensory issues, for the oral peculiar smell of generally existing in current crowd, the situation of carious tooth, tea
The cooperation of leaf extract and Fructus Momordicae fructoside can effectively solve oral peculiar smell, while with the addition of fluorochemical and solve carious tooth
Problem.
As mouthwash main material, chlorhexidine gluconate meets the requirement of Chinese Pharmacopoeia except consideration, because its content is higher,
So should more consider its purity, so should focus on to consider the influence of its tetrachloro phenylamino impurity, the content of tetrachloro phenylamino in raw material
10ppm should be less than.
The content of the invention
It is an object of the invention to provide a kind of Fructus Momordicae fructoside mouthwash, has sterilization, anti-inflammatory, removes removing abnormal flavor in oral cavity, be anti-
The characteristics of carious tooth, comfortable taste；It is scientific and reasonable, simple invention also provides the preparation method of Fructus Momordicae fructoside mouthwash
It is easy.
Fructus Momordicae fructoside mouthwash of the present invention, is made up of the raw material of following percentage by weight：
Fructus Momordicae fructoside mouthwash of the present invention, is preferably made up of the raw material of following percentage by weight：
Fructus Momordicae fructoside mouthwash of the present invention, is preferably made up of the raw material of following percentage by weight：
Fructus Momordicae fructoside mouthwash of the present invention, is preferably made up of the raw material of following percentage by weight：
Fructus Momordicae fructoside mouthwash of the present invention, is preferably made up of the raw material of following percentage by weight：
Fructus Momordicae fructoside mouthwash of the present invention, is preferably made up of the raw material of following percentage by weight：
Described surfactant is one kind in AEO or PEG-3 coconut oleoyl amines.
Described tea extract is one or both of green-tea extract or jasmine tea extract.
Fructus Momordicae fructoside：The sweetener extracted from Momordica grosvenori, pol are 300 times of sucrose.
Purified Water：Eliminate most impurity, electrical conductivity ＜ 1us/cm purified water.
The preparation method of Fructus Momordicae fructoside mouthwash of the present invention, step are as follows：
(1) chlorhexidine gluconate, surfactant, sodium fluoride, xylitol and tea extract are dissolved in Purified Water and obtain A
Liquid；
(2) Fructus Momordicae fructoside is dissolved in Purified Water and obtains B liquid；
(3) B liquid is added in A liquid while stirring after being sufficiently mixed uniformly, stirred evenly, it is filling after standing.
Time of repose described in step (3) is 10h.
The selected sweetener Lo Han Guo glucosides of the present invention, compounds with chlorhexidine gluconate, prepares a kind of comfortable taste
Antibacterial mouthwash.
The present invention compared with prior art, has the advantages that：
The present invention is free of ethanol, using natural plant extracts, complex glucose acid chlorohexidene, can reach sterilization effect
Fruit, while the addition of Fructus Momordicae fructoside can solve the problem that the problem of mouthfeel is bitter, and lingering fragrance is left after gargling, be adapted to mouthfeel requirement compared with
High people, product has simultaneously removes oral peculiar smell, the function of anti-caries.
Embodiment
The present invention is described further with reference to embodiments.
Embodiment 1
Raw material composition is as follows, by weight percentage：
Preparation method is as follows：
(1) chlorhexidine gluconate, AEO, sodium fluoride, xylitol and green-tea extract are dissolved in essence
Water processed obtains A liquid.
(2) Fructus Momordicae fructoside is dissolved in Purified Water and obtains B liquid.
(3) B liquid is added in A liquid while stirring after being sufficiently mixed uniformly, stirred evenly, it is filling after standing 10h.
Embodiment 2
Raw material composition is as follows, by weight percentage：
Preparation method is the same as embodiment 1.
Embodiment 3
Raw material composition is as follows, by weight percentage：
Preparation method is the same as embodiment 1.
Killing action (suspension method) of the invention to microorganism, according to《Disinfection technology standard》(2002 editions) are operated.
It the results are shown in Table 1.
Killing action result of the embodiment 1-3 products of table 1 to microorganism
Claims (10)
1. a kind of Fructus Momordicae fructoside mouthwash, it is characterised in that be made up of the raw material of following percentage by weight：
2. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that by the raw material system of following percentage by weight
Into：
3. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that by the raw material system of following percentage by weight
Into：
4. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that by the raw material system of following percentage by weight
Into：
5. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that by the raw material system of following percentage by weight
Into：
6. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that by the raw material system of following percentage by weight
Into：
7. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that described surfactant is fatty alcohol
One kind in APEO or PEG-3 coconut oleoyl amines.
8. Fructus Momordicae fructoside mouthwash according to claim 1, it is characterised in that described tea extract carries for green tea
Take one or both of thing or jasmine tea extract.
9. the preparation method of any described Fructus Momordicae fructoside mouthwashes of a kind of claim 1-8, it is characterised in that step is as follows：
(1) chlorhexidine gluconate, surfactant, sodium fluoride, xylitol and tea extract are dissolved in Purified Water and obtain A liquid；
(2) Fructus Momordicae fructoside is dissolved in Purified Water and obtains B liquid；
(3) B liquid is added in A liquid while stirring after being sufficiently mixed uniformly, stirred evenly, it is filling after standing.
10. the preparation method of Fructus Momordicae fructoside mouthwash according to claim 9, it is characterised in that described in step (3)
Time of repose be 10h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710825423.0A CN107648095A (en) | 2017-09-14 | 2017-09-14 | Fructus Momordicae fructoside mouthwash and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710825423.0A CN107648095A (en) | 2017-09-14 | 2017-09-14 | Fructus Momordicae fructoside mouthwash and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107648095A true CN107648095A (en) | 2018-02-02 |
Family
ID=61130412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710825423.0A Pending CN107648095A (en) | 2017-09-14 | 2017-09-14 | Fructus Momordicae fructoside mouthwash and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107648095A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114668698A (en) * | 2022-05-10 | 2022-06-28 | 青岛新鲸医疗技术有限公司 | Plant ingredient mouthwash |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479548A (en) * | 2013-09-11 | 2014-01-01 | 上海方木精细化工有限公司 | Momordica grosvenori gargle |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
-
2017
- 2017-09-14 CN CN201710825423.0A patent/CN107648095A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479548A (en) * | 2013-09-11 | 2014-01-01 | 上海方木精细化工有限公司 | Momordica grosvenori gargle |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114668698A (en) * | 2022-05-10 | 2022-06-28 | 青岛新鲸医疗技术有限公司 | Plant ingredient mouthwash |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180202 |
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| RJ01 | Rejection of invention patent application after publication |