CN107636015A - 包含结合蛋白和对IL‑15Rα具有降低亲和力的白介素‑15多肽的融合蛋白及其治疗用途 - Google Patents

包含结合蛋白和对IL‑15Rα具有降低亲和力的白介素‑15多肽的融合蛋白及其治疗用途 Download PDF

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CN107636015A
CN107636015A CN201680025275.8A CN201680025275A CN107636015A CN 107636015 A CN107636015 A CN 107636015A CN 201680025275 A CN201680025275 A CN 201680025275A CN 107636015 A CN107636015 A CN 107636015A
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fusion protein
cells
amino acid
antibody
cancer
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J·冈卓姆
H·萨利赫
C·林德纳
B·洛赫曼
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Deutsches Krebsforschungszentrum DKFZ
Eberhard Karls Universitaet Tuebingen
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Deutsches Krebsforschungszentrum DKFZ
Eberhard Karls Universitaet Tuebingen
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Application filed by Deutsches Krebsforschungszentrum DKFZ, Eberhard Karls Universitaet Tuebingen filed Critical Deutsches Krebsforschungszentrum DKFZ
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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CN201680025275.8A 2015-03-06 2016-03-07 包含结合蛋白和对IL‑15Rα具有降低亲和力的白介素‑15多肽的融合蛋白及其治疗用途 Pending CN107636015A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15157911.7A EP3064507A1 (en) 2015-03-06 2015-03-06 Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof
EP15157911.7 2015-03-06
PCT/EP2016/054729 WO2016142314A1 (en) 2015-03-06 2016-03-07 FUSION PROTEINS COMPRISING A BINDING PROTEIN AND AN INTERLEUKIN-15 POLYPEPTIDE HAVING A REDUCED AFFINITY FOR IL15Ra AND THERAPEUTIC USES THEREOF

Publications (1)

Publication Number Publication Date
CN107636015A true CN107636015A (zh) 2018-01-26

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CN201680025275.8A Pending CN107636015A (zh) 2015-03-06 2016-03-07 包含结合蛋白和对IL‑15Rα具有降低亲和力的白介素‑15多肽的融合蛋白及其治疗用途

Country Status (16)

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US (3) US10906952B2 (https=)
EP (2) EP3064507A1 (https=)
JP (1) JP6757338B2 (https=)
CN (1) CN107636015A (https=)
BR (1) BR112017018975A2 (https=)
CA (1) CA2978808A1 (https=)
CY (1) CY1122494T1 (https=)
DK (1) DK3265478T3 (https=)
ES (1) ES2763598T3 (https=)
HR (1) HRP20192190T1 (https=)
HU (1) HUE047818T2 (https=)
PL (1) PL3265478T3 (https=)
PT (1) PT3265478T (https=)
RS (1) RS59658B1 (https=)
SI (1) SI3265478T1 (https=)
WO (1) WO2016142314A1 (https=)

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CN109207430A (zh) * 2018-09-25 2019-01-15 华东师范大学 一种嵌合抗原受体nk细胞及其制备方法和应用
WO2020048525A1 (en) * 2018-09-07 2020-03-12 Generon (Shanghai) Corporation Ltd. Bispecific antigen binding proteins and uses thereof
CN111372449A (zh) * 2018-09-27 2020-07-03 公益财团法人实验动物中央研究所 免疫缺陷小鼠
CN111690068A (zh) * 2019-11-13 2020-09-22 中国科学技术大学 一种IL-15/SuIL-15Rα-dFc-γ4复合体蛋白及其构造方法、应用
US10870701B2 (en) 2016-03-15 2020-12-22 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
CN112368015A (zh) * 2018-06-18 2021-02-12 安维达生物科技公司 细胞因子融合蛋白及其用途
US11013800B2 (en) 2011-05-16 2021-05-25 Evive Biotech Ltd. Multi-specific Fab fusion proteins comprising a CD3-binding Fab fragment with N-terminal fusion to binding domains and methods of use
WO2021115303A1 (zh) * 2019-12-11 2021-06-17 上海复宏汉霖生物技术股份有限公司 一种抗Claudin18.2单克隆抗体、其制备方法及用途
CN113956346A (zh) * 2021-10-26 2022-01-21 西安龙腾景云生物科技有限公司 一种重组白介素-15变体
US11236140B2 (en) 2015-07-02 2022-02-01 Bj Bioscience Inc. Interleukin 15 fusion protein for tumor targeting therapy
CN114286683A (zh) * 2019-07-17 2022-04-05 新加坡国立大学 由免疫细胞合成和分泌的功能性结合物
CN117186227A (zh) * 2020-12-23 2023-12-08 瑞泽恩制药公司 编码锚修饰的抗体的核酸以及其用途
US12258381B2 (en) 2018-02-09 2025-03-25 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
US12398187B2 (en) 2019-03-05 2025-08-26 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
US12577305B2 (en) 2018-12-24 2026-03-17 Itabmed (Hk) Limited Multispecific antigen binding proteins capable of binding CD19 and CD3, and use thereof

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JP7285828B2 (ja) 2017-09-05 2023-06-02 トルク セラピューティクス， インコーポレイテッド 治療用タンパク質組成物ならびにその作製および使用方法
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