CN107635990A - 新型3‑吲哚取代的衍生物、药物组合物及使用方法 - Google Patents

新型3‑吲哚取代的衍生物、药物组合物及使用方法 Download PDF

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Publication number
CN107635990A
CN107635990A CN201680028408.7A CN201680028408A CN107635990A CN 107635990 A CN107635990 A CN 107635990A CN 201680028408 A CN201680028408 A CN 201680028408A CN 107635990 A CN107635990 A CN 107635990A
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Prior art keywords
fluoro
indol
isothiazole
methyl
yls
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Pending
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CN201680028408.7A
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English (en)
Chinese (zh)
Inventor
S·宁科维奇
S·克罗西尼亚尼
S·A·斯凯尔斯
I·J·麦卡尔平
M·R·柯林斯
A·马代尔纳
M·威思
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Kuyt Medical Oswald
Pfizer Inc
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Kuyt Medical Oswald
Pfizer Inc
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Priority claimed from PCT/IB2015/051957 external-priority patent/WO2015140717A1/en
Application filed by Kuyt Medical Oswald, Pfizer Inc filed Critical Kuyt Medical Oswald
Publication of CN107635990A publication Critical patent/CN107635990A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201680028408.7A 2015-03-17 2016-03-17 新型3‑吲哚取代的衍生物、药物组合物及使用方法 Pending CN107635990A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/IB2015/051957 WO2015140717A1 (en) 2014-03-18 2015-03-17 Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
IBPCT/IB2015/051957 2015-03-17
US201562203032P 2015-08-10 2015-08-10
US62/203,032 2015-08-10
PCT/IB2016/051509 WO2016147144A1 (en) 2015-03-17 2016-03-17 Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use

Publications (1)

Publication Number Publication Date
CN107635990A true CN107635990A (zh) 2018-01-26

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CN201680028408.7A Pending CN107635990A (zh) 2015-03-17 2016-03-17 新型3‑吲哚取代的衍生物、药物组合物及使用方法

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US (1) US9873690B2 (cg-RX-API-DMAC7.html)
EP (1) EP3271354A1 (cg-RX-API-DMAC7.html)
JP (1) JP6775516B2 (cg-RX-API-DMAC7.html)
KR (1) KR102013512B1 (cg-RX-API-DMAC7.html)
CN (1) CN107635990A (cg-RX-API-DMAC7.html)
AU (1) AU2016231832B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017019699A2 (cg-RX-API-DMAC7.html)
CA (1) CA2979616C (cg-RX-API-DMAC7.html)
HK (1) HK1243999A1 (cg-RX-API-DMAC7.html)
IL (1) IL254124A0 (cg-RX-API-DMAC7.html)
MX (1) MX2017011951A (cg-RX-API-DMAC7.html)
RU (1) RU2672252C1 (cg-RX-API-DMAC7.html)
SG (1) SG11201706992TA (cg-RX-API-DMAC7.html)
WO (1) WO2016147144A1 (cg-RX-API-DMAC7.html)

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CN111499592A (zh) * 2020-03-14 2020-08-07 江苏省农用激素工程技术研究中心有限公司 5-氨甲基糖精的合成方法
CN111777557A (zh) * 2020-07-28 2020-10-16 中国科学院上海有机化学研究所 以芳香联苯烯为骨架的新型抗肿瘤先导化合物及其应用
WO2021218912A1 (zh) * 2020-04-30 2021-11-04 南京明德新药研发有限公司 含苯基并内磺酰胺的化合物
CN119707855A (zh) * 2024-12-20 2025-03-28 西南大学 一种光学活性胺类衍生物及其不对称烷基化合成方法和应用

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EP3271354A1 (en) 2018-01-24
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