CN107607473A - A kind of while multi-point shooting is with matching the opto-acoustic three-dimensional imaging received and method - Google Patents
A kind of while multi-point shooting is with matching the opto-acoustic three-dimensional imaging received and method Download PDFInfo
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- CN107607473A CN107607473A CN201710772485.XA CN201710772485A CN107607473A CN 107607473 A CN107607473 A CN 107607473A CN 201710772485 A CN201710772485 A CN 201710772485A CN 107607473 A CN107607473 A CN 107607473A
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Abstract
The invention discloses a kind of while multi-point shooting with matching the opto-acoustic three-dimensional imaging received and method, in device, computer processing system controls the keying of photoacoustic signal activating system, reestablishment imaging is carried out after receiving the data after the processing of photoacoustic signal pretreatment system and processing data, controls the operation of 3 D scanning system；For photoacoustic signal activating system by pulse laser shaping to focus on out multiple optical focus using microlens array after linear light source, multiple optical focus excite sample to produce multi-source photoacoustic signal simultaneously；Photoacoustic signal reception system receives multi-source photoacoustic signal parallel；Photoacoustic signal pretreatment system is amplified and filtered to multi-source photoacoustic signal, sends signal to computer processing system；Sample to be imaged is placed in a tank, and 3 D scanning system is used for the locus for adjusting tank and photoacoustic signal activating system.Quick, large-scale optoacoustic three-dimensional imaging can be achieved using the space layout of microlens array and linear acoustic detection array in the present invention.
Description
Technical field
The present invention relates to photoacoustic imaging research field, more particularly to a kind of while multi-point shooting is with matching the optoacoustic three received
Tie up imaging device and method.
Background technology
Photoacoustic imaging is a kind of imaging technique for combining optical imagery and the non-intrusion type of ultrasonic imaging, and it has simultaneously
The characteristics of high-contrast of optical imagery, high-resolution and high-penetration of ultrasonic imaging.Photoacoustic imaging is established in light generation sound
General principle, when being radiated at short-pulse laser in biological tissue, biological tissue absorb pulse energy expand generation rapidly
Ultrasound, i.e. photoacoustic signal, the image of reflection mechanics of biological tissue and function information can be reconstructed according to photoacoustic signal.Optoacoustic into
As the shortcomings that overcoming some traditional imaging modes, such as：Compared with optical coherent chromatographic imaging (OCT), due to organism optical
Strong scattering causes fathoming for OCT to be limited in the shallow-layer of millimeter magnitude, and photoacoustic imaging technology is up to centimetres；With it is pure
Ultrasonic imaging is compared, very low in the contrast for the region ultrasonic imaging that acoustic impedance is more or less the same, and photoacoustic imaging then utilizes difference
The absorption difference of tissue reconstructs the image of high-contrast, therefore photoacoustic imaging develops rapidly, for Biologic Medical Image
The development in field has impetus.
Image taking speed is improved for photoacoustic imaging and realizes that monitoring dynamic physiology process is significant in real time, still
The repetition rate of pulse laser and the speed of mechanical scanning are limited to, the single optical focus of current most of uses and single sound are burnt
The imaging pattern of point is difficult to realize high speed optoacoustic three-dimensional imaging.Application number 201010139117.X patent application discloses one kind
Rapid three-dimensional photoacoustic imaging system and method based on ultrasonic plane array detector, the invention are established based on planar array detector
Non-scanning mode photoacoustic imaging system realize rapid three-dimensional photoacoustic imaging, but it is non-focusing that the deficiency of the system, which is excitation source,
Laser, therefore the resolution ratio of the system is determined by acoustics resolution ratio, but it is limited to the array element size and battle array of ultrasonic plane array detector
First spacing, the system are difficult to realize high-resolution opto-acoustic microscopic imaging.The patent application of application number 201110171027.3 is public
A kind of fast opto-acoustic three-dimensional imaging is opened, the invention controls each micro- in optical mask by programmable logic array module
The break-make of eyeglass is avoided using mechanical scanner, but most of lenticule is off under the working state of device
So that laser source utilization rate is extremely low, and the circuit that the collection of light source activation and photoacoustic signal is required to send out miscellaneous is controlled and excited
Will strictly it unify with the position of collection and sequential, whole hardware and program is all very complicated is not easy to practice.
The content of the invention
For problems of the prior art, it is an object of the invention to provide a kind of multi-point shooting simultaneously to receive with matching
Opto-acoustic three-dimensional imaging and method, device it is real rationally using the space layout of microlens array and linear acoustic detection array
Now quick, large-scale optoacoustic three-dimensional imaging can be achieved with receiving in efficient photo-acoustic excitation.
The purpose of the present invention is realized by following technical scheme：A kind of while multi-point shooting is with matching the optoacoustic three received
Imaging device is tieed up, including computer processing system, photoacoustic signal activating system, photoacoustic signal reception system, photoacoustic signal are located in advance
Reason system and 3 D scanning system, wherein：
Computer processing system controls the keying of photoacoustic signal activating system, after receiving the processing of photoacoustic signal pretreatment system
Data and processing data after carry out reestablishment imaging, control the operation of 3 D scanning system；
Pulse laser shaping is first linear light source by photoacoustic signal activating system, then using in photoacoustic signal activating system
Microlens array focus on out multiple optical focus, realize that multifocal point Linear excites, multiple optical focus excite simultaneously sample produce it is more
Source photoacoustic signal；
Photoacoustic signal reception system receives above-mentioned multi-source photoacoustic signal parallel；
Photoacoustic signal pretreatment system is amplified and filtered to multi-source photoacoustic signal, passes through multi-channel signal acquiring system
Send signal to computer processing system；
Sample to be imaged is placed in a tank, and 3 D scanning system is used to adjust tank and photoacoustic signal activating system
Locus.
Preferably, the photoacoustic signal activating system includes nanosecoud pulse laser, coupling optical path, linear laser generation thoroughly
Mirror and microlens array, the pulse laser that coupling optical path sends nanosecoud pulse laser, which is coupled in optical fiber, transmits and carries out standard
Straight to obtain collimated light beam, linear laser occurs lens and collimated light beam is converted into the uniform linear laser of Energy distribution, micro-
Lens array is fixed on linear laser and occurred immediately below lens, and using single file lenticule cell array, linear laser passes through micro-
Lens array produces a line optical focus after focusing on.
Further, the coupling optical path includes fiber coupler, single-mode fiber, optical fiber collimator, and nanosecond pulse swashs
The pulse laser that light device is sent by fiber coupler by laser coupled into single-mode fiber, pulse laser transmits through single-mode fiber
To optical fiber collimator, optical fiber collimator occurs lens with linear laser and is coaxially disposed.Using optical element, coupling efficiency can be more than
80%.
Further, the single-mode fiber output end connects optical fiber collimator by FC/PC modular connections.
Further, the linear laser generation lens use Bao Weier prism.Bao Weier prism turns collimated light beam
The ability for changing the uniform linear light source of Energy distribution into is stronger.
Further, the microlens array is the quartz lens of the melting of square grid array, is customized by optics
Only using wherein single file lenticule unit after cutting, microlens shape is circular or square.
Further, the microlens array is coated with the anti-reflection film of 400-900nm wavelength.Light transmission rate is more than 99%,
Linear laser can produce the focus of the spot size of the nearly diffraction limit limitation of a line after being focused on by microlens array.
Preferably, lens occur for the linear laser and microlens array is bonded in an optics by epoxy resin glue
On stainless steel microscope base.
Preferably, the photoacoustic signal reception system uses the linear acoustic detection array of splayed, and the acoustic detection array is by two
The individual sub- ultrasound transducer array in specular distribution is formed, and sub- ultrasound transducer array is made up of multiple acoustic detection array elements,
One light/sound of each optical focus two acoustic detection array element composition corresponding with both sides geometry excites reception matching unit, splayed
Linear acoustic detection array is acquired by phased-array technique to the multi-source photoacoustic signal excited.
Further, described two sub- ultrasound transducer arrays are with certain angle of inclination separation microlens array two
Side, a line optical focus that microlens array focuses on out passes completely through from the center section of two sub- ultrasound transducer arrays to be radiated at
Sample surfaces.After optical focus excites sample to produce photoacoustic signal, the sub- ultrasound transducer array of both sides will not be by lenticule
Array blocking spatially, transducer can be received entirely photoacoustic signal caused by sample.
Preferably, the photoacoustic signal pretreatment system includes three-level multi channel signals amplification module, the band being sequentially connected
Bandpass filter and multi-channel signal acquiring system.
Preferably, the 3 D scanning system includes three dimensional scanning platform, three dimensional scanning platform driver and scan control
Device, scanning monitor are connected with computer processing system, computer processing system control three dimensional scanning platform sweep speed and
Scanning range.
Further, the three dimensional scanning platform includes three one-dimensional ultrasound electric machines, equipped with grating scale, using closed loop
Control.
Further, the shell of the three dimensional scanning platform, the ground wire of three dimensional scanning platform driver, photoacoustic signal connect
Connected between the signal wire ground wire of receipts system, the ground wire of photoacoustic signal pretreatment system by copper wire electrical.
A kind of imaging method based on above-mentioned opto-acoustic three-dimensional imaging, including step：
(1) sample is fixed in screw clamp, sample is located at the underface of microlens array, deionized water will be filled it up with tank
For coupling opto-acoustic signal；
(2) size of signal is swept to adjust the vertical range of microlens array and sample according to A, is located just at sample micro-
The focal point of lens array；
(3) computer processing system is simultaneously to photoacoustic signal activating system, 3 D scanning system and photoacoustic signal pretreatment
System synchronization pulse triggering signal, to carry out parallel scan, collection, storage；
(4) photoacoustic signal collected is reconstructed reflection sample different structure by computer processing system by algorithm for reconstructing
To the three-dimensional photoacoustic image of laser difference absorbing state.
The present invention compared with prior art, has the following advantages that and beneficial effect：
(1) it first with optical element by pulse laser shaping is linear light source that the maximum innovative point of apparatus of the present invention, which is, then
Multiple optical focus are focused on out using microlens array while excite photoacoustic signal, are simplified scanning route, are realized high speed optoacoustic
Three-dimensional imaging.
(2) present invention makes linear excitation light path and linear acoustic detection using the special construction of the linear acoustic detection array of splayed
Do not influenceed between array, enable that lasing light emitter excites sample completely and detector of sound receives photoacoustic signal all, it is ensured that
The signal to noise ratio of photoacoustic image.
(3) present invention using fiber coupler by laser coupled to single-mode fiber, the optics that is used during laser shaping
Element encapsulates with stainless steel, and whole system mobility is strong, is easy to practice.
Brief description of the drawings
Fig. 1 is the system structure diagram of the present embodiment device.
Fig. 2 is the arrangement schematic diagram of the linear array element and 10 optical focus of the linear acoustic detection array of the present embodiment splayed.
Fig. 3 is that one lenticule unit of the present embodiment excites sample and the linear acoustic detection array received photoacoustic signal of splayed
Space schematic diagram.
Fig. 4 is the 3 D stereo example image quickly reconstructed using embodiment described device and imaging method.
Wherein：1- computer processing systems；2- nanosecoud pulse lasers；3- coupling optical paths；Lens occur for 4- linear lasers；
5- microlens arrays；The linear acoustic detection array of 6- splayeds；7- signals amplification module and bandpass filter；8-20 channel signals are adopted
Collecting system；9- three dimensional scanning platforms driver and scanning monitor；10- three dimensional scanning platforms；11- tanks.
Embodiment
Accompanying drawing being given for example only property explanation, it is impossible to be interpreted as the limitation to this patent；It is attached in order to more preferably illustrate the present embodiment
Scheme some parts to have omission, zoom in or out, do not represent the size of actual product；To those skilled in the art,
Some known features and its explanation may be omitted and will be understood by accompanying drawing.The present invention is made with reference to embodiment and accompanying drawing
Further detailed description, but the implementation of the present invention is not limited to this.
Embodiment 1
As shown in figure 1, present embodiment discloses a kind of while multi-point shooting with matching the opto-acoustic three-dimensional imaging received,
The device includes computer processing system 1, photoacoustic signal activating system, photoacoustic signal reception system, photoacoustic signal pretreatment system
System and 3 D scanning system, the 26S Proteasome Structure and Function of each system is specifically described below.
Referring to Fig. 1-3, photoacoustic signal activating system includes nanosecoud pulse laser 2, coupling optical path 3, linear laser and occurred
Lens 4 and microlens array 5, wherein coupling optical path 3 include fiber coupler, single-mode fiber, optical fiber collimator, and nanosecond pulse swashs
The optimal wavelength 532nm of light device 2, highest repetition rate 100KHz, pulsewidth 7ns, nanosecoud pulse laser 2 will by fiber coupler
Laser coupled is into single-mode fiber, and coupling efficiency is more than 80%, and pulse laser is transferred to optical fiber collimator, optical fiber through single-mode fiber
Collimater occurs lens 4 with linear laser and is coaxially disposed, and the pulse laser for nanosecoud pulse laser 2 to be sent is collimated
Obtain collimated light beam.Above-mentioned single-mode fiber output end connects optical fiber collimator by FC/PC modular connections.
In the present embodiment, linear laser occurs lens 4 and is used to collimated light beam being converted into the uniform line of Energy distribution
Shape laser, specifically made using Bao Weier prism, the top of every piece of lens all with the equally distributed aspheric curve of luminous power is made
The core intensity variation obtained in linear laser is less than 30%, compared with cylindrical lens linear light energy distribution can be made more equal
It is even.
In the present embodiment, microlens array 5 is fixed on linear laser and occurred immediately below lens 4, by adjusting linear laser
The spacing of lens 4 and microlens array 5, which occurs, enables laser full illumination on microlens array surface.Microlens array 5 has
Body only utilizes wherein single file lenticule list using the quartz lens of the melting of square grid array after optics custom cut
Member, microlens shape are circular or square, are spaced 300 microns, fill factor 100%, 10 light focuss are focused on out on transverse axis
Point, the focal length of each lenticule is 18.6 millimeters.The microlens array is coated with the anti-reflection film of 400-900nm wavelength.Light is saturating
Rate is crossed more than 99%, linear laser can produce the spot size of the nearly diffraction limit limitation of a line after being focused on by microlens array
Focus.
Referring to Fig. 2,3, photoacoustic signal reception system uses the linear acoustic detection array of splayed, the acoustic detection in the present embodiment
Array is made up of two sub- ultrasound transducer arrays 6 in specular distribution, and two sub- ultrasound transducer arrays 6 are with certain
Angle of inclination separation microlens array 5 both sides.Two sub- ultrasound transducer arrays are located at the both sides of optical focus, and spatial distribution is as schemed
Shown in 3, array contains 20 array elements, 0.2 millimeter, centre frequency 15MHz of array element spacing, bandwidth 60%.Linear light sorurce excite with
Photoacoustic signal collection does not interfere with spatially, ensure that the complete reception excited completely with acoustical signal of light source, sub- ultrasound is changed
The planar array that energy device array is made up of 10 bar shaped battle arrays, the bar shaped array element that the both sides of each optical focus are closest are responsible for collection
The photoacoustic signal that the optical focus excites, the signal that two array elements collect be overlapped, and by photoacoustic signal in media as well
Spread speed and array element receive time of signal to tell the signal distributions on different depth.The linear acoustic detection battle array of splayed
Row parallel acquisition to photoacoustic signal change into electric signal and be amplified by amplifier, then filtered by bandpass filter
Ripple processing, is transmitted finally by 20 channel signal acquisition system parallel acquisitions, and last computer processing system passes through algorithm for reconstructing
Quickly reconstruct optoacoustic 3-D view.
In the present embodiment, for the ease of fixation, lens 4 occur for the linear laser and microlens array 5 passes through epoxy
Resin glue is bonded on an optics stainless steel microscope base.In addition, the quantity of above-mentioned optical focus and the array element of linear acoustic detection array
Quantity is not limited to used in the present apparatus, can flexible customization device specification according to demand.
In the present embodiment, photoacoustic signal pretreatment system includes the three-level multi channel signals amplification module and band being sequentially connected
Bandpass filter 7, the common 65dB of gain amplifier.In the application, the signal after bandpass filter processing is gathered by one 20 channel signals
Device 8 is connected with computer processing system, realizes the collection of signal.20 channel signal collectors, 14bit sampling precisions, 500MS/s
Sample rate, processing can be acquired to pretreated signal parallel.
In the present embodiment, 3 D scanning system includes three dimensional scanning platform 10, three dimensional scanning platform driver and scanning control
Device 9 processed, scanning monitor are connected with computer processing system 1, and computer processing system 1 controls the scanning of three dimensional scanning platform 10
Speed and scanning range.The three dimensional scanning platform includes three one-dimensional ultrasound electric machines, equipped with grating scale, using closed loop control
System, bringing onto load speed are more than 20mm/s, 1 micron of positioning precision, 1 micron of repetitive positioning accuracy.
In the present embodiment, computer processing system 1 simultaneously with photoacoustic signal activating system, photoacoustic signal pretreatment system,
3 D scanning system is connected, for controlling the keying of photoacoustic signal activating system, after receiving the processing of photoacoustic signal pretreatment system
Data and processing data after carry out reestablishment imaging, control the operation of 3 D scanning system.
In the present embodiment, shell, the ground wire of three dimensional scanning platform driver of the three dimensional scanning platform, photoacoustic signal connect
Connected between the signal wire ground wire of receipts system, the ground wire of photoacoustic signal pretreatment system by copper wire electrical.
A kind of imaging method based on above-mentioned opto-acoustic three-dimensional imaging, including step：
(1) sample is fixed in screw clamp, sample is located at the underface of microlens array, deionized water will be filled it up with tank
For coupling opto-acoustic signal；
(2) vertical range of microlens array and sample is adjusted according to the size of scanning signal, is located just at sample
The focal point of microlens array；
(3) computer processing system is simultaneously same to pulse laser, three dimensional scanning platform and multi-channel signal acquiring system
Pace pulse trigger signal carries out high-speed parallel scanning, collection, storage；
(4) it is different quickly to reconstruct the photoacoustic signal collected by algorithm for reconstructing in reflection sample for computer processing system
Three-dimensional photoacoustic image of the structure to laser difference absorbing state.
Fig. 4 is the high speed optoacoustic three-dimensional imaging carried out using above-described embodiment device and imaging method, and image-forming step is as follows：
The mould that a cuboid is made in container is mixed first with 5% technology agar powder and 95% water
Type, the pencil-lead oblique cutting for then taking out two root longs about 7mm, diameter 0.5mm enter in rectangular body Model.Model is integrally fixed to water
Trench bottom, adjusting the height of tank makes the center of sample be located at the focal point of microlens array, i.e. A sweeps signal maximum.Meter
Calculation machine control system is carried out to pulse laser, three dimensional scanning platform and multi-channel signal acquiring system synchronization pulse simultaneously
High-velocity scanning, collection, the signal finally collected complete the reconstruction of image, Fig. 4 using three-dimensional reconstruction algorithm on MTLAB softwares
The photoacoustic image showing after sample three-dimensional reconstruction, areas imaging 10*10*3mm3, 2 minutes used times, realize high speed optoacoustic three
Dimension imaging.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of while multi-point shooting is with matching the opto-acoustic three-dimensional imaging received, it is characterised in that including computer disposal
System, photoacoustic signal activating system, photoacoustic signal reception system, photoacoustic signal pretreatment system and 3 D scanning system, wherein：
Computer processing system controls the keying of photoacoustic signal activating system, receives the number after the processing of photoacoustic signal pretreatment system
According to reestablishment imaging is carried out after simultaneously processing data, the operation of 3 D scanning system is controlled；
Pulse laser shaping is first linear light source by photoacoustic signal activating system, then using micro- in photoacoustic signal activating system
Lens array focuses on out multiple optical focus, realizes that multifocal point Linear excites, and multiple optical focus excite sample to produce multi-source light simultaneously
Acoustical signal；
Photoacoustic signal reception system receives above-mentioned multi-source photoacoustic signal parallel；
Photoacoustic signal pretreatment system is amplified and filtered to multi-source photoacoustic signal, will be believed by multi-channel signal acquiring system
Number it is sent to computer processing system；
Sample to be imaged is placed in a tank, and 3 D scanning system is used for the space for adjusting tank and photoacoustic signal activating system
Position.
2. opto-acoustic three-dimensional imaging according to claim 1, it is characterised in that the photoacoustic signal activating system includes
Lens and microlens array occur for nanosecoud pulse laser, coupling optical path, linear laser, and coupling optical path is by nanosecoud pulse laser
The pulse laser sent, which is coupled in optical fiber, transmits and is collimated to obtain collimated light beam, and lens occur for linear laser by directional light
Beam is converted into the uniform linear laser of Energy distribution, and microlens array is fixed on linear laser and occurred immediately below lens, adopts
With single file lenticule cell array, linear laser produces a line optical focus after being focused on by microlens array.
3. opto-acoustic three-dimensional imaging according to claim 2, it is characterised in that the coupling optical path includes fiber coupling
Device, single-mode fiber, optical fiber collimator, the pulse laser that nanosecoud pulse laser is sent are arrived laser coupled by fiber coupler
In single-mode fiber, pulse laser is transferred to optical fiber collimator through single-mode fiber, and optical fiber collimator and linear laser generation lens are same
Axle is set.
4. opto-acoustic three-dimensional imaging according to claim 3, it is characterised in that the single-mode fiber output end passes through
FC/PC modular connections connect optical fiber collimator；
The linear laser occurs lens and uses Bao Weier prism；
The microlens array is the quartz lens of the melting of square grid array, is only utilized wherein after optics custom cut
Single file lenticule unit, microlens shape are circular or square；
The microlens array is coated with the anti-reflection film of 400-900nm wavelength；
Lens occur for the linear laser and microlens array is bonded in an optics stainless steel microscope base by epoxy resin glue
On.
5. opto-acoustic three-dimensional imaging according to claim 1, it is characterised in that the photoacoustic signal reception system uses
The linear acoustic detection array of splayed, the acoustic detection array are made up of two sub- ultrasound transducer arrays being distributed in specular,
Sub- ultrasound transducer array is made up of multiple acoustic detection array elements, each optical focus two acoustic detection array element corresponding with both sides geometry
One light/sound of composition excites reception matching unit, and the linear acoustic detection array of splayed is by phased-array technique to the multi-source that excites
Photoacoustic signal is acquired.
6. opto-acoustic three-dimensional imaging according to claim 5, it is characterised in that described two sub- ultrasound transducer arrays
With certain angle of inclination separation microlens array both sides, a line optical focus that microlens array focuses on out is changed from two sub- ultrasounds
The center section of energy device array, which passes completely through, is radiated at sample surfaces.
7. opto-acoustic three-dimensional imaging according to claim 1, it is characterised in that the photoacoustic signal pretreatment system bag
Include three-level multi channel signals amplification module, bandpass filter and the multi-channel signal acquiring system being sequentially connected.
8. opto-acoustic three-dimensional imaging according to claim 1, it is characterised in that the 3 D scanning system includes three-dimensional
Scanning platform, three dimensional scanning platform driver and scanning monitor, scanning monitor are connected with computer processing system, computer
Processing system controls the sweep speed and scanning range of three dimensional scanning platform.
9. opto-acoustic three-dimensional imaging according to claim 8, it is characterised in that the three dimensional scanning platform includes three
One-dimensional ultrasound electric machine, equipped with grating scale, using closed-loop control；
Shell, the ground wire of three dimensional scanning platform driver of the three dimensional scanning platform, the signal wire of photoacoustic signal reception system
Ground wire, photoacoustic signal pretreatment system ground wire between connected by copper wire electrical.
A kind of 10. imaging method based on any one of the claim 1-9 opto-acoustic three-dimensional imagings, it is characterised in that bag
Include step：
(1) sample is fixed in screw clamp, sample is located at the underface of microlens array, is used for deionized water is filled it up with tank
Coupling opto-acoustic signal；
(2) size of signal is swept to adjust the vertical range of microlens array and sample according to A, sample is located just at lenticule
The focal point of array；
(3) computer processing system gives photoacoustic signal activating system, 3 D scanning system and photoacoustic signal pretreatment system simultaneously
Lock-out pulse trigger signal, to carry out parallel scan, collection, storage；
(4) photoacoustic signal collected is reconstructed reflection sample different structure to swashing by computer processing system by algorithm for reconstructing
The three-dimensional photoacoustic image of light difference absorbing state.
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