CN102973248A - Photoacoustic tomography device based on adaptive beam forming - Google Patents
Photoacoustic tomography device based on adaptive beam forming Download PDFInfo
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- CN102973248A CN102973248A CN2012105720512A CN201210572051A CN102973248A CN 102973248 A CN102973248 A CN 102973248A CN 2012105720512 A CN2012105720512 A CN 2012105720512A CN 201210572051 A CN201210572051 A CN 201210572051A CN 102973248 A CN102973248 A CN 102973248A
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Abstract
The invention discloses a photoacoustic tomography device based on adaptive beam forming, which comprises a pulse laser, a time schedule controller, a machine controller, an ultrasonic detector and an image reconstruction module, wherein the pulse laser is used for emitting laser to a to-be-detected sample on a sample bracket through a light path processing device; the time schedule controller is used for controlling trigger and acquisition time of signals; the machine controller is used for controlling movement of a two-dimensional translation stage; the ultrasonic detector is used for converting the received photoacoustic signals into electric signals; the electric signals are amplified by an amplifier and input to an A/D (analog-to-digital) converter for quantization; the quantized data is transmitted to the image reconstruction module; and the image reconstruction module preprocesses the acquired data and operates a beam forming algorithm to reconstruct the photoacoustic image. A single-array element detector is adopted to move along a straight line in the equal space, so that the device requires low mechanical precision. The adaptive beam forming technology is adopted to obtain the image which has high signal to noise ratio, high precision and high image quality.
Description
Technical field
The present invention relates to a kind of optoacoustic fault imaging (Photoacoustic Tomography is called for short PAT) technology, relate in particular to a kind of optoacoustic fault imaging device that forms based on adaptive beam.
Background technology
Photoacoustic imaging technology is the new development a kind of non-invasion formula of getting up and the medical imaging technology of unionized formula, photoacoustic imaging technology is based on optoacoustic effect, it combines high-resolution, low decay, the high-penetration characteristic that high contrast features that pure optical imagery has and pure ultra sonic imaging have, can under certain degree of depth, obtain high image resolution ratio and contrast, containing much information of image transfer can provide form and function information.In recent years, photoacoustic imaging technology obtains to develop rapidly, and becomes the forward position hot subject of current international research, is used widely in imaging in biological tissues at present, such as correlational studyes such as lesion detection, blood vessel imaging, cerebral function imagings.
Based on optoacoustic effect, short-pulse laser shines testing sample, local tissue absorption luminous energy produce thermal expansion to around radiate supersonic wave, in diverse location scanning and gather photoacoustic signal, the absorber of diverse location can be out rebuilt through algorithm by ultrasonic detector.In photoacoustic imaging, the filter back-projection algorithm that is based on circular scanning that present most methods adopts, this method Simple fast, but can produce larger pseudo-shadow, cause imaging precision lower.In actual applications, high imaging precision and quality have very important significance, so develop a kind of high-resolution and high-precision acousto-optic imaging method has very important practical significance.
Summary of the invention
The object of the invention is to provide a kind of optoacoustic fault imaging device that forms based on adaptive beam.
For achieving the above object, a kind of optoacoustic fault imaging device that forms based on adaptive beam comprises:
Pulse laser is used for by the testing sample Emission Lasers of optical processing unit on the sample holder;
Time schedule controller is for triggering and the acquisition time of control signal;
Electric machine controller is used for the movement of control two-dimension translational platform;
Ultrasonic detector (3) is converted to the signal of telecommunication with the photoacoustic signal that receives, and the described signal of telecommunication is input to A/D converter and quantizes after amplifier amplifies, and the transfer of data after will quantizing is to image reconstruction module;
Image reconstruction module is carried out pretreatment to the data that collect, and the operation beamforming algorithm reconstructs photoacoustic image.
The present invention adopts single array element detector equidistantly mobile along straight line, requires low to mechanical precision.Adopt from using beam-forming technology, the signal noise ratio (snr) of image that obtains is high, has very high precision and picture quality.
Description of drawings
Fig. 1 is the structural representation according to the optoacoustic fault imaging device that forms based on adaptive beam of the embodiment of the invention;
Fig. 2 is the pie graph according to the optoacoustic fault imaging device image reconstruction module that forms based on adaptive beam of the embodiment of the invention.
The specific embodiment
For making the purpose, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
As shown in Figure 1, be that this optoacoustic fault imaging device comprises: pulse laser (1) according to the structural representation of the optoacoustic fault imaging device that forms based on adaptive beam of the embodiment of the invention; Optical processing unit (2) by completely reflecting mirror (2-1), lens barrel (2-2), concave mirror (2-3) and clouded glass (2-4) formation; Ultrasonic detector (3) is by the signal gathering unit (4) of amplifier (4-1) and A/D converter (4-2) formation; Image reconstruction module (5); Time schedule controller (6); Dynamo-electric translation unit (7) by electric machine controller (7-1), two-dimension translational platform (7-2) formation; Water tank (8); Sample holder (9); And testing sample (10);
Wherein, time schedule controller (6) is electrically connected with pulse laser (1) and A/D converter (4-2), is used for triggering and the acquisition time of accurate control signal; Ultrasonic detector (3), signal gathering unit (4), image reconstruction module (5) connect successively.Ultrasonic detector (3) is converted to the signal of telecommunication with the photoacoustic signal that receives, quantize through being input to A/D converter (4-2) after amplifier (4-1) amplification, with the transfer of data that quantizes to image reconstruction module (5), the data that collect are carried out pretreatment, and operation beamforming algorithm program reconstructs photoacoustic image.Ultrasonic detector (3) adopts unit immersion type class line focus detector, mid frequency 5MHz, and wafer length is 18mm, and the broadband is less than 1mm, and radius of curvature 60mm can produce the effect of similar line focus.Ultrasonic detector (3) is after a station acquisition signal ended, and time schedule controller (6) triggers the movement of electric machine controller (7-1) indirectly control two-dimension translational platform (7-2).
Pulse laser (1) is selected Q-Switched Nd:YAG pulse laser, wavelength is 532nm or 1064nm, pulse width is 6.5ns, but repetition rate 10Hz, and the pulse laser that pulse laser (1) sends incides imaging object and produces acoustical signal.In the optical processing unit (2), the light microscopic that is all-trans (2-1) and lens barrel (2-2) are individually fixed on the same support, and angle is 45 degree between illuminator (2-1) and the pulse laser; Concavees lens (2-3) and clouded glass (2-4) are fixed on the lens barrel (2-2) by semiclosed annulus, control the size that shines the imaging object hot spot by the height of regulating lens barrel.Ultrasonic detector (3) is unit immersion type class line focus detector, mid frequency 5MHz, wafer size 18mm * 0.4mm, radius of curvature 60mm.Signal gathering unit (4) comprises amplifier (4-1) and A/D converter (4-2).Amplifier adopts low-noise amplifier, and the signal gain amplifier is 30-40dB, and band is wider than 50MHz.12 of A/D converter quantization digits, the highest 200MS/s of sample rate, storage depth 10M.Time schedule controller (6) clock control precision is nanosecond, the rising and falling edges pulse of output certain hour able to programme, the synchronous synergetic work of control impuls laser instrument, A/D converter and electric machine controller.
Ultrasonic detector (3) is connected in two-dimension translational platform (7-2) by hack lever, the displacement of electric machine controller (7-1) control two-dimension translational platform (7-2), and drive ultrasonic detector (3) along y axle and the translation of z axle.Two-dimension translational platform (7-2) is 100mm in y axle range, and repetitive positioning accuracy 3 μ m are 200mm in z axle range, repetitive positioning accuracy 3 μ m.
Optoacoustic fault imaging device based on adaptive beam formation shown in Figure 1 comprises that pulse laser, reflecting mirror, concavees lens, clouded glass and lens barrel consist of the trigger module of photoacoustic signal.Pulse laser reflects, expands, shines sample on number after evenly and produce photoacoustic signal, the laser of the 532nm that we adopt in the experiment through optical processing unit.Ultrasonic detector, the signal gathering unit formation signal acquisition module that is electrically connected successively.Sample radiant light acoustical signal outputs to amplifier after the collection of single array element ultrasonic detector amplifies, and analog electrical signal arrives image reconstruction module with digital data transmission after the A/D converter conversion, finish the collection of a photoacoustic signal of an angle position.Time schedule controller control impuls laser instrument and signal gathering unit, after finishing a position signal acquisition storage, give triggering signal of electric machine controller, after electric machine controller receives signal, control two-dimension translational platform moves to next position, time schedule controller is trigger impulse laser instrument emission pulse laser again, begins next time signals collecting, and signal acquisition module restarts acquired signal.
Ultrasonic detector is transferred to image reconstruction module at the signal of diverse location collection, image reconstruction module operation adaptive beam-forming algorithm, the method is passed through along the each mobile equidistance of straight line, gather respectively photoacoustic signal in each position, image reconstruction module is carried out pretreatment to the signal that gathers, and sets up the adaptive beam formation model, according to the minimum variance criterion, find the solution the weight of each array element, and then the output of calculating beamforming.
Fig. 2 is the image reconstruction module pie graph according to the optoacoustic fault imaging device that forms based on adaptive beam of the embodiment of the invention, and image reconstruction module is comprising two submodules: array element weight calculation submodule and wave beam output calculating sub module.Array element weight calculation submodule is according to collecting the covariance matrix of signal and the weight that the array steering vector calculates each array element; Wave beam output calculating sub module is exported with the calculated signals wave beam that each array element collects according to the weight of each array element.
The array element weight computation module is according to following Formula For Solving:
Wherein W is the weight vector of each array element of array, R
XBe signal covariance matrix, a is steering vector.
Wave beam output computing module is according to following Formula For Solving:
y＝W
HX
Wherein X is the signal that array element collects.
According to imaging region, calculate the wave beam output of a plurality of directions of different time, finally form photoacoustic image.
Claims (9)
1. optoacoustic fault imaging device that forms based on adaptive beam comprises:
Pulse laser (1) is used for by the testing sample Emission Lasers of optical processing unit on the sample holder;
Time schedule controller (6) is for triggering and the acquisition time of control signal;
Electric machine controller (7-1) is used for the movement of control two-dimension translational platform (7-2);
Ultrasonic detector (3), the photoacoustic signal that receives is converted to the signal of telecommunication, the described signal of telecommunication is input to A/D converter (4-2) and quantizes after amplifier (4-1) amplifies, and the transfer of data after will quantizing is to image reconstruction module (5);
Image reconstruction module (5) is carried out pretreatment to the data that collect, and the operation beamforming algorithm reconstructs photoacoustic image.
2. device according to claim 1 is characterized in that described ultrasonic detector (3) after a station acquisition signal ended, and time schedule controller (6) triggers the movement of electric machine controller (7-1) control two-dimension translational platform (7-2).
3. device according to claim 1 is characterized in that described pulse laser (1) is Q-Switched Nd:YAG pulse laser.
4. device according to claim 1 is characterized in that, described optical processing unit comprises:
Be all-trans light microscopic (2-1) and lens barrel (2-2) is individually fixed on the same support, and wherein, angle is 45 degree between illuminator (2-1) and the pulse laser;
Concavees lens (2-3) and clouded glass (2-4) are fixed on the described lens barrel (2-2) by semiclosed annulus.
5. device according to claim 1 is characterized in that described ultrasonic detector (3) is unit immersion type class line focus detector, its mid frequency 5MHz, and wafer length is 18mm, the broadband is less than 1mm, radius of curvature 60mm.
6. device according to claim 1 and 2 also drives ultrasonic detector (3) along y axle and the translation of z axle when it is characterized in that the displacement of described electric machine controller (7-1) control two-dimension translational platform (7-2).
7. device according to claim 1 is characterized in that described image reconstruction module (5) comprising:
Array element weight calculation submodule calculates the weight of each array element according to the covariance matrix that collects signal and array steering vector;
Wave beam output calculating sub module, the calculated signals wave beam output that collects according to weight and each array element of each array element.
8. device according to claim 7 is characterized in that described array element weight computation module is according to following Formula For Solving:
Wherein W is the weight vector of each array element of array, R
XBe signal covariance matrix, a is steering vector.
9. device according to claim 7 is characterized in that described wave beam output computing module is according to following Formula For Solving:
y＝W
HX
Wherein X is the signal that array element collects.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961065A (en) * | 2014-05-19 | 2014-08-06 | 汇佳生物仪器（上海）有限公司 | Biological tissue opto-acoustic confocal micro-imaging device and method |
| CN114271795A (en) * | 2022-01-19 | 2022-04-05 | 天津朗原科技有限公司 | Polishing device and operation method |
| CN114451871A (en) * | 2022-04-13 | 2022-05-10 | 常州英诺激光科技有限公司 | Photoacoustic scanning imaging equipment, working method and image scanning method |
| CN114964361A (en) * | 2022-04-26 | 2022-08-30 | 南京大学 | Ocean photoacoustic tomography method and system based on DAS |
| CN116482035A (en) * | 2023-06-21 | 2023-07-25 | 之江实验室 | Photoacoustic tomography method and device based on flexible ultrasonic probe |
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| CN102764139A (en) * | 2012-07-12 | 2012-11-07 | 复旦大学 | Medical ultrasonic beam forming method based on feature space analysis and region identification |
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Patent Citations (5)
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103961065A (en) * | 2014-05-19 | 2014-08-06 | 汇佳生物仪器（上海）有限公司 | Biological tissue opto-acoustic confocal micro-imaging device and method |
| CN114271795A (en) * | 2022-01-19 | 2022-04-05 | 天津朗原科技有限公司 | Polishing device and operation method |
| CN114451871A (en) * | 2022-04-13 | 2022-05-10 | 常州英诺激光科技有限公司 | Photoacoustic scanning imaging equipment, working method and image scanning method |
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| CN114964361B (en) * | 2022-04-26 | 2023-10-10 | 南京大学 | Ocean photoacoustic tomography method and system based on DAS |
| CN116482035A (en) * | 2023-06-21 | 2023-07-25 | 之江实验室 | Photoacoustic tomography method and device based on flexible ultrasonic probe |
| CN116482035B (en) * | 2023-06-21 | 2023-11-17 | 之江实验室 | Photoacoustic tomography method and device based on flexible ultrasonic probe |
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