CN107548418B - 分离和纯化降龙涎醚的方法 - Google Patents

分离和纯化降龙涎醚的方法 Download PDF

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Publication number
CN107548418B
CN107548418B CN201680023665.1A CN201680023665A CN107548418B CN 107548418 B CN107548418 B CN 107548418B CN 201680023665 A CN201680023665 A CN 201680023665A CN 107548418 B CN107548418 B CN 107548418B
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ambrox
gly
ala
leu
arg
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CN107548418A (zh
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E·艾克肖恩
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Givaudan SA
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Givaudan SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/0069—Heterocyclic compounds
    • C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
    • C11B9/0076—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing less than six atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)
  • Treating Waste Gases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680023665.1A 2015-04-24 2016-04-22 分离和纯化降龙涎醚的方法 Active CN107548418B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1507170.7 2015-04-24
GBGB1507170.7A GB201507170D0 (en) 2015-04-24 2015-04-24 Process
PCT/EP2016/058997 WO2016170106A1 (en) 2015-04-24 2016-04-22 Process for isolating and purifying ambrox

Publications (2)

Publication Number Publication Date
CN107548418A CN107548418A (zh) 2018-01-05
CN107548418B true CN107548418B (zh) 2022-05-03

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CN201680023665.1A Active CN107548418B (zh) 2015-04-24 2016-04-22 分离和纯化降龙涎醚的方法

Country Status (13)

Country Link
US (1) US10294211B2 (enExample)
EP (1) EP3286309B1 (enExample)
JP (3) JP7246133B2 (enExample)
CN (1) CN107548418B (enExample)
BR (1) BR112017021789B1 (enExample)
CO (1) CO2017010720A2 (enExample)
ES (1) ES2856887T3 (enExample)
GB (1) GB201507170D0 (enExample)
IL (1) IL254836B2 (enExample)
MX (1) MX381562B (enExample)
RU (1) RU2720094C2 (enExample)
SG (1) SG11201708085TA (enExample)
WO (1) WO2016170106A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201507207D0 (en) 2015-04-24 2015-06-10 Givaudan Sa Enzymes and applications thereof
GB201618090D0 (en) 2016-10-26 2016-12-07 Givaudan Sa Product
WO2018157021A1 (en) * 2017-02-24 2018-08-30 International Flavors & Fragrances Inc. Squalene hopene cyclase and use thereof for producing ambroxan
EP3677683B1 (en) * 2017-09-01 2024-07-17 Niigata University Efficient method for producing ambrein
EP3476822A1 (en) 2017-10-31 2019-05-01 Givaudan SA Process of making organic compounds
GB201917688D0 (en) 2019-12-04 2020-01-15 Givaudan Sa SHC enzymes and enzyme variants
GB202011823D0 (en) * 2020-07-30 2020-09-16 Givaudan Sa Method
GB202115120D0 (en) * 2021-10-21 2021-12-08 Givaudan Sa Organic compounds
CN119876059A (zh) * 2025-01-25 2025-04-25 天津大学浙江研究院(绍兴) 一种降龙涎醚的生物催化合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009060799A (ja) * 2007-09-04 2009-03-26 Kao Corp （−）−アンブロキサンの製造方法
CN102449158A (zh) * 2009-06-05 2012-05-09 巴斯夫欧洲公司 龙涎呋喃的生物催化产生
CN104245647A (zh) * 2012-04-16 2014-12-24 巴斯夫欧洲公司 制备(3e,7e)-高法呢醇的改进方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU910561A1 (ru) * 1980-08-19 1982-03-07 Всесоюзный научно-исследовательский институт синтетических и натуральных душистых веществ Способ получени смеси душистых веществ дитерпеноидного р да
SU1498767A1 (ru) * 1987-06-04 1989-08-07 Институт Химии Ан Мсср Способ получени ( @ ) 3 @ ,6,6,9 @ -тетраметилпергидронафто [2,1-в]фурана
US5463089A (en) * 1994-07-22 1995-10-31 Quest International B.V. Preparation of ambrox
DE19524584A1 (de) * 1995-07-06 1997-01-09 Basf Ag Verfahren zur stereoselektiven Herstellung von (-)3a,6,6,9a-Tetramethyl-perhydronaphtho[2,1-b]furan
DE19649655A1 (de) 1996-11-29 1998-06-04 Haarmann & Reimer Gmbh Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung
JP3207172B2 (ja) 1999-01-07 2001-09-10 科学技術振興事業団 光学活性環状化合物類の製造方法
DE19960106A1 (de) 1999-12-14 2001-06-21 Haarmann & Reimer Gmbh Enzyme und Gene für die Herstellung von Vanillin
AU2003302326A1 (en) 2002-12-02 2004-08-10 The Ohio State University Research Foundation Rapid detection of microorganisms
US20040265850A1 (en) 2002-12-02 2004-12-30 Hua Wang Rapid detection of microorganisms
CN100488940C (zh) * 2004-06-11 2009-05-20 湖南中烟工业有限责任公司 用于制备降龙涎醚或向卷烟烟气释放降龙涎醚的草酸酯及应用
WO2007015481A1 (ja) * 2005-08-04 2007-02-08 Shiseido Co., Ltd. 香料成分の選定方法及び調香方法、嗜好性向上剤
KR101752514B1 (ko) 2009-06-05 2017-06-29 바스프 에스이 소성 변형성 강성 폴리우레탄 발포체, 접착제 및 피복재를 함유하는 복합 부품
US8932839B2 (en) 2010-11-17 2015-01-13 Basf Se Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein
ES2925777T3 (es) 2010-11-17 2022-10-19 Basf Se Procedimiento para la ciclación biocatalítica de terpenos y mutantes de ciclasa que pueden usarse en el mismo
JP2013132226A (ja) 2011-12-26 2013-07-08 Kao Corp （−）−３ａ，６，６，９ａ−テトラメチルドデカヒドロナフト［２，１−ｂ］フランの製造方法
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
JP6429243B2 (ja) 2013-09-05 2018-11-28 国立大学法人 新潟大学 アンブレインの製造方法
GB201318886D0 (en) 2013-10-25 2013-12-11 Givaudan Sa Improvements i or relating to organic compounds
GB201318894D0 (en) 2013-10-25 2013-12-11 Givaudan Sa Improvements in or relating to organic compounds
GB201507207D0 (en) * 2015-04-24 2015-06-10 Givaudan Sa Enzymes and applications thereof
CN105037308B (zh) * 2015-07-06 2017-06-06 四川中烟工业有限责任公司 一种制备降龙涎香醚的方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009060799A (ja) * 2007-09-04 2009-03-26 Kao Corp （−）−アンブロキサンの製造方法
CN102449158A (zh) * 2009-06-05 2012-05-09 巴斯夫欧洲公司 龙涎呋喃的生物催化产生
CN104245647A (zh) * 2012-04-16 2014-12-24 巴斯夫欧洲公司 制备(3e,7e)-高法呢醇的改进方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Enantio- and Diastereoselective Stepwise Cyclization of Polyprenoids Induced by Chiral and Achiral LBAs. A New Entry to (-)-Ambrox, (+)-Podocarpa-8,11,13-triene Diterpenoids, and (-)-Tetracyclic Polyprenoid of Sedimentary Origin;Kazuaki Ishihara 等;《Journal of the American Chemical Society》;20020410;第124卷(第14期);第3647-3655页 *
降龙涎香醚的合成进展;陆佳庆;《香料香精化妆品》;20080228(第1期);第23-30页 *

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CO2017010720A2 (es) 2018-01-31
JP7246133B2 (ja) 2023-03-27
JP7690510B2 (ja) 2025-06-10
JP2018513198A (ja) 2018-05-24
RU2017134436A3 (enExample) 2019-10-09
IL254836B2 (en) 2023-08-01
US20180134678A1 (en) 2018-05-17
US20180346434A9 (en) 2018-12-06
EP3286309B1 (en) 2020-11-25
RU2720094C2 (ru) 2020-04-24
BR112017021789A2 (pt) 2018-07-31
RU2017134436A (ru) 2019-05-24
US10294211B2 (en) 2019-05-21
JP2023093498A (ja) 2023-07-04
EP3286309A1 (en) 2018-02-28
JP2021090423A (ja) 2021-06-17
ES2856887T3 (es) 2021-09-28
IL254836A0 (en) 2017-12-31
CN107548418A (zh) 2018-01-05
SG11201708085TA (en) 2017-11-29
GB201507170D0 (en) 2015-06-10
BR112017021789B1 (pt) 2022-11-29
MX2017013100A (es) 2018-01-26
IL254836B1 (en) 2023-04-01
MX381562B (es) 2025-03-12
WO2016170106A1 (en) 2016-10-27

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