IL254836B2 - Ambrox isolation and purification process - Google Patents
Ambrox isolation and purification processInfo
- Publication number
- IL254836B2 IL254836B2 IL254836A IL25483617A IL254836B2 IL 254836 B2 IL254836 B2 IL 254836B2 IL 254836 A IL254836 A IL 254836A IL 25483617 A IL25483617 A IL 25483617A IL 254836 B2 IL254836 B2 IL 254836B2
- Authority
- IL
- Israel
- Prior art keywords
- ambrox
- homofarnesol
- mixture
- iii
- cells
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0069—Heterocyclic compounds
- C11B9/0073—Heterocyclic compounds containing only O or S as heteroatoms
- C11B9/0076—Heterocyclic compounds containing only O or S as heteroatoms the hetero rings containing less than six atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Furan Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Treating Waste Gases (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1507170.7A GB201507170D0 (en) | 2015-04-24 | 2015-04-24 | Process |
| PCT/EP2016/058997 WO2016170106A1 (en) | 2015-04-24 | 2016-04-22 | Process for isolating and purifying ambrox |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL254836A0 IL254836A0 (en) | 2017-12-31 |
| IL254836B1 IL254836B1 (en) | 2023-04-01 |
| IL254836B2 true IL254836B2 (en) | 2023-08-01 |
Family
ID=53488739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254836A IL254836B2 (en) | 2015-04-24 | 2017-10-02 | Ambrox isolation and purification process |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10294211B2 (enExample) |
| EP (1) | EP3286309B1 (enExample) |
| JP (3) | JP7246133B2 (enExample) |
| CN (1) | CN107548418B (enExample) |
| BR (1) | BR112017021789B1 (enExample) |
| CO (1) | CO2017010720A2 (enExample) |
| ES (1) | ES2856887T3 (enExample) |
| GB (1) | GB201507170D0 (enExample) |
| IL (1) | IL254836B2 (enExample) |
| MX (1) | MX381562B (enExample) |
| RU (1) | RU2720094C2 (enExample) |
| SG (1) | SG11201708085TA (enExample) |
| WO (1) | WO2016170106A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201507207D0 (en) | 2015-04-24 | 2015-06-10 | Givaudan Sa | Enzymes and applications thereof |
| GB201618090D0 (en) * | 2016-10-26 | 2016-12-07 | Givaudan Sa | Product |
| BR112019015747A2 (pt) * | 2017-02-24 | 2020-03-17 | International Flavors & Fragrances Inc. | Vetor recombinante, célula hospedeira recombinante, esqualeno hopeno ciclase recombinante, e, método para produção de ambroxano |
| EP3677683B1 (en) * | 2017-09-01 | 2024-07-17 | Niigata University | Efficient method for producing ambrein |
| EP3476822A1 (en) | 2017-10-31 | 2019-05-01 | Givaudan SA | Process of making organic compounds |
| GB201917688D0 (en) | 2019-12-04 | 2020-01-15 | Givaudan Sa | SHC enzymes and enzyme variants |
| GB202011823D0 (en) * | 2020-07-30 | 2020-09-16 | Givaudan Sa | Method |
| GB202115120D0 (en) * | 2021-10-21 | 2021-12-08 | Givaudan Sa | Organic compounds |
| WO2024181354A1 (ja) | 2023-03-01 | 2024-09-06 | オムロン株式会社 | 制御装置、制御方法、及び制御プログラム |
| EP4685139A3 (en) * | 2023-07-04 | 2026-03-25 | Symrise AG | New forms of ambrocenide® |
| CN119876059A (zh) * | 2025-01-25 | 2025-04-25 | 天津大学浙江研究院(绍兴) | 一种降龙涎醚的生物催化合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010139719A2 (de) * | 2009-06-05 | 2010-12-09 | Basf Se | Biokatalytische herstellung von ambroxan |
| WO2013156398A1 (de) * | 2012-04-16 | 2013-10-24 | Basf Se | Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU910561A1 (ru) * | 1980-08-19 | 1982-03-07 | Всесоюзный научно-исследовательский институт синтетических и натуральных душистых веществ | Способ получени смеси душистых веществ дитерпеноидного р да |
| SU1498767A1 (ru) * | 1987-06-04 | 1989-08-07 | Институт Химии Ан Мсср | Способ получени ( @ ) 3 @ ,6,6,9 @ -тетраметилпергидронафто [2,1-в]фурана |
| US5463089A (en) * | 1994-07-22 | 1995-10-31 | Quest International B.V. | Preparation of ambrox |
| DE19524584A1 (de) * | 1995-07-06 | 1997-01-09 | Basf Ag | Verfahren zur stereoselektiven Herstellung von (-)3a,6,6,9a-Tetramethyl-perhydronaphtho[2,1-b]furan |
| DE19649655A1 (de) | 1996-11-29 | 1998-06-04 | Haarmann & Reimer Gmbh | Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung |
| JP3207172B2 (ja) * | 1999-01-07 | 2001-09-10 | 科学技術振興事業団 | 光学活性環状化合物類の製造方法 |
| DE19960106A1 (de) | 1999-12-14 | 2001-06-21 | Haarmann & Reimer Gmbh | Enzyme und Gene für die Herstellung von Vanillin |
| WO2004063699A2 (en) | 2002-12-02 | 2004-07-29 | The Ohio State University Research Foundation | Rapid detection of microorganisms |
| US20040265850A1 (en) | 2002-12-02 | 2004-12-30 | Hua Wang | Rapid detection of microorganisms |
| CN100488940C (zh) * | 2004-06-11 | 2009-05-20 | 湖南中烟工业有限责任公司 | 用于制备降龙涎醚或向卷烟烟气释放降龙涎醚的草酸酯及应用 |
| US8507564B2 (en) * | 2005-08-04 | 2013-08-13 | Shiseido Co., Ltd. | Method for selecting perfume ingredient, method for formulating fragrance, and preference-enhancing agent |
| JP5236233B2 (ja) * | 2007-09-04 | 2013-07-17 | 花王株式会社 | （−）−アンブロキサンの製造方法 |
| JP5680629B2 (ja) | 2009-06-05 | 2015-03-04 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 塑性変形可能な硬質ポリウレタンフォームと接着剤と被覆材料とからなる複合部品 |
| JP6096667B2 (ja) | 2010-11-17 | 2017-03-15 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | テルペンの生体触媒環化のための方法及びその方法で使用され得るシクラーゼ変異体 |
| US8932839B2 (en) | 2010-11-17 | 2015-01-13 | Basf Se | Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein |
| JP2013132226A (ja) | 2011-12-26 | 2013-07-08 | Kao Corp | （−）−３ａ，６，６，９ａ−テトラメチルドデカヒドロナフト［２，１−ｂ］フランの製造方法 |
| US20130273619A1 (en) * | 2012-04-16 | 2013-10-17 | Basf Se | Process for the Preparation of (3E, 7E)-Homofarnesol |
| JP6429243B2 (ja) | 2013-09-05 | 2018-11-28 | 国立大学法人 新潟大学 | アンブレインの製造方法 |
| GB201318886D0 (en) | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements i or relating to organic compounds |
| GB201318894D0 (en) | 2013-10-25 | 2013-12-11 | Givaudan Sa | Improvements in or relating to organic compounds |
| GB201507207D0 (en) * | 2015-04-24 | 2015-06-10 | Givaudan Sa | Enzymes and applications thereof |
| CN105037308B (zh) * | 2015-07-06 | 2017-06-06 | 四川中烟工业有限责任公司 | 一种制备降龙涎香醚的方法 |
-
2015
- 2015-04-24 GB GBGB1507170.7A patent/GB201507170D0/en not_active Ceased
-
2016
- 2016-04-22 RU RU2017134436A patent/RU2720094C2/ru active
- 2016-04-22 JP JP2017555602A patent/JP7246133B2/ja active Active
- 2016-04-22 CN CN201680023665.1A patent/CN107548418B/zh active Active
- 2016-04-22 EP EP16718334.2A patent/EP3286309B1/en active Active
- 2016-04-22 SG SG11201708085TA patent/SG11201708085TA/en unknown
- 2016-04-22 BR BR112017021789-9A patent/BR112017021789B1/pt active IP Right Grant
- 2016-04-22 MX MX2017013100A patent/MX381562B/es unknown
- 2016-04-22 WO PCT/EP2016/058997 patent/WO2016170106A1/en not_active Ceased
- 2016-04-22 ES ES16718334T patent/ES2856887T3/es active Active
- 2016-04-22 US US15/568,535 patent/US10294211B2/en active Active
-
2017
- 2017-10-02 IL IL254836A patent/IL254836B2/en unknown
- 2017-10-20 CO CONC2017/0010720A patent/CO2017010720A2/es unknown
-
2021
- 2021-01-28 JP JP2021011646A patent/JP2021090423A/ja active Pending
-
2023
- 2023-03-31 JP JP2023057205A patent/JP7690510B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010139719A2 (de) * | 2009-06-05 | 2010-12-09 | Basf Se | Biokatalytische herstellung von ambroxan |
| EP2438182A2 (de) * | 2009-06-05 | 2012-04-11 | Basf Se | Biokatalytische herstellung von ambroxan |
| WO2013156398A1 (de) * | 2012-04-16 | 2013-10-24 | Basf Se | Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2856887T3 (es) | 2021-09-28 |
| BR112017021789A2 (pt) | 2018-07-31 |
| MX381562B (es) | 2025-03-12 |
| MX2017013100A (es) | 2018-01-26 |
| JP2018513198A (ja) | 2018-05-24 |
| SG11201708085TA (en) | 2017-11-29 |
| IL254836B1 (en) | 2023-04-01 |
| JP7246133B2 (ja) | 2023-03-27 |
| CN107548418A (zh) | 2018-01-05 |
| RU2017134436A3 (enExample) | 2019-10-09 |
| JP7690510B2 (ja) | 2025-06-10 |
| IL254836A0 (en) | 2017-12-31 |
| GB201507170D0 (en) | 2015-06-10 |
| CO2017010720A2 (es) | 2018-01-31 |
| CN107548418B (zh) | 2022-05-03 |
| RU2017134436A (ru) | 2019-05-24 |
| BR112017021789B1 (pt) | 2022-11-29 |
| JP2023093498A (ja) | 2023-07-04 |
| WO2016170106A1 (en) | 2016-10-27 |
| US20180134678A1 (en) | 2018-05-17 |
| US20180346434A9 (en) | 2018-12-06 |
| JP2021090423A (ja) | 2021-06-17 |
| US10294211B2 (en) | 2019-05-21 |
| EP3286309B1 (en) | 2020-11-25 |
| EP3286309A1 (en) | 2018-02-28 |
| RU2720094C2 (ru) | 2020-04-24 |
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