CN107412743B - 通过施用重组vwf治疗凝血疾病 - Google Patents

通过施用重组vwf治疗凝血疾病 Download PDF

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Publication number
CN107412743B
CN107412743B CN201611071108.5A CN201611071108A CN107412743B CN 107412743 B CN107412743 B CN 107412743B CN 201611071108 A CN201611071108 A CN 201611071108A CN 107412743 B CN107412743 B CN 107412743B
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Prior art keywords
rvwf
fviii
composition
administered
subject
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Chinese (zh)
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CN107412743A (zh
Inventor
F·沙伊芙林格
P·图雷切克
B·埃文斯汀
Y·W·王
M·T·休特
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Takeda Pharmaceutical Co Ltd
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Baishen Co
Baxalta GmbH
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Publication of CN107412743A publication Critical patent/CN107412743A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201611071108.5A 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病 Active CN107412743B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161495884P 2011-06-10 2011-06-10
US61/495,884 2011-06-10
US201161511901P 2011-07-26 2011-07-26
US61/511,901 2011-07-26
US201161523790P 2011-08-15 2011-08-15
US61/523,790 2011-08-15
CN201280038870.7A CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280038870.7A Division CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Publications (2)

Publication Number Publication Date
CN107412743A CN107412743A (zh) 2017-12-01
CN107412743B true CN107412743B (zh) 2021-07-02

Family

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Application Number Title Priority Date Filing Date
CN201611071108.5A Active CN107412743B (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病
CN201280038870.7A Pending CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病
CN201810079423.5A Pending CN108210889A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

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CN201280038870.7A Pending CN103732244A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病
CN201810079423.5A Pending CN108210889A (zh) 2011-06-10 2012-06-11 通过施用重组vwf治疗凝血疾病

Country Status (23)

Country Link
US (3) US9272021B2 (https=)
EP (3) EP3412305B1 (https=)
JP (3) JP6347468B2 (https=)
KR (3) KR20190041032A (https=)
CN (3) CN107412743B (https=)
AR (1) AR086904A1 (https=)
AU (5) AU2012267458A1 (https=)
CA (1) CA2838845C (https=)
DK (3) DK3858375T3 (https=)
ES (3) ES2682249T3 (https=)
FI (1) FI3858375T3 (https=)
HK (1) HK1257436A1 (https=)
HR (1) HRP20180962T1 (https=)
HU (1) HUE039317T2 (https=)
LT (1) LT2717905T (https=)
MX (2) MX350582B (https=)
PL (3) PL3858375T3 (https=)
PT (3) PT3412305T (https=)
RU (2) RU2680402C2 (https=)
SG (2) SG10201604684WA (https=)
SI (1) SI2717905T1 (https=)
TR (1) TR201808823T4 (https=)
WO (1) WO2012171031A1 (https=)

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FR3034669B1 (fr) * 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
KR102415992B1 (ko) 2016-04-15 2022-07-04 다케다 야쿠힌 고교 가부시키가이샤 약물동역학 약물 투약 요법을 제공하는 방법 및 장치
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
CA3069295A1 (en) 2017-07-07 2019-01-10 Baxalta Incorporated Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf
US20190091298A1 (en) * 2017-07-07 2019-03-28 Baxalta Incorporated Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf
WO2019154867A1 (en) 2018-02-06 2019-08-15 Ablynx Nv Methods of treating initial episode of ttp with immunoglobulin single variable domains
CA3094644A1 (en) * 2018-03-21 2019-09-26 Baxalta Incorporated Separation of vwf and vwf propeptide by chromatographic methods
US12128090B2 (en) 2019-02-01 2024-10-29 Takeda Pharmaceutical Company Limited Methods of prophylactic treatment using recombinant VWF (rVWF)
US20220401524A1 (en) 2019-09-11 2022-12-22 Takeda Pharmaceutical Company Limited Methods of treatment related to complexes of von willebrand factor and complement c1q
KR20220150303A (ko) 2020-02-04 2022-11-10 다케다 야쿠힌 고교 가부시키가이샤 재조합 vwf의 투여에 의한 중증 폰 빌레브란트병 환자의 월경과다 치료
US20240002861A1 (en) * 2020-11-24 2024-01-04 Band Therapeutics, Llc Compositions and methods for treatment of bleeding disorders
WO2024124136A1 (en) * 2022-12-09 2024-06-13 Vega Therapeutics, Inc. Von willebrand disease animal models

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US20120316116A1 (en) 2012-12-13
US20250387455A1 (en) 2025-12-25
PT3858375T (pt) 2024-04-18
ES2682249T3 (es) 2018-09-19
US9272021B2 (en) 2016-03-01
CA2838845C (en) 2019-08-06
TR201808823T4 (tr) 2018-07-23
KR20190041032A (ko) 2019-04-19
AU2022201518A1 (en) 2022-03-24
DK2717905T3 (en) 2018-07-02
JP6347468B2 (ja) 2018-06-27
JP2019048892A (ja) 2019-03-28
AU2012267458A1 (en) 2014-01-09
JP6527114B2 (ja) 2019-06-05
AU2020200026A1 (en) 2020-01-30
US20160184403A1 (en) 2016-06-30
PL3412305T3 (pl) 2021-05-31
LT2717905T (lt) 2018-10-10
KR20140039285A (ko) 2014-04-01
CN103732244A (zh) 2014-04-16
MX2013014543A (es) 2014-06-11
EP2717905B1 (en) 2018-05-23
RU2680402C2 (ru) 2019-02-21
EP3858375B1 (en) 2024-03-20
FI3858375T3 (fi) 2024-04-17
HK1257436A1 (zh) 2019-10-18
WO2012171031A1 (en) 2012-12-13
RU2014100107A (ru) 2015-07-20
RU2628537C2 (ru) 2017-08-18
EP3412305B1 (en) 2021-01-06
AU2016202299A1 (en) 2016-05-05
PT2717905T (pt) 2018-07-02
KR20200091476A (ko) 2020-07-30
JP2017019788A (ja) 2017-01-26
EP2717905A1 (en) 2014-04-16
KR102319868B1 (ko) 2021-11-01
SI2717905T1 (sl) 2018-09-28
AU2017206235A1 (en) 2017-08-03
AU2022201518B2 (en) 2025-07-03
BR112013031795A2 (pt) 2016-12-20
PT3412305T (pt) 2021-01-29
NZ618790A (en) 2015-07-31
PL2717905T3 (pl) 2018-10-31
MX2020000083A (es) 2020-08-06
CA2838845A1 (en) 2012-12-13
ES2976169T3 (es) 2024-07-24
EP3858375A1 (en) 2021-08-04
ES2860450T3 (es) 2021-10-05
AR086904A1 (es) 2014-01-29
HUE039317T2 (hu) 2018-12-28
CN107412743A (zh) 2017-12-01
RU2019103386A3 (https=) 2022-01-24
CN108210889A (zh) 2018-06-29
JP2014516088A (ja) 2014-07-07
AU2017206235B2 (en) 2019-10-17
RU2019103386A (ru) 2020-08-07
KR101969515B1 (ko) 2019-04-16
PL3858375T3 (pl) 2024-05-20
SG10202002591QA (en) 2020-05-28
EP3412305A1 (en) 2018-12-12
DK3858375T3 (da) 2024-04-15
RU2017102679A (ru) 2018-12-19
SG10201604684WA (en) 2016-07-28
HRP20180962T1 (hr) 2018-10-19
MX350582B (es) 2017-09-11
RU2017102679A3 (https=) 2018-12-19
AU2016202299B2 (en) 2017-07-20
DK3412305T3 (da) 2021-03-01

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Effective date of registration: 20210705

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Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd.

Address before: Aupu, Switzerland

Patentee before: BAXALTA GmbH

Patentee before: Baishen Co.