CN107404876B - 抗癌治疗剂 - Google Patents

抗癌治疗剂 Download PDF

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Publication number
CN107404876B
CN107404876B CN201680018509.6A CN201680018509A CN107404876B CN 107404876 B CN107404876 B CN 107404876B CN 201680018509 A CN201680018509 A CN 201680018509A CN 107404876 B CN107404876 B CN 107404876B
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China
Prior art keywords
cancer
compounds
cell
capcna
aoh39
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CN201680018509.6A
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English (en)
Chinese (zh)
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CN107404876A (zh
Inventor
罗伯特·J·基希
琳达·H·马尔卡斯
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RLL LLC
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RLL LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201680018509.6A 2015-04-10 2016-04-08 抗癌治疗剂 Active CN107404876B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/684,259 US10420840B2 (en) 2015-04-10 2015-04-10 Anticancer therapeutic agents
US14/684,259 2015-04-10
PCT/US2016/026619 WO2016164707A1 (en) 2015-04-10 2016-04-08 Anticancer therapeutic agents

Publications (2)

Publication Number Publication Date
CN107404876A CN107404876A (zh) 2017-11-28
CN107404876B true CN107404876B (zh) 2023-04-14

Family

ID=57072079

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680018509.6A Active CN107404876B (zh) 2015-04-10 2016-04-08 抗癌治疗剂

Country Status (12)

Country Link
US (1) US10420840B2 (https=)
EP (2) EP3280261B1 (https=)
JP (1) JP6748704B2 (https=)
CN (1) CN107404876B (https=)
AU (1) AU2016245886B2 (https=)
BR (1) BR122023024844A2 (https=)
CA (1) CA2978965C (https=)
ES (1) ES2991018T3 (https=)
FI (1) FI3878444T3 (https=)
PL (2) PL3878444T3 (https=)
PT (1) PT3878444T (https=)
WO (1) WO2016164707A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250171404A1 (en) * 2022-03-07 2025-05-29 City Of Hope Pcna inhibitors and uses thereof
WO2025054318A1 (en) * 2023-09-06 2025-03-13 City Of Hope Pcna inhibitors and uses thereof
WO2025184571A1 (en) * 2024-03-01 2025-09-04 City Of Hope Pcna inhibitors for the treatment of myc family associated cancers

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627165A (en) 1990-06-13 1997-05-06 Drug Innovation & Design, Inc. Phosphorous prodrugs and therapeutic delivery systems using same
US20050037090A1 (en) 1998-12-23 2005-02-17 Mckearn John P. Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent
MX2007013584A (es) 2005-04-27 2008-04-22 Univ Indiana Res & Tech Corp Anticuerpos de isoforma de cspcna y sus usos.
AU2006261856B2 (en) * 2005-06-27 2012-07-05 Indiana University Research And Technology Corporation csPCNA isoform modifications and uses thereof
CA2638866C (en) * 2006-02-17 2015-11-10 Indiana University Research And Technology Corporation Peptide based inhibition of capcna protein-protein interactions in cancer
US20090123487A1 (en) 2007-09-19 2009-05-14 Katia Rothhaar Precursors and enzymes associated with post translational modification of proteins implicated in isoform generation of PCNA
WO2009079451A2 (en) 2007-12-14 2009-06-25 The Cleveland Clinic Foundation Compositions and methods of promoting wound healing
GB0808282D0 (en) 2008-05-07 2008-06-11 Medical Res Council Compounds for use in stabilizing p53 mutants
CA3023068C (en) * 2008-07-24 2022-06-21 Indiana University Research And Technology Corporation Cancer peptide therapeutics
US20120195978A1 (en) * 2009-10-07 2012-08-02 Indiana University Research And Technology Corpora Capcna peptide therapeutics for cancer
CN103619331A (zh) * 2011-03-23 2014-03-05 印第安纳大学研究及科技公司 抗癌治疗剂
EP3349754B9 (en) * 2015-09-17 2025-10-22 City of Hope Pcna inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Target validation and structure-activity analysis of a series of novel PCNA inhibitors;DILLEHAL K L ET AL;《PHARMACOLOGY RESEARCH AND PERSPECTIVESW》;20150301;第3卷(第2期);e00115 *

Also Published As

Publication number Publication date
CA2978965C (en) 2023-11-14
EP3280261B1 (en) 2020-12-23
BR122023024844A2 (pt) 2024-01-23
EP3280261A4 (en) 2018-12-12
PT3878444T (pt) 2024-11-08
CA2978965A1 (en) 2016-10-13
BR112017019983A2 (pt) 2018-06-19
PL3280261T3 (pl) 2021-09-06
WO2016164707A1 (en) 2016-10-13
PL3878444T3 (pl) 2025-01-07
US10420840B2 (en) 2019-09-24
ES2991018T3 (es) 2024-12-02
EP3878444A1 (en) 2021-09-15
US20160296482A1 (en) 2016-10-13
AU2016245886A1 (en) 2017-10-12
CN107404876A (zh) 2017-11-28
EP3280261A1 (en) 2018-02-14
JP6748704B2 (ja) 2020-09-02
FI3878444T3 (fi) 2024-11-19
AU2016245886B2 (en) 2020-04-30
JP2018510917A (ja) 2018-04-19
EP3878444B1 (en) 2024-10-09

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