CN107362301B - 香苓开胃颗粒 - Google Patents
香苓开胃颗粒 Download PDFInfo
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- CN107362301B CN107362301B CN201710739299.6A CN201710739299A CN107362301B CN 107362301 B CN107362301 B CN 107362301B CN 201710739299 A CN201710739299 A CN 201710739299A CN 107362301 B CN107362301 B CN 107362301B
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- poria cocos
- appetizing
- rhizoma atractylodis
- water
- decocting
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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Abstract
本发明涉及一种治疗小儿厌食症的香苓开胃颗粒，其原料包括如下重量的组分：广藿香28g，茯苓28g，苍术15g，丁香15g，鸡内金15g，佩兰10g，法半夏20g，兰花参8g，山土瓜12g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。该组合物从改变剂型，提高药效，增进口感等方面入手，研制成方便服用、安全有效的香苓开胃颗粒。
Description
技术领域
本发明涉及中药领域，具体涉及一种治疗小儿厌食症的香苓开胃颗粒。
背景技术
小儿厌食症是指非疾病因素导致的较长时期见食不贪、食欲不振、食量减少、甚则拒食的一种常见病，多见于1岁-6岁小儿。病程迁延，常因患儿胃肠功能紊乱、营养缺乏和免疫功能低下致使诸症蜂起，导致反复呼吸道感染、佝偻病等疾病的发生，严重影响儿童的生长发育和身心健康。近年来，儿童厌食症的发病率日趋上升，城市儿童发病率较高，引起了广泛关注。
《素问·痹论》曰：“饮食自倍，肠胃乃伤。”钱乙《小儿药证直诀》中言：“脾胃不和，不能乳食，致肌瘦，亦因大病，或吐泻后脾胃尚弱，不能传化谷气也。”，李东垣云：“百病皆由脾胃衰而生也”，脾胃虚弱，后天之本生化无源，百病乃生”。近代医家认为：饮食不节，喂养不当或长期偏食，损伤脾胃正常运化功能，导致脾胃不和，受纳运化失健是本病发生的主要病因病机。
现代医学认为小儿厌食症除了不良的饮食习惯、喂养不当、心理因素外，还与微量元素锌缺乏、胃肠疾病、Hp感染等也有密切关系。治疗方面应进行喂养指导，配合心理疗法，多酶片能增加消化酶，补锌剂增强味蕾效应，促胃动力药可增强胃肠蠕动、增加有益菌而改善肠道菌群。这些治疗虽然可以增进患儿食欲，但难以整体调理患儿的体质。
临床报道治法众多，从外而治，可运用推拿、针灸、耳压、敷贴等疗法。从内而治，主要从脾胃辨证，以健脾开胃为主。然中医治疗讲究三因治宜，在选方用药上要依据当地气候特点，尽可能使用道地药材。由于全球极端天气频发(冷热无常)、贪凉饮冷、滥用抗生素等导致脾胃失和，运化失常，湿邪阻遏，气机失调的比为湿困型厌食，患儿表现为不思饮食，容易困倦，舌苔厚腻，尊儿科大家江育仁江老“脾健不在补，贵在运，还在醒”用芳香醒脾化湿开胃之法，创制“香苓开胃颗粒”。云南属立体交叉气候，早晚温差大，湿气较重，故治宜芳香化湿，香苓开胃颗粒正是基于本土特点，精选重要南药为君药，故临床疗效确切。但传统汤剂熬煮加工费时，味苦量多，不便服用，儿童依从性差。故发明从改变剂型，提高药效，增进口感等方面入手，研制成方便服用、安全有效的香苓开胃颗粒。
目前本发明已发表的相关文章/学位论文以及研究的基础如下：
[1]王霖,熊磊.二陈汤运用刍议[J].云南中医学院学报,2004,01:23-24.
[2]聂坚,解宇环,陈柏君,熊磊.芳香类中药在儿科临床运用及展望[J].云南中医学院学报,2015,02:87-89+100.
[3]熊磊,杨振邦,杨梅,张惠,徐丽英,陈辉.太子健治疗小儿厌食症的临床研究[J].云南中医中药杂志,2000,01:25-27.
[4]熊磊.小儿厌食从肾论治考略[J].中医函授通讯,2000,02:28-29.
[5]杨梅,熊磊,殷家福.太子健冲剂治疗小儿厌食病的实验研究[J].云南中医学院学报,1998,04:9-14.
[6]杨梅,熊磊,徐丽英.太子健冲剂治疗小儿厌食症35例临床观察[J].江苏中医,1999,07:19-20.
[7]熊磊,杨梅,殷家福,徐丽英.太子健冲剂治疗小儿厌食症的临床和实验研究[J].中国中医药信息杂志,1999,07:37-39.
发明内容
本发明在前期研究和长期临床观察的基础上，提炼精选处方，研制成口感好、成本低、安全、服用方便、疗效可靠、适用范围广的医院制剂，以惠及广大患儿。该处方组成多为云南道地药材，又针对儿童常见病而设，且云南本土尚缺此类医院制剂，故香芩开胃汤具备较好的市场前景和医疗价值，并有助于开发利用我省天然药物资源，促进云南经济社会发展。
香苓开胃汤是云南省名中医熊磊用于治疗小儿厌食症的临床效验方，由藿香、茯苓、太子参、苍术、焦山楂、神曲、益智仁等组成(多为药食同源药，其中藿香、茯苓、益智仁等为重要滇产药及南药)，具有醒脾健运，开胃和中的功效，用于治疗小儿厌食疗效确切，总有效率达91.4％。
本发明的目的即是提供一种效果显著的，用于治疗小儿厌食症的香苓开胃颗粒，其原料包括如下重量的组分：广藿香5-30g，茯苓5-30g，苍术5-30g，丁香5-30g，鸡内金5-30g，佩兰5-30g，法半夏5-30g，兰花参5-30g，山土瓜5-30g，薏苡仁5-30g，桂枝5-30g，白芍5-30g，莱菔子5-30g，佛手5-30g。
优选的，各组分的重量为：广藿香20-28g，茯苓20-28g，苍术10-25g，丁香10-25g，鸡内金5-15g，佩兰5-15g，法半夏10-25g，兰花参5-15g，山土瓜5-15g，薏苡仁5-10g，桂枝5-10g，白芍5-10g，莱菔子5-10g，佛手5-10g。
进一步优选的，各组分的重量为：广藿香28g，茯苓28g，苍术15g，丁香15g，鸡内金15g，佩兰10g，法半夏20g，兰花参8g，山土瓜12g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。
“脾健贵运不贵补”，方中藿香性微温味辛，归脾胃肺经，芳香醒脾，化浊开胃，《本草正义》云“为湿困脾阳，倦怠无力，饮食不好，舌苔浊垢之最捷之药”。茯苓性平味甘淡，利湿而不损正气，免伤小儿脏腑之娇嫩。《本草崇原》云“有土位中央而枢机旋转之功”，二药共为君药，两药合用共奏芳香运脾之效。苍术性温味辛，可疏脾湿而通其滞，为运脾之要药；公丁香性温，味辛，温中降逆，散寒止痛，暖脾胃而行气滞，可止腹痛而消腹胀。法夏性温，味辛，功能燥湿化痰，降逆止呕，则痰鸣呕恶苔腻者得之可愈。其与公丁相配，彰温中降逆之效。三药共为臣药，温中健脾，燥湿化痰。佩兰性温味平，入脾胃经，与藿香配伍，增芳香化湿，醒脾和中之功。鸡内金性甘，味平，消食健脾，积滞得消则气机舒畅，运化有常。山土瓜性平味甘、淡，健脾消积，利湿；兰花参性平，味甘微苦，《滇南本草》云："补虚损，止自汗、盗汗，调养元气，治五劳七伤，诸虚百损，益气滋阴。"四药共为佐药，小儿久病伤脾，气虚不固，配伍此补益之品，自汗盗汗者皆可获效。薏苡仁，利水渗透湿，健脾止泻；桂枝，散寒止痛、通阳化气；白芍，养血调经，敛阴止汗，柔肝止痛，平抑肝阳；莱菔子，用于饮食停滞；佛手疏肝理气，和胄止痛。以上五药共为使药。诸药共用，消补兼施，共奏醒脾健运，开胃和中的功效。
各原料药的功效如下：
藿香：为唇形科植物广藿香或藿香的全草。快气，和中，辟秽，祛湿。治感冒暑湿，寒热，头痛，胸脘痞闷，呕吐泄泻，疟疾，痢疾，口臭。
茯苓：多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核。多于7～9月采挖，挖出后除去泥沙，堆置“发汗”后，摊开晾至表面干燥，再“发汗”，反复数次至现皱纹、内部水分大部散失后，阴干，称为“茯苓个”；或将鲜茯苓按不同部位切制，阴干，分别称为“茯苓皮”及“茯苓块”。利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
苍术：菊科植物茅苍术Atractylodes lancea(Thunb.)DC.或北苍术Atractylodeschinensis(DC.)Koidz.的干燥根茎。春、秋二季采挖，除去泥沙，晒干，撞去须根。燥湿健脾，祛风散寒，明目。用于脘腹胀满，泄泻，水肿，脚气痿躄，风湿痹痛，风寒感冒，夜盲。
丁香：桃金娘科植物丁香Eugenia caryophllata Thunb.的干燥花蕾。当花蕾由绿色转红时采摘，晒干。温中降逆，补肾助阳。用于脾胃虚寒，呃逆呕吐，食少吐泻，心腹冷痛，肾虚阳痿。
鸡内金：雉科动物家鸡Gallus gallus domesticus Brisson的干燥沙囊内壁。杀鸡后，取出鸡肫，趁热立即剥下内壁(不要先用水洗，否则难剥离且易破碎)，洗净，干燥。健胃消食，涩精止遗。用于食积不消，呕吐泻痢，小儿疳积，遗尿，遗精。
佩兰：菊科植物佩兰Eupatorium fortunei Turcz.的干燥地上部分。夏、秋二季分两次采割，除去杂质，晒干。芳香化湿，醒脾开胃，发表解暑。用于湿浊中阻，脘痞呕恶，口中甜腻，口臭，多涎，暑湿表症，头胀胸闷。
法半夏：半夏的炮制加工品。取净半夏，大小分开，用水浸泡至内无干心，取出；另取甘草适量，加水煎煮二次，合并煎液，倒入用适量水制成的石灰液中，搅匀，加入上述已浸透的半夏，浸泡，每日搅拌1～2次，并保持浸液pH值12以上，至剖面黄色均匀，口尝微有麻舌感时，取出，洗净，阴干或烘干，即得。每100kg净半夏,用甘草15kg、生石灰10kg。燥湿化痰。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛。
兰花参：桔梗科植物兰花参的根或带根全草。夏季采收，晒干。补虚，解表。治虚损劳伤，咳血、衄血，自汗、盗汗，妇女白带，伤风咳嗽，胃痛，泻痢，刀伤。
山土瓜：旋花科番薯属植物山土瓜Ipomoea hungaiensis Lingelsh.et Borza，以块根入药。秋季采挖，洗净，切片，晒干。健脾消积，利湿。用于小儿疳积，乳汁缺乏，肝炎，白带；外用治烧烫伤。
薏苡仁，为禾本科植物薏苡Coix lacryma-jobi L.var.mayuen(Roman.)Stapf的干燥成熟种仁。有利水渗透湿，健脾止泻，除痹，排脓，解毒散结的作用。
桂枝，味辛、甘，性温。归肺、心、膀胱经。发汗解表、散寒止痛、通阳化气。
白芍，为毛茛科植物芍药Paeonia tacti lora Pall.的干燥根。味苦、酸，性微寒。养血调经，敛阴止汗，柔肝止痛，平抑肝阳。
莱菔子，为十字花科植物萝卜Raphanus sativus L.的干燥成熟种子。植物的干燥成熟种子。用于饮食停滞，脘腹胀痛，大便秘结，积滞泻痢，痰壅喘咳。
佛手，为芸香科植物佛手CitrusmedicaLvar.sarcodac-tylisSwingle的干燥果实。有疏肝理气，和胄止痛，燥湿化痰的功效。
本发明香苓开胃颗粒的制备方法包括以下步骤：
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加6-10倍量的水蒸馏，提取挥发油；以获得挥发油6-10倍的β-CD 50℃包合2-5小时，自然冷却后置冰箱中冷藏12-36小时，抽滤并置干燥器中干燥24-72小时，得包合物，备用；
(2)取广藿香、苍术、丁香、佩兰药渣与其余药材采用加水煎煮两次，第一次加4-8倍量水，煎煮1-3小时；第二次加3-6倍量水，煎煮0.5-1.5小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达50-90％，搅拌后静置12-36小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，加糊精和蔗糖适量制成颗粒。
优选的，本发明香苓开胃颗粒的制备方法包括以下步骤：
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加8倍量的水蒸馏，提取挥发油；以获得挥发油8倍的β-CD 50℃包合5小时，自然冷却后置冰箱中冷藏24小时，抽滤并置干燥器中干燥48小时，得包合物，备用；
(2)取广藿香药渣与其余药材采用加水煎煮两次，第一次加8倍量水，煎煮2小时；第二次加6倍量水，煎煮1小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达80％，搅拌后静置24小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，加糊精和蔗糖适量制成颗粒。
所述的香苓开胃颗粒，还可以根据实际需要制备为口服液、丸、散、滴丸、胶囊等剂型。
本发明香苓开胃组合物的制备方法包括以下步骤：
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加6-10倍量的水蒸馏，提取挥发油；以获得挥发油6-10倍的β-CD 50℃包合2-5小时，自然冷却后置冰箱中冷藏12-36小时，抽滤并置干燥器中干燥24-72小时，得包合物，备用；
(2)取广藿香、苍术、丁香、佩兰药渣与其余药材采用加水煎煮两次，第一次加4-8倍量水，煎煮1-3小时；第二次加3-6倍量水，煎煮0.5-1.5小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达50-90％，搅拌后静置12-36小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，制备得到所需制剂。
优选的，本发明香苓开胃组合物的制备方法包括以下步骤：
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加8倍量的水蒸馏，提取挥发油；以获得挥发油8倍的β-CD 50℃包合5小时，自然冷却后置冰箱中冷藏24小时，抽滤并置干燥器中干燥48小时，得包合物，备用；
(2)取广藿香药渣与其余药材采用加水煎煮两次，第一次加8倍量水，煎煮2小时；第二次加6倍量水，煎煮1小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达80％，搅拌后静置24小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，制备得到所需制剂。
具体实施方式
实施例1香苓开胃颗粒的制备实施例
取广藿香28g，茯苓28g，苍术15g，丁香15g，鸡内金15g，佩兰10g，法半夏20g，兰花参8g，山土瓜12g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加8倍量的水蒸馏，提取挥发油；以获得挥发油8倍的β-CD 50℃包合5小时，自然冷却后置冰箱中冷藏24小时，抽滤并置干燥器中干燥48小时，得包合物，备用；
(2)取广藿香药渣与其余药材采用加水煎煮两次，第一次加8倍量水，煎煮2小时；第二次加6倍量水，煎煮1小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达80％，搅拌后静置24小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，加糊精和蔗糖适量制成颗粒。
实施例2香苓开胃片剂的制备实施例
取广藿香26g，茯苓25g，苍术18g，丁香12g，鸡内金12g，佩兰8g，法半夏15g，兰花参10g，山土瓜12g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加8倍量的水蒸馏，提取挥发油；以获得挥发油8倍的β-CD 50℃包合5小时，自然冷却后置冰箱中冷藏24小时，抽滤并置干燥器中干燥48小时，得包合物，备用；
(2)取广藿香药渣与其余药材采用加水煎煮两次，第一次加8倍量水，煎煮2小时；第二次加6倍量水，煎煮1小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达80％，搅拌后静置24小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，混合均匀后加入适量淀粉制粒、干燥，混匀，压制成片，包衣。
实施例3香苓开胃胶囊的制备实施例
取广藿香25g，茯苓20g，苍术25g，丁香8g，鸡内金15g，佩兰15g，法半夏12g，兰花参12g，山土瓜15g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加8倍量的水蒸馏，提取挥发油；以获得挥发油8倍的β-CD 50℃包合5小时，自然冷却后置冰箱中冷藏24小时，抽滤并置干燥器中干燥48小时，得包合物，备用；
(2)取广藿香药渣与其余药材采用加水煎煮两次，第一次加8倍量水，煎煮2小时；第二次加6倍量水，煎煮1小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达80％，搅拌后静置24小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，混合均匀后加入适量微粉硅胶和糊精，用95％乙醇制软材，过筛制粒，干燥，整粒，加入步骤(1)获得的包合物，混匀，装胶囊。
实施例4治疗小儿厌食症效果试验
将150例符合纳入标准的脾为湿困型厌食患儿随机分为治疗组和对照组各50例。治疗组口服香苓颗粒，对照1组用吗丁啉，对照2组口服下述颗粒(太子健颗粒)：用太子参25g、白术25g、波蔻25g、枳壳25g、焦山楂20g、陈皮20g、肉豆蔻20g、鸡内金20g、佛手10g、白芍10g、神曲10g、益智仁10g、补骨脂10g；取上述药材加水煎煮两次，第一次加4-10倍量水，第二次加水4-10倍量，每次煎煮1-4小时，过滤，收集滤液，浓缩，干燥，加糊精和蔗糖适量制成颗粒。
三组均连续治疗2周。治疗组和对照组患儿在年龄、性别、病程等方面比较差异无统计学意义(P>0.05)，具有可比性。治疗组总有效率98％，对照1组总有效率82％，对照2组总有效率80％，治疗组总疗效优于对照组，差异有统计学意义(P＜0.05)。
另外，完成小鼠推进排空率和小肠推进率实验。与模型对照组比较，香苓开胃颗粒组能明显提高小鼠胃排空率和小肠推进率(P<0.01)；吗丁啉组可明显降低小鼠胃排空率和小肠推进率(P<0.01)，而太子健颗粒组能提高小鼠的小肠推进率(P<0.01)，但对小鼠胃排空率无明显作用(P>0.05)。此外，香苓开胃颗粒组能提高正常大鼠的胃蛋白酶活力(P<0.01)，促进大鼠胆汁分泌(P<0.01)。而吗丁啉组和太子健颗粒组均无上述作用(P>0.05)。
实施例5对大鼠厌食模型的效果试验
将Wistar大鼠随机分为4组，每组10只。实验前五周，每天均采用模拟病因的方法，用鱼松、奶粉、玉米粉、黄豆粉、白糖、鸡蛋、鲜肥猪肉等市售产品按一定比例制备特制饲料喂养。每日实验进行之前记录前日大鼠全天进食量和当日体重。以模型组大鼠出现进食量低于正常组40-60％，体重低于正常组10-15％，但无腹泻、拱背、蜷卧等显著脾虚症状，为造模成功的标志。
将各组大鼠每日灌胃给药，剂量为2.5mL/100g，至第22日处死，记录每组大鼠的每日进食量。
治疗组采用实施例1制备的香苓开胃颗粒灌胃给药；
阳性对照组采用吗丁啉，灌胃给药，剂量：100mg/100g；
正常组和模型组均采用生理盐水灌胃给药。
在灌胃之前记录每日大鼠饲料剩余量，当日饲料加入量，按照：每日大鼠摄食量＝前日饲料加入量-当日饲料剩余量，计算每天每只大鼠的摄食量，并做前后和平行对比变化。结果如下表所示：
各组大鼠摄食量变化(g)
单位：g；与正常组相比，#P<0.05；与模型组相比，*P<0.05；**P<0.01
结果证实：实验开始时，四组的大鼠的摄食量均无统计学差异。而从第7天时，模型组摄食量明显下降，显示造模成功。同时，第7天时开始到第21天的治疗组合阳性对照组的摄食量均明显高于模型组，并且第14天和第21天，P<0.01。
实施例6典型病例举隅
病案一：
唐某，男，8岁，2016年4月10日
纳差2周，2周前无明显诱因出现纳差，未系统治疗，现纳差，无腹痛，偶有干呕，大便干，小便常，舌质淡苔白。
查：心肺(-)，咽(-)
拟方：香苓开胃颗粒。
开水煎，6剂而愈。
病案二：
张某，女，11岁。2015年10月15日。
纳差3月余。挑食，眠可，大便干结，状如羊粪，1-2日一行，晨起口有异味，舌质红抬黄腻。
查：心肺(-)，咽(+)
拟方：香苓开胃颗粒。
开水煎，6剂而愈。
病案三：
谭某，女，9岁。2014年7月3日。
纳差1月余，挑食，多食则腹胀，眠中易惊醒，会发出怪叫，大便调，1日1行，小便调，舌质红苔腻。
查：咽红(+)，双侧扁桃体Ⅱ°肿大，心肺(-)
拟方：香苓开胃颗粒。
开水煎，6剂而愈。
病案四：
安某，女，3岁。2013年4月20日。
纳差流汗1周。1周前患儿因“疱疹性咽炎”出现发热，经口服抗炎药后症状好转。现证见盗汗，纳差，脸色偏黄，大便干，小便调，眠可，舌质红苔白。
拟方：香苓开胃颗粒。
开水煎，6剂而愈。
病案五：
陈某，男，5岁。2012年5月26.
纳少2年余。厌食油腻，有口臭，易感冒，夜间磨牙，汗多，偶有打鼾，偶有鼻出血，心烦易怒，眠欠安，大便臭秽，粘稠小便黄，舌质红，苔黄腻。
查：心肺(-)，咽(-)
拟方：香苓开胃颗粒。
开水煎，6剂而愈。
Claims (10)
1.香苓开胃颗粒，其原料药由以下组分组成：广藿香5-30g，茯苓5-30g，苍术5-30g，丁香5-30g，鸡内金5-30g，佩兰5-30g，法半夏5-30g，兰花参5-30g，山土瓜5-30g，薏苡仁5-30g，桂枝5-30g，白芍5-30g，莱菔子5-30g，佛手5-30g。
2.如权利要求1所述的香苓开胃颗粒，各组分的重量为：广藿香20-28g，茯苓20-28g，苍术10-25g，丁香10-25g，鸡内金5-15g，佩兰5-15g，法半夏10-25g，兰花参5-15g，山土瓜5-15g，薏苡仁5-10g，桂枝5-10g，白芍5-10g，莱菔子5-10g，佛手5-10g。
3.如权利要求1所述的香苓开胃颗粒，各组分的重量为：广藿香28g，茯苓28g，苍术15g，丁香15g，鸡内金15g，佩兰10g，法半夏20g，兰花参8g，山土瓜12g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。
4.一种权利要求1-3任一项所述的香苓开胃颗粒的制备方法，包括如下步骤：
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加6-10倍量的水蒸馏，提取挥发油；以获得挥发油6-10倍的β-CD 50℃包合2-5小时，自然冷却后置冰箱中冷藏12-36小时，抽滤并置干燥器中干燥24-72小时，得包合物，备用；
(2)取广藿香、苍术、丁香、佩兰药渣与其余药材采用加水煎煮两次，第一次加4-8倍量水，煎煮1-3小时；第二次加3-6倍量水，煎煮0.5-1.5小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达50-90％，搅拌后静置12-36小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，加糊精和蔗糖适量制成颗粒。
5.如权利要求4所述的香苓开胃颗粒的制备方法，包括如下步骤：
(1)粉碎各药物，过40目筛，取广藿香、苍术、丁香、佩兰，加8倍量的水蒸馏，提取挥发油；以获得挥发油8倍的β-CD 50℃包合5小时，自然冷却后置冰箱中冷藏24小时，抽滤并置干燥器中干燥48小时，得包合物，备用；
(2)取广藿香药渣与其余药材采用加水煎煮两次，第一次加8倍量水，煎煮2小时；第二次加6倍量水，煎煮1小时，合并煎液，滤过，减压浓缩至膏状，加乙醇至药液含醇量达80％，搅拌后静置24小时，取上清液滤过，滤液回收乙醇至无醇味，真空干燥，得干浸膏，粉碎成细粉，加入步骤(1)获得的包合物，加糊精和蔗糖适量制成颗粒。
6.权利要求1-3任一项所述的香苓开胃颗粒，将颗粒剂替换为膏、丹、口服液、散、滴丸或胶囊剂型。
7.一种香苓开胃组合物，其原料药由以下组分组成：广藿香5-30g，茯苓5-30g，苍术5-30g，丁香5-30g，鸡内金5-30g，佩兰5-30g，法半夏5-30g，兰花参5-30g，山土瓜5-30g，薏苡仁5-30g，桂枝5-30g，白芍5-30g，莱菔子5-30g，佛手5-30g。
8.如权利要求7所述的香苓开胃组合物，各组分的重量为：广藿香20-28g，茯苓20-28g，苍术10-25g，丁香10-25g，鸡内金5-15g，佩兰5-15g，法半夏10-25g，兰花参5-15g，山土瓜5-15g，薏苡仁5-10g，桂枝5-10g，白芍5-10g，莱菔子5-10g，佛手5-10g。
9.如权利要求8所述的香苓开胃组合物，各组分的重量为：广藿香28g，茯苓28g，苍术15g，丁香15g，鸡内金15g，佩兰10g，法半夏20g，兰花参8g，山土瓜12g，薏苡仁5g，桂枝5g，白芍5g，莱菔子5g，佛手5g。
10.权利要求7-9任一项所述的香苓开胃组合物在制备治疗小儿厌食症药物中的用途。
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| CN103800447A (zh) * | 2013-08-31 | 2014-05-21 | 云南中医学院 | 香芩解热颗粒 |
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| CN103800447A (zh) * | 2013-08-31 | 2014-05-21 | 云南中医学院 | 香芩解热颗粒 |
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