CN107259506A - 一种β‑胡萝卜素纳米级乳剂的制备工艺及应用 - Google Patents
一种β‑胡萝卜素纳米级乳剂的制备工艺及应用 Download PDFInfo
- Publication number
- CN107259506A CN107259506A CN201710477768.1A CN201710477768A CN107259506A CN 107259506 A CN107259506 A CN 107259506A CN 201710477768 A CN201710477768 A CN 201710477768A CN 107259506 A CN107259506 A CN 107259506A
- Authority
- CN
- China
- Prior art keywords
- emulsion
- oil
- beta carotene
- preparation technology
- nanosized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 67
- 238000005516 engineering process Methods 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000012071 phase Substances 0.000 claims abstract description 43
- 239000000463 material Substances 0.000 claims abstract description 25
- 239000002245 particle Substances 0.000 claims abstract description 24
- 239000008346 aqueous phase Substances 0.000 claims abstract description 22
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000007664 blowing Methods 0.000 claims abstract description 7
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 49
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 49
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 47
- 235000013734 beta-carotene Nutrition 0.000 claims description 47
- 239000011648 beta-carotene Substances 0.000 claims description 47
- 229960002747 betacarotene Drugs 0.000 claims description 47
- 239000003921 oil Substances 0.000 claims description 44
- 235000019198 oils Nutrition 0.000 claims description 44
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- -1 fatty acid ester Chemical class 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 12
- 239000003963 antioxidant agent Substances 0.000 claims description 11
- 230000003078 antioxidant effect Effects 0.000 claims description 11
- 235000006708 antioxidants Nutrition 0.000 claims description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- 235000013305 food Nutrition 0.000 claims description 8
- 244000068988 Glycine max Species 0.000 claims description 7
- 235000010469 Glycine max Nutrition 0.000 claims description 7
- 239000007957 coemulsifier Substances 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 7
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 235000019486 Sunflower oil Nutrition 0.000 claims description 3
- 235000013361 beverage Nutrition 0.000 claims description 3
- 235000005687 corn oil Nutrition 0.000 claims description 3
- 239000002285 corn oil Substances 0.000 claims description 3
- NXMUXTAGFPJGTQ-UHFFFAOYSA-N decanoic acid;octanoic acid Chemical compound CCCCCCCC(O)=O.CCCCCCCCCC(O)=O NXMUXTAGFPJGTQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- 239000002600 sunflower oil Substances 0.000 claims description 3
- 239000004250 tert-Butylhydroquinone Substances 0.000 claims description 3
- 235000019281 tert-butylhydroquinone Nutrition 0.000 claims description 3
- 150000005691 triesters Chemical class 0.000 claims description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 2
- 235000019482 Palm oil Nutrition 0.000 claims description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 2
- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 239000002385 cottonseed oil Substances 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 239000008157 edible vegetable oil Substances 0.000 claims description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- 239000002540 palm oil Substances 0.000 claims description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 24
- 238000009826 distribution Methods 0.000 abstract description 9
- 239000003960 organic solvent Substances 0.000 abstract description 6
- 238000004945 emulsification Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 10
- 239000007908 nanoemulsion Substances 0.000 description 10
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 4
- 235000021466 carotenoid Nutrition 0.000 description 3
- 150000001747 carotenoids Chemical class 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 2
- 244000000626 Daucus carota Species 0.000 description 2
- 235000002767 Daucus carota Nutrition 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010054949 Metaplasia Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000002296 dynamic light scattering Methods 0.000 description 2
- 235000002864 food coloring agent Nutrition 0.000 description 2
- 230000015689 metaplastic ossification Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 238000013441 quality evaluation Methods 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000004064 cosurfactant Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 150000002632 lipids Chemical group 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/58—Colouring agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/41—Retaining or modifying natural colour by use of additives, e.g. optical brighteners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本发明公开了一种β‑胡萝卜素纳米级乳剂的制备工艺。将溶解好的水相物料和油相物料同时放料，分别瞬时控制水相和油相的流量，用管线剪切机在线混合剪切乳化、均质，得到纳米级乳剂。此制备工艺使物料的每个区域均能混合均匀，所得的乳剂平均粒径小于100nm、粒径均一、且具有更窄的粒径分布，稳定性强，在使用时可克服普通乳剂稳定性差、易分层的问题；此生产工艺中没有使用有机溶剂，安全性更高；同时，本发明提出的生产工艺可连续性生产，大大提高了生产效率。
Description
技术领域
本发明涉及食品添加剂及功能食品技术领域涉，具体涉及一种食品医药、保健品、化妆品行业中需要使用的一种β-胡萝卜素纳米级乳剂的制备工艺及应用。
背景技术
近年来，类胡萝卜素是国家批准使用的、应用最广泛的食品着色剂，一直处于供不应求的状态，尤其是天然β-胡萝卜素；同时，随着科学研究的深入和人们生活水平的提高，类胡萝卜素具有的许多生理功也逐步被认识和发现，如清除自由基、抗氧化、抗癌、提高机体免疫力、延缓衰老等，因此，它的应用领域也从食品着色逐步扩大到营养食品、保健品、药品、畜牧农业、化妆品等领域。
天然β-胡萝卜素不溶于水，是一种脂溶性色素，它对热稳定，对光和氧气十分敏感，不稳定且易氧化，因此，它非常适合油性产品的开发，却不能应用于水基食品，并且因其极差的稳定性使其在食品、医药等行业的应用受到了很大的限制，使应用范围较窄。例如，通常需要将含β-胡萝卜素的色素、香料、营养素、营养药品、治疗剂或抗氧化剂这样的水不混溶组分掺入到水基组合物中，这些组合物还需要在典型的食品和饮料运输、储藏以及使用条件下呈现出长时期的货架稳定性，由于β-胡萝卜素不溶于水和稳定性差的特性，而很难实施，目前粉剂产品和普通乳剂产品在使用时大都会出现上浮分层和黄色油圈等现象。然而，通过制剂化处理后可大大提高其对环境的适应能力，增强其稳定性。
纳米级乳剂构成胶体系统，基于其物理和化学特性，纳米乳剂属于微乳状液的组类。微乳状液是由被表面活性剂和共表面活性剂单层包围的脂质核组成的均质的、微米级微粒的水分散体。纳米乳剂的特征在于平均粒径(平均直径)小于200nm、经常是小于100nm，以及窄的单分散性粒径分布。它们通常是通过在表面活性剂的存在下使油相在水相中机械破裂而生产的。鉴于纳米级乳剂粒径小、窄的单分散性粒径分布的特点，其具有比普通乳剂更好的稳定性。
传统的β-胡萝卜素乳剂生产都是将油相加入到水相中，然后进行一定时间(10～60分钟)剪切乳化后再均质，传统工艺间歇式生产，效率低，能耗高，不利于大规模连续工业化生产；由于β-胡萝卜素的稳定性较差且乳剂比粉剂对稳定性要求更高的原因，通过传统方法生产的β-胡萝卜乳剂其粒径均一性差，粒径分布广很且难达到纳米级别，产品稳定性差；同时，传统工艺生产乳剂也会使用到一定量的有机溶剂，造成一定安全风险。
专利为98105436.6公开了一种β-胡萝卜素水包油型微滴乳状液，该乳状液的生产过程中没有采用有机溶剂，所用的乳化剂是无毒的，可用于食品、药物和化妆品中，但是生产工艺的局限使该乳状液粒径难以达到纳米级别。
专利为201210035294.2公开了一种类胡萝卜素乳液的生产工艺，该方法首先将油相和水相混合进行剪切乳化，然后再进行一定时间的多次高压均质得到乳液，此生产工艺过程中没有使用有机溶剂，保证了乳剂的安全性，但由于间歇式生产不利于大规模连续工业化生产，且该乳液粒径也未达到纳米级别。
专利为201110399523.4公开了一种无需高压均质的可食用纳米级β-胡萝卜素乳状液及其制备方法，该方法优化了传统上制备纳米乳状液的技术，但是该工艺过程中加入了一定量的有机溶剂，用于食品、药品和化妆品领域时存在一定的安全风险，且生产工艺也是间歇式，不利于大规模工厂生产。
专利为201380038299.3公开了一种类胡萝卜素水包油乳液的生产工艺，利用此生产工艺可以制备粒径小于150nm的乳液，但是此生产工艺为首先将油相和水相混合，然后预乳化一定时间，再进行高压微型流化床进一步乳化，此工艺操作繁琐，不易于进行大规模生产。
发明内容
针对现有技术中存在的技术问题，本发明的目的在于本发明的任务是提供一种在水中就分散稳定性好，对光、热、氧气稳定的β-胡萝卜素纳米级乳剂的制备工艺，本发明的生产工艺简单，工厂规模化生产时成本低；本发明的另一目的在于提供β-胡萝卜素纳米级乳剂的应用。
本发明的技术方案是这样实现的：
一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：包括以下步骤：
(1)将10％～20％甘油、1％～25％改性大豆磷脂、1％～10％聚甘油脂肪酸酯、5％～8％高HLB的辅助乳化剂、40％～82.5％水按比例投到水相罐中，所述比例均为质量百分比，同时常压下升温至50～80℃，待用，此为水相物料；
(2)将5％～25％β-胡萝卜素、1％～10％蔗糖脂肪酸脂、5％～10％辛癸酸甘油酯、1％～20％司盘60、0.1％～1％油相抗氧化剂、54％-86.5％的果油或食用植物油按比例投到油相罐中，充分搅拌混合，所述比例均为质量百分比，同时常压升温至120～170℃，待用，此为油相物料；
(3)将溶解好的水相物料和油相物料同时放料，分别控制水相和油相的流量，按水相：油相＝25:1～1:1(质量比)用管线剪切机在线混合、均质，得到粒径均一的纳米级β-胡萝卜素乳剂。
进一步地，所述步骤(1)中改性大豆磷脂中磷脂酰胆碱含量为90％～95％，所述比例为重量百分数。
进一步地，所述步骤(1)中高HLB的辅助乳化剂选自聚山梨酸酯80、聚氧脱水山梨醇单月桂酸酯、聚甘油-6-月桂酸酯、十甘油月桂酸酯、十甘油油酸酯中的一种或任意多种混合物。
进一步地，所述步骤(2)中油相抗氧化剂为维生素E、抗坏血酸棕榈酸酯、叔丁基对苯二酚(TBHQ)、2，6-二叔丁基-4-甲基苯酚(BHT)中的一种或或一种以上。
进一步地，所述步骤(2)中的植物油为葵花籽油、大豆油、棕榈油、玉米油、橄榄油或棉籽油中的一种或一种以上。
进一步地，所述步骤(3)中，均质的条件为均质温度35-50℃、均质压力40Mpa～70Mpa、均质1次。
进一步地，所述的乳剂为O/W型。
进一步地，所述纳米级乳剂具有小于100nm的平均粒径。
如上述的一种β-胡萝卜素纳米级乳剂的制备工艺制备的β-胡萝卜素纳米级乳剂，所述乳剂应用于食品、饮料、保健品、医药、化妆品中，作为着色剂、营养增补剂和抗氧化剂使用。
本发明的有益效果：(1)本发明公开的一种β-胡萝卜素纳米级乳剂的制备工艺，将溶解好的水相物料和油相物料同时放料，分别瞬时控制水相和油相的流量，用管线剪切机在线混合剪切乳化、均质得到的乳剂平均粒径小于100nm，且具有更窄的粒径分布；(2)此方法使物料的每个区域均能混合均匀，因此该乳剂粒径均一，稳定性强，在使用时可克服普通乳剂稳定性差、易分层的问题；(3)本发明的生产工艺不使用有机溶剂，无安全风险；(4)此方法可大规模连续生产，提高了生产效率。
附图说明
图1为实施例1中β-胡萝卜素乳剂的粒径分布图；
图2为实施例1中β-胡萝卜素乳剂的形态图；
图3为实施例2中β-胡萝卜素纳米乳剂的粒径分布图；
图4为实施例2中β-胡萝卜素纳米乳剂的形态图。
具体实施方式
展示一下实例来具体说明β-胡萝卜素乳剂的生产工艺、粒径及稳定性特征，其中实施例1为采用传统工艺生产，实施例2～4为采用本发明的制备工艺生产，具体实施方式不应解释为限制本发明的范围。对本发明公开的内容可以同时从材料、方法和反应条件进行改进，所有这些改进，均应落入本发明的的精神和范围之内。
实施例1：传统工艺生产β-胡萝卜素乳剂
1、将10公斤的β-胡萝卜素(含量为96％)、大豆油75公斤、中链甘油三酸酯75公斤和维生素E 0.5公斤搅拌均匀成油相，加热至130～140℃使之溶解得到油相物料，待用；
2、将大豆磷脂50公斤、亚硫酸钠0.5公斤、甘油80公斤加入600L水中，常压下升温至70℃充分溶解，待用；
3、将油相加入到水相中，然后剪切乳化20分钟后，在50Mpa-70Mpa均质3次制成最终乳剂。
实施例2：本发明的一种β-胡萝卜素纳米乳剂的制备方法
(1)将140公斤的甘油、15公斤改性大豆磷脂、14.5公斤聚甘油脂肪酸酯、70公斤高HLB辅助乳化剂加入到1000公斤水中，常压下升温至70℃充分溶解，待用；
(2)称取10公斤的β-胡萝卜素(含量为96％)、8公斤蔗糖脂肪酸脂、10公斤辛癸酸甘油酯、20公斤司盘60、油相抗氧化剂维生素E 0.4公斤溶于151.6公斤葵花籽油中，加热至130～140℃时快速搅拌使之溶解，搅拌均匀得到油相物料，待用；
(3)将溶解好的水相物料和油相物料同时放料，分别控制水相和油相的流量，按水相：油相＝6.2:1(质量比)用管线剪切机在线混合、均质，得到粒径均一的纳米级β-胡萝卜素乳剂。
实施例3：本发明的一种β-胡萝卜素纳米乳剂的制备方法
(1)将180公斤的甘油、45公斤改性大豆磷脂、15公斤聚甘油脂肪酸酯、75公斤高HLB辅助乳化剂加入到1000公斤水中，常压下升温至70℃充分溶解，待用；
(2)称取35公斤的β-胡萝卜素(含量为96％)、18公斤蔗糖脂肪酸脂、28公斤辛癸酸甘油酯、52公斤司盘60和油相抗氧化剂维生素E 0.8公斤溶于166公斤橄榄油中，加热至130～140℃时快速搅拌使之溶解，搅拌均匀得到油相物料，待用；
(3)将溶解好的水相物料和油相物料同时放料，分别控制水相和油相的流量，按水相：油相＝4.4:1(质量比)用管线剪切机在线混合、均质，得到粒径均一的纳米级β-胡萝卜素乳剂。
实施例4：本发明的一种β-胡萝卜素纳米乳剂的制备方法
(1)将220公斤的甘油、150公斤改性大豆磷脂、45公斤聚甘油脂肪酸酯、100公斤高HLB辅助乳化剂加入到1000公斤水中，常压下升温至70℃充分溶解，待用；
(2)称取90公斤的β-胡萝卜素(含量为96％)、50公斤蔗糖脂肪酸脂、辛癸酸甘油酯、97公斤司盘60和油相抗氧化剂维生素E 2.2公斤溶于307公斤玉米油中，加热至130～140℃时快速搅拌使之溶解，搅拌均匀得到油相物料，待用；
(3)将溶解好的水相物料和油相物料同时放料，分别控制水相和油相的流量，按水相：油相＝2.78:1(质量比)用管线剪切机在线混合、均质，得到粒径均一的纳米级β-胡萝卜素乳剂。
实验结果分析：β-胡萝卜素纳米乳剂的粒径及其稳定性
观察上述实施例1传统工艺制备的β-胡萝卜素乳剂，流动性较好，无分层、析油、析晶现象。通过光子相关光谱术、PCS评价，结果显示，此种方法得到的β-胡萝卜素乳剂粒径分布范围较宽，具体分布在100μm～600μm之间，如图1所示。将实施例1中的乳剂吸取适量，稀释后，显微镜下观察本品，形态图如图2所示。
观察上述实施例2～4中本发明工艺制备的β-胡萝卜素乳剂，3个实施例中乳剂流动性较好，无挂壁、分层、析油、析晶现象。通过光子相关光谱术、PCS评价，结果显示，此种方法得到的纳米乳剂具有非常一致和可靠的粒径和窄的微粒分布，如图3所示。并且这些特征在长时间和在不同温度下是稳定。将实施例2中的乳剂吸取适量，稀释后，显微镜下观察本品，形态图如图4所示。本发明的工艺生产β-胡萝卜素乳剂的质量评价数据如表1所示。
表1：本发明的生产工艺生产β-胡萝卜素乳剂的质量评价
结果显示，与传统工艺相比，本发明生产工艺生产的纳米乳剂产品质量稳定，表明本发明的处方和制备工艺对于解决β-胡萝卜乳剂其粒径均一性差、粒径分布广很难达到纳米级别、产品稳定性差的技术问题。
Claims (9)
1.一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：包括以下步骤：
(1)将10％～20％甘油、1％～25％改性大豆磷脂、1％～10％聚甘油脂肪酸酯、5％～8％高HLB的辅助乳化剂、40％～82.5％水按比例投到水相罐中，所述比例均为质量百分比，同时常压下升温至50～80℃，待用，此为水相物料；
(2)将5％～25％β-胡萝卜素、1％～10％蔗糖脂肪酸脂、5％-10％辛癸酸甘油酯、1％～20％司盘60、0.1％～1％油相抗氧化剂、54％-86.5％的果油或食用植物油按比例投到油相罐中，充分搅拌混合，所述比例均为质量百分比，同时常压升温至120～170℃，待用，此为油相物料；
(3)将溶解好的水相物料和油相物料同时放料，分别控制水相和油相的流量，按水相：油相＝25:1～1:1(质量比)用管线剪切机在线混合、均质，得到粒径均一的纳米级β-胡萝卜素乳剂。
2.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述步骤(1)中改性大豆磷脂中磷脂酰胆碱含量为90％～95％，所述比例为质量百分数。
3.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述步骤(1)中高HLB的辅助乳化剂选自聚山梨酸酯80、聚氧脱水山梨醇单月桂酸酯、聚甘油-6-月桂酸酯、十甘油月桂酸酯、十甘油油酸酯中的一种或任意多种混合物。
4.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述步骤(2)中油相抗氧化剂为维生素E、抗坏血酸棕榈酸酯、叔丁基对苯二酚(TBHQ)、2，6-二叔丁基-4-甲基苯酚(BHT)中的一种或一种以上。
5.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述步骤(2)中的植物油为葵花籽油、大豆油、棕榈油、玉米油、橄榄油或棉籽油中的一种或一种以上。
6.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述步骤(3)中，均质的条件为均质温度35～50℃、均质压力40Mpa～70Mpa、均质1次。
7.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述的乳剂为O/W型。
8.根据权利要求1所述的一种β-胡萝卜素纳米级乳剂的制备工艺，其特征在于：所述纳米级乳剂具有小于100nm的平均粒径。
9.如权利要求1～8中所述的一种β-胡萝卜素纳米级乳剂的制备工艺制备的β-胡萝卜素纳米级乳剂，其特征在于，所述乳剂应用于食品、饮料、保健品、医药、化妆品中，作为着色剂、营养增补剂和抗氧化剂使用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710477768.1A CN107259506A (zh) | 2017-06-20 | 2017-06-20 | 一种β‑胡萝卜素纳米级乳剂的制备工艺及应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710477768.1A CN107259506A (zh) | 2017-06-20 | 2017-06-20 | 一种β‑胡萝卜素纳米级乳剂的制备工艺及应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107259506A true CN107259506A (zh) | 2017-10-20 |
Family
ID=60068172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710477768.1A Pending CN107259506A (zh) | 2017-06-20 | 2017-06-20 | 一种β‑胡萝卜素纳米级乳剂的制备工艺及应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107259506A (zh) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107998066A (zh) * | 2018-01-04 | 2018-05-08 | 湖北瑞晟生物有限责任公司 | 一种用于精油美容的持久留香精油纳米乳及其生产工艺 |
| CN108208763A (zh) * | 2017-12-27 | 2018-06-29 | 厦门金达威生物科技有限公司 | 一种酸稳定性乳剂组合物及其制备方法 |
| CN108433013A (zh) * | 2018-03-06 | 2018-08-24 | 珠海雅富兴源食品工业有限公司 | 一种天然胡萝卜素制剂的制备方法 |
| CN109105723A (zh) * | 2018-08-29 | 2019-01-01 | 湖北欣和生物科技有限公司 | 一种β-胡萝卜素乳液及其制备方法 |
| CN109157510A (zh) * | 2018-08-23 | 2019-01-08 | 河南中大恒源生物科技股份有限公司 | 一种水溶性类胡萝卜素制剂及其制备方法与应用 |
| CN111471317A (zh) * | 2020-03-26 | 2020-07-31 | 广东省农业科学院蚕业与农产品加工研究所 | 一种稳态化玉米黄色素及其制备方法 |
| CN111955729A (zh) * | 2020-01-13 | 2020-11-20 | 广州市天滋优生物科技有限公司 | 一种光稳定透明水分散β-胡萝卜素的制备方法 |
| CN114680325A (zh) * | 2022-04-25 | 2022-07-01 | 武汉星辰现代生物工程有限公司 | 一种β-胡萝卜素纳米乳剂及其制备方法和应用 |
| CN115844750A (zh) * | 2022-12-23 | 2023-03-28 | 广东省科学院化工研究所 | 一种抗氧化纳米组合物及其制备方法和应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843199A (zh) * | 2006-01-10 | 2006-10-11 | 中国农业大学 | 纳米级β－胡萝卜素乳状液及其制备方法和用途 |
| CN101073557A (zh) * | 2006-05-15 | 2007-11-21 | 武汉星辰现代生物工程有限公司 | 一种天然β－胡萝卜素亚微米乳剂配方和工艺 |
| EP1927287A1 (en) * | 2006-12-01 | 2008-06-04 | FUJIFILM Corporation | Emulsion composition, and foods and cosmetics containing the emulsion composition |
| WO2008140065A3 (en) * | 2007-05-08 | 2009-10-15 | Fujifilm Corporation | Emulsion-containing composition, and method of preventing coagulation of polyphenol compound |
| CN103976353A (zh) * | 2014-04-24 | 2014-08-13 | 武汉星辰现代生物工程有限公司 | 一种β-胡萝卜素微胶囊的生产方法 |
| CN106344510A (zh) * | 2016-08-26 | 2017-01-25 | 晨光生物科技集团股份有限公司 | 番茄红素微乳液的工业化生产方法 |
-
2017
- 2017-06-20 CN CN201710477768.1A patent/CN107259506A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843199A (zh) * | 2006-01-10 | 2006-10-11 | 中国农业大学 | 纳米级β－胡萝卜素乳状液及其制备方法和用途 |
| CN101073557A (zh) * | 2006-05-15 | 2007-11-21 | 武汉星辰现代生物工程有限公司 | 一种天然β－胡萝卜素亚微米乳剂配方和工艺 |
| EP1927287A1 (en) * | 2006-12-01 | 2008-06-04 | FUJIFILM Corporation | Emulsion composition, and foods and cosmetics containing the emulsion composition |
| WO2008140065A3 (en) * | 2007-05-08 | 2009-10-15 | Fujifilm Corporation | Emulsion-containing composition, and method of preventing coagulation of polyphenol compound |
| CN103976353A (zh) * | 2014-04-24 | 2014-08-13 | 武汉星辰现代生物工程有限公司 | 一种β-胡萝卜素微胶囊的生产方法 |
| CN106344510A (zh) * | 2016-08-26 | 2017-01-25 | 晨光生物科技集团股份有限公司 | 番茄红素微乳液的工业化生产方法 |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108208763A (zh) * | 2017-12-27 | 2018-06-29 | 厦门金达威生物科技有限公司 | 一种酸稳定性乳剂组合物及其制备方法 |
| CN108208763B (zh) * | 2017-12-27 | 2021-12-21 | 厦门金达威生物科技有限公司 | 一种酸稳定性乳剂组合物及其制备方法 |
| CN107998066A (zh) * | 2018-01-04 | 2018-05-08 | 湖北瑞晟生物有限责任公司 | 一种用于精油美容的持久留香精油纳米乳及其生产工艺 |
| CN108433013B (zh) * | 2018-03-06 | 2021-04-27 | 珠海雅富兴源食品工业有限公司 | 一种天然胡萝卜素制剂的制备方法 |
| CN108433013A (zh) * | 2018-03-06 | 2018-08-24 | 珠海雅富兴源食品工业有限公司 | 一种天然胡萝卜素制剂的制备方法 |
| CN109157510A (zh) * | 2018-08-23 | 2019-01-08 | 河南中大恒源生物科技股份有限公司 | 一种水溶性类胡萝卜素制剂及其制备方法与应用 |
| CN109157510B (zh) * | 2018-08-23 | 2021-08-06 | 河南中大恒源生物科技股份有限公司 | 一种水溶性类胡萝卜素制剂及其制备方法与应用 |
| CN109105723A (zh) * | 2018-08-29 | 2019-01-01 | 湖北欣和生物科技有限公司 | 一种β-胡萝卜素乳液及其制备方法 |
| CN109105723B (zh) * | 2018-08-29 | 2022-12-09 | 湖北欣和生物科技有限公司 | 一种β-胡萝卜素乳液及其制备方法 |
| CN111955729A (zh) * | 2020-01-13 | 2020-11-20 | 广州市天滋优生物科技有限公司 | 一种光稳定透明水分散β-胡萝卜素的制备方法 |
| CN111471317A (zh) * | 2020-03-26 | 2020-07-31 | 广东省农业科学院蚕业与农产品加工研究所 | 一种稳态化玉米黄色素及其制备方法 |
| CN114680325A (zh) * | 2022-04-25 | 2022-07-01 | 武汉星辰现代生物工程有限公司 | 一种β-胡萝卜素纳米乳剂及其制备方法和应用 |
| CN115844750A (zh) * | 2022-12-23 | 2023-03-28 | 广东省科学院化工研究所 | 一种抗氧化纳米组合物及其制备方法和应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107259506A (zh) | 一种β‑胡萝卜素纳米级乳剂的制备工艺及应用 | |
| Mehmood et al. | Optimization of mixed surfactants-based β-carotene nanoemulsions using response surface methodology: An ultrasonic homogenization approach | |
| Banasaz et al. | Encapsulation of lipid-soluble bioactives by nanoemulsions | |
| Chen et al. | Gypenosides as natural emulsifiers for oil-in-water nanoemulsions loaded with astaxanthin: Insights of formulation, stability and release properties | |
| JP5933709B2 (ja) | 高められた可溶性および安定性を有する封入された組成物を形成する方法 | |
| de Paz et al. | Development of water-soluble β-carotene formulations by high-temperature, high-pressure emulsification and antisolvent precipitation | |
| CN105595158B (zh) | 一种具有着色、加香功能的饮料乳剂及其制备方法 | |
| CN101909654A (zh) | 纳米乳剂 | |
| US20160374375A1 (en) | Method for preparing oil-dispersible carotenoid preparation | |
| CN101921495B (zh) | 一种制备叶黄素油树脂微胶囊的方法 | |
| CN104921005A (zh) | 一种大蒜油的纳米级微乳液及其制备方法 | |
| EP1901837A2 (de) | Emulgatorsystem, emulsion und deren verwendung | |
| CN1843199A (zh) | 纳米级β－胡萝卜素乳状液及其制备方法和用途 | |
| CN111296730A (zh) | 一种稳定性好的叶黄素纳米乳液及其制备方法 | |
| JP2015528292A (ja) | 色相制御したβ−カロテン調合物 | |
| CN111135144A (zh) | 一种纯天然高稳定性大麻素纳米乳液及其制备方法 | |
| Chow et al. | Solid self-microemulsifying system (S-SMECS) for enhanced bioavailability and pigmentation of highly lipophilic bioactive carotenoid | |
| Khalid et al. | Critical review of encapsulation methods for stabilization and delivery of astaxanthin | |
| CN112056558A (zh) | 一种水包油类胡萝卜素微乳液及其制备方法 | |
| JP6667043B1 (ja) | マイクロエマルション、及びマイクロエマルションの利用 | |
| CN114126587B (zh) | 用于制备微型乳剂的组合物、微型乳剂、它们的制造方法、以及微型乳剂的应用 | |
| Dizaj et al. | Nanoemulsion-based delivery systems: preparation and application in the food industry | |
| JP7032260B2 (ja) | 油性組成物 | |
| CN110419595A (zh) | 一种共轭亚油酸甘油酯纳米乳液及其制备方法 | |
| US20170325481A1 (en) | Method of forming encapsulated compositions with enhanced solubility and stability |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171020 |