CN107250153A - 氧代羽扇豆烯衍生物 - Google Patents

氧代羽扇豆烯衍生物 Download PDF

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Publication number
CN107250153A
CN107250153A CN201580071098.2A CN201580071098A CN107250153A CN 107250153 A CN107250153 A CN 107250153A CN 201580071098 A CN201580071098 A CN 201580071098A CN 107250153 A CN107250153 A CN 107250153A
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CN
China
Prior art keywords
alkyl
substituted
mmol
coor
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580071098.2A
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English (en)
Chinese (zh)
Inventor
A.雷盖罗-任
刘峥
J.斯维多尔斯基
N.A.米恩维尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViiV Healthcare UK No 5 Ltd
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ViiV Healthcare UK No 5 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ViiV Healthcare UK No 5 Ltd filed Critical ViiV Healthcare UK No 5 Ltd
Publication of CN107250153A publication Critical patent/CN107250153A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201580071098.2A 2014-11-14 2015-11-12 氧代羽扇豆烯衍生物 Pending CN107250153A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462079977P 2014-11-14 2014-11-14
US62/079977 2014-11-14
PCT/US2015/060344 WO2016077561A1 (en) 2014-11-14 2015-11-12 Oxolupene derivatives

Publications (1)

Publication Number Publication Date
CN107250153A true CN107250153A (zh) 2017-10-13

Family

ID=54697682

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580071098.2A Pending CN107250153A (zh) 2014-11-14 2015-11-12 氧代羽扇豆烯衍生物

Country Status (10)

Country Link
US (1) US9969767B2 (enExample)
EP (1) EP3218387A1 (enExample)
JP (1) JP2017533937A (enExample)
KR (1) KR20170087478A (enExample)
CN (1) CN107250153A (enExample)
AU (1) AU2015346303B2 (enExample)
BR (1) BR112017009850A2 (enExample)
CA (1) CA2967679A1 (enExample)
RU (1) RU2017118489A (enExample)
WO (1) WO2016077561A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108026140A (zh) * 2015-07-28 2018-05-11 葛兰素史克知识产权第二有限公司 用于预防或治疗hiv感染的白桦脂醇衍生物
CN108368071A (zh) * 2015-09-24 2018-08-03 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的化合物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180194799A1 (en) * 2015-07-28 2018-07-12 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
CA3011616A1 (en) * 2016-01-20 2017-07-27 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008057420A2 (en) * 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
US20110077227A1 (en) * 2008-01-03 2011-03-31 Christophe Moinet Novel lupane derivatives
CN102883608A (zh) * 2010-02-11 2013-01-16 葛兰素史密丝克莱恩有限责任公司 白桦脂醇衍生物
CN102985438A (zh) * 2010-06-04 2013-03-20 百时美施贵宝公司 作为hiv成熟抑制剂的经修饰c-3桦木酸衍生物的c-28酰胺
CN103038245A (zh) * 2010-06-04 2013-04-10 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
WO2013090664A1 (en) * 2011-12-16 2013-06-20 Glaxosmithkline Llc Derivatives of betulin
CN103242413A (zh) * 2012-02-08 2013-08-14 陆峰 Lupane三萜系衍生物及其药学用途
WO2013123019A1 (en) * 2012-02-15 2013-08-22 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity
CN103339141A (zh) * 2011-01-31 2013-10-02 百时美施贵宝公司 作为hiv成熟抑制剂的c-3修饰的桦木酸衍生物的c-28胺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
CA2560266A1 (en) 2004-03-17 2005-09-29 Panacos Pharmaceuticals, Inc. Pharmaceutical salts of 3-o-(3',3'-dimethylsuccinyl) betulinic acid
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
EP2250185A4 (en) * 2008-01-03 2011-11-16 Virochem Pharma Inc NEW LUPANDERIVATE
CA2714049A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17.beta. lupane derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008057420A2 (en) * 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
US20110077227A1 (en) * 2008-01-03 2011-03-31 Christophe Moinet Novel lupane derivatives
CN102883608A (zh) * 2010-02-11 2013-01-16 葛兰素史密丝克莱恩有限责任公司 白桦脂醇衍生物
CN102985438A (zh) * 2010-06-04 2013-03-20 百时美施贵宝公司 作为hiv成熟抑制剂的经修饰c-3桦木酸衍生物的c-28酰胺
CN103038245A (zh) * 2010-06-04 2013-04-10 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
CN103339141A (zh) * 2011-01-31 2013-10-02 百时美施贵宝公司 作为hiv成熟抑制剂的c-3修饰的桦木酸衍生物的c-28胺
WO2013090664A1 (en) * 2011-12-16 2013-06-20 Glaxosmithkline Llc Derivatives of betulin
CN103242413A (zh) * 2012-02-08 2013-08-14 陆峰 Lupane三萜系衍生物及其药学用途
WO2013123019A1 (en) * 2012-02-15 2013-08-22 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108026140A (zh) * 2015-07-28 2018-05-11 葛兰素史克知识产权第二有限公司 用于预防或治疗hiv感染的白桦脂醇衍生物
CN108368071A (zh) * 2015-09-24 2018-08-03 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的化合物

Also Published As

Publication number Publication date
RU2017118489A3 (enExample) 2019-02-13
RU2017118489A (ru) 2018-12-14
CA2967679A1 (en) 2016-05-19
US20170334946A1 (en) 2017-11-23
AU2015346303B2 (en) 2018-03-15
EP3218387A1 (en) 2017-09-20
US9969767B2 (en) 2018-05-15
AU2015346303A1 (en) 2017-06-08
KR20170087478A (ko) 2017-07-28
WO2016077561A1 (en) 2016-05-19
BR112017009850A2 (pt) 2018-01-16
JP2017533937A (ja) 2017-11-16

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Application publication date: 20171013