AU2015346303B2 - Oxolupene derivatives - Google Patents

Oxolupene derivatives Download PDF

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Publication number
AU2015346303B2
AU2015346303B2 AU2015346303A AU2015346303A AU2015346303B2 AU 2015346303 B2 AU2015346303 B2 AU 2015346303B2 AU 2015346303 A AU2015346303 A AU 2015346303A AU 2015346303 A AU2015346303 A AU 2015346303A AU 2015346303 B2 AU2015346303 B2 AU 2015346303B2
Authority
AU
Australia
Prior art keywords
alkyl
group
mmol
cycloalkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015346303A
Other languages
English (en)
Other versions
AU2015346303A1 (en
Inventor
Zheng Liu
Nicholas A. Meanwell
Alicia Regueiro-Ren
Jacob Swidorski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViiV Healthcare UK No 5 Ltd
Original Assignee
ViiV Healthcare UK No 5 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ViiV Healthcare UK No 5 Ltd filed Critical ViiV Healthcare UK No 5 Ltd
Publication of AU2015346303A1 publication Critical patent/AU2015346303A1/en
Application granted granted Critical
Publication of AU2015346303B2 publication Critical patent/AU2015346303B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU2015346303A 2014-11-14 2015-11-12 Oxolupene derivatives Ceased AU2015346303B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462079977P 2014-11-14 2014-11-14
US62/079,977 2014-11-14
PCT/US2015/060344 WO2016077561A1 (en) 2014-11-14 2015-11-12 Oxolupene derivatives

Publications (2)

Publication Number Publication Date
AU2015346303A1 AU2015346303A1 (en) 2017-06-08
AU2015346303B2 true AU2015346303B2 (en) 2018-03-15

Family

ID=54697682

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015346303A Ceased AU2015346303B2 (en) 2014-11-14 2015-11-12 Oxolupene derivatives

Country Status (10)

Country Link
US (1) US9969767B2 (enExample)
EP (1) EP3218387A1 (enExample)
JP (1) JP2017533937A (enExample)
KR (1) KR20170087478A (enExample)
CN (1) CN107250153A (enExample)
AU (1) AU2015346303B2 (enExample)
BR (1) BR112017009850A2 (enExample)
CA (1) CA2967679A1 (enExample)
RU (1) RU2017118489A (enExample)
WO (1) WO2016077561A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017017609A1 (en) * 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
CA2993758A1 (en) * 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
AU2016327169A1 (en) * 2015-09-24 2018-04-12 Glaxosmithkline Intellectual Property (No.2) Limited Compounds with hiv maturation inhibitory activity
EP3405474A1 (en) * 2016-01-20 2018-11-28 Glaxosmithkline Intellectual Property (No. 2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153315A1 (en) * 2010-06-04 2011-12-08 Bristol-Myers Squibb Company Modified c-3 betulinic acid derivatives as hiv maturation inhibitors
WO2013117137A1 (en) * 2012-02-08 2013-08-15 Jiangxi Qingfeng Pharmaceutical Inc. Lupane triterpenoid derivatives and pharmaceutical use thereof
US20130210787A1 (en) * 2012-02-15 2013-08-15 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
MXPA06010592A (es) 2004-03-17 2007-06-12 Panacos Pharmaceuticals Inc Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico.
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
AR063546A1 (es) * 2006-11-03 2009-01-28 Panacos Pharmaceuticals Inc DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH.
WO2009082819A1 (en) * 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel lupane derivatives
US8269026B2 (en) * 2008-01-03 2012-09-18 Vertex Pharmaceuticals Incorporated Lupane derivatives useful for treating HIV
EP2257567A1 (en) 2008-02-14 2010-12-08 Virochem Pharma Inc. Novel 17 beta lupane derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
EA201290632A1 (ru) * 2010-02-11 2013-03-29 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Производные бетулина
MX2012013628A (es) 2010-06-04 2012-12-17 Bristol Myers Squibb Co Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
RS54352B1 (sr) * 2011-01-31 2016-02-29 Bristol-Myers Squibb Company C-28 amini c-3 modifikovanih derivata betulinske kiseline kao inhibitori sazrevanja hiv-a
JO3387B1 (ar) * 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153315A1 (en) * 2010-06-04 2011-12-08 Bristol-Myers Squibb Company Modified c-3 betulinic acid derivatives as hiv maturation inhibitors
WO2013117137A1 (en) * 2012-02-08 2013-08-15 Jiangxi Qingfeng Pharmaceutical Inc. Lupane triterpenoid derivatives and pharmaceutical use thereof
US20130210787A1 (en) * 2012-02-15 2013-08-15 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity

Also Published As

Publication number Publication date
BR112017009850A2 (pt) 2018-01-16
US20170334946A1 (en) 2017-11-23
RU2017118489A3 (enExample) 2019-02-13
CA2967679A1 (en) 2016-05-19
CN107250153A (zh) 2017-10-13
JP2017533937A (ja) 2017-11-16
US9969767B2 (en) 2018-05-15
RU2017118489A (ru) 2018-12-14
KR20170087478A (ko) 2017-07-28
AU2015346303A1 (en) 2017-06-08
WO2016077561A1 (en) 2016-05-19
EP3218387A1 (en) 2017-09-20

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired