CN107206045A - 用于基于免疫的治疗的免疫原性mhcii类肽的鉴定 - Google Patents
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- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A—HUMAN NECESSITIES
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- A61K2039/80—Vaccine for a specifically defined cancer
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US2015/041034 | 2015-07-17 | ||
PCT/US2015/041034 WO2016011432A2 (en) | 2014-07-17 | 2015-07-17 | Identification of immunogenic mhc class ii peptides for immune-based therapy |
PCT/US2016/021042 WO2017014810A1 (en) | 2015-07-17 | 2016-03-04 | Identification of immunogenic mhc class ii peptides for immune-based therapy |
USPCT/US2016/021042 | 2016-03-04 | ||
PCT/US2016/026542 WO2017014816A1 (en) | 2015-07-17 | 2016-04-07 | Identification of immunogenic mhc class ii peptides for immune-based therapy |
Publications (1)
Publication Number | Publication Date |
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CN107206045A true CN107206045A (zh) | 2017-09-26 |
Family
ID=57835029
Family Applications (1)
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CN201680002764.1A Pending CN107206045A (zh) | 2015-07-17 | 2016-04-07 | 用于基于免疫的治疗的免疫原性mhcii类肽的鉴定 |
Country Status (5)
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EP (2) | EP3325005A4 (de) |
JP (3) | JP2018527286A (de) |
CN (1) | CN107206045A (de) |
CA (2) | CA2992925A1 (de) |
WO (2) | WO2017014810A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3325005A4 (de) * | 2015-07-17 | 2019-03-27 | Brian J. Czerniecki | Identifikation von immunogenen mhc-klasse-ii-peptiden für immunbasierte therapie |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1703427A (zh) * | 2002-09-20 | 2005-11-30 | 阿斯特拉尔公司 | 通过同时加载和激活抗原呈递细胞的选定的亚型产生并且控制t细胞的效应物谱的方法和组合物 |
US20080057064A1 (en) * | 2002-03-26 | 2008-03-06 | Zensun (Shanghai) Science And Technology Limited | Erbb3 Based Methods and Compositions for Treating Neoplasms |
US20140112931A1 (en) * | 2011-05-19 | 2014-04-24 | Universite De Montpellier 1 | Anti-human her3 antibodies and uses thereof |
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US5183884A (en) * | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
IL145926A0 (en) * | 2001-10-15 | 2002-07-25 | Mor Research Applic Ltd | Peptide epitopes of mimotopes useful in immunomodulation |
US7700299B2 (en) * | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
JP2009532393A (ja) * | 2006-04-07 | 2009-09-10 | コペンハーゲン ユニバーシティ | ErbB受容体由来ペプチド断片 |
ES2401484T3 (es) * | 2006-06-15 | 2013-04-22 | Novartis Ag | Régimen de vacunación contra la gripe multidosis ahorrador de adyuvantes |
WO2010097186A1 (en) * | 2009-02-24 | 2010-09-02 | Roche Diagnostic Gmbh | Use of s-erbb-3 as a marker for cancer |
JP2010200693A (ja) * | 2009-03-04 | 2010-09-16 | Chiyoda Kako Kensetsu Kk | 樹状細胞ワクチン製造用培養装置並びに樹状細胞の製造方法 |
US8765383B2 (en) * | 2009-04-07 | 2014-07-01 | Genomic Health, Inc. | Methods of predicting cancer risk using gene expression in premalignant tissue |
CA2768552A1 (en) * | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
JP2013522309A (ja) * | 2010-03-15 | 2013-06-13 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 活性化した成熟樹状細胞を調製し保存するシステムおよび方法 |
EA036739B1 (ru) * | 2011-12-05 | 2020-12-15 | Новартис Аг | Антитела к рецептору эпидермального фактора роста 3 (her3) |
SG11201602291TA (en) * | 2013-09-30 | 2016-04-28 | Daiichi Sankyo Co Ltd | Nucleic acid biomarker and use thereof |
WO2016011432A2 (en) * | 2014-07-17 | 2016-01-21 | Czerniecki Brian J | Identification of immunogenic mhc class ii peptides for immune-based therapy |
EP3325005A4 (de) * | 2015-07-17 | 2019-03-27 | Brian J. Czerniecki | Identifikation von immunogenen mhc-klasse-ii-peptiden für immunbasierte therapie |
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2016
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- 2016-03-04 CA CA2992925A patent/CA2992925A1/en not_active Abandoned
- 2016-03-04 JP JP2017502790A patent/JP2018527286A/ja active Pending
- 2016-04-07 JP JP2017502788A patent/JP2018521953A/ja active Pending
- 2016-04-07 WO PCT/US2016/026542 patent/WO2017014816A1/en active Application Filing
- 2016-04-07 CA CA2992937A patent/CA2992937A1/en not_active Abandoned
- 2016-04-07 CN CN201680002764.1A patent/CN107206045A/zh active Pending
- 2016-04-07 EP EP16828163.2A patent/EP3324990A4/de not_active Withdrawn
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2020
- 2020-10-14 JP JP2020173500A patent/JP2021043204A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080057064A1 (en) * | 2002-03-26 | 2008-03-06 | Zensun (Shanghai) Science And Technology Limited | Erbb3 Based Methods and Compositions for Treating Neoplasms |
CN1703427A (zh) * | 2002-09-20 | 2005-11-30 | 阿斯特拉尔公司 | 通过同时加载和激活抗原呈递细胞的选定的亚型产生并且控制t细胞的效应物谱的方法和组合物 |
US20140112931A1 (en) * | 2011-05-19 | 2014-04-24 | Universite De Montpellier 1 | Anti-human her3 antibodies and uses thereof |
Non-Patent Citations (1)
Title |
---|
MEGAN JO MILLER等: "HER-3 peptide vaccines/mimics: Combined therapy with IGF-1R, HER-2, and HER-1 peptides induces synergistic antitumor effects against breast and pancreatic cancer cells", 《ONCOIMMUNOLOGY》 * |
Also Published As
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JP2021043204A (ja) | 2021-03-18 |
EP3324990A4 (de) | 2019-04-03 |
WO2017014816A1 (en) | 2017-01-26 |
CA2992925A1 (en) | 2017-01-26 |
EP3324990A1 (de) | 2018-05-30 |
CA2992937A1 (en) | 2017-01-26 |
WO2017014810A1 (en) | 2017-01-26 |
EP3325005A1 (de) | 2018-05-30 |
EP3325005A4 (de) | 2019-03-27 |
JP2018527286A (ja) | 2018-09-20 |
JP2018521953A (ja) | 2018-08-09 |
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