CN107200706A - 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途 - Google Patents

一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途 Download PDF

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CN107200706A
CN107200706A CN201610149958.6A CN201610149958A CN107200706A CN 107200706 A CN107200706 A CN 107200706A CN 201610149958 A CN201610149958 A CN 201610149958A CN 107200706 A CN107200706 A CN 107200706A
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China
Prior art keywords
acid
compound
trans
fluoro
methyl
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Chinese (zh)
Inventor
柳红
李佳
王江
苏明波
王姝妮
周宇波
朱未
徐威
李淳朴
蒋华良
陈凯先
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Shanghai Institute of Materia Medica of CAS
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Shanghai Institute of Materia Medica of CAS
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Priority to CN201610149958.6A priority Critical patent/CN107200706A/zh
Priority to CA3021608A priority patent/CA3021608C/en
Priority to EP17765864.8A priority patent/EP3431471A4/en
Priority to JP2018548895A priority patent/JP7605579B2/ja
Priority to SG11201808017PA priority patent/SG11201808017PA/en
Priority to CN201780017669.3A priority patent/CN108779096B/zh
Priority to PCT/CN2017/076967 priority patent/WO2017157322A1/zh
Priority to US16/085,311 priority patent/US10836743B2/en
Priority to KR1020187029900A priority patent/KR102196050B1/ko
Priority to RU2018136336A priority patent/RU2746323C9/ru
Publication of CN107200706A publication Critical patent/CN107200706A/zh
Pending legal-status Critical Current

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201610149958.6A 2016-03-16 2016-03-16 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途 Pending CN107200706A (zh)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN201610149958.6A CN107200706A (zh) 2016-03-16 2016-03-16 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
CA3021608A CA3021608C (en) 2016-03-16 2017-03-16 Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
EP17765864.8A EP3431471A4 (en) 2016-03-16 2017-03-16 FLUORINATED CYCLOPROPYLAMINE COMPOUND, METHOD OF MANUFACTURING THEREOF, PHARMACEUTICAL COMPOSITION, AND USES THEREOF
JP2018548895A JP7605579B2 (ja) 2016-03-16 2017-03-16 フッ素置換シクロプロピルアミン系化合物並びにその製造方法、薬物組成物及び使用
SG11201808017PA SG11201808017PA (en) 2016-03-16 2017-03-16 Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and users thereof
CN201780017669.3A CN108779096B (zh) 2016-03-16 2017-03-16 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
PCT/CN2017/076967 WO2017157322A1 (zh) 2016-03-16 2017-03-16 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
US16/085,311 US10836743B2 (en) 2016-03-16 2017-03-16 Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
KR1020187029900A KR102196050B1 (ko) 2016-03-16 2017-03-16 불소로 치환된 시클로프로필아민계 화합물 및 이의 제조 방법, 약물 조성물 및 용도
RU2018136336A RU2746323C9 (ru) 2016-03-16 2017-03-16 Фторированное соединение циклопропиламина, способ получения, фармацевтическая композиция и ее использование

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CN201610149958.6A CN107200706A (zh) 2016-03-16 2016-03-16 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途

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CN112939846B (zh) * 2019-11-26 2023-12-26 中国科学院上海药物研究所 一种乙酰胆碱酯酶抑制剂的晶型及其制备方法和应用
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