CN107183670B - 一种增免儿童青少年型多矿多维制剂及其制备方法 - Google Patents
一种增免儿童青少年型多矿多维制剂及其制备方法 Download PDFInfo
- Publication number
- CN107183670B CN107183670B CN201710427394.2A CN201710427394A CN107183670B CN 107183670 B CN107183670 B CN 107183670B CN 201710427394 A CN201710427394 A CN 201710427394A CN 107183670 B CN107183670 B CN 107183670B
- Authority
- CN
- China
- Prior art keywords
- parts
- vitamin
- stirring
- croscarmellose sodium
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 229940088594 vitamin Drugs 0.000 title claims abstract description 19
- 239000011782 vitamin Substances 0.000 title claims abstract description 19
- 239000011707 mineral Substances 0.000 title claims abstract description 17
- 230000036039 immunity Effects 0.000 title claims abstract description 16
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 14
- 230000006872 improvement Effects 0.000 title description 2
- 238000003756 stirring Methods 0.000 claims abstract description 46
- 229920002785 Croscarmellose sodium Polymers 0.000 claims abstract description 42
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims abstract description 42
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229960001681 croscarmellose sodium Drugs 0.000 claims abstract description 36
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 24
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 17
- 239000003765 sweetening agent Substances 0.000 claims abstract description 17
- 239000002562 thickening agent Substances 0.000 claims abstract description 17
- 230000000366 juvenile effect Effects 0.000 claims abstract description 16
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 13
- 108010073771 Soybean Proteins Proteins 0.000 claims abstract description 13
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 13
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 13
- 235000019710 soybean protein Nutrition 0.000 claims abstract description 13
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 12
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 12
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 12
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 12
- 235000002332 ferrous fumarate Nutrition 0.000 claims abstract description 12
- 229960000225 ferrous fumarate Drugs 0.000 claims abstract description 12
- 239000011773 ferrous fumarate Substances 0.000 claims abstract description 12
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 12
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims abstract description 12
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 12
- 239000011719 vitamin A Substances 0.000 claims abstract description 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 12
- 239000011718 vitamin C Substances 0.000 claims abstract description 12
- 229940045997 vitamin a Drugs 0.000 claims abstract description 12
- 235000006076 zinc citrate Nutrition 0.000 claims abstract description 12
- 229940068475 zinc citrate Drugs 0.000 claims abstract description 12
- 239000011746 zinc citrate Substances 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 11
- 230000002708 enhancing effect Effects 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 11
- 235000019698 starch Nutrition 0.000 claims abstract description 11
- 238000005406 washing Methods 0.000 claims abstract description 11
- 238000001816 cooling Methods 0.000 claims abstract description 10
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 8
- 239000011710 vitamin D Substances 0.000 claims abstract description 8
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 8
- 229940046008 vitamin d Drugs 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 17
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 7
- 229930189775 mogroside Natural products 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000811 xylitol Substances 0.000 claims description 7
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 7
- 235000010447 xylitol Nutrition 0.000 claims description 7
- 229960002675 xylitol Drugs 0.000 claims description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 6
- 239000001814 pectin Substances 0.000 claims description 6
- 235000010987 pectin Nutrition 0.000 claims description 6
- 229920001277 pectin Polymers 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- 229960003563 calcium carbonate Drugs 0.000 claims description 4
- 235000010216 calcium carbonate Nutrition 0.000 claims description 4
- 235000005282 vitamin D3 Nutrition 0.000 claims description 4
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 4
- 239000011647 vitamin D3 Substances 0.000 claims description 4
- 229940021056 vitamin d3 Drugs 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 4
- 208000026106 cerebrovascular disease Diseases 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000002526 effect on cardiovascular system Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000007910 chewable tablet Substances 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 206010008118 cerebral infarction Diseases 0.000 description 2
- 229940068682 chewable tablet Drugs 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229940069978 calcium supplement Drugs 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- -1 sodium carboxymethyl cellulose compound Chemical class 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/262—Cellulose; Derivatives thereof, e.g. ethers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pediatric Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明公开了一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙35‑45份，柠檬酸锌25‑33份，富马酸亚铁20‑30份，维生素A 0.5‑1.5份，维生素D3 1‑3份，维生素C 10‑18份，甜味剂5‑10份，增稠剂6‑12份，淀粉170‑190份。交联羧甲基纤维素钠复合物采用如下工艺制备：将大豆分离蛋白、透明质酸、交联羧甲基纤维素钠搅拌，搅拌状态下加入至液体石蜡中，置于冰盐浴中降温，加入乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。本发明还公开了上述增免儿童青少年型多矿多维制剂的制备方法。
Description
技术领域
本发明涉及保健品技术领域，尤其涉及一种增免儿童青少年型多矿多维制剂及其制备方法。
背景技术
目前不良的嗜好加速了骨质的疏松。碳酸饮料、酒精会瓦解钙离子和维生素，影响人体对钙质的吸收。因此，适当的补充钙，对男士有很好的保健功效。目前多维多矿营养咀嚼片，不仅可强健骨骼，且补充多种营养，抵抗自由基，预防心脑血管疾病，另外还可降低血脂，减少心脑血管粥样硬化的形成，在一定程度上能预防冠心病、脑出血和脑梗塞等疾病发生。但目前多维多矿营养咀嚼片存在储存易破碎，且不易崩解的问题。
发明内容
基于背景技术存在的技术问题，本发明提出了一种增免儿童青少年型多矿多维制剂及其制备方法，制品硬度、脆度适宜，并可对有效成分进行包覆，延长有效成分保质期，而且便于消化，进入肠胃后吸水膨胀，快速崩解，便于人体吸收，有效增强儿童青少年免疫力。
本发明提出的一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙35-45份，柠檬酸锌25-33份，富马酸亚铁20-30份，维生素A 0.5-1.5份，维生素D3 1-3份，维生素C 10-18份，甜味剂5-10份，增稠剂6-12份，淀粉170-190份。
优选地，甜味剂按重量份包括：木糖醇3-7份，罗汉果甜苷2-4份。
优选地，增稠剂按重量份包括：交联羧甲基纤维素钠复合物2-4份，海藻酸钠1-2份，果胶3-9份。
优选地，交联羧甲基纤维素钠复合物采用如下工艺制备：将大豆分离蛋白、透明质酸、交联羧甲基纤维素钠搅拌，搅拌状态下加入至液体石蜡中，置于冰盐浴中降温，加入乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
优选地，交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将10-16份大豆分离蛋白、4-10份透明质酸、6-10份交联羧甲基纤维素钠搅拌，搅拌状态下加入至25-35份液体石蜡中，置于冰盐浴中降温至零下，加入240-280份浓度为85-95wt％乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
优选地，交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将10-16份大豆分离蛋白、4-10份透明质酸、6-10份交联羧甲基纤维素钠搅拌4-8h，搅拌温度为80-90℃，搅拌速度为2000-3000r/min，搅拌状态下加入至25-35份温度为55-65℃液体石蜡中，置于冰盐浴中降温至零下，加入240-280份浓度为85-95wt％乙醇溶液，搅拌35-55min，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
本发明还提出的上述增免儿童青少年型多矿多维制剂制备方法，包括如下步骤：
S1、将甜味剂和增稠剂混合，加水得到粘合剂溶液；
S2、将碳酸钙、富马酸亚铁、柠檬酸锌、维生素A、维生素D3、维生素C加入至淀粉中搅拌，搅拌状态下加入粘合剂溶液，然后制粒，筛分，整粒，压片机压片得到增免儿童青少年型多矿多维制剂。
本发明可补充多种营养，强健骨骼，增强人体对钙质的吸收，保健功效显著，且可抵抗自由基，预防心脑血管疾病，另外还可降低血脂，减少心脑血管粥样硬化的形成，在一定程度上能预防冠心病、脑出血和脑梗塞等疾病发生；另外提高免疫力功效显著，可有效预防感冒的发生；其中采用碳酸钙、富马酸亚铁、柠檬酸锌、维生素A、维生素D3、维生素C作为有效成分，配合交联羧甲基纤维素钠复合物，制品稳定性极高，即使不添加香精，也可对其中的酸味和苦味进行掩盖；在羧甲基纤维素钠复合物中，大豆分离蛋白与透明质酸、交联羧甲基纤维素钠分散性好，加入至液体石蜡中，使本发明在压片时流动性好、可压性强，片剂硬度、脆度适宜，并可对有效成分进行包覆，延长有效成分保质期，而且便于消化，进入肠胃后吸水膨胀，快速崩解，便于在儿童青少年体内吸收；进一步辅以木糖醇、罗汉果甜苷，咀嚼后没有苦味，更加爽口，提升了口感，便于儿童青少年食用，本发明通过各原料的配合，可有效提高产品的外观、硬度、碎脆度、崩解时间等性能，其崩解时间≤10min，吸收快，生物利用度高，且无不良反应，质量稳定。
具体实施方式
下面，通过具体实施例对本发明的技术方案进行详细说明。
实施例1
本发明提出的一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙35份，柠檬酸锌33份，富马酸亚铁20份，维生素A 1.5份，维生素D3 1份，维生素C 18份，甜味剂5份，增稠剂12份，淀粉170份。
本发明还提出的上述增免儿童青少年型多矿多维制剂制备方法，包括如下步骤：
S1、将甜味剂和增稠剂混合，加水得到粘合剂溶液；
S2、将碳酸钙、富马酸亚铁、柠檬酸锌、维生素A、维生素D3、维生素C加入至淀粉中搅拌，搅拌状态下加入粘合剂溶液，然后制粒，筛分，整粒，压片机压片得到增免儿童青少年型多矿多维制剂。
实施例2
本发明提出的一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙45份，柠檬酸锌25份，富马酸亚铁30份，维生素A 0.5份，维生素D3 3份，维生素C 10份，甜味剂10份，增稠剂6份，淀粉190份。
甜味剂按重量份包括：木糖醇3份，罗汉果甜苷4份。增稠剂按重量份包括：交联羧甲基纤维素钠复合物2份，海藻酸钠2份，果胶3份。
交联羧甲基纤维素钠复合物采用如下工艺制备：将大豆分离蛋白、透明质酸、交联羧甲基纤维素钠搅拌，搅拌状态下加入至液体石蜡中，置于冰盐浴中降温，加入乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
实施例3
本发明提出的一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙38份，柠檬酸锌31份，富马酸亚铁22份，维生素A 1.2份，维生素D3 1.5份，维生素C 16份，甜味剂6份，增稠剂10份，淀粉175份。
甜味剂按重量份包括：木糖醇7份，罗汉果甜苷2份。增稠剂按重量份包括：交联羧甲基纤维素钠复合物4份，海藻酸钠1份，果胶9份。
交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将13份大豆分离蛋白、7份透明质酸、8份交联羧甲基纤维素钠搅拌，搅拌状态下加入至30份液体石蜡中，置于冰盐浴中降温至零下，加入260份浓度为90wt％乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
实施例4
本发明提出的一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙42份，柠檬酸锌27份，富马酸亚铁28份，维生素A 0.8份，维生素D3 2.5份，维生素C 12份，甜味剂8份，增稠剂8份，淀粉185份。
甜味剂按重量份包括：木糖醇4份，罗汉果甜苷3份。增稠剂按重量份包括：交联羧甲基纤维素钠复合物3份，海藻酸钠1.8份，果胶5份。
交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将10份大豆分离蛋白、10份透明质酸、6份交联羧甲基纤维素钠搅拌8h，搅拌温度为80℃，搅拌速度为3000r/min，搅拌状态下加入至25份温度为65℃液体石蜡中，置于冰盐浴中降温至零下，加入240份浓度为95wt％乙醇溶液，搅拌35min，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
实施例5
本发明提出的一种增免儿童青少年型多矿多维制剂，其原料按重量份包括：碳酸钙40份，柠檬酸锌29份，富马酸亚铁25份，维生素A 1份，维生素D3 2份，维生素C 14份，甜味剂7份，增稠剂9份，淀粉180份。
甜味剂按重量份包括：木糖醇6份，罗汉果甜苷2.5份。增稠剂按重量份包括：交联羧甲基纤维素钠复合物3.5份，海藻酸钠1.2份，果胶7份。
交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将16份大豆分离蛋白、4份透明质酸、10份交联羧甲基纤维素钠搅拌4h，搅拌温度为90℃，搅拌速度为2000r/min，搅拌状态下加入至35份温度为55℃液体石蜡中，置于冰盐浴中降温至零下，加入280份浓度为85wt％乙醇溶液，搅拌55min，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。
Claims (5)
1.一种增免儿童青少年型多矿多维制剂，其特征在于，其原料按重量份包括：碳酸钙35-45份，柠檬酸锌25-33份，富马酸亚铁20-30份，维生素A 0.5-1.5份，维生素D3 1-3份，维生素C 10-18份，甜味剂5-10份，增稠剂6-12份，淀粉170-190份；
所述增稠剂按重量份包括：交联羧甲基纤维素钠复合物2-4份，海藻酸钠1-2份，果胶3-9份；交联羧甲基纤维素钠复合物采用如下工艺制备：将大豆分离蛋白、透明质酸、交联羧甲基纤维素钠搅拌，搅拌状态下加入至液体石蜡中，置于冰盐浴中降温，加入乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
2.根据权利要求1所述增免儿童青少年型多矿多维制剂，其特征在于，甜味剂按重量份包括：木糖醇3-7份，罗汉果甜苷2-4份。
3.根据权利要求1或2所述增免儿童青少年型多矿多维制剂，其特征在于，交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将10-16份大豆分离蛋白、4-10份透明质酸、6-10份交联羧甲基纤维素钠搅拌，搅拌状态下加入至25-35份液体石蜡中，置于冰盐浴中降温至零下，加入240-280份浓度为85-95wt％乙醇溶液，搅拌，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
4.根据权利要求1或2所述增免儿童青少年型多矿多维制剂，其特征在于，交联羧甲基纤维素钠复合物采用如下工艺制备：按重量份将10-16份大豆分离蛋白、4-10份透明质酸、6-10份交联羧甲基纤维素钠搅拌4-8h，搅拌温度为80-90℃，搅拌速度为2000-3000r/min，搅拌状态下加入至25-35份温度为55-65℃液体石蜡中，置于冰盐浴中降温至零下，加入240-280份浓度为85-95wt％乙醇溶液，搅拌35-55min，脱水，洗涤，干燥得到交联羧甲基纤维素钠复合物。
5.一种如权利要求1-4任一项所述增免儿童青少年型多矿多维制剂制备方法，其特征在于，包括如下步骤：
S1、将甜味剂和增稠剂混合，加水得到粘合剂溶液；
S2、将碳酸钙、富马酸亚铁、柠檬酸锌、维生素A、维生素D3、维生素C加入至淀粉中搅拌，搅拌状态下加入粘合剂溶液，然后制粒，筛分，整粒，压片机压片得到增免儿童青少年型多矿多维制剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710427394.2A CN107183670B (zh) | 2017-06-08 | 2017-06-08 | 一种增免儿童青少年型多矿多维制剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710427394.2A CN107183670B (zh) | 2017-06-08 | 2017-06-08 | 一种增免儿童青少年型多矿多维制剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107183670A CN107183670A (zh) | 2017-09-22 |
| CN107183670B true CN107183670B (zh) | 2019-12-10 |
Family
ID=59877846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710427394.2A Active CN107183670B (zh) | 2017-06-08 | 2017-06-08 | 一种增免儿童青少年型多矿多维制剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107183670B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107647411A (zh) * | 2017-10-25 | 2018-02-02 | 太和县三九药业有限公司 | 一种青少年用易吸收多维矿物制剂及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2388581A (en) * | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| CN101721388A (zh) * | 2008-10-27 | 2010-06-09 | 杜凯源 | 含有维生素d3的微囊 |
| CN106539091A (zh) * | 2016-10-29 | 2017-03-29 | 芜湖市诺康生物科技有限公司 | 一种维生素矿物质片及其制备方法 |
-
2017
- 2017-06-08 CN CN201710427394.2A patent/CN107183670B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107183670A (zh) | 2017-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1052865C (zh) | 营养补给组合物 | |
| WO2018077312A1 (zh) | 一种增强免疫力的泡腾片及其制备方法 | |
| CN101390560B (zh) | 椰果冰淇淋及其制备方法 | |
| CN103976023A (zh) | 一种黄秋葵酸乳饮料及其制备方法 | |
| CN102823874A (zh) | 一种石榴泡腾片及其制备方法 | |
| CN103169120A (zh) | 一种西芹百合饮料的制备方法 | |
| CN108208741B (zh) | 一种功能性食用盐、低钠盐及咸味调味料及其制备方法 | |
| CN101390638B (zh) | 椰果奶茶及其制备方法 | |
| CN102349676B (zh) | 一种纳米黑木耳降脂饮料及其制备方法 | |
| CN107361282A (zh) | 一种维生素ce泡腾片及其制备方法 | |
| JPH0272843A (ja) | 糖アルコールを含有するミネラル補給剤 | |
| CN107183670B (zh) | 一种增免儿童青少年型多矿多维制剂及其制备方法 | |
| CN103766919B (zh) | 果汁夹心珠的制作方法 | |
| CN104757689A (zh) | 一种松黄维生素固体饮料及其制备方法 | |
| CN102150708A (zh) | 一种怀山药乳乳酸菌植物蛋白饮料及其制法 | |
| CN105249128A (zh) | 一种维生素b族固体饮料 | |
| CN104305464A (zh) | 蓝莓c+e泡腾片 | |
| AU2020103926A4 (en) | Nutrition-enhanced colostrum tablet candy and preparation method thereof | |
| CN1679628A (zh) | 牦牛骨髓钙片 | |
| CN102919374A (zh) | 一种怀山药植物蛋白饮料及其制法 | |
| CN104667254A (zh) | 一种鱼低聚肽泡腾片及其制备方法 | |
| CN114982882A (zh) | 一种柠檬气泡水饮料 | |
| CN108077893A (zh) | 一种洋葱木耳酱 | |
| CN104413324A (zh) | 一种菠萝蜜香蕉果冻 | |
| CN1303904C (zh) | 橄榄钙片 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 236000 21 Xinhua Road, economic development zone, Yingdong District, Fuyang City, Anhui Province Patentee after: ANHUI QUANKANG PHARMACEUTICAL CO.,LTD. Address before: 236000 Anhui Fuyang Taihe County Chengguan Town Industrial Park West Quankang Pharmaceutical Co.,Ltd. Patentee before: ANHUI QUANKANG PHARMACEUTICAL CO.,LTD. |