CN107162928B - 抗纤维化剂的卤代类似物 - Google Patents

抗纤维化剂的卤代类似物 Download PDF

Info

Publication number
CN107162928B
CN107162928B CN201710172053.5A CN201710172053A CN107162928B CN 107162928 B CN107162928 B CN 107162928B CN 201710172053 A CN201710172053 A CN 201710172053A CN 107162928 B CN107162928 B CN 107162928B
Authority
CN
China
Prior art keywords
optionally substituted
group
groups
alkyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201710172053.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN107162928A (zh
Inventor
达伦·詹姆斯·凯利
斯彭切尔·约翰·威廉斯
史蒂文·扎米特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celta Medical Co Ltd
Original Assignee
Celta Medical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celta Medical Co ltd filed Critical Celta Medical Co ltd
Publication of CN107162928A publication Critical patent/CN107162928A/zh
Application granted granted Critical
Publication of CN107162928B publication Critical patent/CN107162928B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201710172053.5A 2007-12-21 2008-12-19 抗纤维化剂的卤代类似物 Active CN107162928B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1613407P 2007-12-21 2007-12-21
US61/016,134 2007-12-21
PCT/AU2008/001868 WO2009079692A1 (en) 2007-12-21 2008-12-19 Halogenated analogues of anti-fibrotic agents
CN2008801221536A CN102164887A (zh) 2007-12-21 2008-12-19 抗纤维化剂的卤代类似物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2008801221536A Division CN102164887A (zh) 2007-12-21 2008-12-19 抗纤维化剂的卤代类似物

Publications (2)

Publication Number Publication Date
CN107162928A CN107162928A (zh) 2017-09-15
CN107162928B true CN107162928B (zh) 2022-03-11

Family

ID=40800565

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710172053.5A Active CN107162928B (zh) 2007-12-21 2008-12-19 抗纤维化剂的卤代类似物
CN2008801221536A Pending CN102164887A (zh) 2007-12-21 2008-12-19 抗纤维化剂的卤代类似物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2008801221536A Pending CN102164887A (zh) 2007-12-21 2008-12-19 抗纤维化剂的卤代类似物

Country Status (12)

Country Link
US (1) US8624056B2 (https=)
EP (2) EP2220028B1 (https=)
JP (2) JP5730578B2 (https=)
KR (2) KR20160017139A (https=)
CN (2) CN107162928B (https=)
AU (1) AU2008341010B2 (https=)
CA (1) CA2709937C (https=)
MX (2) MX337320B (https=)
NZ (1) NZ584613A (https=)
SG (1) SG10201506526QA (https=)
WO (1) WO2009079692A1 (https=)
ZA (1) ZA201003376B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2035369T3 (da) 2006-07-05 2014-10-06 Fibrotech Therapeutics Pty Ltd Terapeutiske
WO2009079692A1 (en) 2007-12-21 2009-07-02 Fibrotech Therapeutics Pty Ltd Halogenated analogues of anti-fibrotic agents
EP2491030B1 (en) 2009-10-22 2015-07-15 Fibrotech Therapeutics PTY LTD Fused ring analogues of anti-fibrotic agents
MX382978B (es) * 2010-11-24 2025-03-12 Occurx Pty Ltd Método para tratar enfermedades de los ojos asociadas con inflamación o proliferación vascular.
CN110201144B (zh) * 2013-03-15 2024-01-02 得克萨斯州大学系统董事会 用Nutlin-3a和肽抑制肺纤维化
WO2015080943A1 (en) * 2013-11-26 2015-06-04 Yale University Novel cell-penetrating compositions and methods using same
JP6533997B2 (ja) * 2014-12-26 2019-06-26 株式会社ヤクルト本社 Ｚｎｆ１４３阻害活性を有する化合物およびその利用
CA3052036A1 (en) 2017-02-03 2018-08-09 Certa Therapeutics Pty Ltd. Anti-fibrotic compounds
CN110357789B (zh) * 2018-04-11 2022-09-30 华东理工大学 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途
IL305480A (en) * 2021-03-17 2023-10-01 Occurx Pty Ltd Compounds for the treatment of disorders and their salts and polymorphs
CN116730977A (zh) * 2022-03-04 2023-09-12 华东理工大学 新型芳基杂环类化合物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940422A (en) * 1973-01-18 1976-02-24 Kissei Yakuhin Kogyo Kabushiki Kaisha Aromatic carboxylic amide derivatives
EP0074725A1 (en) * 1981-09-01 1983-03-23 Kissei Pharmaceutical Co. Ltd. A method for the production of nuclear substituted cinnamoylanthranilic acid derivatives and intermediates thereof
WO2006087393A2 (en) * 2005-02-21 2006-08-24 Relivia S.R.L. Structural analogues of avenanthramides, their use in compositions useful in the treatment of dermatological disorders

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5830302B2 (ja) * 1974-04-16 1983-06-28 キツセイヤクヒンコウギヨウ カブシキガイシヤ シンキホウコウゾクカルボンサンアミドユウドウタイ ノ セイゾウホウホウ
JPS511440A (ja) * 1974-04-18 1976-01-08 Kissei Pharmaceutical Shinkihokozokukarubonsanjudotai no seizohoho
JPS5848545B2 (ja) 1974-04-18 1983-10-28 キツセイヤクヒンコウギヨウ カブシキガイシヤ シンキホウコウゾクカルボンサンアミドユウドウタイ ノ セイゾウホウホウ
GB1484413A (en) * 1974-04-18 1977-09-01 Kissei Pharmaceutical Aromatic amidocarboxylic acid derivatives
JPS5576852A (en) 1978-12-01 1980-06-10 Hisamitsu Pharmaceut Co Inc Novel derivative of anthranilic acid
JPS5817186B2 (ja) 1981-01-23 1983-04-05 キツセイ薬品工業株式会社 新規芳香族カルボン酸誘導体の製造方法
US4587356A (en) * 1981-09-01 1986-05-06 Kissei Pharmaceutical Co., Ltd. Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives
JPS6019754A (ja) 1983-07-14 1985-01-31 Kissei Pharmaceut Co Ltd 芳香族カルボン酸アミド誘導体の製造方法
JPS60152454A (ja) 1984-01-18 1985-08-10 Terumo Corp アミド誘導体およびこれを有効成分として含有する５−リポキシゲナ−ゼ作用阻害剤
JPH07116029B2 (ja) * 1989-04-04 1995-12-13 キッセイ薬品工業株式会社 トラニラスト水溶液製剤
DK0468054T3 (da) * 1990-02-08 1997-06-16 Eisai Co Ltd Benzensulfonamidderivat
US5248825A (en) * 1990-09-20 1993-09-28 Merrell Dow Pharmaceuticals Inc. Calcium uptake inhibitors
DK0657422T3 (da) * 1993-12-09 1998-10-12 Ono Pharmaceutical Co Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister
NZ331339A (en) 1996-02-15 2001-02-23 Kissei Pharmaceutical Neovascularization inhibitor comprising N-(3, 4-dimethoxycinnamoyl)anthranilic acid
JPH09278653A (ja) 1996-04-05 1997-10-28 Santen Pharmaceut Co Ltd 網膜疾患治療剤
DE19624155A1 (de) 1996-06-18 1998-01-08 Hoechst Ag Substituierte Benzoesäurederivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten
JPH10259129A (ja) 1997-01-16 1998-09-29 Kissei Pharmaceut Co Ltd 血管新生阻害剤
FR2759368B1 (fr) * 1997-02-10 2001-06-01 Galderma Rech Dermatologique Composes biaromatiques, compositions les contenant et utilisations
JPH10306024A (ja) * 1997-03-07 1998-11-17 Kissei Pharmaceut Co Ltd 糸球体疾患の予防および治療剤
JPH10330254A (ja) 1997-04-01 1998-12-15 Kissei Pharmaceut Co Ltd 翼状片の進行および術後の再発抑制剤
US6127392A (en) * 1997-08-05 2000-10-03 American Home Products Corporation Anthranilic acid analogs
DE19935219A1 (de) * 1999-07-27 2001-02-01 Boehringer Ingelheim Pharma Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
AU2002306604B2 (en) * 2001-02-28 2007-09-13 Onconova Therapeutics, Inc. N-(Aryl)-2-arylethenesulfonamides and therapeutic uses thereof
US7429593B2 (en) * 2001-09-14 2008-09-30 Shionogi & Co., Ltd. Utilities of amide compounds
JP4851671B2 (ja) 2001-10-11 2012-01-11 ニチバン株式会社 トラニラスト経皮吸収貼付剤およびその製造方法
MXPA04005427A (es) 2001-12-10 2005-04-19 Amgen Inc Ligandos de receptor vainilloide y su uso en tratamientos.
CN1596240A (zh) * 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
WO2003055847A1 (en) * 2001-12-27 2003-07-10 Taisho Pharmaceutical Co.,Ltd. Carboxylic acid derivative
US7351719B2 (en) * 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
DE10254872A1 (de) * 2002-11-25 2004-06-03 Symrise Gmbh & Co. Kg Anthranilsäureamide und deren Derivate als kosmetische und pharmazeutische Wirkstoffe
US7250444B2 (en) * 2003-08-11 2007-07-31 Pfizer Inc. Pyrrole-based HMG-CoA reductase inhibitors
GB0319126D0 (en) * 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
DE10346913A1 (de) * 2003-10-09 2005-05-04 Merck Patent Gmbh Acylhydrazonderivate
US7592373B2 (en) * 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004030987A1 (de) 2004-06-26 2006-01-12 Merck Patent Gmbh Ortho-substituierte (3-Hydroxyphenyl)-essigsäure-benzyliden-hydrazide
US7671077B2 (en) * 2004-07-19 2010-03-02 Leu-Fen Hou Lin Neuroprotective small organic molecules, compositions and uses related thereto
CA2586156A1 (en) * 2004-11-04 2006-05-18 Merck & Co., Inc. Niacin receptor agonists, compositions containing such compounds and methods of treatment
EP1824469A4 (en) 2004-11-17 2008-07-30 Nuon Therapeutics Pty Ltd METHOD FOR MODULATING B-CELL FUNCTION
JP2008520715A (ja) * 2004-11-23 2008-06-19 メルク エンド カムパニー インコーポレーテッド ナイアシン受容体アゴニスト、そのような化合物を含む組成物、および治療方法
US20060223837A1 (en) 2005-03-24 2006-10-05 Ellen Codd Biaryl derived amide modulators of vanilloid VR1 receptor
KR20080016859A (ko) * 2005-05-16 2008-02-22 앤지오젠 파마슈티칼스 피티와이. 리미티드 통증의 치료를 위한 방법 및 조성물
WO2006134013A1 (en) 2005-06-14 2006-12-21 Symrise Gmbh & Co. Kg Mixtures comprising anthranilic acid amides and cooling agents as cosmetic and pharmaceutical compositions for alleviating itching
WO2007015744A1 (en) 2005-07-21 2007-02-08 Incyte Corporation Disubstituted thienyl compounds and their use as pharmaceuticals
WO2007062957A1 (en) * 2005-11-30 2007-06-07 Symrise Gmbh & Co. Kg Mixtures comprising anthranilic acid amides and antidandruff agents as cosmetic and pharmaceutical compositions for alleviating itching
US20070286892A1 (en) * 2006-06-13 2007-12-13 Uri Herzberg Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals
ES2462925T3 (es) * 2006-06-14 2014-05-26 Symrise Ag Compuestos con efecto antimicrobiano para el tratamiento de fetidez oral
DK2035369T3 (da) * 2006-07-05 2014-10-06 Fibrotech Therapeutics Pty Ltd Terapeutiske
KR100832747B1 (ko) 2006-10-27 2008-05-27 한국화학연구원 아미노피라졸 유도체, 이의 제조 방법 및 이를 함유하는허혈성 질환의 예방 또는 치료용 조성물
EP2089355A2 (en) 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
EP2030617A1 (en) * 2007-08-17 2009-03-04 Sygnis Bioscience GmbH & Co. KG Use of tranilast and derivatives thereof for the therapy of neurological conditions
EP2225214A1 (en) 2007-11-28 2010-09-08 NeuroSearch AS Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators
US20090163586A1 (en) 2007-12-20 2009-06-25 Astrazeneca Ab Bis-(Sulfonylamino) Derivatives in Therapy 205
WO2009079692A1 (en) 2007-12-21 2009-07-02 Fibrotech Therapeutics Pty Ltd Halogenated analogues of anti-fibrotic agents
EP2179984A1 (en) * 2008-10-27 2010-04-28 Congenia S.r.l. Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940422A (en) * 1973-01-18 1976-02-24 Kissei Yakuhin Kogyo Kabushiki Kaisha Aromatic carboxylic amide derivatives
EP0074725A1 (en) * 1981-09-01 1983-03-23 Kissei Pharmaceutical Co. Ltd. A method for the production of nuclear substituted cinnamoylanthranilic acid derivatives and intermediates thereof
WO2006087393A2 (en) * 2005-02-21 2006-08-24 Relivia S.R.L. Structural analogues of avenanthramides, their use in compositions useful in the treatment of dermatological disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Masayuki Isaji等.Selective Inhibition of Collagen Accumulation by N-(3,4-Dimethoxycinnamoyl)anthranilic Acid(N-5’)in Granulation Tissue.《Biochemical Pharmacology》.1987,第36卷(第4期),第469-474页. *
Selective Inhibition of Collagen Accumulation by N-(3,4-Dimethoxycinnamoyl)anthranilic Acid(N-5’)in Granulation Tissue;Masayuki Isaji等;《Biochemical Pharmacology》;19871231;第36卷(第4期);第469-474页 *
有抗疟活性的丙烯酰胺类化合物的合成和三维定量构效关系研究(英文);程卯生等;《药学学报》;20030728;第38卷(第7期);第505-510页 *

Also Published As

Publication number Publication date
EP2220028B1 (en) 2016-03-09
JP2015180624A (ja) 2015-10-15
US8624056B2 (en) 2014-01-07
KR20160017139A (ko) 2016-02-15
JP2011506490A (ja) 2011-03-03
EP2220028A4 (en) 2011-02-16
NZ584613A (en) 2011-07-29
AU2008341010A1 (en) 2009-07-02
AU2008341010B2 (en) 2013-04-18
MX337320B (es) 2016-01-06
CN107162928A (zh) 2017-09-15
SG10201506526QA (en) 2015-09-29
KR101593708B1 (ko) 2016-02-12
ZA201003376B (en) 2011-02-23
CN102164887A (zh) 2011-08-24
CA2709937C (en) 2016-03-22
JP6063985B2 (ja) 2017-01-18
EP3045170A1 (en) 2016-07-20
US20120059188A9 (en) 2012-03-08
WO2009079692A1 (en) 2009-07-02
CA2709937A1 (en) 2009-07-02
MX2010006787A (es) 2010-10-04
EP3045170B1 (en) 2018-07-04
MX372721B (es) 2020-05-11
JP5730578B2 (ja) 2015-06-10
EP2220028A1 (en) 2010-08-25
US20110021815A1 (en) 2011-01-27
KR20100099134A (ko) 2010-09-10

Similar Documents

Publication Publication Date Title
CN107162928B (zh) 抗纤维化剂的卤代类似物
JP6437060B2 (ja) 縮合環類似体の抗線維症剤
WO2010144959A1 (en) Analogues of anti-fibrotic agents
KR100258657B1 (ko) 피롤리딘일 하이드록삼산 화합물 및 그의 제조 방법
JP3826400B2 (ja) ラクタム化合物及びその医薬用途
NO328015B1 (no) Nye hydronaftalenforbindelsen fremstilt ved rhodiumkatalysert ringapningsreaksjon i naervaer av fosfinligand, samt preparater som innbefatter slike forbindelser
US6828345B2 (en) O-substituted 6-methyltramadol derivatives
EP2036887A1 (en) Novel 6-5 bicycic heterocyclic derivative and medical use thereof
HU227558B1 (en) 4-substituted piperidine derivatives and pharmaceutical compositions containing them
JP7478251B2 (ja) イオンチャネルアンタゴニスト／遮断剤およびその用途
CN112745284B (zh) 一种天然查尔酮衍生物及其制备方法和用途
KR101267937B1 (ko) 미토콘드리아 기능 조절제로서의 아릴옥심 유도체
HU196751B (en) Process for production of derivatives of 4-phenil-prophilindole
CN115677703A (zh) 吡啶酮类化合物及其用途
HK1217951B (en) Fused ring analogues of anti-fibrotic agents
CN114591202A (zh) 一种阿魏酸衍生物及制备方法和用途
HK1129897A (en) Novel 6-5 bicycic heterocyclic derivative and medical use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20191031

Address after: Victoria, Australia

Applicant after: CELTA Medical Co., Ltd

Address before: Victoria, Australia

Applicant before: Fibrotech Therapeutics Pty Ltd.

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant