CN107158135A - A kind of externally applied liniment for the treatment of of arthritis and preparation method thereof - Google Patents
A kind of externally applied liniment for the treatment of of arthritis and preparation method thereof Download PDFInfo
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- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：The 74mL of d-Bomeol liquid 70, the 10mL of turpentine oil 8, the 5mL of wintergreen 4, the 5mL of caryophyllus oil 4, the 11mL of auxiliary agent 9；The auxiliary agent is made up of the raw material below according to parts by weight：15 18 parts of prepared rhizome of rehmannia, 8 12 parts of lopseed.The invention also discloses the preparation method of the externally applied liniment of the treatment of arthritis.Externally applied liniment of the present invention can effective treatment of arthritis, reduce the pain of arthritic, effect significantly, and has no toxic side effect, easy to use, is cleaned by external application, is more easy to be received by many patients.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically a kind of externally applied liniment for the treatment of of arthritis and preparation method thereof.
Background technology
Arthritis refers to generation in human synovial and its inflammatory disease of surrounding tissue, can be divided into tens of kinds.The pass of China
The scorching patient of section has more than 100,000,000, and number is being continuously increased.Clinical manifestation is the red, swollen, hot of joint, pain, dysfunction and joint
Deformity, severe patient causes joint deformity, influence patients ' life quality.The medicine of presently disclosed treatment of arthritis is more, wherein
Medicine for oral administration accounts for certain proportion, such as steroids antalgesic and the Chinese patent drug containing toxic ingredient, and they have obvious pair more
Effect can not long term usage；And plaster, vina, powder etc. account for significant proportion in externally applied drug, and flavour of a drug are a lot, to preparation and the upper production of use
Raw inconvenience.In addition, the medicine of existing disclosed treatment of arthritis, the not good defect of generally existing drug effect.
The content of the invention
It is an object of the invention to provide a kind of externally applied liniment for the treatment of of arthritis and preparation method thereof, to solve the above-mentioned back of the body
The problem of being proposed in scape technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：It is right
Revolve borneol liquid 70-74mL, turpentine oil 8-10mL, wintergreen 4-5mL, caryophyllus oil 4-5mL, auxiliary agent 9-11mL；The auxiliary agent by with
Under be made according to the raw material of parts by weight：15-18 parts of prepared rhizome of rehmannia, 8-12 parts of lopseed.
It is used as further scheme of the invention：The raw material composition of externally applied liniment per 100mL treatment of arthritis is as follows：Dextrorotation
Borneol liquid 72mL, turpentine oil 9mL, wintergreen 4.5mL, caryophyllus oil 4.5mL, auxiliary agent 10mL；The auxiliary agent is by below according to weight
The raw material of part is made：17 parts of prepared rhizome of rehmannia, 10 parts of lopseed.
It is used as further scheme of the invention：The d-Bomeol liquid is passed through using the fresh branches and leaves of canella borneol camphor tree
Extraction is processed into.
The preparation method of the externally applied liniment of the treatment of arthritis, step is as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 30-50 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 10-12 times of weight, soak 2-3h, heating and refluxing extraction
1-2h, obtains an extract solution and once extracts residue, collect an extract solution, will once extract residue and add 6-8 times again
The alcoholic solution of weight, soaks 1-2h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, collects two
Secondary extract solution, an extract solution and secondary raffinate is merged, filtering, obtains reflux extracting liquid, standby；
3) it is relative density is 1.28-1.30 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added
In the alcoholic solution of 2-3 times of weight, stir evenly, stand 36-40h, filtration takes filtrate, you can obtain auxiliary agent；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, be well mixed, produced treatment and close
Save scorching externally applied liniment.
It is used as further scheme of the invention：Step 2) in, the alcoholic solution is the alcohol water of volumetric concentration 65%
Solution.
It is used as further scheme of the invention：Step 3) in, the alcoholic solution is the alcohol water of volumetric concentration 90%
Solution.
Compared with prior art, the beneficial effects of the invention are as follows：
Externally applied liniment of the present invention can effective treatment of arthritis, reduce the pain of arthritic, effect is significantly, and nontoxic
Side effect, it is easy to use, cleaned by external application, be more easy to be received by many patients；Externally applied liniment of the present invention, prescription letter
It is single, easily manufacture, it is easy to promote.
Embodiment
Technical scheme is described in more detail with reference to embodiment.
Embodiment 1
A kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：It is right
Revolve borneol liquid 70mL, turpentine oil 10mL, wintergreen 5mL, caryophyllus oil 5mL, auxiliary agent 10mL；The auxiliary agent is by below according to parts by weight
Raw material be made：15 parts of prepared rhizome of rehmannia, 8 parts of lopseed；Wherein, the d-Bomeol liquid uses the fresh branch of canella borneol camphor tree
Leaf is extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment of arthritis, step is as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 30 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 10 times of weight, soaked 2h, heating and refluxing extraction 1h, obtain
Obtain an extract solution and once extract residue, collect an extract solution, will once extract the alcohol that residue adds 6 times of weight again
Solution, soaks 1h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, secondary raffinate is collected, by one
Secondary extract solution and secondary raffinate merge, filtering, obtain reflux extracting liquid, standby, wherein, the alcoholic solution is volumetric concentration
65% alcohol water blend；
3) it is relative density is 1.28 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added into 2 times of weights
In the alcoholic solution of amount, stir evenly, stand 36h, filtration takes filtrate, you can obtain auxiliary agent, wherein, the alcoholic solution is volume
The alcohol water blend of concentration 90%；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, be well mixed, produced treatment and close
Save scorching externally applied liniment.
Embodiment 2
A kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：It is right
Revolve borneol liquid 74mL, turpentine oil 8mL, wintergreen 4mL, caryophyllus oil 4mL, auxiliary agent 10mL；The auxiliary agent is by below according to parts by weight
Raw material be made：16 parts of prepared rhizome of rehmannia, 9 parts of lopseed；Wherein, the d-Bomeol liquid uses the fresh branch of canella borneol camphor tree
Leaf is extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment of arthritis, step is as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 35 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 10 times of weight, soak 2.5h, heating and refluxing extraction 1h,
Obtain an extract solution and once extract residue, collect an extract solution, will once extract the wine that residue adds 6 times of weight again
Smart solution, soaks 1.5h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, collects secondary raffinate,
Extract solution and secondary raffinate are merged, filtering, obtain reflux extracting liquid, it is standby, wherein, the alcoholic solution is volume
The alcohol water blend of concentration 65%；
3) it is relative density is 1.28 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added into 2 times of weights
In the alcoholic solution of amount, stir evenly, stand 37h, filtration takes filtrate, you can obtain auxiliary agent, wherein, the alcoholic solution is volume
The alcohol water blend of concentration 90%；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, be well mixed, produced treatment and close
Save scorching externally applied liniment.
Embodiment 3
A kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：It is right
Revolve borneol liquid 72mL, turpentine oil 9mL, wintergreen 4.5mL, caryophyllus oil 4.5mL, auxiliary agent 10mL；The auxiliary agent is by below according to weight
The raw material of amount part is made：17 parts of prepared rhizome of rehmannia, 10 parts of lopseed；Wherein, the d-Bomeol liquid is using canella borneol camphor tree
Fresh branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment of arthritis, step is as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 40 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 11 times of weight, soak 2.5h, heating and refluxing extraction
1.5h, obtains an extract solution and once extracts residue, collect an extract solution, will once extract residue and add 7 times of weights again
The alcoholic solution of amount, soaks 1.5h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, collects secondary
Extract solution, an extract solution and secondary raffinate is merged, filtering, obtains reflux extracting liquid, standby, wherein, the alcohol is molten
Liquid is the alcohol water blend of volumetric concentration 65%；
3) it is relative density is 1.29 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added into 2.5 times
In the alcoholic solution of weight, stir evenly, stand 38h, filtration takes filtrate, you can obtain auxiliary agent, wherein, the alcoholic solution is body
The alcohol water blend of product concentration 90%；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, be well mixed, produced treatment and close
Save scorching externally applied liniment.
Embodiment 4
A kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：It is right
Revolve borneol liquid 72mL, turpentine oil 10mL, wintergreen 4.5mL, caryophyllus oil 4.5mL, auxiliary agent 9mL；The auxiliary agent is by below according to weight
The raw material of amount part is made：17 parts of prepared rhizome of rehmannia, 12 parts of lopseed；Wherein, the d-Bomeol liquid is using canella borneol camphor tree
Fresh branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment of arthritis, step is as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 45 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 11 times of weight, soak 3h, heating and refluxing extraction 1.5h,
Obtain an extract solution and once extract residue, collect an extract solution, will once extract the wine that residue adds 7 times of weight again
Smart solution, soaks 2h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, collects secondary raffinate, will
Extract solution and secondary raffinate merge, filtering, obtain reflux extracting liquid, standby, wherein, the alcoholic solution is that volume is dense
The alcohol water blend of degree 65%；
3) it is relative density is 1.30 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added into 3 times of weights
In the alcoholic solution of amount, stir evenly, stand 39h, filtration takes filtrate, you can obtain auxiliary agent, wherein, the alcoholic solution is volume
The alcohol water blend of concentration 90%；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, be well mixed, produced treatment and close
Save scorching externally applied liniment.
Embodiment 5
A kind of externally applied liniment for the treatment of of arthritis, the raw material composition of the externally applied liniment per 100mL treatment of arthritis is as follows：It is right
Revolve borneol liquid 71mL, turpentine oil 9mL, wintergreen 4.5mL, caryophyllus oil 4.5mL, auxiliary agent 11mL；The auxiliary agent is by below according to weight
The raw material of amount part is made：18 parts of prepared rhizome of rehmannia, 12 parts of lopseed；Wherein, the d-Bomeol liquid is using canella borneol camphor tree
Fresh branches and leaves are extracted to be processed into.
In the present embodiment, the preparation method of the externally applied liniment of the treatment of arthritis, step is as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 50 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 12 times of weight, soaked 3h, heating and refluxing extraction 2h, obtain
Obtain an extract solution and once extract residue, collect an extract solution, will once extract the alcohol that residue adds 8 times of weight again
Solution, soaks 2h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, secondary raffinate is collected, by one
Secondary extract solution and secondary raffinate merge, filtering, obtain reflux extracting liquid, standby, wherein, the alcoholic solution is volumetric concentration
65% alcohol water blend；
3) it is relative density is 1.30 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added into 3 times of weights
In the alcoholic solution of amount, stir evenly, stand 40h, filtration takes filtrate, you can obtain auxiliary agent, wherein, the alcoholic solution is volume
The alcohol water blend of concentration 90%；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, be well mixed, produced treatment and close
Save scorching externally applied liniment.
Externally applied liniment of the present invention as major ingredient, contains 28 kinds of active ingredients, energy using d-Bomeol liquid in d-Bomeol liquid
Enough anti-inflammatory, analgesic, detumescence, promoting blood circulation and removing blood stasis, penetration by force, auxiliary material, winter is used as using wintergreen, turpentine oil, caryophyllus oil and auxiliary agent
Blue or green oil can stimulate the circulation of the blood and cause the muscles and joints to relax, and increase blood circulation, and analgesic antiphlogistic, compatibility d-Bomeol liquid energy enough strengthens infiltration dynamics, turpentine oil
Can permeate capillary, anti-inflammatory, qualcomm meridian, blood-activating analgetic, caryophyllus oil compatibility d-Bomeol liquid anti-inflammatory analgetic, absorption function and
Grain is dredged, auxiliary agent can strengthen the externally applied liniment to arthritic therapeutic effect.
176 arthritics are treated, effective percentage reaches more than 90%, and effect is notable by externally applied liniment of the present invention.
Externally applied liniment of the present invention can effective treatment of arthritis, reduce the pain of arthritic, effect is significantly, and nontoxic
Side effect, it is easy to use, cleaned by external application, be more easy to be received by many patients；Externally applied liniment of the present invention, prescription letter
It is single, easily manufacture, it is easy to promote.
The better embodiment to the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
, can also be on the premise of present inventive concept not be departed from formula, the knowledge that one skilled in the relevant art possesses
Various changes can be made.
Claims (6)
1. a kind of externally applied liniment for the treatment of of arthritis, it is characterised in that per the raw material group of the externally applied liniment of 100mL treatment of arthritis
Into as follows：D-Bomeol liquid 70-74mL, turpentine oil 8-10mL, wintergreen 4-5mL, caryophyllus oil 4-5mL, auxiliary agent 9-11mL；It is described
Auxiliary agent is made up of the raw material below according to parts by weight：15-18 parts of prepared rhizome of rehmannia, 8-12 parts of lopseed.
2. the externally applied liniment for the treatment of of arthritis according to claim 1, it is characterised in that per 100mL treatment of arthritis
The raw material composition of externally applied liniment is as follows：D-Bomeol liquid 72mL, turpentine oil 9mL, wintergreen 4.5mL, caryophyllus oil 4.5mL, auxiliary agent
10mL；The auxiliary agent is made up of the raw material below according to parts by weight：17 parts of prepared rhizome of rehmannia, 10 parts of lopseed.
3. the externally applied liniment for the treatment of of arthritis according to claim 1, it is characterised in that the d-Bomeol liquid uses camphor tree
The fresh branches and leaves of section plant borneol camphor tree are extracted to be processed into.
4. a kind of preparation method of the externally applied liniment for the treatment of of arthritis as described in claim 1-3 is any, it is characterised in that step
It is rapid as follows：
1) prepared rhizome of rehmannia, lopseed are weighed, is cleaned, is dried, is crushed, 30-50 mesh sieves are crossed, merged, mixture is obtained；
2) mixture is put into container, adds the alcoholic solution of 10-12 times of weight, soak 2-3h, heating and refluxing extraction 1-2h,
Obtain an extract solution and once extract residue, collect an extract solution, once extraction residue is added into 6-8 times of weight again
Alcoholic solution, soaks 1-2h, heating and refluxing extraction 0.5h, obtains secondary raffinate and second extraction residue, collects second extraction
Liquid, an extract solution and secondary raffinate is merged, filtering, obtains reflux extracting liquid, standby；
3) it is relative density is 1.28-1.30 at 60 DEG C lotion to be concentrated by evaporation reflux extracting liquid, and lotion is added into 2-3 times
In the alcoholic solution of weight, stir evenly, stand 36-40h, filtration takes filtrate, you can obtain auxiliary agent；
4) d-Bomeol liquid, turpentine oil, wintergreen, caryophyllus oil and auxiliary agent are taken according to formula, is well mixed, produces treatment of arthritis
Externally applied liniment.
5. the preparation method of the externally applied liniment for the treatment of of arthritis according to claim 4, it is characterised in that step 2) in,
The alcoholic solution is the alcohol water blend of volumetric concentration 65%.
6. the preparation method of the externally applied liniment for the treatment of of arthritis according to claim 4, it is characterised in that step 3) in,
The alcoholic solution is the alcohol water blend of volumetric concentration 90%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1029346B1 (en) * | 2021-09-16 | 2022-11-25 | Jiangxi Wenxu Biological Tech Co Ltd | ARTHRITIS TINCTURE AND PROCESS OF PRODUCTION |
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| CN103251750A (en) * | 2013-06-06 | 2013-08-21 | 韩太顺 | Externally applied medicinal oil for treating middle-aged and old-aged rheumatic diseases |
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| 赵一等: ""卢荣初止痛油"的药效学实验研究", 《广西中医学院学报》 * |
| 马汴梁: "《常见病中医小方手册》", 31 March 2014, 金盾出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1029346B1 (en) * | 2021-09-16 | 2022-11-25 | Jiangxi Wenxu Biological Tech Co Ltd | ARTHRITIS TINCTURE AND PROCESS OF PRODUCTION |
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