CN103251750A - Externally applied medicinal oil for treating middle-aged and old-aged rheumatic diseases - Google Patents

Abstract

The invention relates to a traditional Chinese medicine and a preparation method thereof and in particular relates to externally applied medicinal oil for treating middle-aged and old-aged rheumatic diseases. The externally applied medicinal oil comprises the following components: peppermint oil, wintergreen oil, turpentine oil, pseudo-ginseng, garden balsam stem, borneol, garden balsam, radix aconiti, radix aconiti agrestis, saffron crocus, radix angelicae pubescentis, and ginseng. The preparation method of the externally applied medicinal oil comprises the following steps of: (A), crushing and uniformly mixing a part of solid components to obtain raw material powder; (B), wrapping the raw material powder by using cotton gauze, immersing the raw material powder in an ethanol solution, and immersing to obtain a medicinal stock solution; and (C), adding the wintergreen oil, the peppermint oil and the turpentine oil into the medicinal stock solution, and uniformly stirring to obtain the externally applied medicinal oil for treating middle-aged and old-aged rheumatic diseases. Various components are organically combined in the medicinal oil; pharmacological actions of various components are sufficiently played; and the externally applied medicinal oil disclosed by the invention has the effects of promoting local blood circulation, relieving swelling, stopping pain, improving arthrocele, pain and rigidity, and reducing systemic symptoms and has the advantages of being treated both in symptoms and root causes, safe, effective and low in side effect.

Description

A kind of medicine for external use oil for the treatment of person in middle and old age's rheumatism

Technical field

The present invention relates to a kind of Chinese medicine medicine and preparation method thereof, especially a kind of medicine for external use oil for the treatment of person in middle and old age's rheumatism.

Background technology

Rheumatism is that a kind of joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue of invading is main disease, and wherein majority is autoimmune disease.Rheumatism has arthropathy and symptom mostly, can be up to 70-80%, and about 50% only has pain, heavy then red, swollen, hot, pain and the performance of function inflammation comprehensively such as impaired; Mostly being multi-joint gets involved.Invade and the joint is neglected disease greatly and planted and difference arranged; Same rheumatism has different subtype, and owing to genetic background, pathogenic factor difference, mechanism is also different, thereby the type of clinical manifestation, symptom, weight and therapeutic response also are not quite similar; Mostly rheumatism is to invade the disease of multisystem, and the pathology of numerous disease has overlapping more, and symptom is similar; Occur multiple antibody and immune complex in rheumatisant's the serum, and can be deposited in tissue or the organ pathogenic.Diagnosis and treatment all acquire a certain degree of difficulty.Modern medicine thinks that rheumatismal pathogenic factor can be summed up as multiple factors such as immunoreation, genetic background, infective agent, endocrine factor, environment and physical factor.The medicine for the treatment of rheumatism can be divided into following a few class: 1. nonsteroidal anti-inflammatory agent (NSAIDs): the effect of this type of medicine, be mainly analgesic, antiinflammatory and analgesia, and reach reduce inflammation reaction and purpose.Be that aspirin (aspirin) is so far still for treating the active drug of acute rheumatic fever and rheumatic arthritis the earliest.Produced various salicylic acid medicines afterwards, commonly used have ibuprofen, diclofenac, indomethacin, piroxicam, a naproxen etc.2. adrenocortical hormone: mainly refer to glucocorticoid, because this class medicine has antiinflammatory and immunosuppressive action, have more by force and diminish inflammation fast and various symptoms that inflammatory reaction brings, as heating, arthroncus and pain.So to various rheumatism, often be used as the first line medicine.That uses clinically has fugitive, middle effect and a preparation such as long-acting.Usage has oral, muscle or intraarticular injection, and intravenous injection can be according to the disease kind, and the state of an illness is done different selections.But because it is not the radical cure medicine, long-term a large amount of uses can be brought out infection, osteoporosis, femur head necrosis, diabetes, peptic ulcer, hypertension, psychological problem etc.; And as the too fast easy generation state of an illness rebound phenomenon of drug withdrawal.3. the antirheumatic (DMARDs) that improves the state of an illness is called again and acts on antirheumatic slowly.This type of medicine comprises numerous species structure difference, the different medicine of effect.Their general character is that onset is slow, and certain cumulative action is arranged, so after the drug withdrawal, effect disappears also slower, still can keep a period of time.They there is no direct anti-inflammatory analgetic effect, but can play antiinflammatory and immunity or immunosuppressive action by different mechanism.Thereby, also can improve arthroncus, pain, stiff and mitigation system symptom reduces acute phase reactive protein, erythrocyte sedimentation rate.Longer as service time, also can improve other immune indexes, as RF, ANA etc.The irradiation image that still can make that has improves.The medicine of DMARDs class includes antimalarial-chloroquine, oxychloroquine, sulfasalazine, methotrexate, azathioprine, ring phosphinylidyne ammonia, penicillamine, golden preparation, ciclosporin A and leflunomide.The toxic action that the internal organs that above-mentioned these medicines are wanted body weight for humans (liver, kidney, bladder, lung, gastrointestinal, gonad) and tissue (bone marrow) are had nothing in common with each other.

Summary of the invention

The purpose of this invention is to provide medicine for external use oil of the little treatment person in middle and old age rheumatism of a kind of good effect, side effect and preparation method thereof.

A kind of medicine for external use oil for the treatment of person in middle and old age's rheumatism of the present invention is characterized in that comprising the composition of following parts by weight: Oleum menthae 10, wintergreen oil 30, Oleum Terebinthinae 30, Radix Notoginseng 10, Herba speranskiae tuberculatae 2, Borneolum Syntheticum 2, Flos Impatientis 2, Radix Aconiti 2, Radix Aconiti Kusnezoffii 2, Stigma Croci 2, Radix Angelicae Pubescentis 2, Radix Ginseng 4.

The preparation method of the medicine for external use oil for the treatment of person in middle and old age rheumatism according to claim 1 is characterized in that making step is as follows:

A) the solid composition of following parts by weight is pulverized and mix homogeneously, obtained material powder

Radix Notoginseng 10, Herba speranskiae tuberculatae 2, Borneolum Syntheticum 2, Flos Impatientis 2, Radix Aconiti 2, Radix Aconiti Kusnezoffii 2, Stigma Croci 2, Radix Angelicae Pubescentis 2, Radix Ginseng 4;

B) the above-mentioned raw materials powder is wrapped up with cotton cloth, immerse 90-150 weight portion, concentration and be in 80% the alcoholic solution, soaked 7-10 days, take out filter and wrap and use the pressure filter filter pressing, pressing filtering liquid is mixed with soak, obtain medicine stock solution;

C) wintergreen oil with 20 weight portions adds in the said medicine stock solution, stir, left standstill 2-6 hour, and then add the wintergreen oil of 10 weight portions and the Oleum menthae of 10 weight portions, and stir, left standstill 20-24 hour, the Oleum Terebinthinae that adds 30 weight portions again, stir, left standstill 3-5 days, obtain the medicine for external use oil of described treatment person in middle and old age rheumatism.

Oleum menthae: for fresh stem and the Ye Jing vapor distillation of labiate Herba Menthae gets oily.Be colourless or flaxen supernatant liquid.Special refrigerant fragrance is arranged, and flavor is hot, back cold just.Deposit with the passing of time, the color gradual change is dark.Oleum menthae in the traditional Chinese medical science as aromatic drug, remedium corrigens and carminative.Can be used for skin or mucosa produces refrigerant sense and is not suitable for main pain to alleviate.

Wintergreen oil: i.e. methyl salicylate, colourless to faint yellow or blush oily liquids, have the Ilicis Purpureae flavor.Main as spice ingredients, analgesic, insecticide, polish, printing ink etc.

Oleum Terebinthinae: be the terpenes mixture, Main Ingredients and Appearance is pinene.Can make from Colophonium, pine torch or the processing of sulfate process Masson Pine pulp gas condensed fluid.Have the enhancement local blood circulation, alleviate swelling and slight analgesic effect.Can be used for alleviating myalgia, arthralgia, neuralgia and sprain.

Radix Notoginseng: having another name called Radix Notoginseng, is the dry root of panax araliaceae plant.Have good hemostasia effect, significant hemopoietic function, can tighten and improve the arteria coronaria microcirculation, the effect of blood vessel dilating; Stronger analgesic activity is arranged, the effect that have resisting fatigue, improves the learning and memory ability; Anti-inflammatory effect; Effect with immunomodulator can make too high or too low immunoreation return to normally, but the not normal immunoreation of interference body; Antitumor action; Defying age, antioxidation; Blood fat reducing and cholesterol effect.

Herba speranskiae tuberculatae: have another name called distiller grass, Staggergrass etc., perennial herb, the part of being used as medicine is the plant herb.Blood circulation promoting and blood stasis dispelling, diuresis detoxifcation, the deep effect of stimulating the menstrual flow are arranged.

Borneolum Syntheticum: having another name called Borneolum Syntheticum, sheet brain, Fructus Citri tangerinae sheet, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., is that resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum extracts the crystallization that obtains, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.It can be used for for the excess syndrome of stroke coma, is used for conjunctival congestion and swelling pain, the sore throat aphtha, is used for skin infection and swells and ache, and does not hold back after bursting etc.

Flos Impatientis: another name: Flos Impatientis, Herba speranskiae tuberculatae, buttercup, spill JINHUA, water caltrop water caltrop grass, Semen Impatientis, Hai Nahua, false Flos persicae, little pink.Flower is used as medicine, and traumatic injury is controlled in the relieving distension of can invigorating blood circulation; Spend outer putting on the skin can control tinea manuum, can remove bromhidrosis again; The seed soft extracts is put on the skin outward, can control numbness and ache.Promoting blood circulation to restore menstrual flow, wind-expelling pain-stopping, external detoxifcation; Be used for amenorrhea, traumatic injury, swelling and pain due to blood stasis, rheumatic arthritis, carbuncle furuncle furuncle, venom, the tinea manuum.

Radix Aconiti, Radix Aconiti Kusnezoffii: be all ranunculaceae plant, Radix Aconiti is that dry parent root, the Radix Aconiti Kusnezoffii of Aconitum carmichjaelii Debx. is the dried root of Aconitum kusnezoffii Reichb, its nature and flavor suffering, hardship, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.

Stigma Croci: claiming Stigma Croci, Stigma Croci again, is the dry stigma of Iridaceae perennial grass wood plant Stigma Croci.Have the powerful physical activity, calmness is arranged, eliminate the phlegm, spasmolysis, sweet in flavor and cold in property, effects such as blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia are similar to Flos Carthami, but effect is stronger.In addition, Stigma Croci also has the effect of removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization, is commonly used to diseases such as the treatment melancholy is unhappy, palpitation with fear is gone mad.

Radix Angelicae Pubescentis:Dry root for the heavy peristome Radix Angelicae Sinensis of samphire.Its acrid in the mouth, hardship, tepor.Has expelling wind and dampness; The effect of dispersing cold for relieving pain.Be used for anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, headache toothache.

Radix Ginseng: another name SHANSHEN, Park Ginseng, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), wooden club, Rhizoma Panacis Japonici, SHENCAO, Sphallerocarpus gracilis, Herba Wedeliae Wallichii, Herba Stellariae Saxatilis etc.Dry root for the Araliaceae Radix Ginseng.Has the multiple health preserving effect that gets rid of illness.Tradition pharmacopeia record, Radix Ginseng can consolidate Hui Yuan, protect that life is kept fit, life lengthening.

The medicine for external use oil of this treatment person in middle and old age rheumatism organically combines above-mentioned various compositions, give full play to the pharmacological action of various compositions, have the local blood circulation of enhancement, alleviate swelling and analgesic effect, played the effect of improving arthroncus, pain, stiff and mitigation system symptom, the method treating both the principal and secondary aspects of a disease, safety, effective, side effect is little.Selected for 100 example ages in the test of 40-75 year patient clinical comparison at random, rheumatic arthritis patient 50 people wherein, rheumatoid patient 15 people, scapulohumeral periarthritis patient 15 people, reactive arthritis 20 people, medication oil massage cooperates course for the treatment of of hot compression therapy, produce effects is 65 examples, effectively is 25 examples; After treating two courses for the treatment of, produce effects is 85 examples, effectively is 15 examples.

The specific embodiment

Embodiment 1:

A kind of medicine for external use oil for the treatment of person in middle and old age's rheumatism of the present invention comprises the composition of following parts by weight: Oleum menthae 10, wintergreen oil 30, Oleum Terebinthinae 30, Radix Notoginseng 10, Herba speranskiae tuberculatae 2, Borneolum Syntheticum 2, Flos Impatientis 2, Radix Aconiti 2, Radix Aconiti Kusnezoffii 2, Stigma Croci 2, Radix Angelicae Pubescentis 2, Radix Ginseng 4.

The preparation method of the medicine for external use oil of above-mentioned treatment person in middle and old age rheumatism is as follows:

A) the solid composition of following parts by weight is pulverized and mix homogeneously, obtained material powder

Radix Notoginseng 10, Herba speranskiae tuberculatae 2, Borneolum Syntheticum 2, Flos Impatientis 2, Radix Aconiti 2, Radix Aconiti Kusnezoffii 2, Stigma Croci 2, Radix Angelicae Pubescentis 2, Radix Ginseng 4;

B) the above-mentioned raw materials powder is wrapped up with cotton cloth, immerse 90-150 weight portion, concentration and be in 80% the alcoholic solution, soaked 7-10 days, take out filter and wrap and use the pressure filter filter pressing, pressing filtering liquid is mixed with soak, obtain medicine stock solution;

C) wintergreen oil with 20 weight portions adds in the said medicine stock solution, stir, left standstill 2-6 hour, and then add the wintergreen oil of 10 weight portions and the Oleum menthae of 10 weight portions, and stir, left standstill 20-24 hour, the Oleum Terebinthinae that adds 30 weight portions again, stir, left standstill 3-5 days, obtain the medicine for external use oil of described treatment person in middle and old age rheumatism.

For preventing photochemical reaction, adopt the Brown Glass Brown glass bottles and jars only encapsulation.During use, every day, the medicine for external use oil with above-mentioned treatment person in middle and old age rheumatism spread upon the affected part, and cooperated hot compress and massage, made drug effect see through skin and was absorbed by the body.Per 7 days is a course for the treatment of.

Patient Song, the woman, 46 years old, because of local climate cold, suffered from rheumatic arthritis 20 years, knee joint, articulations digitorum manus stiffness and deforming, pain unbearably can't operate as normal.Adopt the present embodiment medicine to cooperate hot compress and massage treatment, once a day, 7 times is a course for the treatment of.After treating 1 course for the treatment of, the ankylosis state takes a turn for the better to some extent; Pain obviously alleviates after 2 courses for the treatment of, and the skin at swelling position recovers natural gloss, recovered part function of joint; Pain disappears substantially after 3 courses for the treatment of, can be engaged in simple muscle power work.

Patient Korea Spro, the man, 76 years old, be engaged in building operation in one's early years, suffered from the fatigability scapulohumeral periarthritis 30 years, arm is raised and can not be surpassed 45 degree, and the pain relieving of throughout the year forcing on adopts the present embodiment medicine to cooperate hot compress and massage treatment, and once a day, 7 times is a course for the treatment of.After treating 1 course for the treatment of, readme pain obviously alleviates; Pain disappears substantially after 3 courses for the treatment of, arm can lift with take on fair.

Claims (2)

1. medicine for external use oil for the treatment of person in middle and old age's rheumatism is characterized in that comprising the composition of following parts by weight: Oleum menthae 10, wintergreen oil 30, Oleum Terebinthinae 30, Radix Notoginseng 10, Herba speranskiae tuberculatae 2, Borneolum Syntheticum 2, Flos Impatientis 2, Radix Aconiti 2, Radix Aconiti Kusnezoffii 2, Stigma Croci 2, Radix Angelicae Pubescentis 2, Radix Ginseng 4.

2. the medicine for external use oil for the treatment of according to claim 1 person in middle and old age rheumatism is characterized in that making step is as follows:

A) the solid composition of following parts by weight is pulverized and mix homogeneously, obtained material powder

Radix Notoginseng 10, Herba speranskiae tuberculatae 2, Borneolum Syntheticum 2, Flos Impatientis 2, Radix Aconiti 2, Radix Aconiti Kusnezoffii 2, Stigma Croci 2, Radix Angelicae Pubescentis 2, Radix Ginseng 4;

B) the above-mentioned raw materials powder is wrapped up with cotton cloth, immerse 90-150 weight portion, concentration and be in 80% the alcoholic solution, soaked 7-10 days, take out filter and wrap and use the pressure filter filter pressing, pressing filtering liquid is mixed with soak, obtain medicine stock solution;

C) wintergreen oil with 20 weight portions adds in the said medicine stock solution, stir, left standstill 2-6 hour, and then add the wintergreen oil of 10 weight portions and the Oleum menthae of 10 weight portions, and stir, left standstill 20-24 hour, the Oleum Terebinthinae that adds 30 weight portions again, stir, left standstill 3-5 days, obtain the medicine for external use oil of described treatment person in middle and old age rheumatism.