CN102552812A - Traumatic injury curative for external use and production method thereof - Google Patents

Traumatic injury curative for external use and production method thereof Download PDF

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Publication number
CN102552812A
CN102552812A CN2012100247912A CN201210024791A CN102552812A CN 102552812 A CN102552812 A CN 102552812A CN 2012100247912 A CN2012100247912 A CN 2012100247912A CN 201210024791 A CN201210024791 A CN 201210024791A CN 102552812 A CN102552812 A CN 102552812A
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mass parts
radix
rhizoma
traumatic injury
jiulongchuan
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CN102552812B (en
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黎忠文
林琼芳
袁华军
李开静
陈武
杨德炎
何忠
何科
吴勇梅
吴越
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YULIN ORTHOPAEDIC HOSPITAL
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YULIN ORTHOPAEDIC HOSPITAL
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Abstract

The invention discloses a traumatic injury curative for external use and a production method thereof. The traumatic injury curative for external use comprises shinyleaf prickly ash root, giant knotweed, hiraute shiny bugleweed herb, safflower, giantleaf ardisia rhizome, Chinese silkvine root-bark, coral ardisia root, Ardisia hancana, Radix araliae armatae, Jiulongchuan, curcuma zedoary, Securidaca inappendieulata Hassk and Radix et Caulis Ventilaginis leiocarpae. The production method comprises the following production steps of: (1) preparing all the medicines in proportion; (2) processing the medicines into decoction pieces and placing into a wine jar after uniform mixing; (3) adding 1000g of rice wine with the alcohol content being 46%, sealing and dipping, stirring once a day, stirring once a week after seven days, and dipping for more than two mouths; and (4) extracting supernatant, squeezing dregs of a decoction, mixing squeezed liquid with the supernatant, filtering through a 80-mesh sieve No. 5, clarifying and sub-packaging, and obtaining the traumatic injury curative. The traumatic injury curative disclosed by the invention has an obvious and stable therapy effect particularly for a patient suffered from a closed injury, and is convenient to use, simple in production technology, stable in quality of a finished product, and low in cost.

Description

Wipe with medicine for treating traumatic injury and production method thereof outward
Technical field
Patent of the present invention relates to a kind of linear Chinese medicine composition that is used to treat traumatic injury, soft tissue injury, fracture, more particularly, relates to a kind of outer wiping and is used to treat medicine for treating traumatic injury and production method thereof.
Background technology
At present, on the pharmaceutical market of treatment traumatic injury, soft tissue injury, the Chinese medicine medicated wine agent that is used for outer wiping treatment is few.Particularly the Chinese medicine medicated wine of pure Chinese medicine still less, but extensive, and clinical efficacy is remarkable, receives patient's welcome deeply in the clinical practice of orthopaedics training.Therefore people urgently hope to develop a kind of treatment traumatic injury, and soft tissue injury, fracture reach the outer wiping that reducing swelling and alleviating pain soon, can not cause side effect and use medicine for treating traumatic injury.
Summary of the invention
The object of the present invention is to provide a kind of pure Chinese medicine, instant effect, can not cause that the outer wiping of side effect uses medicine for treating traumatic injury.Particularly will reach traumatic injury, soft tissue injury, to play reducing swelling and alleviating pain fast for fracture, the outer wiping Chinese medicine medicated wine and the production method of satisfactory effect.
The inventor uses the traditional Chinese medical science, Chinese medicine rationale in order to achieve the above object, aspect the medication of the side of choosing, has carried out deep research and experiment.The result finds; The pharmaceutical composition that utilization is formed in specific ratio with Radix Zanthoxyli, Rhizoma Polygoni Cuspidati, Herba Lycopi, Flos Carthami, Rhizoma Ardisiae Gigantifoliae, Cortex Periplocae, Zhu Shagen, DALUOSAN, Radix araliae armatae, JIULONGCHUAN, Rhizoma Curcumae, five tastes rattan, red Radix Cudraniae etc. 13 flavor and 46 ° of rice wine can reach blood circulation promoting and blood stasis dispelling through outer wiping; Reducing swelling and alleviating pain; The effect of relaxing muscles and tendons and activating QI and blood in the collateral can be improved patient's clinical sign, symptom more effectively.Thereby make the local reducing swelling and alleviating pain of patient, the reduction of the fracture is good, thereby because this result of the test has been accomplished the present invention.
Technical scheme of the present invention is following:
1. outer a wiping used medicine for treating traumatic injury, it is characterized in that wherein the proportioning of various material compositions is following: Radix Zanthoxyli 10-30 mass parts, Rhizoma Polygoni Cuspidati 10-30 mass parts, Herba Lycopi 5-20 mass parts, Flos Carthami 5-20 mass parts, Rhizoma Ardisiae Gigantifoliae 10-30 mass parts, Cortex Periplocae 10-30 mass parts, Radix Ardisiae Crenatae 10-30 mass parts, DALUOSAN 10-30 mass parts, Radix araliae armatae 10-30 mass parts, JIULONGCHUAN 5-20 mass parts, Rhizoma Curcumae 5-20 mass parts, five tastes rattan 5-20 mass parts, red Radix Cudraniae 10-30 mass parts.
2. use medicine for treating traumatic injury like technical scheme 1 described outer the wiping, it is characterized in that wherein the proportioning of various material compositions is following: Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts.
3. like a kind of outer production method of wiping with medicine for treating traumatic injury; It is characterized in that this method comprises following step: (1) is ready to Radix Zanthoxyli 10-30 mass parts, Rhizoma Polygoni Cuspidati 10-30 mass parts, Herba Lycopi 5-20 mass parts, Flos Carthami 5-20 mass parts, Rhizoma Ardisiae Gigantifoliae 10-30 mass parts, Cortex Periplocae 10-30 mass parts, Radix Ardisiae Crenatae 10-30 mass parts, DALUOSAN 10-30 mass parts, Radix araliae armatae 10-30 mass parts, JIULONGCHUAN 5-20 mass parts, Rhizoma Curcumae 5-20 mass parts, five tastes rattan 5-20 mass parts, the red Radix Cudraniae 10-30 mass parts as raw material; (2) by above-mentioned steps (1) Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts mixings are put in the wine vat; (3) add 46 ° of rice wine 1000g; The sealing dipping; Stir once every day, changes into after seven days weekly stirring once.Dipping is more than two months, and supernatant is extracted in (4), the medicinal residues squeezing, and pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.
4. use the medicine for treating traumatic injury production method like technical scheme 3 described outer wipings, it is characterized in that wherein the proportioning of various material compositions is following: Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts.
5. like technical scheme 3 said outer production methods of wiping with medicine for treating traumatic injury; It is characterized in that step (2): Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts mixings are put in the wine vat; (3) add 46 ° of rice wine 1000g; The sealing dipping; Stir once every day, changes into after seven days weekly stirring once.Dipping is more than two months.(4) extract supernatant, the medicinal residues squeezing, pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.
6. like technical scheme 3 or 5 described outer wipings, it is characterized in that step (4) extracts supernatant with medicine for treating traumatic injury and production method thereof, the medicinal residues squeezing, pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.
Beneficial effect of the present invention is following:
(1) to treating various traumatic injury, fast, evident in efficacy and stable effect that soft tissue injury, fracture play reducing swelling and alleviating pain.
(2) these article are the outer medication of wiping, and patient is easy to use.
(3) there is not other untoward reaction.
(4) production technology is simple, and end product quality is stable.
(5) cheap.
The specific embodiment
Enumerate embodiment and clinical practice example below and come further to explain the present invention
1, this preparation pharmacological property principles of formulating prescriptions: pharmacology is that Radix Zanthoxyli bitter in the mouth, suffering, property are flat, slightly poisonous in the side, promoting the circulation of QI to relieve pain, and promoting blood circulation to remove blood stasis, collateral dredging dispels the wind, and is used for traumatic injury, rheumatic arthralgia.The little hardship of Rhizoma Polygoni Cuspidati, be slightly cold.Expelling wind and removing dampness, the dissipating blood stasis analgesic therapy is used for arthralgia, traumatic injury.Rhizoma Ardisiae Gigantifoliae is hot, temperature, wind-damp dispelling, strengthening bone and muscle, blood circulation promoting and blood stasis dispelling.Herba Lycopi's bitter in the mouth, suffering, slightly warm in nature.Blood circulation promoting and blood stasis dispelling, line water detumescence is used for abdominal pain due to blood stasis, edema.Flos Carthami acrid in the mouth, warm in nature, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain is used for traumatic injury.DALUOSAN bitter in the mouth, cold in nature, heat-clearing and toxic substances removing, detumescence and drawing out poison.Be used for rheumatic ostalgia, treating swelling and pain by traumatic injury.Radix Ardisiae Crenatae bitter in the mouth, sweet, hot, warm in nature, promoting blood flow to regulate menstruation, expelling wind and removing dampness is used for rheumatic arthralgia, traumatic injury.The JIULONGCHUAN acrid in the mouth, warm in nature, the function detumescence of dispeling the wind, rheumatic arthralgia, traumatic injury.Five tastes rattan bitter in the mouth, suffering, slightly warm in nature, slightly poisonous, expelling wind and removing dampness, eliminating stasis to stop pain.Be used for rheumatic arthritis, lumbago and skelalgia, wound stasis of blood pain.Rhizoma Curcumae is hot, bitter, warm, the circulation of qi promoting removing blood stasis, and the removing food stagnancy pain relieving is used for purplish or white patches on the skin abdominal mass, blood stasis.Cortex Periplocae acrid in the mouth, hardship, warm in nature, wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening is used for rheumatic arthralgia, and the muscles and bones flaccidity is soft.Red Radix Cudraniae is sweet, and is light, and tepor is enriched blood and dispeled the wind, relaxing muscles and tendons and activating QI and blood in the collateral.Be used for rheumatic arthritis, lumbar muscle strain.All medicine compatibilities gather promoting blood circulation to remove blood stasis altogether, reducing swelling and alleviating pain, the effect of relaxing muscles and tendons and activating QI and blood in the collateral.
2, from the single medicinal material to the compatibility, use, passed through my institute and put into practice for a long time and progressively sum up, thereby confirmed as best component proportion, clinical practice reaches optimum efficiency.It is the principal mode of middle medical drugs that the compatibility of medicine is used, and medicine makes up by certain law, and confirms certain component proportion, processes appropriate dosage forms, also is the higher form that compatibility of drugs is used.
Embodiment 1
Decoction pieces mixings such as Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts are put in the wine vat.Add 46 ° of rice wine 1000g, the sealing dipping, stir once every day, changes into after seven days weekly stirring once.Dipping is more than two months.Extract supernatant, the medicinal residues squeezing, pressed liquor and supernatant merge, and filter (No. 5 sieves) clarification, packing.Promptly get.This batch product is 820ml altogether, total solid: be 2.0%.
Embodiment 2
Taking by weighing decoction pieces mixings such as recipe quantity Radix Zanthoxyli 10 mass parts, Rhizoma Polygoni Cuspidati 10 mass parts, Herba Lycopi's 5 mass parts, Flos Carthami 5 mass parts, Rhizoma Ardisiae Gigantifoliae 10 mass parts, Cortex Periplocae 10 mass parts, Radix Ardisiae Crenatae 10 mass parts, DALUOSAN 10 mass parts, Radix araliae armatae 10 mass parts, JIULONGCHUAN 5 mass parts, Rhizoma Curcumae 5 mass parts, five tastes rattan 5 mass parts, red Radix Cudraniae 10 mass parts puts in the wine vat.(3) add 46 ° of rice wine 1000g, the sealing dipping, stir once every day, changes into after seven days weekly stirring once.Dipping is more than two months.(4) extract supernatant, the medicinal residues squeezing, pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.This batch product is 890ml altogether, total solid: be 1.95%.
Embodiment 3
Decoction pieces mixings such as Radix Zanthoxyli 30 mass parts, Rhizoma Polygoni Cuspidati 30 mass parts, Herba Lycopi's 20 mass parts, Flos Carthami 20 mass parts, Rhizoma Ardisiae Gigantifoliae 30 mass parts, Cortex Periplocae 30 mass parts, Radix Ardisiae Crenatae 30 mass parts, DALUOSAN 30 mass parts, Radix araliae armatae 30 mass parts, JIULONGCHUAN 20 mass parts, Rhizoma Curcumae, five tastes rattan 20 mass parts, red Radix Cudraniae 30 mass parts are put in the wine vat.(3) add 46 ° of rice wine 1000g, the sealing dipping, stir once every day, changes into after seven days weekly stirring once.Dipping is more than two months.(4) extract supernatant, the medicinal residues squeezing, pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.This batch product is 650ml altogether, total solid: be 2.2%
Clinical instance
2,4,6 three lesiones of in-patient department of the inventor location city-level hospitals of traditional Chinese and western medicine (Yulin City of Guangxi Zhuang Autonomous orthopaedics hospital) use medicated wine of the present invention that 100 routine closed injurys are suffered from and have carried out hospitalization and clinical observation record.
In this group patient 100 examples, male's 70 examples, women's 30 examples are the age in the 22-55 adult patients in year.The course of disease is for hindering the back 1-3 days.
This is organized 100 routine patients and uses medicated wine of the present invention, and the affected part is applied in outer wiping of medicated wine or wet absorbent cotton, every day 2 times, uses continuously 7-15 days.
Undertaken by People's Republic of China's pharmaceuticals industry standard " disease of tcm diagnosis criterion of therapeutical effect " when during treating, carrying out clinical observation.All itemized record are on record for symptoms, sign, lab testing result, adverse effect etc.Observe to this course of treatment always and finish.
After being admitted to hospital, all observation case fracture patients all make routine blood test, routine urinalysis, fecal occult blood, liver function, renal function, Electrocardioscopy and X line fluoroscopic examination.
Curative effect judging standard:
1. cure: hinder limb local stasis of blood, swelling, tenderness and disappear basically, pain disappears basically.
2. take a turn for the better: hinder limb local stasis of blood, swelling, tenderness and partly disappear, pain alleviates to some extent.
3. do not heal: hinder limb local stasis of blood, swelling, tenderness and do not see and disappear, pain is not seen and is alleviated.
Therapeutic outcome: suffer from whole 100 routine closed injurys, wipe or the deposited affected part of wet absorbent cotton, every day 2 times, used continuously 7-15 days by above-mentioned usage and dosage is outer.The patient hinders limb local stasis of blood, swelling, disappears basically, and pain disappears basically, cures to account for 89%; Hinder that limb local stasis of blood, swelling, tenderness partly disappear, pain alleviates to some extent, take a turn for the better and account for 11%.
Can find out that from above-mentioned experimental result medicated wine of the present invention suffers from curative effect preferably to closed injury, the clinical effect that has obtained satisfaction.

Claims (6)

1. outer a wiping used medicine for treating traumatic injury, it is characterized in that wherein the proportioning of various material compositions is following: Radix Zanthoxyli 10-30 mass parts, Rhizoma Polygoni Cuspidati 10-30 mass parts, Herba Lycopi 5-20 mass parts, Flos Carthami 5-20 mass parts, Rhizoma Ardisiae Gigantifoliae 10-30 mass parts, Cortex Periplocae 10-30 mass parts, Radix Ardisiae Crenatae 10-30 mass parts, DALUOSAN 10-30 mass parts, Radix araliae armatae 10-30 mass parts, JIULONGCHUAN 5-20 mass parts, Rhizoma Curcumae 5-20 mass parts, five tastes rattan 5-20 mass parts, red Radix Cudraniae 10-30 mass parts.
2. use medicine for treating traumatic injury according to described outer wiping of claim 1, it is characterized in that wherein the proportioning of various material compositions is following: Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts.
3. a wiping outward is with the production method of medicine for treating traumatic injury; It is characterized in that this method comprises following step: (1) is ready to Radix Zanthoxyli 10-30 mass parts, Rhizoma Polygoni Cuspidati 10-30 mass parts, Herba Lycopi 5-20 mass parts, Flos Carthami 5-20 mass parts, Rhizoma Ardisiae Gigantifoliae 10-30 mass parts, Cortex Periplocae 10-30 mass parts, Radix Ardisiae Crenatae 10-30 mass parts, DALUOSAN 10-30 mass parts, Radix araliae armatae 10-30 mass parts, JIULONGCHUAN 5-20 mass parts, Rhizoma Curcumae 5-20 mass parts, five tastes rattan 5-20 mass parts, the red Radix Cudraniae 10-30 mass parts as raw material; (2) by above-mentioned steps (1) Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts mixings are put in the wine vat; (3) add 46 ° of rice wine 1000g; The sealing dipping; Stir once every day; Change into after seven days weekly and stirring once, dipping is more than two months, and supernatant is extracted in (4); The medicinal residues squeezing; Pressed liquor and supernatant merge, and the 80 order filtrations of No. 5 sieves, clarification, packing promptly get.
4. according to the described outer production method of wiping of claim 3, it is characterized in that wherein the proportioning of various material compositions is following: Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts with medicine for treating traumatic injury.
5. according to the described outer production method of wiping of claim 3 with medicine for treating traumatic injury; It is characterized in that step (2): Radix Zanthoxyli 16 mass parts, Rhizoma Polygoni Cuspidati 16 mass parts, Herba Lycopi's 10 mass parts, Flos Carthami 7 mass parts, Rhizoma Ardisiae Gigantifoliae 16 mass parts, Cortex Periplocae 16 mass parts, Radix Ardisiae Crenatae 16 mass parts, DALUOSAN 16 mass parts, Radix araliae armatae 16 mass parts, JIULONGCHUAN 10 mass parts, Rhizoma Curcumae 10 mass parts, five tastes rattan 10 mass parts, red Radix Cudraniae 16 mass parts mixings are put in the wine vat, and (3) add 46 ° of rice wine 1000g, the sealing dipping; Stir once every day; Change into after seven days weekly and stirring once, dipping is more than two months, and supernatant is extracted in (4); The medicinal residues squeezing; Pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.
6. according to claim 3 or 5 described outer production methods of wiping, it is characterized in that step (4) extracts supernatant with medicine for treating traumatic injury, the medicinal residues squeezing, pressed liquor and supernatant merge, and through the 80 order filtrations of No. 5 sieves, clarification, packing, promptly get.
CN201210024791.2A 2012-02-06 2012-02-06 Traumatic injury curative for external use and production method thereof Expired - Fee Related CN102552812B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104435279A (en) * 2014-11-19 2015-03-25 唐建雄 Medicine for treating bone fractures and injuries from falls and preparation method of medicine
CN106581251A (en) * 2016-10-27 2017-04-26 金秀瑶族自治县瑶医医院 Traumatic injury treating Yao medicine external application medicinal wine and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104435279A (en) * 2014-11-19 2015-03-25 唐建雄 Medicine for treating bone fractures and injuries from falls and preparation method of medicine
CN106581251A (en) * 2016-10-27 2017-04-26 金秀瑶族自治县瑶医医院 Traumatic injury treating Yao medicine external application medicinal wine and preparation method thereof

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