CN107050136A - Treat the nanometer emulsifiable paste of neurodermatitis - Google Patents

Treat the nanometer emulsifiable paste of neurodermatitis Download PDF

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Publication number
CN107050136A
CN107050136A CN201710165346.0A CN201710165346A CN107050136A CN 107050136 A CN107050136 A CN 107050136A CN 201710165346 A CN201710165346 A CN 201710165346A CN 107050136 A CN107050136 A CN 107050136A
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CN
China
Prior art keywords
neurodermatitis
emulsifiable paste
skin
nanometer
clever
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CN201710165346.0A
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Chinese (zh)
Inventor
成钢
成进学
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Nantong Snakes Treating Institute
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Nantong Snakes Treating Institute
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Priority to CN201710165346.0A priority Critical patent/CN107050136A/en
Publication of CN107050136A publication Critical patent/CN107050136A/en
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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Abstract

It is to belong to fine chemistry industry miscellaneous goods emulsifiable paste configuration production technical field the invention discloses a kind of clever nanometer emulsifiable paste of refreshing skin.Neurodermatitis class nanometer emulsifiable paste and frutus cnidii favus skin are controlled by the scorpio snake oil, zaocys dhumnade brevicaude pit viper gall, fruit of summer cypress frutus cnidii controls neurodermatitis, eczema, pruritus vulvue, psoriasic externally-applied liniment, and capsule nanometer emulsifiable paste, yellow lead golden cypress control the emulsifiable paste composition of neurodermatitis stubborn dermatitis.Neurodermatitis is the common property pruritus dermatopathy for clinically becoming violent itch with skin lichen, and general treatment is difficult recovery from illness, and the present invention empirically substantially uses superfine nanometer pulverization technology in traditional clinical, makes Traditional Chinese medicine permeation power.The big drug effect of active area is stronger, more extensively, and bioavilability and clinical efficacy to the next breakthrough progress of Chinese medicine clinic and reach unexpected result to the treatment of neurodermatitis.

Description

Treat the nanometer emulsifiable paste of neurodermatitis
Technical field：
It is to belong to fine chemistry industry miscellaneous goods nanometer emulsifiable paste to prepare production skill the invention discloses a kind of clever nanometer emulsifiable paste of refreshing skin Art field.
Background technology：
The clever nanometer emulsifiable paste of refreshing skin is special for treating neurodermatitis through modernizing high-tech nano powder crushing colloidal grinding The nanometer emulsifiable paste that emulsifying is made.
Neurodermatitis is also known as chronic simple lichen, be it is a kind of with skin lichenification and violent itch be characterized it is normal See chronic pruritus dermatopathy.The cause of disease still not it is clear that but have obvious relation with psychoneural factor more, as spirit is overexcited Or worried, undue sadness etc..Clinic is mainly shown as violent itch, after scratching can secondary pachyderma, sulci of skin deepen form tongue Moss change etc..Clinic has point of limitation and general hair, using limitation to be common.
Doctor trained in Western medicine mainly takes whole body therapeutic, local treatment and physical treatment etc..The traditional Chinese medical science is referred to as " neurodermatitis " or " ox-hide Tinea ".It is many accumulate resistance, liver depression forming fire, deficiency of blood literary excellence etc. because of rheumatism caused by, treatment also many combinations of inner and outside, curative effect is preferable.
The content of the invention：
It is an object of the invention to provide a kind of clever nanometer emulsifiable paste of refreshing skin.
The present invention technical solution be.
1st, the clever nanometer emulsifiable paste of a kind of refreshing skin, it is characterized in that：The scorpio snake oil controls neurodermatitis, matches somebody with somebody by following mass parts Than composition %
Preparation method：
Above-mentioned material is ground into addition to vaseline Moschus to 60 mesh coarse powder jointly plus 8 times of water is made suspension, then with equal Matter mulser is uniformly refined, and the Chinese medicine nanometer that particle diameter is made at 0.1-2 μm is handled with Nano Particle Ultrafine device Particle diameter small molecule, can enter blood through skin, pore, sweat pore quickly, improve and strengthen the bioavilability and clinic of medicine Curative effect, breakthrough unexpected effect is brought to Chinese medicine clinic.Nanometer particle size yardstick Chinese medicine nano powder addition vaseline is added Temperature stirs to be eventually adding Moschus powder and be eventually adding Moschus powder and be continuously stirring to cold be made to 60 DEG C controls neurodermatitis Nanometer emulsifiable paste.
Application method：Ointment is applied to above gauze a little, affected part is spread on and properly wraps up, one time a day, or 2~3 days change 1 time.Such as medication excessively, it is local easily to form bleb reaction, during treatment, the pungent irritable food of fasting.
Adapt to illness：Neurodermatitis.
Clinical efficacy：32 are treated altogether, are cured.
Experience and cognition：Sulphur iodine detoxifies desinsection, and antipruritic eliminating dampness coordinates arsenolite corrosion to attack poison, and priming reaches table, scorpio, great burdock achene, Cicada slough dispelling wind dissipating bind, dredging collateral relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and assistant is with pseudo-ginseng, Moschus promoting blood circulation to remove blood stasis, and priming infiltration is stagnant in promoting circulation of blood.This product has eliminating dampness to dissipate It is cold, promoting blood circulation and detoxication it, though toxic, clinical practice, any adverse reaction is not found.
2nd, the clever nanometer emulsifiable paste of a kind of refreshing skin, it is characterized in that：The frutus cnidii favus skin controls neurodermatitis, by following masses Part proportioning composition %
Preparation method：
Above-mentioned material is in addition to yellow wax rosin snake oil, the remaining nano powder that 0.1-2 μm of particle diameter is made of nanometer pulverization technology, will Pallas pit viper oil is boiled from fire and then adds yellow wax, rosin, and produced nanometer mixed powder is added when medicine is cooled to 50 DEG C to be needed quickly Stirring makes nano powder be evenly distributed, cooling bottling packing storage.
Application method：
Perilesional is first applied and mixes a circle vaseline by the used time, and its purpose is to protect surrounding normal skin, then by lesion The clever nanometer emulsifiable paste of the thick refreshing skins of last layer 1-1.5mm is applied, then is used in conjunction once a day 6 days with gauze wrapping, is discontinued 1 day, is within 14 days One course for the treatment of.
We have eliminating dampness Anti-Puritic and insecticidal, influence sleep and worker to have preferable treatment limitation neurodermatitis acute pruritus Effect.
3rd, the clever nanometer emulsifiable paste of a kind of refreshing skin, it is characterized in that：The zaocys dhumnade brevicaude pit viper skin controls neurodermatitis, by following masses Part proportioning composition %
Wherein (1) Nano capsule powder, is constituted by following proportion by weight
Preparation method：
By more than each material extracted with conventional carbon dioxide or with 60% alcohol, with the method extraction of extraction, through film Evaporation, recovered alcohol, and 1: the 1 i.e. every milliliter 1g of crude drug containing source is condensed into, relative density is used for 1.03-1.05 liquid extract.With When by liquid extract be dried in vacuo it is finely ground mixed jointly with unclassified stores, be mixed material nanometer particle size Ultrafine generalization The macromolecular of material is crushed, emulsified by device, homogeneous, scattered, so as to be granulated into the small molecule of Nano Particle, mistake 2000-2600 mesh sieves, medium particle diameter is 0.1-2 μm, because the absorption of medicine is often dominated by drug absorption position dissolution rate, And reduce particle diameter, it is possible to increase in the table specific area of exposure in media as well, and promote dissolving, and then improve the trap and profit of medicine With rate, drug effect and therapeutic effect are increased.Manufactured nano powder is encapsulated.
Usage：Every 0.5g, 1-2 times for each person every day, two every time, it is a course for the treatment of to be used in conjunction two weeks, and a general course for the treatment of is same When applies nanometer emulsifiable paste outside, and to apply the clever nanometer emulsifiable paste of refreshing skin outside daily 2-3 times, there is more preferable effect.
(2) the clever nanometer cream preparation method of refreshing skin is constituted by following proportion by weight
Preparation method：
The above-mentioned finely ground material into nano powder is tuned into the clever nanometer emulsifiable paste of refreshing skin, daily 2-3 times externally painting with vaseline At skin damaged, it is used in conjunction one week, drug withdrawal 3-5 days, then with one week, heals within general 3-5 weeks.
Prescription brief analysis：Earthworm is salty-cold in side relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat-clearing dredging collateral；Zaocys dhumnade property sweet taste is nontoxic, and dispelling wind and removing obstruction in the meridians is antipruritic, interior Internal organs are walked, outer thorough skin can search all skin ailment said due to cold or exposure；Brevicaude pit viper skin can control refractory skin.
Tribulus terrestris dispelling wind and arresting itching, is often used when treating scaling or pruritus dermatopathy；Rabdosia rubescens heat clearing and inflammation relieving；It is raw Ground vapour is thin rich, cool internal heat, moves back blood-head, goes agitation；Radix Angelicae Sinensis, safflower, rhizome of chuanxiong promoting blood circulation by removing wind；Rhizoma atractylodis expelling wind and eliminating dampness；In radix scutellariae Banlangen in baicalein and kuh-seng has very strong anti-allergy action；RADIX POLYGONI MULTIFLORI PREPARATA kidney tonifying enriching yin, strengthens the body resistance to consolidate the constitution；Jiaoshan Hill Short, bristly hair or beard helps digestion and stomach.All medicines share, treats both principal and secondary aspect of disease, that is, goes the wind-heat in table, but it is clear in blood-head, righting enriching yin faces card and still needs root According to state of an illness flexible Application.
Medical record is illustrated：Bavin, female, 30 years old, on April 5th, 2015 went to a doctor.Whole skin itch 5 years, whenever winter-spring season plus Weight, food is not fragrant, can not sleep, agonizing.Once in the ground hospitalize such as Beijing and Shanghai, successively used chlorpheniramine, Astemizole Diphenhydramine, dexamethasone, calcium gluconae, oxygen bitterness and happiness are bright and Chinese medicine etc., produce little effect, or take small effect without lasting.The nearly moon Remaining acute pruritus, neck, fossa cubitalis, popliteal nests portion pachyderma are had the fidgets, and dry receives difference, lies awake all night, general weakness looks into its tongue Sharp red, tongue is few, rapid pulse.It is changed into Sheng in blood-head, is attacked outside by ailment said due to cold or exposure, wind-heat stasis is in fleshy exterior.Control and work as removing pattogenic heat from the blood and toxic material from the body, wind-dispelling stops Itch.Dragons and snakes is given to disappear the Tang Huazai that itches：Each 15g of earthworm, zaocys dhumnade, Radix Angelicae Sinensis, kuh-seng, each 10g of Rabdosia rubescens, tribulus terrestris, the dried rhizome of rehmannia, radix glycyrrhizae, Each 40g of Concha Haliotidis mother-of-pearl, daily 1 dose of (being decocted first), is decocted in water for oral dose, and external application magical effect spirit nanometer emulsifiable paste is applied, and 3 times a day.It is multiple after 3 days Examine：Itch subtracts greatly, and evening can rest a few hours.No more side effects, enters 3 doses again, and neck, four limbs, tail sacrum portion are confined to daytime itch more. Enter 5 doses, the only most of shank of scratch, bloodstain, neck, fossa cubitalis, popliteal nest, tail sacrum portion dry skin, furfur again.Enter alone after 3 doses again Wiped outside the clever nanometer emulsifiable paste of refreshing skin, inform that disease has been cured after 10 days, follow-up no relapse after half a year.
【Plus-minus】If the obvious person of blood-head, rhizoma atractylodis, rhizome of chuanxiong, plus the root bark of tree peony, Asian puccoon are gone；Acute pruritus is with dysphoria and insomnia person, plus Cape jasmine Son, Polygonum multiflower knotweed, mother-of-pearl, Concha Haliotidis；Skin damaged plumpness plus centipede, the red sage root, full worm；The physically weak weak person of course of disease length, plus radix scutellariae, too Son ginseng, sealwort；Skin damaged adds the root of kudzu vine neck；In upper limbs plus river Qiang；In lower limb plus the root of bidentate achyranthes, in external genital plus frutus cnidii.Cure mainly： Neurodermatitis.
4th, the clever nanometer emulsifiable paste of a kind of refreshing skin, it is characterized in that：The fruit of summer cypress frutus cnidii controls neurodermatitis eczema vulva scabies Itch psoriasis, % is constituted by following mass distribution ratio
Wherein (1) applies nano-emulsion tincture and constituted by following mass parts outside
Preparation method：
Above-mentioned Chinese medicine is made nano powder, adds and hydrargyrum chloratum compositum Moschus is added in alcohol.
This product has expelling wind and clearing away heat, detoxifying and relieving itching, promoting blood circulation to remove blood stasis, the function of anti-inflammation.
Indication：Local neurodermatitis.Chronic eczema, pudendal pruritus, prurigo nodularis etc. are also imitated.
Usage：This product is dipped in cotton balls and embrocates affected part, for several times daily.Also it can be added water in right amount, after decocting, soaked while hot with nano powder Steep or smoke and wash affected part, daily 1 dose, every dose can use 2~3 times, each 30min.
Prescription brief analysis：The clearing heat and detoxicating dehumidifying of kuh-seng in side, fruit of summer cypress dispelling wind is antipruritic, frutus cnidii, alum removing dampness and destroying parasites, Chinese prickly ash Warm sun dredging collateral.All medicines, which are closed, decocts hot wash, can dredge train of thought, qi and blood is smooth, receives softening skin damaged, the evil effect for going to itch only.
Plus-minus：Lopseed 60g is added to the stupid thick one of skin damaged；Occurring in YIN part of the body portion person adds smilax 30g；Send out in anus person plus the tuber of stemona 20g。
Medical record is illustrated：Tan, female, 24 years old, workman.First visit on June 5 in 2014.Main suit：Cervical vertebra goes out " psoriasis " 2 years, inspection Look into：See that cervical vertebra rear lateral portion there are about 4cm*3cm Tai Hua areas, pars affecta skin is coarse thickening, and there are scratch, scab in surface.
(2) the clever nanometer emulsifiable paste of the refreshing skin of wind-dispelling removing toxic substances, is constituted by following proportion by weight
Preparation method：
The encapsulated every 0.5g of nano powder that particle diameter is 0.1-2 μm is made in above-mentioned material, with warm water delivery service medication period Between avoid pungent food, the product that pungent rotten, pure wine is rich.
Take above-mentioned Chinese medicine nano powder 20g to add and be configured to 20% nanometer of emulsifiable paste heating stirring with albolene or pallas pit viper oil 80g The clever snake oil nanometer emulsifiable paste of refreshing skin is made to apply outside daily 2-3 times until recovery from illness.
Indication：Psoriasis
Prescription brief analysis：We are helped with Chinese ephedra, almond, windproof, fruit of summer cypress wind dispelling facilitaing lung with Siwu Tang blood-nourishing and battalion and are defended solid Table is clearing heat and detoxicating with kuh-seng, indigo naturalis, tinea skin, golden cypress, centipede, radix glycyrrhizae.Pallas pit viper meat wind dispelling is antipruritic to be moisturized.
Plus-minus：The dry reality of stomach fire, constipation person increase yellow；Coughing with a lot of sputum person adds the tuber of pinellia, melon to wither；Heart-fire hyperactivity person adds courage grass, Cape jasmine Son；The deficiency of blood, which is itched, notably reuses kuh-seng, radix glycyrrhizae, Radix Angelicae Sinensis.
5th, the clever nanometer emulsifiable paste of a kind of refreshing skin, it is characterized in that：The yellow lead golden cypress controls neurodermatitis stubborn dermatitis, by following masses Part proportioning composition %
Preparation method：
Above-mentioned Chinese medicine is ground into impalpable powder homogeneous emulsifying machine superfine nanometer pulverization device, particle diameter is made less than 0.1-2 μm Nano powder, add snake oil and vaseline and be heated up to 85 DEG C and stir, be tuned into a nanometer emulsifiable paste external application.
This product has desinsection antipruritic, eliminating dampness removing toxic substances, with controlling neurodermatitis stubborn dermatitis.
The present invention makes full use of the natural animal and plant medicine of nature on the basis of inheriting tradition treatment by Chinese herbs neurodermatitis On, the clever nanometer emulsifiable paste of refreshing skin for making full use of modern nanometer pharmaceutical technology to be made applies to clinical acquirement better effects.
It is understood that nanometer technology since the advent of the world has been widely used in multiple fields, and achieve breakthrough. Its infiltration on pharmaceutical field is obvious with influence.Research shows that the application of nanometer biotechnology can improve medicine Absorb, change transportation of the medicine in human body, strengthen drug effect.Nano particle can be used as DNA, antineoplastic, protein and many The delivery vehicles of the multi-medicaments such as peptide.In the 21 century being the theme with life science, nanometer technology will enter one with pharmaceutical science Step is combined closely, and promotes developing rapidly for study of pharmacy.
Natural autonomic drug is applied to the treatment of neurodermatitis, is that modern Chinese herbal medicine creams class moves towards nature and avoids chemical drugs Toxic side effect and one kind for using of adverse reaction is outer wipes, applies, applying, washing, drenching, through skin pore sweat gland, capillary infiltration is inhaled Receive the modern Chinese herbal medicine cosmetics development trend for reaching moistening skin beautifying.People know the trap of medicine usually by medicine in absorption portion The domination of position dissolution rate, and the surface area exposed in media as well can be increased and promote dissolving by reducing particle diameter, and then improve medicine The trap of thing；The macromolecular of medicine is granulated into the small molecule of nanoparticle diameter grade, just can by skin pore sweat gland entrance or Tissue space is penetrated, can also be wide into internal and distributed pole by human body most tiny capillary, thus carry significantly The high bioavilability of medicine.Nano medication is smaller due to particle diameter, surface area increase, is improved with the adherence of biomembrane, because This is conducive to increasing the contact area of medicine and skin, extends contact time, so as to be conducive to absorbing, improves external used medicine biological Availability.Therefore the treatment of a variety of refractory skins is applied to natural autonomic drug, it is necessary to walk modern nanosecond science and technology Road for development.
The present invention is further elucidated with reference to examples of implementation：
Specific implementation method：
Embodiment 1：A kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The scorpio snake oil controls neurodermatitis, by following matter Measure part proportioning composition %
Embodiment 2：A kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The frutus cnidii favus skin controls neurodermatitis, presses Row proportion by weight constitutes %
Embodiment 3：A kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The zaocys dhumnade brevicaude pit viper skin controls neurodermatitis, presses Row proportion by weight constitutes %
Wherein (1) Nano capsule powder, is constituted by following proportion by weight
(2) the clever nanometer cream preparation method of refreshing skin is constituted by following proportion by weight
Embodiment 4：A kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The fruit of summer cypress frutus cnidii controls neurodermatitis eczema Pruritus vulvue psoriasis, % is constituted by following mass distribution ratio
Wherein (1) applies nano-emulsion tincture and constituted by following mass parts outside
(2) the clever nanometer emulsifiable paste of the refreshing skin of wind-dispelling removing toxic substances, is constituted by following proportion by weight
Embodiment 5：A kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The yellow lead golden cypress controls neurodermatitis stubborn dermatitis, presses Row proportion by weight constitutes %

Claims (5)

1. a kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The scorpio snake oil controls neurodermatitis, by following proportion by weight group Into %
2. a kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The frutus cnidii favus skin controls neurodermatitis, matches somebody with somebody by following mass parts Than composition %
3. a kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The zaocys dhumnade brevicaude pit viper skin controls neurodermatitis, matches somebody with somebody by following mass parts Than composition %
Wherein (1) Nano capsule powder, is constituted by following proportion by weight
(2) the clever nanometer cream preparation method of refreshing skin is constituted by following proportion by weight
4. a kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The fruit of summer cypress frutus cnidii controls neurodermatitis eczema pruritus vulvue ox Psoriasis, % is constituted by following mass distribution ratio
Wherein (1) applies nano-emulsion tincture and constituted by following mass parts outside
(2) the clever nanometer emulsifiable paste of the refreshing skin of wind-dispelling removing toxic substances, is constituted by following proportion by weight
5. a kind of clever nanometer emulsifiable paste of refreshing skin, it is characterized in that：The yellow lead golden cypress controls neurodermatitis stubborn dermatitis, matches somebody with somebody by following mass parts Than composition %
CN201710165346.0A 2017-03-13 2017-03-13 Treat the nanometer emulsifiable paste of neurodermatitis Withdrawn CN107050136A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108619093A (en) * 2018-04-12 2018-10-09 南通蛇类治疗研究所 Animals and plants nano-emulsion controls the stubborn dermatitis fungal infection of the hand

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906203A (en) * 2015-04-24 2015-09-16 南通蛇类治疗研究所 Tinea manus and pedis treatment painless nano emulsifiable paste
CN105943795A (en) * 2016-06-22 2016-09-21 朱明浩 Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906203A (en) * 2015-04-24 2015-09-16 南通蛇类治疗研究所 Tinea manus and pedis treatment painless nano emulsifiable paste
CN105943795A (en) * 2016-06-22 2016-09-21 朱明浩 Traditional Chinese medicine composition for treating eczema and neurodermatitis, external preparation as well as preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108619093A (en) * 2018-04-12 2018-10-09 南通蛇类治疗研究所 Animals and plants nano-emulsion controls the stubborn dermatitis fungal infection of the hand

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Application publication date: 20170818